Epithelial cell shape. Medical search. Frequent questions

The goal of the project is to develop new strategies for the synthetic morphogenesis of epithelial tissues. (ibecbarcelona.eu)
While many studies have demonstrated the importance of cTEC and mTEC during T-cell development, thymic stromal microenvironments also contain heterogenous non-epithelial stromal (NES) populations in a similar manner to that seen in peripheral lymphoid tissues. (frontiersin.org)
Systems toxicology, therefore, aims at understanding and exploring the way that different biological components are orchestrated as an ensemble in cells, tissues, and organisms. (brill.com)
The LMU team analyzed the motions of two types of hair-like cell protrusions made up of proteinaceous filaments-the so-called flagella found on the unicellular green alga Chlamydomonas reinhardtii and the primary cilium found on many epithelial tissues in multicellular organisms. (genengnews.com)
g ) Epithelial tissues follow the AW law (black line). (elifesciences.org)
The renal capsule provides a stiff outer shell to maintain the shape of the soft inner tissues. (innerbody.com)
As the National Society for Histotechnology notes, histology is the science that deals with the structure of cells and their formation into tissues and organs. (jeffreysglassman.com)
M ost animals rely on changes in cell shape to move tissues around during development, but these alterations are usually slow and are rare in adult animals. (the-scientist.com)
Mechanochemical Principles of Spatial and Temporal Patterns in Cells and Tissues. (mpi-cbg.de)
Patterns are ubiquitous in living systems and underlie the dynamic organization of cells, tissues, and embryos. (mpi-cbg.de)
Cells and tissues are not static structures, but during development they change their size and shape and migrate. (helsinki.fi)
We are interested in how cells are coordinated and keep connected with each other in tissues, while undergoing changes in their shape or motility. (helsinki.fi)
Animal tissues exhibit complex spatial architectures that emerge from cell-cell interactions. (math.ca)
Ivaylo Ivanov is studying how commensal bacteria (green) interact with intestinal tissues (pink) to activate immune cells in the gut to fight infection. (columbia.edu)
Animal tissues can be classified into four main groups based on their main functions: epithelial tissue, connective tissue, nerve tissue, and muscle tissue. (britannica.com)
Epithelial tissues-also known as epithelium-form the coverings and linings of surfaces in and on the animal's body. (britannica.com)
The cells in epithelial tissues tend to be packed tightly together, with very little intercellular material. (britannica.com)
in other tissues, the cells are stacked atop each other in two or more staggered layers. (britannica.com)

Unique Transcriptional Architecture in Airway Epithelial Cells and Macrophages Shapes Distinct Responses following Influenza Virus Infection Ex Vivo . (bvsalud.org)
The nanotube bundles are similar to the potential of nanotubes to induce genetic damage size of microtubules that form the mitotic spindle in normal lung cells, cultured primary and immor- and may be incorporated into the mitotic spindle talized human airway epithelial cells were apparatus. (cdc.gov)

Cortical thymic epithelial cells (cTECs) form unique parenchyma cell population of the thymus which critically contribute to the development of T cells. (wikipedia.org)
Major role of thymic epithelial cells is to test, whether TCRs are "functional" and on the other hand "harmless" to our body. (wikipedia.org)
While cTECs control the functionality of TCRs during the process called positive selection, Medullary thymic epithelial cells (mTECs) that home in the inner part of the thymus- medulla, present on their MHC molecules self-peptides, generated mostly by protein Autoimmune regulator, to eliminate T cells with self-reactive TCRs via processes of central tolerance e.g. negative selection and protect the body against development of autoimmunity. (wikipedia.org)
Extensive research on thymic epithelial cells (TEC) within the cortex and medulla has defined their essential roles during T-cell development. (frontiersin.org)
Arguably, the most recognized and well-studied stromal populations in thymus biology are thymic epithelial cells (TEC) within the cortical and medullary areas, which are defined by their anatomical separation and function. (frontiersin.org)

In early experiments, physical separation of mesenchymal and epithelial stroma from embryonic murine thymus resulted in defective thymus development when epithelium was cultured in vitro in the absence of mesenchyme ( 7 ). (frontiersin.org)
Surrounding the glomerulus is the glomerular capsule, a cup-shaped double layer of simple squamous epithelium with a hollow space between the layers. (innerbody.com)
As noted by the U.S. National Library of Medicine , the epithelium refers to the layer of cells that line the hollow organs and glands. (jeffreysglassman.com)
When they recently used a fluorescent dye to visualize the cell membranes, they saw that cells in the top layer of epithelium contracted their surfaces more than 50 percent over the span of a single second-an observation that Prakash describes as "a huge surprise. (the-scientist.com)
In contrast to the M cells, the sites where lymphocytes invaded the dome epithelium were not arranged in radial strips, but randomly distributed over the domes. (nih.gov)

