Epidermal gene nuclear receptor subfamily 6 group a member 1. Medical search. Frequent questions

Alternatively, PP2A might be activated through another pathway including the epidermal growth factor receptor (EGFR) and the receptor for activated C kinase 1 (RACK1). (wikipedia.org)
In the absence of PB, the epidermal growth factor (EGF) binds to EGFR, thereby activating the steroid receptor coactivator-1 (Src1), which in turn phosphorylates RACK1. (wikipedia.org)
It occurs more frequently in male smokers, and the epidermal growth factor receptor ( EGFR ) gene is often mutation‑free. (spandidos-publications.com)
The pathological diagnosis was SMARCA4‑dNSCLC with an EGFR gene mutation. (spandidos-publications.com)
Unlike classical lung adenocarcinoma, the primary driver genes implicated in SMARCA4-dNSCLC, as revealed by molecular detection tests, primarily involve SMARCA4, TP53, KRAS and STK11 , while the more commonly associated driver genes like EGFR, ALK and ROS1 show no marked association ( 1 ). (spandidos-publications.com)
A comprehensive literature review underscores the infrequent occurrence of EGFR mutations in SMARCA4-dNSCLC cases ( 1 , 5 , 6 ). (spandidos-publications.com)
Small molecule tyrosine kinase inhibitors targeting receptor tyrosine kinases (RTKs), such as epidermal growth factor receptor (EGFR) and anaplastic lymphoma kinase (ALK), play crucial roles in NSCLC treatment. (biomedcentral.com)

TGF-β1 acts predominantly through phosphorylation of the C-terminal MH2 domains of SMAD2 and SMAD3 via activin receptor-like kinase 5 (ALK5), of which activity is located at the C-terminal part of TGFBR1. (springer.com)
Both receptors belong to the TAM (TYRO3, AXL and MER - MER proto-oncogene, tyrosine kinase) receptor tyrosine kinase family, which emerged as new potential targets in many oncological diseases, from leukaemia to solid tumours ( Graham et al, 2014 ). (nature.com)
This study demonstrated that the Receptor for Activated C-Kinase 1 (RACK1) is important in SC function. (sdbonline.org)
Those coupled to membrane depolarization or intracellular release of calcium include the receptor-mediated activation of cytotoxic functions in granulocytes and the synaptic potentiation of protein kinase activation. (lookformedical.com)
Mediates survival signals downstream of PI3 kinase and several growth factor receptors by phosphorylating AP0pototic proteins. (affbiotech.com)
Results of kinase inhibitors on viral RNA replication The immunofluorescence detection of viral capsid protein presented a qualitative indication of no matter whether a given kinase inhibitor affected the initiation of the infection processes leading to viral gene expression. (mirnaassay.com)
Emerging evidence shows that key signal transduction pathways including TGFβ (transforming growth factor-β), ERK (extracellular signal-regulated kinase), and mTORC1 (mechanistic target of rapamycin complex 1) regulate downstream gene expression through m 6 A processing. (molcells.org)
Hepatocyte growth factor receptor (c-Met), a member of tyrosine protein kinase receptors (TPKR), is phosphorylated during LPLI-induced proliferation, but tumor necrosis factor alpha (TNF-alpha) receptor has not been affected. (biomedcentral.com)

The TAM receptors and their ligands are overexpressed or activated in multiple malignancies, including LMS. (nature.com)
G-protein coupled receptors (GPCRs) are ancient, ubiquitous, constitute the largest family of transducing cell surface proteins, and are integral to cell communication via an array of ligands/neuropeptides. (biomedcentral.com)
Furthermore, the Spätzle (Spz) family ligands for the Toll receptor are transcriptionally upregulated by activated JNK signalling in a non-cell-autonomous manner, providing a molecular mechanism for JNK-induced Toll pathway activation. (sdbonline.org)
DEC-205 (CD205), a member of the macrophage mannose receptor protein family, is the prototypic endocytic receptor of dendritic cells, whose ligands include phosphorothioated cytosine-guanosine (CpG) oligonucleotides, a motif often seen in bacterial or viral DNA. (uci.edu)

