• The acquisition of Labrys brings to Teva LBR-101, a fully humanized monoclonal antibody that binds to calcitonin gene-related peptide (CGRP), which is currently in Phase IIb clinical trials for prevention of chronic and episodic migraine. (tevapharm.com)
  • It's an exciting opportunity to develop a much needed treatment option for people suffering from the impact of chronic and episodic migraine. (tevapharm.com)
  • It is currently in Phase IIb clinical trials for prevention of episodic and chronic migraine. (tevapharm.com)
  • Chronic migraine is characterized by headaches on at least 15 days per month and high frequency episodic migraine shares many similarities with chronic migraine. (tevapharm.com)
  • Consequently, prophylactic treatment of episodic and chronic migraine continues to present considerable challenges, and there remains a significant medical need for new, safe and effective migraine prophylactic treatment options. (tevapharm.com)
  • and opioid treatments for chronic pain, acute pain, and episodic migraine pain (details including questions are available in the full AHRQ reports) ( 1 - 5 ). (cdc.gov)
  • From the CaMEO study, [ 4 ] we see that migraine causes stress in the lives of patients with migraine, even when those patients are not actually suffering from an attack. (medscape.com)
  • In fact, one third of spouses of people with episodic migraine and one half of spouses of those with the chronic form of the disease report that they avoid the person with migraine because of the headaches. (medscape.com)
  • [ 5 , 6 ] Cost in predictors of lost productivity time has shown us that the cost to men with chronic migraine is about $200 more per week than to men with episodic migraine. (medscape.com)
  • What Contributes To Quality Of Life In Patients With Episodic And Chronic Cluster Headache? (researchsquare.com)
  • There is a paucity of research on what factors, other than pain and disability, influence QoL in Chronic CH (CCH) and Episodic CH (ECH). (researchsquare.com)
  • Two subtypes of CH, episodic (ECH) and chronic (CCH), are clinically distinguished primarily on the basis of the frequency of the attacks, while the nature and severity of pain experienced by the two subtypes is comparable. (researchsquare.com)
  • Doctors divide tension headaches into two types - episodic and chronic. (lamppachiropractic.com)
  • The indirect costs, translated as lost productivity, amount to about $1700 per year for patients with the episodic form and $3300 per year for those with the chronic form. (medscape.com)
  • Team Fortress 2 , part of Valve's 2007 Orange Box collection (which included Half-Life 2, its two episodic expansions, and Portal), raised the bar for multiplayer FPS games to a height unmatched for years. (techspot.com)
  • Half-Life 2: Episode Two -- the second installment in Valve's episodic trilogy advances the award-winning story, leading the player to new locations outside of City 17. (interactive.org)
  • INTRODUCTION: In 2017, all people with severe haemophilia B (PWSHB) in Ireland switched from standard half-life (SHL) recombinant FIX (rFIX) to rFIX Fc fusion protein (rFIXFc) prophylaxis. (bvsalud.org)
  • An episodic video game is a video game of a shorter length that is commercially released as an installment to a continuous and larger series. (wikipedia.org)
  • In an episodic series there is no dominant '"first" game': each installment, although perhaps of the same length and price point as an expansion, is a main event that drives the core experience forward. (wikipedia.org)
  • Having built its popularity on Half-Life 2, the game's second episodic instalment - part of The Orange Box - helped to drive sales while other publishers continued to back it with high-profile releases like Call of Duty 4 and BioShock. (eurogamer.net)
  • Episodic production in this manner has become increasingly popular among video game developers since the advent of low-cost digital distribution systems, which can immensely reduce their distribution overhead and make episodes financially viable. (wikipedia.org)
  • Examples of episodic video games include most Telltale games, Alan Wake, BioShock Infinite: Burial at Sea, Grand Theft Auto: Episodes from Liberty City, Life Is Strange, Resident Evil: Revelations (and Revelations 2), Half-Life 2: Episode One (and Two) and Star Trek Online. (wikipedia.org)
  • Some developers choose the episodic model because they lack the resources to complete a full-length game, and hope the sales of episodes will fund further development. (wikipedia.org)
  • Notable episodic series that have been aborted early include Sin Episodes, Bone, and Insecticide. (wikipedia.org)
  • They need to focus on fixing the bugs with whatever they have, cut a few corners with models and graphic design for the pieces they have in place, and build in a system releasing adding episodic content a la Half-Life 2: Episodes 1-3. (techdirt.com)
