Epithelial receptors cell surface. Medical search. Frequent questions

5-HT2C receptors are also found on epithelial cells lining the ventricles. (wikipedia.org)
green) was not found on epithelial surface of small and large intestines but in lamina propria cells. (cdc.gov)
They are found on epithelial, endothelial, mesangial, and glomerular cells of the kidney, as well as microvascular endothelial cells of the brain and intestine. (marlerblog.com)

C ) Probiotic bacteria releases antimicrobial substances (such as bacteriocins, biosurfactants, lactic acid, hydrogen peroxide, nitric oxide, organic acids) and intestinal mucins from mucosal cells, which can effectively inhibit virus proliferation. (news-medical.net)
H ) CD4 + cells differentiate into Th2 cells, which induce B-cells' proliferation that produces antibodies like IgA, IgG, and IgM. (news-medical.net)
CD30 ligation by CD30L mediates pleiotropic effects including cell proliferation, activation, differentiation and cell death by apoptosis. (rndsystems.com)
Extracellular ST6GAL1, present in cancer exosomes or the freely soluble recombinant sialyltransferase, compensates for insufficient intrinsic ST6GAL1 by boosting cancer cell proliferation and increasing invasiveness. (nature.com)
Our data indicate that extracellular ST6GAL1 from remote sources can compensate for cellular ST6GAL1-mediated aggressive tumor cell proliferation and invasive behavior and has great clinical potential for extracellular ST6GAL1 as these molecules are in the extracellular space should be easily accessible targets. (nature.com)
Normally, HGF stimulates proliferation, motility and morphogenesis in a wide spectrum of cell types, contributing to embryonic development and to tissue repair in adulthood. (cancer.gov)
To clarify the mechanism underlying the difference in the cachexia-inducing ability of these cells, we conducted DNA microarray analysis, focusing on cell proliferation and the production of leukemia inhibitory factor (LIF), a cachexia-inducing factor. (oncotarget.com)
Stimulation of both cells with TLR4 (lipopolysaccharide) or TLR5 (flagellin) agonists did not affect proliferation. (oncotarget.com)
FAK seems also to have a role in the proliferation of tumor cells by its biochemical and biological association to cytoplasmic kinases such as src and ERK. (aacrjournals.org)
Treatment of an high proliferative melanoma cell line with the Rock inhibitor Y27632 partially decreased the levels of P-FAKSer732, the cellular proliferation and impaired the mitotic spindle formation. (aacrjournals.org)
We proposed to develop novel, well-defined, synthetic extracellular matrices that support survival and proliferation of human embryonic stem cells. (ca.gov)
Second, using an interdisciplinary approach, we developed a novel method to screen peptides from these proteins for their ability to support adhesion and proliferation of the stem cells. (ca.gov)
Second, using an interdisciplinary approach, we developed novel hydrogels using click chemistry that support adhesion and proliferation of the stem cells. (ca.gov)
Our approach is to first understand how hESC interact with extracellular matrix materials by analyzing candidate adhesive substrate proteins and integrin receptors that mediate attachment, survival, proliferation and differentiation. (ca.gov)
Additionally, moderate proliferation of the fibrous connective tissue and the myoepithelial cells near the proliferating acini was evident. (scielo.br)
As was anticipated, the overexpression of Ntn-4 led to a marked decrease in the proliferation, migration and invasion of NSCLC cells. (bvsalud.org)
Notably, RNA-binding protein quaking 5 (Qki-5) was found to exhibit antitumor activity in lung cancer, not only by enhancing the level of Ntn-4 by binding to Ntn-4 mRNA, but also by suppressing the proliferation, invasion and migration of NSCLC cells. (bvsalud.org)

Cell lysates were then loaded (40 μg/lane) in a 4-12% SDS-PAGE gel to separate proteins and transferred to nitrocellulose membrane. (bio-cavagnou.info)
Megalin is embedded in the membrane of cells that line the surfaces and cavities of the body (epithelial cells). (medlineplus.gov)
The tea extracts and components displayed various degrees of antibacterial activity that may involve damage to the bacterial cell membrane and the chelation of iron. (nature.com)
The tubules are all made of the same water-repellant fatty membrane that surrounds the cell, separating their interior from the watery cytoplasm. (alzforum.org)
There is also traffic in the opposite direction: molecules are transported into the cell from outside, including worn-out or excess receptor and channel proteins from the outside of the cell membrane. (alzforum.org)
Many are taken in by endocytosis, sinking into pits in the membrane that pinch off to form vesicles that drop into the cell, where they are known as early endosomes. (alzforum.org)
It has been reported that various hosts recognize lipopolysaccharides in the cell membrane structure through TLR9 and activate downstream mitogen-activated protein kinase (MAPK) and nuclear transcription factor- κ B (NF- κ B) pathways mediated by MyD88 to promote the MAPK protein phosphorylation, and NF- κ B enters the nucleus, further releasing cellular inflammatory factors [ 12 ]. (hindawi.com)
Although activating mutations of the anaplastic lymphoma kinase (ALK) membrane receptor occur in ∼10% of neuroblastoma (NB) tumors, the role of the wild-type (WT) receptor, which is aberrantly expressed in most non-mutated cases, is unclear. (dana-farber.org)
Rationale: Pattern recognition receptors such as membrane bound Toll-Like Receptors (TLRs) and cytoplasmic Nod-like receptors (NLRs) of surface epithelial cells and antigen presenting cells detect airborne pathogens and activate innate immune response providing the first line of defense against these inflammatory agents. (cdc.gov)
3) After primary infection, EBV spreads directly across the lateral membrane to adjacent epithelial cells. (selfgrowth.com)
This is associated with an epithelium and basement membrane, which interact with the preskeletal cells, causing them to undergo condensation. (edu.au)
One attractive target, within viral cell entry, is the binding of the viral spike protein to the surface receptor ACE2 , a host cell membrane protease . (tocris.com)
However, they have a unique cell membrane that contains sterols, which are not present in either bacteria or viruses. (medscape.com)
They have sterols in the cell membrane. (medscape.com)