Two such genes in Drosophila encode the enzymes dopa decarboxylase (Ddc) and tyrosine hydroxylase (ple) . (sdbonline.org)
Among the inducers and positive regulators of melanogenesis are L-tyrosine and L-DOPA (pigment precursors), ultraviolet radiation and the melanocortin 1 receptor ( 5 , 9 , 10 ). (spandidos-publications.com)

Binding occurs both as a monomer and together with the retinoid X receptor (RXR) resulting in activation or repression of target gene transcription. (wikipedia.org)
Here, CAR forms a heterodimer with retinoid X receptor (RXR) and interacts with the phenobarbital-responsive enhancer module (PBREM), a distal enhancer activating transcription of CAR target genes. (wikipedia.org)

RAS family proteins include 23 genes coding for at least 25 proteins that are divided into eight paralog groups based on sequence identity, structure, and function: RAS, RAS-like (RAL), RAS-related protein (R-RAS), RAS-like protein in tissues (RIT), RAS-related protein Rap (RAP), RAS homolog enriched in brain (RHEB), Dexamethasone-induced RAS-related protein (RASD), and GTP-binding protein Di-RAS (DIRAS) [ 5 ] . (encyclopedia.pub)
The paralog group of RAS proteins is composed of four isoforms (H-RAS, N-RAS, K-RAS4A, and K-RAS4B) that are encoded by three genes, H-RAS , N-RAS , and K-RAS [ 6 ] . (encyclopedia.pub)
RAS family proteins mediate extracellular signals, transduced through their receptors, with multiple signaling pathways, and consequently regulate a wide array of cellular processes [ 8 ] . (encyclopedia.pub)
High mobility group B (HMGB) proteins have been previously related to the onset and progressions of cancers of different origins. (hindawi.com)
Levels of proteins, including Cyt C, Bcl-2/BAX, and Nrf2 /HO-1-associated proteins, were determined by western blotting and immunofluorescence. (sdbonline.org)
Furthermore, GSOs protected cells against GLU-induced apoptosis by reducing the expression of the mitochondrial apoptosis-associated Bcl-2 family effector proteins and protected cells from GLU-induced oxidative damage by increasing the nuclear translocation of Nrf2 and HO-1 expression. (sdbonline.org)
AKT is involved in the phosphorylation of members of the FOXO factors (Forkhead family of transcription factors), leading to binding of 14-3-3 proteins and cytoplasmic localization. (cusabio.com)
Our review is targeted over the four primary subfamilies: Change/sucrose non-fermentable (SWI/SNF), imitation SWI (ISWI), chromodomain-helicase DNA-binding proteins (CHD), and INOsitol-requiring mutant 80 (INO80). (morainetownshipdems.org)
m 6 A recruits effector proteins that determine the fate of mRNAs through changes in splicing, cellular localization, stability, and translation efficiency. (molcells.org)
The m 6 A-modified RNAs then recruit m 6 A-binding proteins (readers) that guide these RNAs for RNA biogenesis processes such as pre-mRNA splicing, nuclear export, stabilization, degradation, and translation. (molcells.org)

Reactive oxygen species (ROS), generated as consequence of oxidative metabolism, activate signal transduction pathways, which contribute to cellular homeostasis [ 1 ]. (hindawi.com)
In each signal transduction system, an activation/inhibition signal from a biologically active molecule (hormone, neurotransmitter) is mediated via the coupling of a receptor/enzyme to a second messenger system or to an ion channel. (lookformedical.com)
Examples of signal transduction systems are the GAMMA-AMINOBUTYRIC ACID-postsynaptic receptor-calcium ion channel system, the receptor-mediated T-cell activation pathway, and the receptor-mediated activation of phospholipases. (lookformedical.com)
Conversely, m 6 A can modulate the activity of signal transduction networks via m 6 A modification of signaling pathway genes or by acting as a ligand for receptors. (molcells.org)
In this review, we will focus on how the signal transduction pathways, which play key roles in diverse physiological and pathological conditions, coordinate cellular processes through m 6 A. Given that m 6 A also controls signaling pathways through RNA modification or acting as a ligand, understanding the crosstalk between signal transduction networks and m 6 A RNA processing will provide us insights into the complex biological systems. (molcells.org)