  • The episodes for at least the first half of the series are "slice of life" stories. (animeworld.com)
  • Would an episodic Halo be a neat idea? (bungie.org)
  • Would an episodic Halo in the vain of Spartan Ops be a neat idea? (bungie.org)
  • Half-Life 2 and Halo 2 (2004) had budgets comparable to SquareSoft's legendary RPG, despite being primarily linear shooters showcasing advanced graphics and tech. (techspot.com)
  • So, if that's anything like Valve and Half life 2, it'll be good but each episode will be really short and released years apart. (ukresistance.co.uk)
  • Some guy, who some other guy said works at Valve, wore a Half-Life 3 t-shirt to a "local game development event. (pcgamer.com)
  • One of the original Half-Life developers, Doug Wood, has announced that he will be retiring from Valve after working for the company for almost 19 years. (lambdageneration.com)
  • The recent news of Half-Life series writer Marc Laidlaw retiring from Valve has sent shockwaves through the community. (lambdageneration.com)
  • Big news, gaming fans: it appears IGN and Valve may be preparing to announce Half-Life 3, or at least something pertaining to the Half-Life universe. (neowin.net)
  • Half-LifeĀ® 2: Episode Two is the second in a trilogy of new games created by Valve that extends the award-winning and best-selling Half-LifeĀ® adventure. (steampowered.com)
  • Asthma is a clinical syndrome characterized by episodic reversible airway obstruction, increased bronchial reactivity, and airway inflammation. (medscape.com)
  • Most episodic content is distributed primarily or exclusively over the internet, to offset the potential extra costs of distributing more physical copies to retail (e.g. 5 hard copies for 5 chapters over 4 years as opposed to shipping a single item once). (wikipedia.org)
  • Advisors had previously appeared in Half-Life 2, primarily in Episode Two, but that particular slice of code was not in the Episode Two SDK. (pcgamer.com)
  • Then, they switch gears to briefly discuss episodic binge-watching, tackling several television shows, including "The Man in the High Castle", "The Marvelous Mrs. Maisel", "Norm Macdonald Has a Show" and more! (chillpakhollywood.com)
  • Episodic games differ from conventional video games in that they often contain less content but are developed on a more frequent basis. (wikipedia.org)
  • 3DS owners can look forward to Shantae And The Pirate's Curse later this year, but the company made headlines recently when it launched a Kickstarter campaign for Shantae: Half-Genie Hero . (nintendolife.com)
  • In terms of the narrative framework, episodic games tend to end in cliffhangers because it serves as a tool to deploy a seamless transition. (wikipedia.org)
  • Virtually any contemporary single-player action-adventure draws inspiration from the narrative techniques in Half-Life 2 (2004), Mass Effect and BioShock (both 2007), intentionally or otherwise. (techspot.com)
  • Alprolix is the new extended half life treatment that will be available to haemophilia B patients in Ireland from April 2017. (haemophilia.ie)
  • The study results reinforce the long-term safety and efficacy of prophylactic treatment with ALPROLIX over a median duration of more than three years in adults/adolescents and more than a year and a half in children under 12 years of age. (haemophilia.ie)
  • The VR exclusive Half-Life: Alyx is a standalone prequel to HL2 starring a lone Alyx going up against the Combine with a pair of gravity gloves. (pcgamer.com)
  • Even with all of the Half-Life: Alyx hubbub, we're likely to still hear rumors of Half-Life 3. (pcgamer.com)
  • The good news is that, after the launch of Half-Life: Alyx, prospects are bright for more Half-Life games in the future (in whatever forms they'll take). (pcgamer.com)
  • Known Bugs: 1 I am aware that the model is in the normal Half Life 2 problems with the neck of Alyx that problem tread unfortunately only with the normal Half Life 2. (nudepatch.net)
  • I wanted to see what Trek might look like given the advances in television story telling over the last half of my life. (hearye.org)
  • Patient-reported outcomes (PROs) and health-related quality of life (HRQoL) are important to evaluate with new treatments. (bvsalud.org)
  • Our findings highlight additional factors to consider in the clinical management of CH and to incorporate in cognitive behavioral therapy with CH patients to reduce disability and the psychosocial impact of CH on daily life. (researchsquare.com)
  • We previously developed and validated the cluster headache quality of life scale (CH-QoL), the first disease-specific patient-reported outcome measure to monitor QoL in patients with CH in clinical care and research (6). (researchsquare.com)