Receptor proteins have specific sites into which certain other proteins, called ligands, fit like keys into locks. (medlineplus.gov)
The green and black tea extracts, EGCG, and theaflavins decreased the adherence of F. nucleatum to oral epithelial cells and matrix proteins. (nature.com)
At the Ipsen Foundation's 23rd Colloquium on Alzheimer's Disease, held 28 April 2008 in Paris, the focus shifted from the rogue proteins that characterize these diseases to the regulation of their movements around the cell. (alzforum.org)
The details of how proteins are moved around within a cell are being deciphered with high-powered microscopy combined with sophisticated techniques for labeling individual molecules, including fluorescent or "quantum dot" tags and antibodies tailored to adhere to a protein in a particular state of activation. (alzforum.org)
The interaction of LF with microbial surfaces-OMPs of Gram-negative bacteria in particular-has led to other antimicrobial mechanisms, such as the inhibition of microbial attachment to sub-epithelial matrix proteins and detachment of bacteria from mucosal surfaces. (ift.org)
1. The cell biology of MHC class I-restricted antigen processing and presentation: My laboratory continues to explore the forces that drive the extremely rapid MHC class I-restricted presentation of both cytosolic and endoplasmic reticulum-targeted proteins, and how differential processing could impact both the induction and effector phases of CD8+ T cell responses. (upenn.edu)
2. The cell biology of MHC class II-restricted antigen processing and presentation: A generally accepted paradigm in fundamental immunology is that CD4+ T cells recognize peptides derived from exogenous (internalized) sources of antigen while CD8+ recognize peptides derived from endogenous sources of antigen (generally, proteins synthesized within the antigen-presenting cell). (upenn.edu)
These viral proteins are expressed on the surface of both epithelial and blood mononuclear cells. (hhv-6foundation.org)
Thus, if the viruses infected thyroid cells, these viral proteins could be recognized and attacked by the immune response, injuring the thyroid cells. (hhv-6foundation.org)
First, we characterized the cell surface receptors for matrix proteins on stem cells and identified specific proteins that will support adhesion and growth of the cells. (ca.gov)
Based on our characterization of cell surface receptors for matrix proteins on stem cells completed in the first year, we went on to test specific, purified proteins that will support adhesion and growth of the cells. (ca.gov)
The Toll-like receptor (TLR) family in mammals comprises a set of transmembrane proteins characterized by multiple copies of leucine rich repeats in the extracellular domain, and in the IL-1 receptor motif in the cytoplasmic domain. (novusbio.com)
NTHi utilizes a variety of proteins to adhere to and colonize the surface of epithelial cells, which is crucial for its invasion. (lu.se)
We have obtained some preliminary data that suggest a group of NTHi surface proteins are capable of binding to CRL. (lu.se)
Currently, our focus is to determine whether the interaction between NTHi surface proteins and CRL can trigger an immune response, as this information will be valuable in identifying potential vaccine candidates. (lu.se)
In addition to these autoantibodies, patients with thymoma-associated MG produce autoantibodies to various neuromuscular antigens, including antibodies to the skeletal muscle calcium release channel (ryanodine receptor of sarcoplasmic reticulum) and antibodies to cytoplasmic filamentous proteins (particularly titin) or neurofilaments. (medscape.com)

In the nasopharynx, the bacteria multiply, bind to specific receptors, and are taken up by epithelial cells, which transport the meningococci across the mucosal epithelium. (cdc.gov)
Asthma results from complex interactions among inflammatory cells, their mediators, airway epithelium and smooth muscle, and the nervous system. (medscape.com)

The online database brings together data on all the known somatic mutations (tumor derived - tumor specific) in a molecule called epithelial growth factor receptor (EGFR). (eurekalert.org)
So we worked on the assumption that a comprehensive list of all somatic EGFR mutations coupled with data on the response of non-small-cell lung cancers treated with tyrosine kinase inhibitors (TKIs) would help clinicians determine whether a specific mutation was likely to correlate with clinical benefit. (eurekalert.org)
The family of tyrosine-kinase receptors, including those for epithelial growth factor (EGFR) and the transporter for the neurotransmitter dopamine (DAT), are regulated in this way. (alzforum.org)

Boston) - Researchers from the Boston University School of Medicine (BUSM) have demonstrated that commensal species of the genus Neisseriae are low inducers of human airway epithelial cell responses as compared to the pathogenic species. (scienceblog.com)
Thus cells exposed to T1 LPS is expected to produce more fluorescence than that exposed to PM1 indicating that later cause less airway inflammation. (cdc.gov)
Recent studies have shown that CRL can recognize NTHi and enhance the proinflammatory response against this pathogen in human airway epithelial cells. (lu.se)
http://dx.doi.org/10.1016/j.jaci.2014.02.015 epithelial cells and airway smooth muscle cells. (cdc.gov)
For these short fibers, which can be fully engulfed by lung cells and do not dissolve in airway fluids in less than a few weeks, their clearance will be similar to other mineral and vitreous particles. (cdc.gov)