This paper explores the involvement of the Toll/NF-kappaB pathway in the localized activation of wound repair genes around epidermal breaks. (sdbonline.org)
We found significant dysregulation of genes encoding drug-metabolizing enzymes and stress response components of the NRF2- mediated oxidative damage pathway, potentially representing key genes in African-American esophageal squamous carcinogenesis. (biomedcentral.com)
Down-regulation of TP53 pathway components represented the most common feature in ESCC of all ethnic groups. (biomedcentral.com)
Mechanistically, knockdown resulted in decreased activation from the JAK2/STAT3 pathway, inhibition of STAT3 phosphorylation and decreased transcription of STAT3 focus on genes [85]. (morainetownshipdems.org)
Similarly, inhibition of the PI3K-mTOR pathway by addition of the PI3K inhibitor 2-[4-morpholinyl]-8-phenyl-4H-1-benzopyran-4-one (LY294002) or the mTOR inhibitor rapamycin, although reducing several parameters of transformation, also failed to block transformation. (embl.de)

The Ki‑67 positivity index was 75%, and the thyroid transcription factor‑1, NapsinA, p40, nuclear protein in testis, CD34, Sal‑like protein 4, SRY‑box transcription factor 2 and synaptophysin were negative. (spandidos-publications.com)
It also modulates gene transcription and recombination [ 7 ]. (hindawi.com)
OBJECTIVE- Sulforaphane is an activator of transcription factor NF-E2-related factor-2 (nrf2) that regulates gene expression through the promoter antioxidant response element (ARE). (diabetesjournals.org)
ATAC-seq evaluation showed decreased chromatin accessibility, and additional research pointed these sites correlate with gain access to of transcription elements to enhancers linked to acinar identification genes [94]. (morainetownshipdems.org)
In response to environmental changes, signaling pathways rewire gene expression programs through transcription factors. (molcells.org)
The ETS family transcription factor ESE-1 is often overexpressed in human breast cancer. (biomedcentral.com)
The human ETS (E26 Transformation-Specific) protein family is a diverse group of 27 known transcription factors that regulate such varied cellular processes as differentiation and apoptosis, but also appear to induce oncogenesis when mutated or aberrantly expressed [ 1 - 4 ]. (biomedcentral.com)
While previous publications have established ESE-1's transcription factor function, we have reported that ESE-1 initiates transformation of MECs via a novel non-nuclear, non-transcriptional mechanism [ 13 ]. (biomedcentral.com)
Genes having at least one occurrence of the highly conserved motif M129 RRAGTTGT in the regions spanning 4 kb centered on their transcription starting sites [-2kb,+2kb]. (gsea-msigdb.org)

Loss of activity of drug metabolizing enzymes would confer increased sensitivity of esophageal cells to xenobiotics, such as alcohol and tobacco smoke, and may account for the high incidence and aggressiveness of ESCC in this ethnic group. (biomedcentral.com)
It is a reversible chemical mark catalyzed by the enzymes that deposit and remove methyl groups. (molcells.org)
Indeed, cells tightly regulate m 6 A modification using specialized enzymes, m 6 A writers and erasers. (molcells.org)
Aberrant m 6 A modifications by overactivation or suppression of these enzymes lead to human diseases such as cancer, diabetes, and neurological disorders. (molcells.org)
Members of a subfamily of these enzymes share a specific domain that was first identified in the yeast Sac1 protein [1]. (embl.de)

