Epithelial cadherins. Medical search. Frequent questions

Epithelial to mesenchymal transition (EMT) facilitates tissue remodelling during embryonic development and is viewed as an essential early step in tumour metastasis. (nih.gov)
Conversely, ectopic expression of these microRNAs in mesenchymal cells initiated mesenchymal to epithelial transition (MET). (nih.gov)
Here we show that the T-box transcription factor Brachyury induces in tumor cells epithelial-mesenchymal transition (EMT), an important step in the progression of primary tumors toward metastasis. (jci.org)
Its role is often interpreted in the context of the epithelial-mesenchymal transition. (iiarjournals.org)
The experimental and physiological observations regarding the tumor-suppressor role of E-cadherin are often interpreted in the context of the epithelial-mesenchymal transition. (iiarjournals.org)
There is increasing evidence that epithelial to mesenchymal transition (EMT) is involved in cancer progression. (aacrjournals.org)
Therefore, an improved understanding of the functions and the underlying molecular mechanisms of these proteins, particularly in epithelial-mesenchymal transition, may provide novel insights into the breast tumorigenesis and progression, and enable the development of effective anti-cancer therapeutics. (spandidos-publications.com)
To investigate the effects of zerumbone on cell invasion, epithelial-mesenchymal transition (EMT) and the potential signaling pathway involved in ovarian cancer cells. (ajol.info)
The formation of the mammalian respiratory unit is initiated during the transition between the pseudoglandular and canalicular/saccular stages and is characterized by coordinated proliferation and differentiation of epithelial and mesenchymal cells. (biomedcentral.com)
After co-culture with tumour-associated pancreatic stellate cells (TPSCs), pancreatic cancer cells displayed up to 8-fold reduction in levels of epithelial-mesenchymal transition (EMT) markers E-cadherin and ZO-1, while β-catenin and vimentin levels were increased. (lu.se)
When injected via tail vein, KALLU+ lung SCC cells that highly expressed TNFR1/TNF, Sox2, c-Myc, Twist1, Bcl2, and UBCH10, generated dedifferentiated spindle cell carcinomas with epithelial-mesenchymal transition markers in mouse lungs. (bvsalud.org)
It was also found that LTD4 could induce Epithelial-Mesenchymal Transition (EMT) in SW480 colon cancer cells by i) reducing membrane E-cadherin, ii) increase levels of nuclear β-catenin, iii) increase EMT marker such as vimentin and snail which leads to increase migration of SW480 colon cancer cells. (lu.se)

Disruption of these cell-cell contacts perturbs the polarity of epithelial tissues leading to their disorganization and ultimately to aggressive carcinomas. (pasteur.fr)
In non-epithelial tissues, the role of cadherins in the development of cancer is still debated. (pasteur.fr)
The exact physiological role of CDHR3 is not known, but as the CDHR3 protein is expressed in epithelial tissues and has six extracellular cadherin domains plus a short transmembrane segment, it is believed to be related to the function of similar cadherins which function in cell adhesion and cell-to-cell signaling. (wikipedia.org)
E-cadherin helps neighboring cells stick to one another (cell adhesion) to form organized tissues. (medlineplus.gov)
A lack of E-cadherin also impairs cell adhesion, increasing the likelihood that cancer cells will not come together to form a tumor but will invade the stomach wall and metastasize as small clusters of cancer cells into nearby tissues. (medlineplus.gov)
It is a calcium-regulated adhesion molecule expressed in most normal epithelial tissues ( 2 ). (iiarjournals.org)
Even though the frequencies of the different polygon types differ widely between different epithelial tissues, all epithelia analysed to date indeed meet this topological constraint in that their cells have on average close to six neighbours ( Fig. 1d,e ). (biorxiv.org)
Using immunohistochemistry in a well-characterized set of adenocarcinoma tissues, we showed down-regulation of epithelial markers (E-cadherin and cytokeratin 18) and up-regulation of mesenchymal markers (vimentin and α-smooth muscle actin) with concomitant transforming growth factor-β1 (TGF-β1) expression at the invasive margin compared with the central tumor. (aacrjournals.org)
Our approach provides a tool for modelling the development of defined biological abnormalities in epithelial and other biological tissues, raising novel predictions for future experimental testing. (hud.ac.uk)
E-cadherin could be demonstrated in formalin or paraformaldehyde fixed tissues but not in glutaraldehyde fixed tissue. (cdc.gov)