Results from immunohistochemical testing with antibodies to factor XIIIa, which label dermal dendritic cells, are frequently positive in dermatofibroma, while antibodies to MAC 387, which label monocyte-derived macrophages (histiocytes), show less consistent results. (medscape.com)
Factor XIIIa-positive dendritic cells also are present, but the presence of CD68-positive histiocytes was inconsistent, especially between histologic variants. (medscape.com)
E ) Upon virus attack in epithelial cells, probiotics mediate their antiviral effects by eliciting immune responses by activating macrophages and dendritic cells. (news-medical.net)
Dendritic cells-based therapeutic approach may be a potential strategy for SARS-CoV-2 infection. (medsci.org)
Basis of treatment based dendritic cells to combat coronavirus infections is summarized. (medsci.org)
The CD8 α/α homodimer is expressed on a subset of γ/δ TCR-bearing T cells, NK cells, intestinal intraepithelial lymphocytes, and lymphoid dendritic cells. (biolegend.com)
Dendritic cells and macrophages found in large quantities at the corticomedullary junction arise from mesodermal tissues (bone marrow). (medscape.com)
The lymphocytes' selection process and developmental progression are influenced by direct contact between the TCR-CD3 complex on the thymocyte and the major histocompatibility complex (MHC)-antigen complex on thymic epithelial cells, dendritic cells, and B lymphocytes. (medscape.com)

Epithelial cells along human gastrointestinal mucosal surface express pathogen-recognizing receptors and actively participate in the regulation of inflammatory reactions in response to microbial infection. (bio-cavagnou.info)
Meningococci are Gram-negative, aerobic diplococci that can attach to the surface of mucosal cells of the nasopharynx. (cdc.gov)
Furthermore, the immobilization of LF to mucosal surfaces containing sulfated glycans such as heparan sulfate or its closely related analogs, including galactose-rich polysaccharide (a water-soluble fraction from agar) and carrageenans, were found to enhance the antimicrobial spectrum of LF multi-fold. (ift.org)
Oral mucosal epithelial cells are the first threshold for their invasive host cells. (selfgrowth.com)
Elevated levels of anti-EBV-specific antigen IgA were found in mucosal secretions of NPC patients, and this EBV-IgA-SC-mediated endocytosis may represent a physiological pathway for EBV to invade nasopharyngeal epithelial cells in vivo. (selfgrowth.com)

This is followed by polymorphonuclear neutrophil (PMN) recruitment, adhesion to vascular endothelial cells, diapedesis (or transmigration), and accumulation or swarming. (frontiersin.org)
ACE2 is highly expressed on epithelial and endothelial cells particularly in the lungs and gastrointestinal tract. (tocris.com)
Previous studies in neural and endothelial cells (EC) have shown a new role for FAK in the regulation of centrosome functions during mitosis dependent on Ser732 phosphorylation. (aacrjournals.org)
In addition to their expression in neurons, Neuropilin 1 (NRP1) is expressed in epithelial cells and endothelial cells, while Neuropilin 2 (NRP2) is expressed in endothelial cells (both vascular and lymphatic) and visceral smooth muscle cells. (navbo.org)
David's project focuses on the structure and function of neuropilin 2 isoforms in endothelial cells and smooth muscle cells. (navbo.org)
She established a pro-tumorigenic role for NRP2 in human breast cancer cells and a pro-angiogenic role for NRP2 in breast tumor endothelial cells. (navbo.org)

Dr. Bottaro's research on the role of epithelial growth factors in the onset and progression of solid tumors began with the discovery of the cell surface receptors for keratinocyte growth factor (KGF) and hepatocyte growth factor (HGF). (cancer.gov)
Its ELAHERE (Mirvetuximab Soravtansine) is a first-in-class ADC targeting folate receptor alpha (FRa), a cell-surface protein over-expressed in a number of epithelial tumors, including ovarian, endometrial, and non-small-cell lung cancers. (stockhouse.com)
At present, tumors related to EBV infections include epithelial tumors such as nasopharyngealcarcinoma(NPC), gastric carcinoma (GC), lymphatic hematopoietic malignant tumors such as Hodgkin's Lymphoma (HL) and Non-Hodgkin Lymphoma (NHL), BL, pyropogy-related lymphoma (PAL) and NK/T cell lymphoma and other rare tumors (such as EBV-related smooth fibroids, neuromuscular endocrine cancer). (selfgrowth.com)
NK cells, CD8+ T cells, and γδ T cells observed in EBV-associated T/NK lymphocyte tumors are typical of EBV-infected cells and belong to the type of killer cells that attempt to kill EBV-infected B cells or epithelial cells. (selfgrowth.com)
The finding of a novel role for FAK in tumor cells might provide the underpinning for therapeutic strategies in selected solid tumors. (aacrjournals.org)
This definition excludes other tumors that may affect the thymus, such as lymphoma and germ cell tumors. (medscape.com)

CD8 is an antigen co-receptor on T cells that interacts with MHC class I on antigen-presenting cells or epithelial cells. (biolegend.com)