Unlike most nuclear receptors, this transcriptional regulator is constitutively active in the absence of ligand and is regulated by both agonists and inverse agonists. (wikipedia.org)
The TAM receptor and ligand expression was evaluated in LMS cell lines and 358 sarcoma samples by either gene expression or immunohistochemistry. (nature.com)
These data highlight that ESE-1 contains NLS and NES signals that play a critical role in regulating its subcellular localization and function, and that an intact SAR domain mediates MEC transformation exclusively in the cytoplasm, via a novel nontranscriptional mechanism, whereby the SAR motif is accessible for ligand and/or protein interactions. (biomedcentral.com)

All members of transforming growth factor superfamily are synthesized as pre-pro-peptides that consist of a short N-terminal signalling peptide, a latency-associated protein (LAP) domain and the mature TGF domain [ 42 ]. (springer.com)

Seven deleterious SNPs were identified in TNFSF11 , NR4A2 or ITGB4 genes. (biomedcentral.com)

Actin filaments widely involve into multiple cellular processes such as nuclear positioning, germinal vesicle breakdown, spindle migration, chromosome segregation, spindle rotation and polar body extrusion in oocyte mammalian meiosis. (bioone.org)
The overall results provide a systematic view of gene regulation in the human, which will be refined as additional mammalian genomes become available. (gsea-msigdb.org)

TCPOBOP) or indirect regulation by phenobarbital (PB), a common seizure medication, facilitating the dephosphorylation of CAR through protein phosphatase 2 (PP2A) (Fig. 1). (wikipedia.org)
By influencing gene expression in multiple tissues, calcitriol influences many physiological processes besides calcium/phosphate homeostasis including muscle and keratinocyte differentiation, insulin secretion, blood pressure regulation, and the immune response. (anti-agingfirewalls.com)
Among these candidate genes, CUGBP and Elav-like family member 1 ( CELF1 ) are potential targets of TUG1 in-trans regulation. (biomedcentral.com)
Three GPCRs clustered with recently identified putative CHH receptors (CHHRs), and differential expression over the molt cycle suggests that they are associated with ecdysteroidogenesis regulation. (biomedcentral.com)
Two putative Corazonin receptors showed much higher expression in the YOs compared with all other GPCRs, suggesting an important role in molt regulation. (biomedcentral.com)
Orthologs of receptors that were found to be involved in molt regulation in insects were also identified, including LGR3 and Corazonin receptor, the latter of which was expressed at much higher level than all other receptors, suggesting a key role in YO regulation. (biomedcentral.com)
Epigenetic modification of the transcribed RNA can be another layer of gene expression regulation. (molcells.org)

The ovary is a dynamic female reproductive organ that undergoes many structural and functional transformations as it fulfills its two significant roles of producing female gametes and synthesizing sex steroid hormones [ 1 ] . (encyclopedia.pub)

Our results suggest that previous estimates of the number of human miRNA genes were low, and that miRNAs regulate at least 20% of human genes. (gsea-msigdb.org)

We used a high density SNP array (600 K, Affymetrix) to estimate genomic heritability, perform genome-wide association analysis, and identify genomic regions and positional candidate genes (PCGs) associated with internal organ traits in an F2 chicken population. (biomedcentral.com)
Thus, the discovery of genomic regions and positional candidate genes (PCGs) for intestine length or weights and percentages of heart, liver, gizzard or lungs, is a first step for understanding their genetic architecture. (biomedcentral.com)
According to the bioinformatic analysis result of TUG1 4C sequencing data, 83 candidate genes and their interaction regions were identified. (biomedcentral.com)

Three putative CHH receptors were identified and could include an MIH receptor whose activation negatively regulates molting. (biomedcentral.com)
To map the minimal functional nuclear localization (NLS) and nuclear export (NES) signals, we fused in-frame putative NLS and NES motifs between GFP and the SAR domain. (biomedcentral.com)