E-cadherin is a protein expressed on the surface of normal epithelial cells that plays a key role in mediating intercellular adhesion via calcium-dependent homotypic interactions. (hud.ac.uk)
Thus, in the lung, e-cadherin immunofluorescence can demonstrate abnormal and normal epithelial cell junctions, facilitate demonstration of airway epithelial changes, and distinguish podoplaninexpressing alveolar type I cells from lymphatic endothelium. (cdc.gov)

Low levels of e-cadherin expression in type I cells allowed the double labeled type I cells to be distinguished from lymphatic endothelium and facilitated diagnosis of lymphangiectasia. (cdc.gov)

We determined the effect of vapour on oxidative stress-induced, PAFR-dependent pneumococcal adhesion to airway epithelial cells in vitro , and on pneumococcal colonisation in the mouse nasopharynx. (ersjournals.com)

Cadherin related family member 3 (CDHR3), also known as CDH28 or its abbreviation CDHR3, is a protein that in humans is encoded by the CDHR3 gene. (wikipedia.org)
SHE78-7 exposure increased epithelial permeability to mannitol, inulin, and 9.5 kDa and 77 kDa dextrans and caused fragmentation and loss of the tight junction protein, ZO-1, from the cell borders in some areas. (ox.ac.uk)
The CDH1 gene provides instructions for making a protein called epithelial cadherin or E-cadherin. (medlineplus.gov)
This protein is found within the membrane that surrounds epithelial cells, which are the cells that line the surfaces and cavities of the body. (medlineplus.gov)
E-cadherin has many other functions including acting as a tumor suppressor protein, which means it prevents cells from growing and dividing too rapidly or in an uncontrolled way. (medlineplus.gov)
The encoded protein is a calcium dependent cell-cell adhesion glycoprotein comprised of five extracellular cadherin repeats, a transmembrane region and a highly conserved cytoplasmic tail. (origene.com)
Sections were immunostained for estrogen receptor (ER), progesterone receptor (PR), human epidermal growth factor receptor 2 (Her2), basal cytokeratin CK5, nuclear protein Ki67 and E-cadherin with a Leica Bond-Max autostainer. (iiarjournals.org)
E-cadherin is a metastasis-suppressor protein and its loss of function is associated with malignant progression. (hud.ac.uk)
This association links the cadherin protein to the cytoskeleton. (rndsystems.com)
Mouse P-Cadherin is an 822 amino acid (aa) protein with a 27 aa signal sequence and a 795 aa propeptide. (rndsystems.com)
Mechanisms such as mRNA expression, cytokine modulation, and protease-mediated turnover modulate N-cadherin protein levels during development. (bdbiosciences.com)
Thus, N-cadherin is an integral adhesion molecule whose function is regulated by protein-protein interactions and phosphorylation/dephosphorylation events. (bdbiosciences.com)
Cadherins form protein complexes with cytoplasmic proteins (catenins) that convert the specific, homophilic-binding capacity of the extracellular domain into stable cell adhesion. (embl.de)
The protein encoded by this gene is a calcium-dependent glycoprotein that is a member of the desmocollin subfamily of the cadherin superfamily. (nih.gov)
Lastly, we revealed that addition of type IV collagen protein induced myofibroblast proliferation and migration in monolayer culture and increased the formation of mesenchymal-epithelial septal-like structures in co-culture. (biomedcentral.com)

Among intercellular junctions, cadherin-based adherens junctions mediate strong physical interactions and transmit information from the cell microenvironment to the cytoplasm. (pasteur.fr)
The assembly of tight junctions between epithelial cells seems to require theprior formation of adherens junctions. (ostatic.com)
Anti-cadherin antibodies that block theformation of adherens junctions, for example, also block the formation of tightjunctions.Desmosomes Connect Intermediate Filaments from Cell toCellDesmosomes are buttonlike points of intercellular contact that rivet cellsTogether. (ostatic.com)
Cadherins are a group of transmembrane proteins that serve as the major adhesion molecules located within adherens junctions. (embl.de)
Molecular and functional analysis of cadherin-based adherens junctions. (embl.de)
Adherens junctions are specialized forms of cadherin-based adhesive contacts important for tissue organization in developing and adult organisms. (embl.de)