The signaling pathways involved in initiating the EMT seem to primarily involve the Smad-dependent pathway, whereby TGFbeta binding to specific high affinity cell surface receptors activates the receptor-Smad/Smad4 complex. (nih.gov)
Increasing attention is now being directed at the network of signaling pathways that effect the EMT in lens epithelial cells, with the aim of identifying potential therapeutic targets to inhibit cataract, particularly PCO, which remains a significant clinical problem in ophthalmology. (nih.gov)
We have found that a variety of endogenous processing pathways are the major drivers of the primary CD4+ T cell response to influenza and also rabies. (upenn.edu)
These signaling pathways, and the roles of heparan sulfate proteoglycans as KGF and HGF co-receptors, became his primary research interests after becoming an NCI Principal Investigator in 1994. (cancer.gov)
Pathogen-associated molecular patterns, such as lipopolysaccharide (LPS) in bacterial cell walls and bacterial flagella, acts as ligands to trigger for downstream pathways that release inflammatory mediators such as TNF-alpha and interleukins (IL1B, IL2, IL6 and IL18). (cdc.gov)
Whereas the mechanisms activating mechanotransduction are well studied, the reversibility of this process, whereby cells disassemble and reverse force-activated signalling pathways upon cessation of mechanical stimulation is far less understood. (ibecbarcelona.eu)
The term "oncotarget" encompasses all molecules, pathways, cellular functions, cell types, and even tissues that can be viewed as targets relevant to cancer as well as other diseases. (oncotarget.com)
Neuropilins are interesting receptors in that they can bind to multiple ligands with disparate signaling pathways and elicite a broad spectrum of responses. (navbo.org)
Most significantly enriched pathways include cardiac hypertrophy signaling, B-cell receptor signaling, and netrin signaling. (bvsalud.org)

The discovery of germline mutations in the hepatocyte growth factor (HGF) receptor, Met, that predispose affected individuals to papillary renal cell carcinoma (HPRC) type 1, significantly strengthened mounting evidence of the oncogenic potential of this signaling pathway. (cancer.gov)
Leukemia inhibitory factor via the Toll-like receptor 5 signaling pathway involves aggravation of cachexia induced by human gastric cancer-derived 85As2. (oncotarget.com)
However, in 82As2 cells, LIF production was significantly increased by stimulation with TLR5, which was suppressed by an inhibitor of interleukin-1 receptor-associated kinase-1/4, which are important factors in the TLR5 signaling pathway. (oncotarget.com)
The increase in LIF production resulting from activation of the TLR5 signaling pathway may contribute to the cachexia-inducing ability of 85As2 cells. (oncotarget.com)

G ) CD4 + T lymphocytes cells differentiate into Th1, which activates phagocytosis through NK cells and macrophages, promoting pathogen killing. (news-medical.net)
One such input is mechanical force, which activates signalling and regulates cell behaviour in the process of mechanotransduction. (ibecbarcelona.eu)
ATP activates P2X receptors in the apical surface of kidney epithelial cells. (ucl.ac.uk)

Adhesion molecules, epithelial cell surface receptors and extracellular matrix molecules initiate condensation and set its boundaries. (edu.au)
FAK is identified as a key mediator of signaling by integrins, the major family of cell surface receptors for extracellular matrix, as well as by other receptors in both normal and cancer cells. (aacrjournals.org)

Prompt commencement of an inflammatory response is accomplished with the help of unique and conserved PRRs present on the surface of myeloid cells, lung epithelial cells, and lymphoid tissue. (hindawi.com)
Studies have shown that both primitive T lymphocytes and lymphoid progenitor cells can express CD21, and EBV can also infect primitive T cells and lymphoid progenitor cells by attaching to T lymphocytes through CD21. (selfgrowth.com)
1. To be able to describe the role of innate lymphoid cells (ILCs) in Date of Original Release: April 2014. (cdc.gov)
CRTH2: Chemoattractant receptor-homologous molecule expressed includes nonallergic asthma phenotypes, such as asthma on TH2 cells associated with exposure to air pollution, infection, or obesity, ILC: Innate lymphoid cell that require innate rather than adaptive immunity. (cdc.gov)
NKT: Natural killer T innate lymphoid cells and their role in asthma. (cdc.gov)
The term lymphoepithelioma has been used in cases in which the thymoma contains a large number of lymphoid cells. (medscape.com)
From the corticomedullary junction, the cells enter the medulla or circulate in the periphery to other lymphoid structures (ie, lymph nodes). (medscape.com)

Viral glycoproteins including gp350, gHgL, gB and gp42 mediate the preferential binding of EBV to B cells by interacting with the complement receptor CR2 (CD21) on the surface of B cells, and then the envelope glycoprotein gp42 and gp85/gp25 form a fusion protein triple molecule Complex. (selfgrowth.com)
The anti-EBV antigen polymer IgA can mediate the invasion of EBV into pharyngeal epithelial cells through endocytosis, and EBV bound to IgA can invade pharyngeal epithelial cells through endocytosis mediated by secretory corpuscle (SC). (selfgrowth.com)

Following attachment, mycoplasmal organisms may cause direct cytotoxic damage to epithelial cells because of hydrogen peroxide generation or cytolysis via an inflammatory response mediated by mononuclear cells or antigen-antibody reactions. (medscape.com)

In epithelial cells miR-200a suppresses SIRT1 expression and subsequently SB225002 regulates epithelial to mesenchymal transition-like transformation [18]. (bio-cavagnou.info)
Current interest in this process, which is described as an epithelial-mesenchymal transition (EMT), stems from its developmental importance and its involvement in several adult pathologies. (rupress.org)
In a recent study published in Cell, first author, Hao Huang, PhD, and senior author, Rani George, MD, PhD , show that extracellular domain (ECD) cleavage of the ALK cell surface tyrosine kinase receptor mediates neuroblastoma cell migration through induction of an epithelial-to-mesenchymal transition (EMT) gene signature. (dana-farber.org)
FAK plays a prominent role in tumor progression and metastasis regulating cellular processes including migration, invasion, epithelial to mesenchymal transition, and angiogenesis. (aacrjournals.org)

A Toll-like receptor (TLR) is a transmembrane protein encoded by the Toll gene, which is one of cell transmembrane receptors and pathogen pattern recognition receptors (PRRs) in the innate immune system [ 9 ]. (hindawi.com)
related to other transmembrane receptors. (who.int)