CAR is a member of the nuclear receptor superfamily, and is a key regulator of xenobiotic and endobiotic metabolism. (wikipedia.org)
SWI/SNF‑related, matrix‑associated, actin‑dependent regulator of chromatin, subfamily a, member 4 (SMARCA4)‑deficient non‑small cell lung cancer (dNSCLC) is a rare malignant tumor that originates in the lungs. (spandidos-publications.com)
SWI/SNF-related, matrix-associated, actin-dependent regulator of chromatin, subfamily a, member 4 (SMARCA4)- deficient non-small cell lung cancer (SMARCA4-dNSCLC) is an uncommon yet notable malignancy originating within the lung. (spandidos-publications.com)

Nearly one-half are associated with microRNAs (miRNAs), leading to the discovery of many new miRNA genes and their likely target genes. (gsea-msigdb.org)

Finally, the convergence theory states that a combination of several pathways is necessary for the development of vitiligo, such as genetic background, susceptibility to environmental changes, altered epidermal microenvironment, an intrinsic melanocyte defect and an autoimmune response ( 13 , 14 ). (spandidos-publications.com)

TYRO3 or AXL gene knockdown reduced cell proliferation/colony formation. (nature.com)
Very similar findings were seen in a prior study which figured ARID1B may be the preferential gene necessary for the success of in knockdown in cell lines led to reduced proliferation and decreased invasion [85,97]. (morainetownshipdems.org)
Early embryonic pancreas-specific removal of resulted in decreased multipotent pancreatic progenitor cell proliferation and led to pancreas hypoplasia [48], indicating its essential function in modulating gene appearance during AG-99 development. (morainetownshipdems.org)
Other two pathways, ΔΨm/ATP/cAMP/JNK/AP-1 and ROS/Src, are also involved in LPLI-induced proliferation. (biomedcentral.com)

14(1): 7000, 2023 Nov 02. (bvsalud.org)
2023 Jul 12;22(1):173. (uni-luebeck.de)
2023 May 30;14(1):3106. (uni-luebeck.de)
2023 Mar 22;14(1):1588. (uni-luebeck.de)
2023 Jan;164(1):6-28. (uni-luebeck.de)

ESE-1 initiates transformation of MCF-12A cells via a non-transcriptional, cytoplasmic process that is mediated by a unique 40-amino acid serine and aspartic acid rich (SAR) subdomain, whereas, ESE-1's nuclear transcriptional property is required to maintain the transformed phenotype of MCF7, ZR-75-1 and T47D breast cancer cells. (biomedcentral.com)

Many of the bolded characters in the characterization above are apomorphies of more or less inclusive clades of streptophytes along the lineage leading to the embryophytes, not apomorphies of crown-group embryophytes per se . (mobot.org)

A-González N, Castrillo A. (2011) Liver X receptors as regulators of macrophage inflammatory and metabolic pathways. (guidetomalariapharmacology.org)

The first miRNA was discovered in 1993 by Lee, Freinbaum and Ambros ( 6 , 7 ), and since then an increasing load of literature data have pointed that they can act as both tumor suppressors and oncogenes ( 1 - 3 ). (frontiersin.org)

The MACOM complex does not have catalytic activity, but it is necessary for efficient m 6 A methylation by recruiting RNA substrates and stabilizing the MAC-MACOM complex in the nucleus and nuclear speckles. (molcells.org)

Recent genome-wide association studies, gene expression profiling, DNA methylation and proteomic studies conducted in Japanese and Chinese ESCCs (reviewed in [ 6 ]) have identified multiple risk variants and gene signatures associated with ESCC. (biomedcentral.com)
N 6 -adenosine methylation (m 6 A) is one of the most common modifications on mRNA. (molcells.org)
N 6 -methyladenosine (m 6 A) is a methylation modification of adenosine on RNA. (molcells.org)

CAR-regulated genes are involved in drug metabolism and bilirubin clearance. (wikipedia.org)

Melanocytes are found in the basal layer of the epidermis and together with the surrounding keratinocytes form the epidermal unit, whose main function is to produce and distribute melanin by a complex process called melanogenesis ( 4-7 ). (spandidos-publications.com)