Knockout of E-cadherin has been associated with non-viability and abnormal epithelial morphogenesis ( 4 ). (iiarjournals.org)

Sandwich enzyme-linked immunesorbent assay (ELISA) for the determination of E-Cadherin in human serum, plasma body fluids, tissue lysates or cell culture supernates. (ibl-america.com)
Two single-cell RNA expression studies furthermore found CDHR3 to be highly selectively expressed in ciliated epithelial cells, compared to other cell types in the respiratory epithelium, and thereby to be a marker for ciliated cells in respiratory airway tissue. (wikipedia.org)
These data demonstrate a critical role for DNMT3A in orchestrating intestinal epithelial homeostasis and response to tissue damage and suggest an involvement of impaired epithelial DNMT3A function in the etiology of IBD. (nature.com)
Intestinal epithelial cells (IECs) have evolved to build a complex physiological barrier that separates the intestinal lumen from the underlying mucosal tissue. (nature.com)
Based on our theoretical framework, we explain how cell growth and division as well as mechanical constraints act together to drive epithelial tissue organization. (biorxiv.org)
b , A typical epithelial tissue from the Drosophila larval eye disc peripodial epithelium (dPE), coloured according to the number of neighbours per cell. (biorxiv.org)
Cadherins play a role in development, specifically in tissue formation. (rndsystems.com)

Overexpression of Brachyury in human carcinoma cells induced changes characteristic of EMT, including upregulation of mesenchymal markers, downregulation of epithelial markers, and an increase in cell migration and invasion. (jci.org)
Brachyury overexpression also repressed E-cadherin transcription, an effect partially mediated by Slug. (jci.org)
The defects of hai1 mutants can be phenocopied by overexpression and can be fully rescued by simultaneous inactivation of the serine protease Matriptase1a(St14a), indicating that Hai1 promotes epithelial integrity by inhibiting Matriptase1a. (biologists.com)

This gene is a classical cadherin from the cadherin superfamily. (origene.com)
P-Cadherin is a classical cadherin molecule. (rndsystems.com)

The purpose of this study was to apply an agent-based simulation paradigm in order to examine the emergent growth properties of mixed populations consisting of normal and E-cadherin defective cells in monolayer cell culture. (hud.ac.uk)

SOX4 has been revealed to induce EMT, a key process during organ development and the progression of epithelial tumors to metastatic cancers ( 9 ), via its activation of the Wnt and transforming growth factor β signaling pathways in cancer cells ( 10 , 11 ). (spandidos-publications.com)

Cowin P. Unraveling the cytoplasmic interactions of the cadherin superfamily. (bdbiosciences.com)

Cadherins are calcium-dependent transmembrane proteins, which bind to one another in a homophilic manner. (rndsystems.com)
Classical cadherins consist of a large extracellular domain which contains DXD and DXNDN repeats responsible for mediating calcium-dependent adhesion, a single-pass transmembrane domain, and a short carboxy-terminal cytoplasmic domain responsible for interacting with the catenins. (rndsystems.com)
E-cadherin is a calcium dependent adhesion molecule with important roles in epithelial intercellular adhesion and cellular structure. (cdc.gov)

Affected individuals make antibodiesagainst one of their own desmosomal cadherin proteins. (ostatic.com)
The transmembrane adhesion proteins in these cell-matrixjunctions are integrins a large family of proteins distinct from the cadherins.Focal adhesions enable cells to get a hold on the extracellular matrix through integrins that link intracellularly to actin filaments. (ostatic.com)
We investigated the use of e-cadherin immunofluorescence in different species (rat and mouse), with different fixatives (10% neutral buffered formalin, 4% paraformaldehyde, and 2.5% glutaraldehyde ), with and without antigen retrieval, and as a dual label with immunofluorescence for other proteins. (cdc.gov)
E-cadherin immunofluorescent double labeling can also be used with activated caspase 3 or â-catenin immunofluorescence to localize the expression of these proteins in damaged airways. (cdc.gov)
Cadherins are evolutionary related to the desmogleins which are component of intercellular desmosome junctions involved in the interaction of plaque proteins. (embl.de)
However, proteins are designated as members of the broadly defined cadherin family if they have one or more cadherin repeats. (embl.de)
This entry represents the extracellular repeated domains found in cadherins and related proteins. (embl.de)
H. pylori secretes the enzyme HtrA, which cleaves adhesion proteins like E-cadherin and allows H. pylori to cross the epithelium. (oercommons.org)
These desmosomal family members, along with the desmogleins, are found primarily in epithelial cells where they constitute the adhesive proteins of the desmosome cell-cell junction and are required for cell adhesion and desmosome formation. (nih.gov)

