• dopamine
  • Apomorphine (brand names Apokyn, Ixense, Spontane, Uprima) is a type of aporphine having activity as a non-selective dopamine agonist which activates both D2-like and, to a much lesser extent, D1-like receptors. (wikipedia.org)
  • A recent study indicates that apomorphine might be a suitable marker for assessing central dopamine system alterations associated with chronic heroin consumption. (wikipedia.org)
  • emetic
  • Historically, apomorphine has been tried for a variety of uses including as a way to relieve anxiety and craving in alcoholics, an emetic (to induce vomiting), for treating stereotypies (repeated behaviour) in farmyard animals and more recently in treating erectile dysfunction. (wikipedia.org)
  • The emetic properties of apomorphine are exploited in veterinary medicine to induce therapeutic emesis in canines that have recently ingested toxic or foreign substances. (wikipedia.org)
  • As awareness of alcoholism and its treatment spread, apomorphine was one of the earliest used pharmacotherapies, at first as an emetic. (wikipedia.org)
  • A torn pharmaceutical label that the prosecution says is from morphine hydrochloride, the poison, is rather a scrap from a label for apomorphine hydrochloride, an emetic, made clear because the m was lower case. (wikipedia.org)
  • rapidly
  • in minute doses it is much more rapidly efficient in stilling the dipsomaniac craving than strychnine or atropine… Four or even 3m [minim - roughly 60 microlitres] of the solution usually checks for some hours the incessant demands of the patient… when he awakes from the apomorphine sleep he may still be demanding alcohol, though he is never then so insistent as before. (wikipedia.org)
  • cause
  • OFF episodes can cause severe disruption for someone living with PD, often causing a major disturbance in a person's ability to maintain everyday activities. (rdmag.com)
  • time
  • This use of small, continuous doses (1/30th of a grain, or 2.16mg by Douglas) of apomorphine to reduce alcoholic craving comes some time before Pavlov's discovery and publication of the idea of the "conditioned reflex" in 1903. (wikipedia.org)