The genomic alteration and mutation regularity of is leaner in comparison to (Desk 1). (morainetownshipdems.org)

The distinct characteristics of SMARCA4-dNSCLC were first proposed in 2017 by Agaimy et al ( 1 ) who highlighted the expression of cytokeratin 7 (CK7) and the loss of the BRG1 protein as the defining features of the disease. (spandidos-publications.com)
Immunohistochemistry performed in 107 sarcomas showed higher expression of TYRO3 and GAS6 in LMS vs other sarcomas and nuclear TYRO3 only in LMS. (nature.com)
Microarray gene expression performed in 251 sarcomas revealed significantly higher expression of TYRO3 and GAS6 in LMS than other sarcomas. (nature.com)
Indeed, it has been shown that miRNAs play an important role in gene expression, mainly when associated with the monitoring of several cell and metabolic pathways, being also an essential component of the gene silencing machinery in most eukaryotic organisms ( 4 , 8 ). (frontiersin.org)
The blog post Klotho anti-aging gene in the news describes how " Klotho expression is also important for averting premature aging due to overexpression of Vitamin D," citing a number of papers relevant to that topic. (anti-agingfirewalls.com)
RESULTS- Activation of nrf2 by sulforaphane induced nuclear translocation of nrf2 and increased ARE-linked gene expression, for example, three- to fivefold increased expression of transketolase and glutathione reductase. (diabetesjournals.org)
To determine whether certain genes are uniquely altered in African-American ESCC we performed a meta-analysis of ESCC expression profiles in our African-American samples and those of several Asian samples. (biomedcentral.com)
The heparan Golgi-resident selenide receptors in interconnectivity a state of interactions that are to mitochondrial influx membrane used by the irreversible expression( HA) response, and the sustained polypeptide of the archival distinct knot km2 into the tail of the complex dementia. (evakoch.com)
The Rac1 inhibitor NSC23766 did not block viral gene expression at any time level. (mirnaassay.com)
The PI3K inhibitors LY294002 and wortmannin had been effective in diminishing viral gene expression only when extra at 0 or two hpi, with the time range of effectiveness just like that with the ERK inhibitor. (mirnaassay.com)
MK 2206, another Akt inhibitor, did not have an impact on viral gene expression, suggesting that block ade of Akt had minor impact on HAstV1 infection. (mirnaassay.com)
Not remarkably, drugs that didn't inhibit viral gene expression-inhibitors of MAPK p38s, JNK, Akt, and PKA -had no measurable result within the extent of viral RNA replica tion. (mirnaassay.com)
gene expression profiles with analytical tools derived from ecology and systems biology to reverse engineer interaction networks between immune responses, other organismal characteristics and the environment (including symbiont exposures), revealing regulatory architecture. (clinical-research-informatics.com)
sequencing and analysis of nucleic acids are revolutionizing the measurement of gene expression in nonmodel organisms, with promising applications in the study of the immune system 1. (clinical-research-informatics.com)
The heterogeneous expression of markers, together with their rare frequency (1-10 CTCs in 8 mL of blood) are the main intrinsic factors hampering CTC isolation and limiting in-depth study of these cells in patients with melanoma. (nature.com)
The ER81 ETS protein, for example, is activated in human breast cancer cells by the oncoprotein HER-2, resulting in over-expression of the prosurvival telomerase reverse transcriptase (hTERT) gene [ 6 ]. (biomedcentral.com)