Thymus tissue is compartmentalized into cortex and medulla and each of these two compartments comprises its specific thymic epithelial cell subset. (wikipedia.org)
Epithelial-mesenchymal transformation is now recognised as an important feature of tissue remodelling. (ersjournals.com)
Reports from several laboratories suggest that a phenomenon termed epithelial-mesenchymal transformation, in which epithelial cells transform into fibroblasts capable of producing connective tissue matrix, is an important feature of tissue remodelling 10 , 11 . (ersjournals.com)
Conization - Abnormal tissue is removed with a scalpel in a cone-shaped piece. (familydoctor.org)
The Integrative Cell and Tissue Dynamics Group is looking for Postdoctoral Researcher to work on engineering organoid systems. (ibecbarcelona.eu)
Our findings revealed that cells reduce tension upon deformation by thinning the cell monolayer, thereby providing excess tissue area. (tu-dresden.de)
a ) Schematic representation of an epithelial tissue layer. (elifesciences.org)
These cells are square-shaped, and they grow right next to one another mostly via local expansion into surrounding tissue. (jeffreysglassman.com)
Histotechnology involves detecting abnormalities in the cells and employs the use of chemicals and dyes to produce colors and make it easier to distinguish different tissue structures. (jeffreysglassman.com)
The contractions didn't result in obvious rearrangements of the cells or ruptures in the tissue. (the-scientist.com)
As these cells are pushed outward, they are keratinized into a hard tissue that slides forward over the nail bed to which it remains attached. (quizlet.com)
In mammary gland development, Notch-dependent heterotypic signaling between resident tissue macrophages and mammary stem cells supports survival and function of the normal mammary stem cell 20 . (nature.com)
Cytotoxic CD8+ T cells may be drivers of tissue destruction in Sjögren's syndrome. (harvard.edu)
DNN predictions were supplemented with traditional machine-learning algorithms that identified shape and texture features of single cells that were used to predict tissue function and iPSC donor identity. (jci.org)
In biology , a tissue consists of a group of similar cells and their intercellular material that work together to perform a function. (britannica.com)
Meristematic tissue is an "immature" tissue in that it is the tissue in which cell division and thus growth occurs. (britannica.com)
Meristematic tissue (also known simply as meristem) is the primary site of cell division in vascular plants, such as angiosperms and gymnosperms. (britannica.com)
Collenchyma tissue is similar to parenchyma, but its cells have thick deposits of cellulose in their cell walls. (britannica.com)
Sclerenchyma tissue is composed of hard, woody cells that characteristically provide support and strength to the plant. (britannica.com)
However, it is not known if CXCR1 is expressed on the apical or basolateral poles in polarized Caco-2 BBE cells or human intestinal tissue or whether the direction of TLR signalling influences the direction of IL-8 secretion. (biomedcentral.com)
Additionally, we determined the localization of the CXCR1 receptor in Caco-2 BBE cells and human intestinal tissue samples and investigated the role of IL-8 autocrine signalling using transcriptomics. (biomedcentral.com)
Recent advances in live imaging and genetics of mammalian division, movement and cell differentiation leading to development which integrate observations of biochemical tissue formation [14 ]. (lu.se)
of the most critical events which lead to tissue patterning involves mechanisms going beyond single cells. (lu.se)