  • An episodic treatment arm was also available for adult and adolescent patients. (hemophiliafed.org)
  • We're in the so-called Golden Age of television, and the episodic nature of TNG has long since been replaced by grand story arcs, sophisticated treatment of themes, and great acting. (hearye.org)
  • These results come from the longest-term study of an extended half-life therapy for hemophilia B and provide physicians across the globe with important insights and information about the treatment of hemophilia B. (haemophilia.ie)
  • An episodic treatment arm is also available only to adult and adolescent participants. (haemophilia.ie)
  • Such moves are an essential part of curbing the overdose crisis, as evidence-based treatment saves lives. (rstreet.org)
  • So if we want to save lives right now, we must look beyond treatment and embrace harm reduction. (rstreet.org)
  • And if we focus on treatment alone, we will miss an opportunity to empower the majority of people who use drugs to protect their health and their lives-including those who use functionally, casually or experimentally, as well as individuals living with a SUD who are unwilling, unable or just not ready to quit. (rstreet.org)
  • The game recently came out on Steam as a free mod for Half-Life 2, and so far, it has received a positive response from the community. (lambdageneration.com)
  • This could make a real and meaningful difference to patients' lives" said Michael Hayden, Teva's President of Global R&D and Chief Scientific Officer. (tevapharm.com)
  • Quality of life (QoL) is accepted as a critical measure in health care as it includes the patients' perspective of their health. (researchsquare.com)
  • more than half of all expenditures are attributed to the 10-20% of patients with the most severe disease. (medscape.com)
  • However, about half of patients don't respond to the antidepressant that they are initially prescribed, and more than one quarter report adverse effects. (medscape.com)
  • Recorded in Philadelphia with Hop Along's Joe Reinhart and written through a 12-month period which delivered sudden family illness and a deteriorating relationship, "Episodic" is fashioned from ten feverish bouts of guitar-pop, led by Browne's fearsome and fearless vocal and informed by an instrumental backing that underpins the entire record with a vibrant concoction of guitar, drums and keys. (revhq.com)
  • Here, you get to spend each day helping millions of people around the world enjoy healthier lives. (tevapharm.com)
  • After all, people use both legal and illegal drugs for a wide array of reasons, from recreation to coping with the struggles of daily life. (rstreet.org)
  • This suggests that for most people, such drug use tends to be episodic and temporary. (rstreet.org)
  • Imagine all of the people, possessions, and activities you love the most in life being right in front of you, but being in so much pain that you cannot reach out to grab them. (medscape.com)
  • Although asthma cannot be cured, appropriate management can control the disease and enable people to enjoy a good quality of life. (who.int)
  • Drums, bells and brass add color to the score, but the large number of short tracks means the score rarely gets the chance to soar, making it feel at times episodic instead of a flowing whole. (maintitles.net)
  • As a writer/producer, Pruitt has worked with a number of emerging and established filmmakers developing a range of short film and episodic projects. (santafefilmfestival.com)
  • The PROBE questionnaire has four domains: demographics, general health, haemophilia-specific, and European Quality of Life 5-Dimensions (EQ-5D-5L) questionnaire. (bvsalud.org)
  • Essentially, the business model of the episodic gaming is still considered high-risk for developers due to the fact that this type of game is still new compared to traditional video games and its development, thus, entails a number of risks. (wikipedia.org)
  • Experts cite that this can be demonstrated in the limited number of successes of episodic game ventures. (wikipedia.org)
  • The years since have not resulted in Episode 3 or a proper Half-Life 3, but miraculously, a new Half-Life game is out right now. (pcgamer.com)
  • We recently sat down with Richard Seabrook, the developer of the upcoming fan-made Half-Life: Opposing Force sequel, Prospekt , to ask him some questions about the game and it's development. (lambdageneration.com)
  • If you've been following the Half-Life 2 modding community lately, chances are, you've probably heard of an upcoming game called Prospekt. (lambdageneration.com)
  • LambdaGeneration is a website dedicated to the video game Half-Life. (lambdageneration.com)
  • Portal - a pioneering type of single player action game that rewrites the rules for how players approach and manipulate their environment - much like how Half-Life 2's Gravity Gun reinvented the way gamers interact with objects in the game. (interactive.org)