CAR is a member of the nuclear receptor superfamily and along with pregnane X receptor (PXR) functions as a sensor of endobiotic and xenobiotic substances. (wikipedia.org)

however, nuclear accumulations of pSMAD2-C and CLDN3 redistribution were observed with similar time course in ciliated and non-ciliated cells. (springer.com)
In eukaryotic cells the genetic material is surrounded by a membrane system called the nuclear envelope (NE). (brookes.ac.uk)
The Nuclear Envelope is a hallmark of eukaryotic cells. (brookes.ac.uk)
Commonly used radio- and chemotherapies are prooxidant strategies that alter cancer cells through ROS modulation and induce cell death [ 5 , 6 ]. (hindawi.com)
After epidermal injury, barrier repair requires activation of many wound response genes in epidermal cells surrounding wound sites. (sdbonline.org)
RESEARCH DESIGN AND METHODS- Human microvascular HMEC-1 endothelial cells were incubated in low and high glucose concentrations (5 and 30 mmol/l, respectively), and activation of nrf2 was assessed by nuclear translocation. (diabetesjournals.org)
Cell stainings had been performed on fixed and permeabilized cells with the primary antibody, rabbit monoclonal to Paxillin, followed by anti rabbit secondary antibody tagged with all the fluorescent dye Alexa Fluor 488, and with DNA binding dye 4,6 diamidino 2 phenylindole. (mirnaassay.com)
The very next day, the cells was centrifuged at 931 RCF for 6 mins, cleaned in HBSS (Gibco BRL-Life Systems, Rockville, MD) and incubated in 0.02% EDTA (Sigma, St. Louis, MI) for one hour at 37C. (bms-911543.com)
Isolated cells and bits of Descemets membrane from an individual cornea had been plated in a single well of 6-well or 12-well cells tradition plates pre-coated with FNC Layer Blend (US Biological, Salem, MA) for quarter-hour at space temperatures. (bms-911543.com)

Some of the prepared cyclitol derivatives (i.e. 9, 11, 12, and 14) proved to be very powerful and specific irreversible inhibitors of PI4K230 at or below a concentration of 1 mM. (embl.de)

A total of 13,748 annotated sequence SNPs were in the 14 PCGs, including 156 SNPs in coding regions (124 synonymous, 26 non-synonymous, and 6 splice variants). (biomedcentral.com)

Review: the total protein of unphosphorylated PI3K (t-PI3K), phosphorylated PI3K (p-PI3K), unphosphorylated AKT protein (t-AKT), and phosphorylated AKT protein (p-AKT) were detected and analysed using western blot in the presence of housekeeping protein β-Actin as a loading control at 4, 6, and 24 h intervals. (cusabio.com)
Nuclear positioning, germinal vesicle breakdown, spindle migration, spindle rotation, chromosome segregation, and polar body extrusion are the most critical cellular processes during oocyte meiosis I and II, and a growing number of studies primarily using the mouse oocyte model revealed that actin filaments were critical for these processes, especially for spindle migration. (bioone.org)

SUMMARY: The broad tissue distribution of the 25-hydroxyvitamin D 1alpha-hydroxylase enzyme and the vitamin D receptor establish a role for 1,25-dihydroxyvitamin D in the pathophysiology of various disease states and provide new therapeutic targets for vitamin D and its analogues. (anti-agingfirewalls.com)
GhIMP10D, an inositol monophosphates family gene, enhances ascorbic acid and antioxidant enzyme activities to confer alkaline tolerance in Gossypium hirsutum L. (biomedcentral.com)

These findings indicate that GSOs protect against GLU-induced neuronal oxidative damage through Nrf2/HO-1 activation. (sdbonline.org)

Overexpression of one ETS protein in particular, the epithelium-specific ETS factor ESE-1, is implicated in human mammary transformation. (biomedcentral.com)

In contrast with other ions, magnesium is treated differently in two major respects: (1) bone, the principal reservoir of magnesium, does not readily exchange magnesium with circulating magnesium in the extracellular fluid space and (2) only limited hormonal modulation of urinary magnesium excretion occurs. (medscape.com)

It has light-absorbing properties that confer photoprotection ( 4 , 6-8 ). (spandidos-publications.com)

Thus, activated, type I subunits recruit and phosphorylate receptor SMADs (R-smad), which are the first intracellular mediators of TGF-β signalling. (springer.com)
Approximately 99% of total body magnesium is intracellular or bone-deposited, with only 1% present in the extracellular space. (medscape.com)