The EMT International Association was formed in 2002 to provide an international body for those interested in EMT and the reverse process, mesenchymal-epithelial transition, and, most importantly, to bring together those working on EMT in development, cancer, fibrosis, and pathology. (rupress.org)
2.5 µm in diameter (PM2.5) consists mainly of combustion-derived carbonaceous particles (fine and ultrafine sizes) with organic compounds and transition metals adsorbed on the surfaces (Stoeger et al. (who.int)

Our study shows that Jurkat human T cells have a molecule that reacts with both anti-CR2 antibodies and the third component of complement, C3. (nih.gov)
Immunoprecipitation experiments with anti-CR2 antibodies and SDS-PAGE analysis reveal a protein with an apparent molecular mass of 155 kDa which is higher than the one seen in B cells. (nih.gov)
Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. (abcam.com)
When fluorochrome conjugated antibodies are bound to BD® CompBeads, they have spectral properties very similar to cells. (bdbiosciences.com)
Inhibition of cell/substrate adhesion with specific anti-integrin antibodies demonstrated that P-FAKSer732 activation is not induced by integrin clustering. (aacrjournals.org)
This study provides some evidence that one mechanism by which infection of thyroid tissue by HHV-6A/B could provoke an immune response that damages thyroid tissue: viral epitopes displayed on the surface of thyroid cells could be the target of tissue-damaging antibodies. (hhv-6foundation.org)
EF-Tu From Non-typeable Haemophilus influenzae Is an Immunogenic Surface-Exposed Protein Targeted by Bactericidal Antibodies. (lu.se)

The C-Type Lectin receptor (CRL) is known as the major β-glucan receptor expressed in myeloid cells and is responsible for targeting respiratory fungal pathogens. (lu.se)

Later work helped define the structural basis of growth factor-receptor interaction and the role of heparan sulfate proteoglycans as co-receptors. (cancer.gov)

A ) Probiotic bacteria can hinder the adsorption process via directly binding to the virus and inhibiting entry into epithelial cells. (news-medical.net)
B ) Binding of probiotic bacteria to the epithelial surface can cause steric hindrance and block the virus's attachment to the host cell receptor. (news-medical.net)
Activated lactoferrin (ALF) is a new form of a naturally occurring protein from milk that acts as a powerful deterrent to pathogenic bacteria that may be present on a meat surface. (ift.org)
As the droplets are sneezed out, they carry the infectious bacteria and land on any surface they find. (wonderopolis.org)
The bacteria rapidly multiply in the gut, causing inflammation and diarrhea (colitis) as they tightly bind to cells that line the large intestine. (marlerblog.com)
Mycoplasma species have also been mistakenly believed to be L-forms of bacteria, which also lack cell walls. (medscape.com)
Unlike mycoplasmal organisms, L-form bacteria do not have sterols in the cell membranes, and they can revert to their walled parental forms. (medscape.com)

Mucin-4 may play a role in regulating cellular adhesion and in cell surface signaling from the ERBB-2 RECEPTOR PROTEIN-TYROSINE KINASE. (bvsalud.org)
Little is known about molecular mecha- desmosomal glycoproteins, resulting in the nisms affecting mast cell and T lympho- loss of keratinocyte cell-cell adhesion [ 1 ]. (who.int)

which means both copies of the gene in each cell have mutations. (medlineplus.gov)
Somatic mutations in this cell-surface molecule are known to affect treatment with the newer tyrosine kinase inhibitor class of drugs. (eurekalert.org)
Cancer cell-extrinsic mechanisms, which are poorly understood, are also believed to contribute to disease progression and the heterogeneous genetic mutations with diverse presentations. (nature.com)
Following the discovery of oncogenic HGF receptor mutations in kidney cancer, Dr. Bottaro joined the NCI's Urologic Oncology Branch (UOB) in 2003 to study growth factor signaling in urological malignancies and support diagnostic and therapeutic development as Head of the Molecular Therapeutics Facility. (cancer.gov)

PRRs comprise TLRs, RIG-I-like receptors (RLRs), and NOD-like receptors (NLRs). (hindawi.com)

Thus our data suggest that regulates SIRT1 expression in human biliary epithelial cells in response to microbial challenge suggesting a new role of in the regulation of NF-κB-mediated epithelial innate immune response. (bio-cavagnou.info)

It is a G protein-coupled receptor (GPCR) that is coupled to Gq/G11 and mediates excitatory neurotransmission. (wikipedia.org)

[ 4 ] CD14 + monocytes have been proposed as the cell of origin of dermatofibromas. (medscape.com)
CD30L is expressed on the cell surface of activated T cells, B cells, and monocytes. (rndsystems.com)
DDR1 is expressed on epithelial tissues, activated monocytes and neutrophils, and in several cancers. (rndsystems.com)
CD14+ monocytes expressed the highest level of TLR2 followed by CD15+ granulocytes, and CD19+ B-cells, CD3+ T-cells, and CD56+ NK cells did not express TLR2. (novusbio.com)

Intestinal distribution of influenza virus receptors and in vitro binding of inactivated seasonal influenza A (H1N1) and A (H3N2) viruses to human duodenal and colonic tissues. (cdc.gov)
The epithelial cells and these other stromal tissues of the thymus influence the selection and maturation of the T lymphocytes. (medscape.com)

Studies have shown that EBV-infected T/NK lymphocytes often express cytotoxic molecules, such as perforin, granzyme B, and T cell intracytoplasmic antigen (TIA-1). (selfgrowth.com)