Several functional components of the epithelium contribute to this unique role, among them the secretion of a mucus layer and life-long regeneration of the different epithelial cell types from a stem cell compartment, allowing for quick repair of barrier defects 2 . (nature.com)

Immunofluorescent double-labeling with e-cadherin can be used with immunofluorescent detection of podoplanin, a lymphatic endothelial cell marker that is also expressed by alveolar type I cells in the lung. (cdc.gov)
Here in, a comprehensive analysis of two mouse models of pulmonary fibrosis developed in our lab demonstrated that lung damage-induced ferroptosis of alveolar epithelial Type2 cells (AEC2) significantly accumulates during the development of pulmonary fibrosis while ferroptosis suppressor genes GPX4 and FSP1 are dramatically inactivated. (bvsalud.org)

In wound healing and development, large epithelial sheets migrate collectively, in defined directions, and maintain tight cell-cell adhesion. (ca.gov)
Furthermore, E-cadherin blocking antibodies abolished migration of cell sheets. (ca.gov)
We recently found that downregulation of N-cadherin in malignant glioma-the most frequent primary brain tumor-results in cell polarization defects leading to abnormal motile behavior with increased cell speed and decreased persistence in directionality. (pasteur.fr)
Re-expression of N-cadherin in glioma cells restores cell polarity and limits glioma cell migration, providing a potential therapeutic tool for diffuse glioma. (pasteur.fr)
We probed the CSK through integrins and E-cadherins in confluent epithelial cell lines (MCF7). (illinois.edu)
In addition, there was substantial cell spreading on collagen I-coated dishes, in contrast to little spreading on dishes coated with E-cadherin antibody. (illinois.edu)
This result, together with observations of a relatively high cell stiffness probed through integrins compared with the small stiffness probed through E-cadherins, suggests that mechanical force transmission might also be important in regulating cell spreading. (illinois.edu)
Potard, USB, Butler, JP & Wang, N 1997, ' Cytoskeletal mechanics in confluent epithelial cells probed through integrins and E-cadherins ', American Journal of Physiology - Cell Physiology , vol. 272, no. 5 41-5, pp. (illinois.edu)
Maintenance of the epithelial barrier in a bronchial epithelial cell line is dependent on functional E-cadherin local to the tight junctions. (ox.ac.uk)
The bronchial epithelial cell line, 16HBE14o-expresses E- and P-cadherin, but not N-cadherin. (ox.ac.uk)
Analysis of epithelial penetration by SHE78-7 revealed discrete, local defects in the apical barrier at the top of some cell hills that permitted rapid access of the antibody to E-cadherin near the apical surface. (ox.ac.uk)
Genetic deletion of Dnmt3a in intestinal epithelial cells ( Dnmt3a ΔIEC ) in mice confirms the phenotype of an altered epithelial ultrastructure with shortened apical-junctional complexes, reduced Goblet cell numbers and increased intestinal permeability in the colon in vivo. (nature.com)
When both copies of the CDH1 gene are mutated in a particular cell, that cell cannot produce any functional E-cadherin. (medlineplus.gov)
This important process includes changes that lead to the transient down-regulation of epithelial cell characteristics such as apical-basal polarization and organized cell-cell adhesion and the acquisition of a mesenchymal cellular phenotype, which is less adherent and more migratory ( 7 ). (iiarjournals.org)
Our discovery provides a link between epithelial organisation, cell division and growth and has implications for the general understanding of epithelial dynamics. (biorxiv.org)
Placental Cadherin (P-Cadherin or PCAD) is a member of the cadherin family of cell adhesion molecules, designated CDH3. (rndsystems.com)
Miyatani S, Shimamura K, Hatta M. Neural cadherin: role in selective cell-cell adhesion. (bdbiosciences.com)
In addition, SCARA5 repressed OSCC cell epithelial-mesenchymal transformation (EMT), evidenced by increased E-cadherin expression and reduced N-cadherin expression. (degruyter.com)
Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. (embl.de)
Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium. (embl.de)
Solution structure of the epithelial cadherin domain responsible for selective cell adhesion. (embl.de)
Amagai M, Klaus-Kovtun V, Stanley JR. Autoantibodies against a novel epithelial cadherin in pemphigus vulgaris, a disease of cell adhesion. (medscape.com)