Guinea pig primary peripheral lung epithelial cells (PLECs) transfected with adenovirus E1A (E1A-PLECs) were compared to guinea pig normal lung fibroblasts (NLFs) transfected with E1A (E1A-NLFs). (ersjournals.com)
E1A transfection results in the transformation of peripheral lung epithelial cells and normal lung fibroblasts to a phenotype intermediate between that of the two primary cells. (ersjournals.com)
Adenoviral DNA is retained by peripheral epithelial cells of the lung (PLECs) in humans in whom the viral E1A gene is expressed 4 without replication of a complete virus 5 . (ersjournals.com)
Case-control studies have shown that the E1A DNA from group C adenoviruses is present in greater amounts in the lungs of patients with COPD than in controls with normal lung function matched for age, sex and smoking history 5 , and that the excess inflammation in the lungs of smokers with severe emphysema is associated with increased numbers of alveolar epithelial cells expressing E1A 6 . (ersjournals.com)
The absence of detectable viral mented in other mammals and birds, H5N1 viral replication antigen-positive cells in previous reports may relate to the in humans may be restricted to the lung and intestine, and fact that the patients died during the late phase of the dis- the major site of H5N1 viral replication in the lung is the pneumocyte. (cdc.gov)
Most often epithelial cancer cells will look like adenocarcinoma, which is a type of lung cancer. (jeffreysglassman.com)
Computerized axial tomography (CAT) scanning of the thorax revealed an irregularly shaped, nodular mass measuring 4 cm in diameter, in the upper region of the right lower lobe of the lung. (ispub.com)
The results of cytological examination of bronchial excretions however, proved positive for non-small cell carcinoma of the lung. (ispub.com)
The human lung epithelial cells (A549) were exposed for 24 h and 72 h to five different NC particles to determine how variations in properties contribute to cellular outcomes, including cytotoxicity, oxidative stress, and cytokine secretion. (cdc.gov)

This behavior was also observed in demixed cell monolayers of ZO-1/2 double knockdown (dKD) cells, cells exposed to varying temperatures, and following the removal of cholesterol from the plasma membrane. (tu-dresden.de)
QBAM images of iPSC-RPE were used to train DNNs that predicted iPSC-RPE monolayer transepithelial resistance, predicted polarized vascular endothelial growth factor (VEGF) secretion, and matched iPSC-RPE monolayers to the stem cell donors. (jci.org)
Here we investigated whether polarized monolayers of intestinal epithelial cells might regulate inflammatory responses by secreting IL-8 in a vectorial fashion (i.e. apical versus basolateral) depending on the location of the TLR stimulus. (biomedcentral.com)

The conversion of an epithelial cell to a mesenchymal cell is critical to metazoan embryogenesis and a defining structural feature of organ development. (rupress.org)

So-called fiber cells reside in between the epithelia. (the-scientist.com)
Some key findings illustrated by the mutations isolated are the importance of epithelia, epithelial polarization and movement, and changes in cell shape ( Knust, 2003 ). (peerj.com)

At each original cell body of the seam syncytium, where the nuclei are positioned, the seam completely interrupts hyp 7 (section through B in inset ), whereas at the ends of the cells, the seam is so thin that hyp 7 runs behind it, enfolding it completely (section through C in inset ). (wormatlas.org)
The large dark blue oval shaped structures are nuclei. (canadiannaturephotographer.com)
The nuclei and the silver-stained nucleolar organizer region-associated proteins (AgNORs) in the normal, the dysplastic and the cancer cells of 38 cases of esophageal squamous cell carcinoma were measured by an image analysis system. (ac.be)
In normal control adult mouse eyes, ETS-1 was mostly present in the nuclei of all neuroretinal layers whereas ETS-2 was mostly localized in the cytosol of the cell bodies of these layers with a smaller amount present in the nuclei. (molvis.org)
Histologically, ALCL is characterized by sheets of large pleomorphic cells with abundant cytoplasm, horseshoe- or wreath-shaped nuclei, and multiple prominent nucleoli. (medscape.com)

Adherens junctions (AJs) are thought to be key landmarks for establishing epithelial cell polarity, but the origin of epithelial polarity in Drosophila remains unclear. (rupress.org)
Thus, we examined epithelial polarity establishment during early Drosophila development. (rupress.org)
We found apical accumulation of both Drosophila E-Cadherin (DE-Cad) and the apical cue Bazooka (Baz) as cells first form. (rupress.org)

Our scientists pursue every aspect of cancer research-from exploring the biology of genes and cells, to developing immune-based treatments, uncovering the causes of metastasis, and more. (mskcc.org)
Indeed, loss of epithelial cell polarity is associated with tumor development and metastasis. (rupress.org)
Of course, mesothelioma in general results in fast division and tumor growth, but the good news for those with epithelioid mesothelioma is that because of the tendency of epithelial cells to stick together, metastasis is slowed. (jeffreysglassman.com)
Cancer stem cells (CSCs) play an important role during metastasis, but the dynamic behavior and induction mechanisms of CSCs are not well understood. (nature.com)

Medullary epithelial cells (mTEC), in conjunction with dendritic cells, then take over control of developing thymocytes. (frontiersin.org)
In addition to intrathymic selection, and during this medullary residency period, CD4 + and CD8 + single positive (CD4SP, CD8SP) thymocytes acquire the ability to proliferate in response to TCR stimulation, and undergo licensing for cytokine production, prior to exiting the thymus to join the peripheral T-cell pool as Recent Thymus Emigrants (RTE) ( 5 , 6 ). (frontiersin.org)