Together, ligands and their receptors trigger signals that affect cell development and function. (medlineplus.gov)
The receptor helps move its ligands from the cell surface into the cell (endocytosis). (medlineplus.gov)
The laboratory is especially interested in the role of neuropilins in cancer cells and examining the use of soluble neuropilin isoforms or inhibitory class 3 semaphorin ligands as inhibitors of tumor-associated angiogenesis and lymphangiogenesis. (navbo.org)
This finding suggests that this receptor may have the ability to detect ligands from a broader spectrum of pathogens, not limited to fungal origins. (lu.se)

It has been reported that the host-side viral receptor ACE2 *1 and the serine protease enzyme TMPRSS2, *2 a protein that facilitates viruses' entry into host cells, are involved in the transmission of SARS-CoV-2, the virus that causes COVID-19 (Figure 1). (lion.co.jp)
As my specialty is diagnostic pathology, I'm very familiar with tissue staining, so I decided immediately to investigate whether viral receptors, such as ACE2 and TMPRSS2, were present in oral cavity tissue. (lion.co.jp)
We believe that the loss of taste or taste abnormalities observed as long-lasting symptoms of COVID-19 may be due to the effects of cell destruction and abnormal cell metabolism caused by viral infection of the taste buds. (lion.co.jp)
EBV initially enters the body through the oropharyngeal mucosa and infects B cells through the binding of the viral envelope protein gp350 to CD21 on the surface of B cells. (selfgrowth.com)
Key areas of research include viral cell entry , viral replication and the hyperactive host immune response, known as cytokine storm . (tocris.com)
Both viruses contain two genes, U12 and U51, that encode viral chemokine receptors that are putative homologues of human G-protein-coupled receptors (GPCRs). (hhv-6foundation.org)

Therefore a better understanding of the molecular mechanisms of immune responses in epithelial cells including cholangiocytes (epithelial cells lining the biliary tract) is critical to the development of new therapeutic strategies for contamination. (bio-cavagnou.info)
F ) Activation of immune response leads to differentiating CD8 + T lymphocytes into CTLs, capable of destroying virus-infected cells. (news-medical.net)
Cells may become infected with EBV through close contact at immune synapses. (selfgrowth.com)
Dendritic cell as sentinel of the immune system plays an irreplaceable role. (medsci.org)
The expression of TLR2 on different cell types are regulated by different immune response modifiers. (novusbio.com)
There were also significant differences in microbial composition in dust samples and in innate immune cells between the two groups of children. (medscape.com)

CD8 promotes T cell activation through its association with the TCR complex and protein tyrosine kinase lck. (biolegend.com)

The 5-HT2C receptor is a subtype of 5-HT receptor that binds the endogenous neurotransmitter serotonin (5-hydroxytryptamine, 5-HT). (wikipedia.org)
In the present study, for the first time, protective effects of three microalgal strains, including their extracts and active compounds, against both endogenous and exogenous AGEs in cell -based models were investigated. (rsc.org)
Results showed that in cultured human-derived retinal pigment epithelial ARPE-19 cells , the extract of Chlorella zofingiensis and its nutritional ingredient astaxanthin exhibited significant inhibitory effects on the formation of endogenous N ε -carboxymethyllysine (CML), a key AGE representative, through the suppression of intracellular oxidative stress. (rsc.org)
It was confirmed that oocytes lack endogenous P2X receptors, and were unaffected by P2X receptor antagonists and allosteric modulators. (ucl.ac.uk)

Endocytosis is one way of limiting the responses of a cell to signals coming from outside. (alzforum.org)

It has been reported that Toll-like receptors (TLRs) play a vital role in swine pneumonia progression. (hindawi.com)

B) In vitro virus binding showing that neither seasonal influenza A (H1N1) nor A (H3N2) viruses bind to epithelial surface of small and large intestines but only to a subset of intestinal CD45+ leukocytes interspersed in the lamina propria and submucosa. (cdc.gov)
To induce toxicity in target cells, Shiga toxins must first bind to specific receptors on their surface (Gb3 receptors). (marlerblog.com)

We found that shRNA knockdown of intrinsic ST6GAL1 expression resulted in decreased ST6GAL1 cargo in the exosome-like vesicles as well as decreased breast tumor cell growth and invasive behavior in 3D in vitro cultures. (nature.com)
They grow on cell-free media in vitro. (medscape.com)

EBV shows obvious tendency to B lymphocytes, which is easy to infect B cells and convert initial B cells into proliferative lymphocytes. (selfgrowth.com)
T/NK lymphocytes neither express CD21 nor HLA class II, but T/NK lymphocytes express some integrins, which increase when stimulated and can act as receptors for T/NK lymphocytes. (selfgrowth.com)
The double infection of T lymphocytes and NK cells in patients with chronic active EBV infection (CAEBV) has been reported in the literature, further supporting that EBV may infect the common progenitor cells of T cells and NK cells. (selfgrowth.com)
EBV can also be transmitted from EBV-infected B cells or epithelial cells to T/NK lymphocytes by cell-to-cell infection. (selfgrowth.com)
In the normal thymus, bone marrow-derived precursor cells destined to become thymocytes (or T lymphocytes) enter the thymus at the corticomedullary junction and differentiate as they pass through the thymus. (medscape.com)
Le pourcentage de CD44 dans les lymphocytes T périphériques était significativement plus élevé chez les patients que chez les témoins, comme détecté par la cytométrie en flux. (who.int)

Intracellular events, such as blocking of microbial attachment factors such as fimbriae (hairlike structures) and other adhesins (putative receptors), have been observed (Naidu and Bidlack, 1998). (ift.org)