1,4-bis[2-(3,5-dichloropyridyloxy)]benzene (TCPOBOP) is thought to bind directly to mouse CAR, thus inducing its translocation into the nucleus. (wikipedia.org)

ARID1B appearance is normally low in PDAC tumors (Desk 2), as well as the gene is normally proposed to truly have a tumor-suppressive function. (morainetownshipdems.org)

We demonstrate that TGF-β1 activates TGF-β1 receptors TGFBR1 and TGFBR2 resulting in ALK5-mediated phosphorylation of SMAD2. (springer.com)
Phosphorylation of PTPN1 at 'Ser-50' negatively modulates its phosphatase activity preventing dephosphorylation of the insulin receptor and the attenuation of insulin signaling. (cusabio.com)

Cytochrome P450 family 1 subfamily A member 1 (CYP1A1) was the most significantly upregulated gene at 24 and 48 h after L-Arginine treatment. (bvsalud.org)
Member of the p53 family, TP63 gene gives rise to transcripts that encode either full-length isoforms containing an amino-transactivation (TA) domain (TAp63) or truncated isoforms that lacks this TA domain (ΔNp63). (oncotarget.com)
However, despite growing biological and clinical significance, little is known about the structural arrangement of this receptor or any of its family members. (uci.edu)
Here we describe the 3.2 Å cryo-EM structure of human DEC-205, thereby illuminating the structure of the mannose receptor protein family. (uci.edu)
tectonic family member 3 [So. (gsea-msigdb.org)
TBC1 domain family member 22. (gsea-msigdb.org)

As of January 1, 2022, Oncotarget has shifted to a continuous publishing model. (oncotarget.com)
2022 Dec;31(6):e13734. (uni-luebeck.de)

The process of ischemia and reperfusion is known to cause inducible nitric oxide synthase induction and activation, and there is evidence that interleukin (IL)-1β (46), IL-1 receptor (47), and IL-1 receptor along with nuclear factor-kappa beta (48) may have an important role in that induction. (ectrx.org)

As a leading cause of cancer-related mortality worldwide, lung cancer has been investigated in numerous molecular genetic studies aimed at developing new treatment strategies [ 1 ]. (biomedcentral.com)

In conclusion, the data demonstrates the importance of specific glycans in a clinically relevant human model of HSV-1 infection and highlights the utility of genetic engineering to elucidate the roles of specific viral and cellular carbohydrate structures. (bvsalud.org)
Genetic and transcriptome analyses on African-American ESCC have been particularly limited which highlights the lack of understanding of the genetic architecture of ESCC in this ethnic group. (biomedcentral.com)

The lncRNA taurine-upregulated gene 1 ( TUG1 ) is a nonprotein-coding gene located on chromosome 22q12.2 that transcribes to a 6.7-kilobase-long, spliced, and polyadenylated RNA. (biomedcentral.com)

Anatomy9

Organisms2

Chemicals and Drugs65

Analytical, Diagnostic and Therapeutic Techniques and Equipment7

Phenomena and Processes23

Information Science4

EGFR7

Kinase8

Ligands4

Tyrosine2

Retinoid X recept2

Proteins10

Signal transduction5

Pathway5

Transcription9

Enzymes5

Ligand3

Growth1

Deleterious1

Mammalian2

Regulation7

Steroid1

Regulate1

Candidate genes3

Putative2

Regulator3

Target genes1

Microenvironment1

Proliferation4

20235

Transcriptional1

Characterization1

Macrophage1

MiRNA1

Catalytic1

Methylation3

Metabolism1

Keratinocytes1

Genomic1

Expression16

Superfamily1

Cells9

Inhibitors1

Variants1

Actin2

Enzyme2

Oxidative damage1

Overexpression1

Occurs1

Confer1

Intracellular2

Nucleus1

Tumor1

Phosphorylation2

Family6

20222

Activation1

Molecular1

Genetic2

Chromosome1