Precursors of T cells originate in the bone marrow from which they migrate via bloodstream into thymic cortex, where they encounter stromal cells including cTECs, which form the microenvironment crucial for proliferation and development of T cells by expression of DLL4 (delta-like notch ligand 4), cytokines IL-7, TGFβ or stem cell factor and chemokines CCL25, CXCL12 or CCRL1 etc. (wikipedia.org)
These microenvironments are classically defined as distinct cortex and medulla regions that each contain specialized subsets of stromal cells. (frontiersin.org)
Significantly, there are additional non-epithelial stromal cells (NES) that exist alongside TEC within thymic microenvironments, including multiple subsets of mesenchymal and endothelial cells. (frontiersin.org)
While adult lymphoid progenitor cells are produced by the bone marrow, their lineage commitment and development into mature T-cells is dependent on their migration into the thymus, where essential interactions with heterogeneous thymic stromal cells take place ( 1 ). (frontiersin.org)

AJs localize to the boundary between the apical and basolateral domains, and are thought to be critical landmarks for establishing epithelial polarity ( Nelson, 2003 ). (rupress.org)

Thus, Baz acts upstream of AJs during epithelial polarity establishment. (rupress.org)
Thus, although epithelial polarity develops in the absence of AJs, AJs play specific roles in maintaining epithelial architecture and segregating basolateral cues. (rupress.org)
In particular, epithelial cell polarity is critical for the development, remodeling, and maintenance of epithelial structure. (rupress.org)
chem mutations genetically interact with mutations in cytoskeletal genes ( arm ) and with mutations in the epithelial polarity genes coracle, crumbs, and yurt . (peerj.com)
chem mutants dorsal open defects are similar to those present in yurt mutants, and, likewise, they have epithelial polarity defects. (peerj.com)
Genetic analysis has uncovered that genes necessary for epithelial polarity code for cytoskeletal proteins and their regulators, like the par-3 protein Bazooka ( Kuchinke, Grawe & Knust, 1998 ) or the EGF and laminin domains-containing protein Crumbs ( Tepass, Theres & Knust, 1990 ). (peerj.com)
In addition, we show that these alleles genetically interact with epithelial polarity genes, and have epithelial polarity defects. (peerj.com)

MDCK cells also form multicellular cysts, such as acini or spheroids, consisting of a closed monolayer of polarized cells enclosing a liquid. (tu-dresden.de)
For instance, transitions between individual cells and multicellular groups occur widely in embryonic development, wound healing, and tumor progression. (math.ca)

Essential part of T cell development forms process called VDJ recombination, mediated by RAG recombinases, that stochastically changes DNA sequences of T cell receptors (TCR) and endows them with diverse recognition specificity. (wikipedia.org)
In the synthetic niche, interactions with the functionalized scaffold are expected to provide the signals needed for T-cell activation (with or without antigen specificity), lineage selection, proliferation, and survival. (weizmann.ac.il)
in this study, CIC with a separation and distortion of epithelial cells specificity of 94% and sensitivity of 93%, and losses of mucin-secreting goblet cells, was used [14]. (who.int)

In this study, the protective effect of a fermented wheat germ extract (FWGE) against LPS-induced inflammation and oxidative stress in IPEC-J2 porcine intestinal epithelial cells was studied. (hindawi.com)
Using microscopic imaging technology developed in Bjorkman's lab at Caltech, he and Bjorkman have found that intestinal cells ingest pieces of bacteria in tiny membrane vesicles. (columbia.edu)
These results show that IL-8 induces autocrine signalling via an apical CXCR1 in Caco-2 BBE intestinal epithelial cells and that this receptor is also expressed on the apical surface of differentiated human intestinal epithelial cells in vivo , suggesting an autocrine function for IL-8 secreted in the lumen. (biomedcentral.com)
Intestinal epithelial cells (IECs) play a key role in the inflammatory response to colonizing or invading microorganisms via the secretion of interleukin-8 (IL-8). (biomedcentral.com)
Here we investigated IL-8 secretion in response to TLR signalling using intestinal Caco-2 BBE cells grown in the Transwell system. (biomedcentral.com)