Furthermore SIRT1 has been identified as a target for more than 16 miRNAs in both malignant and non-malignant human cell types [17]. (bio-cavagnou.info)
H69 cells (a gift of Dr. D. Jefferson Tufts University) are SV40-transformed human biliary epithelial cells originally derived from normal liver harvested for transplant [14 19 Before infecting cells oocysts were treated with 1% sodium hypochlorite on ice for 20 min followed by extensive washing with Dulbecco's modified Eagle medium (DMEM)-F12. (bio-cavagnou.info)
HTR2C denotes the human gene encoding for the receptor, that in humans is located at the X chromosome. (wikipedia.org)
Mouse myeloma cell line NS0-derived human CD30 Ligand/TNFSF8. (rndsystems.com)
The sialyltransferase ST6GAL1 that adds α2-6 linked sialic acids to N-glycans of cell surface and secreted glycoproteins is prominently associated with many human cancers. (nature.com)
Here, we show that in human epithelial cells this arises from the orientation of cortical flows at AJs. (ibecbarcelona.eu)
We previously created a rat model of cancer cachexia using MKN45cl85 and 85As2 cells derived from human gastric cancer. (oncotarget.com)
Finally, we identified a cyclic RGD peptide that supports growth of human embryonic stem cells. (ca.gov)
There is a critical need for new technologies to facilitate growth and differentiation of human embryonic stem cells (hESC) using clinically acceptable, animal-free reagents. (ca.gov)
In transfected human TLR2 cell lysate, a 90 kDa band is observed. (novusbio.com)
TLR2 is differentially expressed in human cells. (novusbio.com)

We have found that EGF stimulation of selected starved melanoma, thyroid and high stage ovarian tumor cells induced, in dividing cells, accumulation of phosphorylated (P-)FAK on Ser732. (aacrjournals.org)

Both ACE2 and TMPRSS2 are present in the epithelial cells on the tongue surface, providing perfect conditions for SARS-CoV-2 to invade. (lion.co.jp)
The taste buds also have ACE2 and TMPRSS2 receptors, setting up an ideal environment for the virus. (lion.co.jp)
Host cell entry is effected by the binding of receptor binding domain (RBD) of the spike (S) protein on the nucleocapsid to ACE2, a protease on the host cell surface. (tocris.com)
The binding of the S protein to ACE2 is facilitated by another host cell protease, TMPRSS2 (transmembrane protease, serine 2). (tocris.com)

Tumor-native ST6GAL1 promotes tumor cell behaviors such as invasion and resistance to cell stress and chemo- and radio-treatments. (nature.com)

Cardinal signs of resolution are: (1) limitation/cessation of PMN infiltration, (2) sequestration and counter-regulation of pro-inflammatory chemical mediators, (3) apoptosis of PMN and removal (e.g., by efferocytosis), (4) clearance of pathogens, inflammatory stimuli, and cell debris, and (5) tissue repair. (frontiersin.org)
A transmembrane mucin that is found in a broad variety of epithelial tissue. (bvsalud.org)
Tissue factor is a receptor and cofactor for factor VII and is expressed on epithelial cells to help form a hemostatic barrier. (msdmanuals.com)

CD30 was originally identified as a cell surface antigen of Hodgkin's and Reed-Sternberg cells using the monoclonal antibody Ki-1. (rndsystems.com)

The inside of a cell is a very busy place-a microscopic world of molecules that interact dynamically in groups, in sequences, or in networks. (alzforum.org)
This shift comes with the growing realization that neurodegeneration is less a problem of toxic molecules per se but rather of the way these molecules disrupt the basic biological processes of the cell-their effects on the cell as a system. (alzforum.org)
Each cell produces thousands of different protein and lipid molecules. (alzforum.org)
But, unlike in the production line of a manufacturing plant, the cell may be making many different molecules at the same time, so labels and locations are needed to separate out these simultaneous processes. (alzforum.org)
It inactivates the receptors that respond to the signal, or the transporter molecules that suck up the signal chemical by removing them from the cell surface. (alzforum.org)
The GP42 in the complex is combined with the HLA II molecular molecules, and caused the virus cell fusion under the participation of GP85/GP25 and GP110 glycoprotein. (selfgrowth.com)
EBV-infected B cells can activate NK cells to acquire CD21 molecules through synaptic transfer, and the ectopic receptor leads to the binding of EBV to NK cells. (selfgrowth.com)
CD117 by immunohistochemical methods sion molecules, involved in cell-cell and in order to clarify the role of the infiltrating cell matrix interactions and thought to take inflammatory cells in the pathomechanisms part in cell motility [ 2,3 ]. (who.int)

The 53-6.7 antibody has been reported to block antigen presentation via MHC class I and inhibit T cell responses to IL-2. (biolegend.com)

Within the target organ, Shiga toxins disrupt the cellular machinery, resulting in cell injury and/or death. (marlerblog.com)

Bacteriostasic effect is enhanced when LF binds to a microbial cell surface (Dalamastri et al. (ift.org)

Fibroblast growth factors, in concert with other growth factors, are key regulators of lens fiber cell differentiation. (nih.gov)
The next step in bone formation is differentiation of the cells to chondrocytes or osteoblasts. (edu.au)
In addition, we examined whether these substrates will support differentiation of retinal pigmented epithelial cells, an important, clinically relevant cell type that is currently in clinical trials for eye disease. (ca.gov)
This surface proved to be efficient at supporting growth of undifferentiated hESC as well as differentiation of useful cell types. (ca.gov)
that regulate the differentiation and activation of these cells. (cdc.gov)

The protein is also constitutively expressed on granulocytes and medullary thymic epithelial cells. (rndsystems.com)
Thymoma is a neoplasm of thymic epithelial cells. (medscape.com)