  • Every single time a player loses a life and either starts their next one or continues the game, not only do all enemies on the screen get knocked down (a common procedure in these games), but they also lose a noticeable amount of life. (honestgamers.com)
  • The music that was included (from Half-Life 2 soundtrack) did not match at all with the feeling I was getting when playing this mod. (thegamersjournal.com)
  • The series endured for 11 seasons and concluded with the most-viewed episodic television event in history. (life.com)
  • Finally, Dean and Phil wrap things up by celebrating the lives of a brilliant comedic actor, the male half of one of the most iconic recording duos of the 1970's, and a nun who became a television star. (chillpakhollywood.com)
  • Half-Life is rich with lore, and because of this, things have constantly changed during the series development. (lambdageneration.com)
  • The Half-Life series can be quite glum at times, especially with no resolution in sight for the series. (lambdageneration.com)
  • Faster games to market, as many high production titles often take anywhere from 2-5 years to complete - with episodic gaming, the wait time is often reduced to an annual or semi-annual basis. (wikipedia.org)
  • Half-Life 2: Episode 3, in time for Christmas 2007! (pcgamer.com)
  • A brief, very strange video clip containing a hex string led to the discovery of a small Half-Life 2 map on Megaupload. (pcgamer.com)
  • The Half-Life connection at that point was pretty thin but that's the conclusion everyone jumped to because we were all so desperate for some crumb of hope, and it did have the distinct look of an ARG in its early stages . (pcgamer.com)
  • It's that look that sets the whole thing in motion - the moment upon which all other moments are built, from Half-Life 2 to the tragic, heart-rending conclusion of Episode Two . (ghost.io)
  • Half-life 3 fakes started pretty much as soon as The Orange Box was out the door. (pcgamer.com)
  • To consumers, episodic games are very similar in nature to expansion packs. (wikipedia.org)
  • Growing up in a beautiful but conservative mountain town in Colorado, I have always found nature to be comforting and recharging in my life, no matter what issues I might have been going through - be it struggling with my sexuality or the challenges of my parents' divorce. (santafefilmfestival.com)
  • In his act, Maron shared that, "For the first nine years of my life, I was a fat kid. (cracked.com)
  • Pharmacogenomic testing also led to gains of .064 life-years and .381 quality-adjusted life-years (QALYs) per patient, or 12,436 life-years and 74,023 QALYs for all of British Columbia over 20 years. (medscape.com)
  • Two young husbands retreat to their favorite camping spot to hash out some life-altering news and the ramifications it will have on their marriage and their future together. (santafefilmfestival.com)
  • Both actors brought so much real life emotional experience and depth to their roles, it was a gift to work with them. (santafefilmfestival.com)
  • Revived from stasis, you are tasked with assisting Gordon Freeman with his trip to Nova Prospekt during the events of Half-Life 2. (lambdageneration.com)
  • And while the National Survey on Drug Use and Health finds that roughly half of respondents age 12 and older report ever having used an illicit drug, only around 14% have done so in the past month. (rstreet.org)
  • Their work as head writers on As the World Turns and consultants for One Life to Live stirred things up and added sizzle to both of these long-running daytime staples. (informit.com)
  • A Place in the West is a fan-made comic set in the world of Half-Life . (ghost.io)
  • He also expressed worry about over-committing to Half-Life 3, saying that if the studio got too deep into it, "We have to sell two million copies or else we're fucked. (pcgamer.com)
  • From a cost perspective, the $121 million CAD cost of pharmacogenomic testing and $524 million CAD increase in episodic care were offset by a decrease in the cost of refractory MDD care. (medscape.com)
  • Nothing is more unprofessional to me than adding Half-Life 2 characters and having captions of speech. (thegamersjournal.com)
  • This mod had everything going for it, and then with the inclusion of the Half-Life 2 elements, like the music and characters it was basically ruined for me. (thegamersjournal.com)
  • They forged new directions in episodic dramas with their work on Dynasty , Falcon Crest , Flamingo Road, Matlock , and Knot's Landing . (informit.com)
  • Here is a list of ten things you will use frequently in the course of your work that will hopefully make your life a little easier. (vivariumstudio.net)