Also covered in detail was the basic cell biology of EMT and its role in cancer and fibrosis, as well as the identification of new markers to facilitate the observation of EMT in vivo. (rupress.org)
With the recent advances in human-cell cultivation techniques, allowing in vivo -like in vitro long-term functionality, there is a shift in focus towards the mechanistic details of the adverse effects "over time" aimed at a better understanding of the dynamics of biological processes. (brill.com)
We are now looking for enthusiastic new members in our research group to study how changes in cellular shape and motility are regulated in vivo . (helsinki.fi)

Researchers discussed the published work , as well as ongoing studies into the purpose of the super fast cellular contractions, in three presentations at the American Society for Cell Biology (ASCB) annual meeting in San Diego this week. (the-scientist.com)
Previous experience in cell biology, confocal microscopy or imaging analysis is an advantage. (helsinki.fi)

Seam cells have increased in number to 16 on each side through post-embryonic seam divisions. (wormatlas.org)
Mutations in genes with less extreme phenotypes may result in impaired cell movement and cell shape changes, hampering or preventing embryonic dorsal closure and head involution ( Rios-Barrera & Riesgo-Escovar, 2013 ). (peerj.com)

Besides double positive-single positive transition, TCR-MHC interaction also triggers the expression of CCR7, chemokine receptor which recognizes chemokines CCL19 and CCL21, that are largely produced by mTECs in the medulla, and positively selected T cells start to migrate to medulla via their gradient. (wikipedia.org)
Current interest in this process, which is described as an epithelial-mesenchymal transition (EMT), stems from its developmental importance and its involvement in several adult pathologies. (rupress.org)
The EMT International Association was formed in 2002 to provide an international body for those interested in EMT and the reverse process, mesenchymal-epithelial transition, and, most importantly, to bring together those working on EMT in development, cancer, fibrosis, and pathology. (rupress.org)
d ) Planar cell neighbour exchange (T1 transition). (elifesciences.org)
Notch signaling has been implicated in many microenvironmental processes associated with cancer progression such as vascular remodeling, immunosuppression, epithelial to mesenchymal transition (EMT), as well as maintenance of the CSC pool 21 . (nature.com)

Glandular cells produce mucus in your cervix and uterus. (familydoctor.org)

They have developed a method that can differentiate between the active motions characteristic of living cells and those driven by the random molecular movements that give rise to passive diffusion. (genengnews.com)
To differentiate between epithelial mesothelioma and the other forms, doctors will rely on histology - or more specifically, histopathology. (jeffreysglassman.com)
Only dome epithelial cells that derive from these specialized crypts differentiate into M cells. (nih.gov)

These structures maintain apical Baz, accumulate apical Crumbs, and organize polarized cytoskeletons, but display abnormal cell morphology and fail to segregate the basolateral cue Discs large from the apical domain. (rupress.org)
Stimulation of polarized Caco-2 BBE cells with Pam2CSK4 and Pam3CSK4, agonists for TLR2/6 and TLR2/1 from the apical or basolateral sides induced secretion of IL-8 predominantly into the apical compartment regardless of the location of the stimulus, although basolateral stimulation induced smaller amounts of IL-8 compared to apical stimulation. (biomedcentral.com)
C An example showing a moderate to intense but incomplete (U-shaped or showing a moderate to intense but incomplete (U-shaped or basolateral) HER2 staining pattern (score: 2+). (who.int)

Broadly separated into mesenchymal and endothelial cells, NES have been implicated in thymus organogenesis, thymocyte development, tolerance induction and development/maintenance of epithelial stroma. (frontiersin.org)
In this review, we cover how the non-epithelial compartment of thymic stroma represent essential cell populations in regulating thymus function. (frontiersin.org)
Light microscopy shows irregular thickening and thinning of the epithelial layer, which offset the ridges and furrows in the underlying stroma and the focal absences of the epithelial basement membrane. (aao.org)

The curves mark theoretical predictions when polygonal cell layers follow either the linear Lewis' law ( Equation 2 , black line) or the quadratic law ( Equation 3 , yellow line). (elifesciences.org)

Pathology can also provide researchers with insights into the details of mesothelioma cells. (mesothelioma.com)

At the core of AJs, cadherins mediate cell-cell adhesion through Ca 2+ -dependent homophilic interactions between their extracellular domains. (rupress.org)
Prominent among the molecular adhesion components are integrins (β1 and β2), that mediate the interactions of a variety of immune cells to extracellular matrices, and to other immune cells, respectively. (weizmann.ac.il)
Near the apical side, cells adhere tightly via adhesion junctions (green). (elifesciences.org)
Epithelial integrity requires the adhesion of cells to each other as well as to an underlying basement membrane. (biologists.com)