5-HT2C receptors exhibit constitutive activity in vivo, and may retain the ability to influence neurotransmission in the absence of ligand occupancy. (wikipedia.org)
Peptide binding of the ligand takes place in an elongated surface groove as an anti-parallel beta-strand interacts with the beta-B strand and the B helix. (embl.de)

For instance, one mouse model showed that probiotics promoted influenza virus clearance and neutralizing antibody production, via T-helper cells type 1 (Th1). (news-medical.net)
An ADC with the Company's technology comprises an antibody that binds to a target found on tumor cells and is conjugated to one of its potent anti-cancer agents as a payload to kill the tumor cell once. (stockhouse.com)
This antibody has also been used for depletion of CD8a + cells. (biolegend.com)
Detection of TLR2 in transfected cell lysate using this antibody. (novusbio.com)
The antibody response to this receptor results in production of the anti-I antibody or cold agglutinin, which acts as an autoantibody. (medscape.com)

Canonically, functioning ST6GAL1 resides within the intracellular ER-Golgi secretory complex, where sialylation of nascent cell surface and secreted components occurs cell-autonomously. (nature.com)

Probiotics may trap the virus in respiratory infection, as well as inhibit binding of the virus to the host cell receptor. (news-medical.net)
If you touch any surface which has the bacterial droplets on them and then touch your nose or mouth with your contaminated hands, the infection then starts spreading in you. (wonderopolis.org)
Infection of naive B cells present in Waldeyer's ring of tonsils. (selfgrowth.com)
EBV infection of glandular epithelial cells can cause gastric cancer and bile duct cancer, and the mechanism is unclear. (selfgrowth.com)
We focus on the essential functions of dendritic cell in severe SARS-CoV-2 infection. (medsci.org)
Mycoplasma organisms cause infection primarily as extracellular parasites, attaching to the surface of ciliated and nonciliated epithelial cells of the respiratory and genital tracts. (medscape.com)

Extracellular vesicles released by mesenchymal stem/stromal cells (MSC-EV) are promising agents to positively influence joint homeostasis in the osteoarthritic surroundings. (bvsalud.org)

Also covered in detail was the basic cell biology of EMT and its role in cancer and fibrosis, as well as the identification of new markers to facilitate the observation of EMT in vivo. (rupress.org)

In many of these cancers, HGF/Met signaling drives cell invasiveness and tumor metastasis, advancing disease beyond current effective therapies. (cancer.gov)

The Company is advancing PVEK in clinical trials for patients with blastic plasmacytoid dendritic cell neoplasm (BPDCN) and acute myeloid leukemia (AML). (stockhouse.com)

They also show that ECD cleavage is caused by matrix metalloproteinase 9 (MMP-9), whose inhibition leads to decreased NB cell migration. (dana-farber.org)
In contrast, AJs found between leader cells in the same migrating sheet have cortical flows aligned in the same direction, and no such mechanical inhibition takes place. (ibecbarcelona.eu)

The specific receptor for CD30L is CD30/TNFRSF8, a type I transmembrane glycoprotein belonging to the TNF receptor superfamily. (rndsystems.com)
DURHAM, N.C. - Researchers at the Duke Cancer Institute who have been studying prostate cancer cells for decades now think they know why PSA (prostate-specific antigen) levels reflect cancer progression. (scienceblog.com)
It is strongly recommended that when using a reagent for the first time, users compare the spillover on cells and BD CompBeads to ensure that BD® CompBeads are appropriate for your specific cellular application. (bdbiosciences.com)
1 Indeed, allergen-specific TH2 cells play a critical publication February 11, 2014. (cdc.gov)

In the LCMB he helped identify keratinocyte growth factor (KGF), hepatocyte growth factor (HGF), and their respective cell surface receptors. (cancer.gov)

Research indicates that some suicide victims have an abnormally high number of 5-HT2C receptors in the prefrontal cortex. (wikipedia.org)
[ 8 ] TGF-beta, along with other fibrinogenic factors, may be produced by mast cells, which have been reported to occur in abnormally high numbers in dermatofibromas. (medscape.com)

Anatomy51

Organisms23

Diseases1

Chemicals and Drugs94

Analytical, Diagnostic and Therapeutic Techniques and Equipment26

Psychiatry and Psychology6

Phenomena and Processes56

Disciplines and Occupations2

Technology, Industry, Agriculture1

Information Science3

Health Care1

Found on epithelial3

Proliferation17

Membrane14

Proteins16

Epithelium2

EGFR3

Airway5

Dendritic cells8

Mucosal5

Endothelial cells6

Tumors6

Antigen prese1

Pathways9

Signaling pathway4

Activates3

Extracellular matrix2

Lymphoid7

Mediate2

Mononuclear cells1

Mesenchymal transition4

Transmembrane receptors2

Transition2

Antibodies7

Myeloid cells1

Growth factor r1

Bacteria7

Adhesion2

Mutations4

NLRs1

Innate immune r1

Mediates1

Monocytes4

Tissues2

Cytotoxic1

Ligands4

Viral6

Immune6

Tyrosine kinase1

Endogenous4

Endocytosis1

TLRs1

Bind2

Vitro2

Lymphocytes6

Putative1

Human11

Ovarian1

ACE24

Invasion1

Tissue3

Monoclonal1

Molecules8

Responses1

Disrupt1

Microbial1

Differentiation5

Thymic2

Ligand2

Antibody5

Secretory1

Infection6

Stromal1

Vivo1

Cancers1

Neoplasm1

Inhibition2

Specific4

Keratinocyte1

Abnormally high2