Constitutive P-Cadherin expression is found in the epidermis, mesothelium, corneal epithelium, and uterine decidua. (rndsystems.com)

Homo sapiens cadherin 1 (CDH1), transcript variant 1, mRNA. (origene.com)
In practical applications, E-cadherin is used as a phenotypic marker of the lobular subtype of cancer, where loss of hetero zygosity in chromosome region 16q22.1, the gene region encoding E-cadherin ( CDH1 ) is frequent ( 6 ). (iiarjournals.org)

Selective loss of E-cadherin can cause de-differentiation and invasiveness in human carcinomas, leading this marker to be classified as a tumor suppressor ( 5 ). (iiarjournals.org)

In contrast, after basal exposure, antibody initially engaged with E-cadherin nearer the basal surface and only accessed apical E-cadherin later. (ox.ac.uk)
beta-Catenin regulates P-cadherin expression in mammary basal epithelial cells. (igbmc.fr)

Cadherins are a family of Ca2+-dependent intercellular adhesion molecules that play a central role in controlling morphogenetic movements during development. (bdbiosciences.com)

Although the role of E-cadherin as a tumor suppressor has been established, in recent years, alternative roles for E-cadherin in tumor progression have become apparent. (iiarjournals.org)

Tight junctions (TJ) are essential components of polarized epithelia, and E-cadherin is important for their formation and maintenance. (ox.ac.uk)
Taken together with the TER measurements, these data suggest compartmentalization of E-cadherin function within 16HBE14o-cells, with only the apical E-cadherin adjacent to the tight junctions contributing to the function of the latter. (ox.ac.uk)

Cadherins depend on calcium for their function: calcium ions bind to specific residues in each cadherin repeat to ensure its proper folding, to confer rigidity upon the extracellular domain and is essential for cadherin adhesive function and for protection against protease digestion. (embl.de)

Cytoplasmic interactions can influence the function of the ectodomain by a number of potential mechanisms, including redistribution of binding sites into clusters, providing cytoskeletal anchorage, and mediating physiological regulation of cadherin function. (embl.de)
Studies of viral attachment to cells on porous collagen-I coated microcarrier beads under cultured gastrointestinal epithelial cells (Caco-2) using conditions of physiological fluid shear in rotating wall ves- recombinant virus-like particles or infectious noroviruses sel bioreactors. (cdc.gov)

These antibodies bindto and disrupt the desmosomes that hold their skin epithelial cells(keratinocytes) together. (ostatic.com)
Mouse monoclonal anti-e-cadherin antibodies (BD Biosciences, San Jose, CA) in conjunction with fluorochrome-conjugated donkey anti-mouse antibodies clearly delineated sites of e-cadherin expression in lungs of rats or mice. (cdc.gov)