Flagella are used by microorganisms to swim through liquid media, whereas primary cilia act primarily as motile sensors on epithelial surfaces. (genengnews.com)
We further demonstrate such broken detailed balance in the nonperiodic fluctuations of primary cilia of epithelial cells. (genengnews.com)
A collection of cilia attached to basal cushions and made up of polster cells. (githubusercontent.com)

The domes of Peyer's patches were supplied with epithelial cells that derived from two types of crypt: specialized dome-associated crypts and ordinary crypts differing not only in shape, size, and cellular composition but also in the presence of M cell precursors. (nih.gov)

The adult alae are commonly used as an indicator of hypodermal seam cell terminal differentiation. (wormatlas.org)
This did not primarily affect lineage commitment and differentiation, but above all elicited altered epithelial morphology and cell-to-cell interaction. (uni-muenchen.de)

Once T cell precursors enter the thymic cortex, they start their transformation from double negative stages (T cell without surface expression of CD4 and CD8 co-receptors) to a double positive stage (T cell with surface expression of both co-receptors) that expresses fully recombined TCR. (wikipedia.org)

Establishing a staging system for thymic epithelial tumors (TETs) has been difficult due to the rarity of these tumors. (medscape.com)

While mesothelioma accounts for less than 2 percent of all known cancers, epithelial mesothelioma is the most common type of this malignancy. (jeffreysglassman.com)
In breast cancers from patients, the density of TMEM doorways correlates with the proportion of cancer cells expressing stem cell markers, indicating that in human breast cancer TMEM doorways are not only cancer cell intravasation portals but also CSC programming sites. (nature.com)
90% of head and neck cancers are squamous cell (epidermoid) carcinomas. (msdmanuals.com)

Studying the development of mouse embryos can teach researchers about how mutations affect cells and later lead to cancer and other defects. (mskcc.org)
The defects of hai1 mutants can be phenocopied by overexpression and can be fully rescued by simultaneous inactivation of the serine protease Matriptase1a(St14a), indicating that Hai1 promotes epithelial integrity by inhibiting Matriptase1a. (biologists.com)

These cell changes are usually more serious than ASC (atypical squamous cells). (familydoctor.org)

In this study, we explore how the dynamics of cell sheets change in relation to the integrity of cell-cell junctions, specifically focusing on tight junctions. (tu-dresden.de)

Porcine aortic endothelial cell, double-labeled for actin (green) and phospho-tyrosine (red). (weizmann.ac.il)

The researchers will study how the commensal bacteria that live in our bodies and make up our microbiome interact with cells in the small intestine through an unusual mechanism. (columbia.edu)
In a 2009 study in Cell , Ivanov, then a postdoctoral researcher at NYU, showed that a type of common microbe, segmented filamentous bacteria, could trigger the formation of specialized immune cells in the small intestine of mice and protect the mice from infection. (columbia.edu)
The CXCR1 receptor for IL-8 was expressed only on the apical membrane of Caco-2 BBE cells and differentiated epithelial cells in the human small intestine and colon. (biomedcentral.com)

For example, researchers found a protein on the outside of several types of cancer cells in the 1990s. (mesothelioma.com)
That protein is now called mesothelin, and mesothelioma cells make a lot of it. (mesothelioma.com)
Transmission electron microscopy shows subepithelial electron-dense, rod-shaped bodies, which are immunopositive for the TGFBI protein, keratoepithelin. (aao.org)
Transcriptome analyses revealed that Caco-2 BBE cells respond to stimulation with IL-8 supporting the hypothesis that IL-8 induces G protein-coupled receptor signalling. (biomedcentral.com)

Epithelial cells are responsible to enclose and protect the organs, and most produce some type of secretion, such as mucus. (jeffreysglassman.com)

A. Schematic view of left lateral seam cells in an L1-stage larva. (wormatlas.org)
B. Schematic view of left lateral seam cells in adult hermaphrodite. (wormatlas.org)
C. Schematic view of seam cells embedded in the hypodermis, looking from the inside out. (wormatlas.org)

There are several subtypes of epithelial mesothelioma. (jeffreysglassman.com)

a) Lymph node-residing and infiltrating T-cells and dendritic cells (DC) migrate on a 3D network of fibroblastic reticular cells (FRCs) and their associated ECM. (weizmann.ac.il)

Chronic inflammatory and autoimmune disease in which the salivary and lacrimal glands undergo progressive destruction by lymphocytes and plasma cells resulting in decreased production of saliva and tears. (harvard.edu)
It is controversial whether the membranous (M) cells of the Peyer's patches represent a separate cell line or develop from enterocytes under the influence of lymphocytes on the domes. (nih.gov)
epithelioid histocytes, neutrophil cells, plasma cells, M. paragordonae is often isolated from hospital water and lymphocytes in the dermal layer. (cdc.gov)

Bronchial biopsy revealed the presence of blood clots and desquamated bronchial epithelial cells, without signs of malignancy. (ispub.com)

Scientists first stained cells and bacteria with water soluble dyes to make them more visible in the microscope. (canadiannaturephotographer.com)
The smaller pill shaped structures are bacteria on the cell surface. (canadiannaturephotographer.com)

Seven cone-shaped renal pyramids form the renal medulla deep to the renal cortex. (innerbody.com)

a perivascular arrangement of tumor cells resulting in a palisading effect may be seen. (medscape.com)
CSCs display the slow-migratory, invadopod-rich phenotype that is the hallmark of disseminating tumor cells. (nature.com)
60% of circulating tumor cells. (nature.com)
ALCL was recognized in 1985, when tumor cells consistently demonstrated labeling by the monoclonal antibody Ki-1, a marker later shown to recognize the CD30 antigen. (medscape.com)

Cathepsin S which is produced by most of the antigen- presenting cells along with mTECs is absent in cTECs. (wikipedia.org)
CD4 + T cell calibration of antigen-presenting cells optimizes antiviral CD8 + T cell immunity. (bvsalud.org)

a1) T cells can also interact with, and be activated by, DCs presenting via MHC/HLA a specific antigen matching the T-cell receptor, and accompanied by co-stimulatory (CD80/CD86 DCs, and CD28 T cells) and adhesive molecules (ICAM-1/LFA-3 DCs, and LFA-1/CD2 T cells). (weizmann.ac.il)

Lacrimal Gland Epithelial Cells Shape Immune Responses through the Modulation of Inflammasomes and Lipid Metabolism. (harvard.edu)
Fibrillar vs crystalline nanocellulose pulmonary epithelial cell responses: cytotoxicity or inflammation? (cdc.gov)

In vitro methods, based on human primary cells, cell lines, and genetically modified reporter cell lines, have greatly expanded the scope of in vitro toxicology. (brill.com)

When Stanford University's Manu Prakash was starting his lab about eight years ago, he wanted to be able to connect the behavior of an animal's cells with that of the entire organism. (the-scientist.com)
The researchers also confirmed previous work showing that actin bundles appear on the surface of Trichoplax cells, as is the case for nonmuscle contractile cells in other animals, and determined that homologs of human myosins were present in the animal's genome. (the-scientist.com)

The fibers irritate mesothelial cells, causing inflammation. (mesothelioma.com)

a2,3) Both DCs and T cells interact with FRCs and their secreted chemokines (CCL19, CCL21), as well as cytokines (IL-6, IL-7), which promote their migration and survival. (weizmann.ac.il)
The chemi- appear to interact with the structural elements of the cell, cal analysis was assessed at DATA CHEM Laboratories using plasma- with apparent binding to the cytoskeleton [Porter et al. (cdc.gov)

These cells were characterised by PCR, immunocytochemistry, electron microscopy, and Western and Northern blot analyses. (ersjournals.com)
On electron microscopy, curly fibers (9-15 nm) rather than rod-shaped bodies are apparent, distinguishing this dystrophy from RBCD. (aao.org)

Squamous cells form the surface of your cervix. (familydoctor.org)
This result means the squamous cells don't look normal. (familydoctor.org)
Stratified squamous epithelial cells in the region known as the nail root form nails. (quizlet.com)
Chen Mao-huai & Wu Ming-yao , «Morphometric study on AgNORs of esophageal squamous cell carcinoma and paraneoplastic epithelial cells», Acta Stereologica [En ligne], Volume 11 (1992), Number 2 - Dec. 1992, 205-209 URL : https://popups.ulg.ac.be/0351-580x/index.php?id=1952. (ac.be)