Together, these microRNAs cooperatively regulate expression of the E-cadherin transcriptional repressors ZEB1 (also known as deltaEF1) and SIP1 (also known as ZEB2), factors previously implicated in EMT and tumour metastasis. (nih.gov)
Expression of the miR-200 family was also lost in regions of metaplastic breast cancer specimens lacking E-cadherin. (nih.gov)
whereas gene expression of E-cadherin was decreased. (nih.gov)
DNMT3A expression is downregulated in intestinal epithelial cells from IBD patients and upon tumor necrosis factor treatment in murine intestinal organoids. (nature.com)
The aim of this study was to determine the evolution of E-cadherin expression in no special type (NST) primary breast carcinoma and to correlate this with that in distant, paired nodal metastases (LNM) and molecular classification. (iiarjournals.org)
Conclusion: E-Cadherin expression is not stable during the metastatic process. (iiarjournals.org)
E-Cadherin expression in primary sites positively correlates with E-cadherin from LNM. (iiarjournals.org)
CXCR4-overexpressing HUMSCs not only improved histopathological changes but also decreased the radiation-induced expression of SDF-1, TGF- β 1, α -SMA, and collagen I and inhibited the radiation-induced decreased expression of E-cadherin. (hindawi.com)
There was no difference in baseline nasal epithelial PAFR expression between vapers (n=11) and controls (n=6). (ersjournals.com)
In this study, we found that the SCARA5 expression was lower in CAL-27 and SCC-9 cells than that in human normal oral epithelial keratinocytes. (degruyter.com)

All detectable E-cadherin was bound to beta- and gamma-catenins. (ox.ac.uk)
Without association with the catenins, the cadherins are non-adhesive. (rndsystems.com)

Furthermore, Tg-K5.TNFR1;KA/KA mice, which expressed transgenic TNFR1 in keratin 5-positve epithelial cells, developed more poorly differentiated and metastatic lung SCCs than those found in KA/KA mice. (bvsalud.org)

Western blot analysis of N-Cadherin on HeLa lysate. (bdbiosciences.com)

The use of e-cadherin immunofluorescence in pulmonary toxicologic pathology studies. (cdc.gov)

In addition, N-cadherin function is indirectly regulated by endogenous kinases and phosphatases. (bdbiosciences.com)

Cadherin repeats. (embl.de)

In this study, immortalized esophageal epithelial cells and EAC cells (EACCs) were cultured with or without cigarette smoke condensate (CSC) under relevant exposure conditions. (bvsalud.org)
The CSC repressed miR-145 and upregulated LOXL2 in immortalized esophageal epithelial cells and EACCs. (bvsalud.org)

Marquage par immunofluorescence d'astrocytes tumoraux ou astrocytomes (lignée cellulaire humaine U373), montrant en rouge, APC et en vert, la tubuline des microtubules. (pasteur.fr)

N-cadherin mRNA is found at elevated levels in brain and heart and at a much lower level in liver. (bdbiosciences.com)

In the developing lung, the specific temporal-spatial interactions between mesenchymal and epithelial cells are carefully orchestrated to permit the gradual establishment of an effective blood-gas barrier (BGB) [ 1 , 2 ]. (biomedcentral.com)

We investigated involvement of E-cadherin with epithelial integrity using an E-cadherin specific, function-blocking antibody, SHE78-7. (ox.ac.uk)

Since invasive pneumococcal strains adhere to, and translocate across, respiratory tract epithelial cells, adhesion is a prerequisite for establishing pneumococcal disease [ 4 ]. (ersjournals.com)

However, N-cadherin also interacts with a PTP1B-like phosphatase that dephosphorylates β-catenin and promotes N-cadherin/actin association. (bdbiosciences.com)

We now provide evidence that the observed apical epithelial packing minimizes surface energy at the intercellular apical adhesion belt. (biorxiv.org)

These were examined the genome of dividing gastric epithelial 20% [12]. (who.int)

A single positive correlation of E-cadherin with ER (p≤0.007) LNM was found. (iiarjournals.org)

Using mouse models, we discovered that mutations in murine Col4a1 and Col4a2 genes affected the balance between lung epithelial progenitors and differentiated cells. (biomedcentral.com)
The lung is a complex, precisely structured organ in which the vascular network is intimately associated with epithelial-lined tubes and sacs for the prime purpose of gas exchange. (biomedcentral.com)

We suggest that close follow-up together with periodic endoscopic examination for all patients with persistent H. pylori infection and serum soluble E-cadherin level above 5 µg/mL is essential. (who.int)

Anatomy17

Organisms1

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Phenomena and Processes22

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Transition12

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Normal epithelial2

Levels of e-cadherin1

Airway epithelial cells1

Protein15

Adherens junctions6

Morphogenesis1

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Classical cadherin2

Cells in monolayer1

Tumors1

Superfamily1

Calcium dependent3

Proteins9

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CDH12

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Extracellular domain1

Physiological2

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