Most of the organs in the human body are composed of epithelial sheets, which are layers of cells. (tu-dresden.de)
Combined treatment of FWGE and 5-fluorouracil or dacarbazine resulted in a synergistic effect in the HCR-25 human cancer cell line and B16 murine melanoma cell line [ 6 ]. (hindawi.com)
Komor, Badran and Liu, 2017 ) have opened up tremendous opportunities for the development of cell lines, especially those of human origin ( Tobita, Guzman-Lepe and de L'Hortet, 2015 ). (brill.com)
Above are live human cheek epithelial cells stained with Methylene Blue. (canadiannaturephotographer.com)
Finally, we consider topological cell shape generators trained using human neutrophils from healthy donors and septic patients. (math.ca)
CXCR1 is expressed in the human IEC line Caco-2 BBE [ 3 ], which is in agreement with our own microarray data using Caco-2 BBE cell mRNA (see below). (biomedcentral.com)

Their research unveils the mechanism by which the mutation affects cell shape and prevents cells from properly forming important body structures. (mskcc.org)
Epithelial mesothelioma - also sometimes referred to as epithelioid mesothelioma - is so named because it affects the epithelial cells. (jeffreysglassman.com)
Berges, Julian (2021): H4K20 di-methylation and multiciliogenesis: how a ubiquitous epigenetic mark affects a specific cell organelle. (uni-muenchen.de)

Secretion of IL-2 by activated T-cells induces an autocrine- and paracrine-induced proliferative effect on adjacent T-cells. (weizmann.ac.il)

Some epithelial structures are retained, however. (rupress.org)
But, dotted around the body, in numerous places, these cells form little structures that can secrete an array of different chemicals: we call these exocrine glands. (thenakedscientists.com)
The exocrine glands are exquisitely arranged with a mix of different cell types in specific structures. (thenakedscientists.com)
Auxiliary genes include proteases, such as chitinase, which are dedicated to the degradation of host structures and the prevention of host cell death (Luque et al, 2001). (kenyon.edu)
Instead these plants absorb water and nutrients directly through leaflike and stemlike structures or through specialized cells. (britannica.com)

FWGE has significant antiproliferative effects and kills tumour cells by the induction of apoptosis via the caspase-poly (ADP-ribose) polymerase pathway [ 9 ]. (hindawi.com)

The reason epithelioid mesothelioma is deemed the most treatable is that the way the cells are shaped and grow. (jeffreysglassman.com)

In addition, mTEC screen thymocytes for their expression of high affinity αβ-TCRs, with negative selection limiting the release of these reactive T-cells into the peripheral pool ( 4 ). (frontiersin.org)

Seam cells are linked to the hypodermis by small adherens junctions along their apical borders and by small gap junctions on their lateral membranes ( SeamFIG 2 ).In a newly hatched animal, there are ten seam cells on each side of the animal (H1-H2, V1-V6 and T). All seam cells, except for H0, divide in a stem-cell-like pattern before each molt. (wormatlas.org)
At this stage, ten embryonically born individual seam blast cells contact each other through adherens junctions. (wormatlas.org)
Adherens junctions (AJs) play key roles in establishing and maintaining epithelial structure ( Nelson, 2003 ). (rupress.org)
Epithelial cells come in many shapes and sizes - some are rather boring, looking like a sheet of bricks bonded together with tight junctions. (thenakedscientists.com)

Cell-cell and cell-matrix adhesions are known to play key roles in the recruitment and activation of immune T-cells. (weizmann.ac.il)

Anatomy33

Organisms2

Diseases1

Chemicals and Drugs15

Analytical, Diagnostic and Therapeutic Techniques and Equipment10

Phenomena and Processes24

Disciplines and Occupations1

Information Science3

Tissues18

Airway Epithelial Cells2

Thymic epithelial cells5

Epithelium5

Tissue23

Lung9

Monolayers3

Mesenchymal cell1

Epithelia2

Nuclei5

Drosophila3

Metastasis4

Medullary2

Stromal4

Apical and basolateral1

Polarity7

Multicellular2

Specificity3

Intestinal5

Vivo3

Biology2

Embryonic2

Transition5

Glandular1

Differentiate3

Basolateral3

Stroma3

Polygonal1

Insights1

Adhesion4

Cilia3

Cellular1

Differentiation2

Precursors1

Tumors1

Cancers3

Defects2

Atypical1

Dynamics1

Porcine1

Small intestine3

Protein4

Mucus1

Schematic3

Subtypes1

Dendritic cells1

Lymphocytes3

Malignancy1

Bacteria2

Medulla1

Tumor cells4

Antigen- pres2

Receptor1

Responses2

Genetically1

Animal's2

Inflammation1

Interact2

Microscopy2

Squamous4

Human6

Affects3

Secretion1

Structures5

Induction1

Epithelioid1

Peripheral1

Junctions4

Roles1