• With the availability of effective anti-EGFR therapies for various solid malignancies, such as non-cell small lung cancer, colorectal cancer and squamous cell carcinoma of the head and neck, the knowledge of EGFR and K-RAS status becomes clinically important. (biomedcentral.com)
  • The aim of this study was to analyse EGFR expression, EGFR gene copy number and EGFR and K-RAS mutations in two cohorts of squamous cell carcinomas, specifically anal canal and tonsil carcinomas. (biomedcentral.com)
  • EGFR immunoreactivity was present in 36/43 (83.7%) of anal canal and in 20/24 (83.3%) of tonsil squamous cell carcinomas. (biomedcentral.com)
  • EGFR mutations were absent from squamous cell carcinoma of the anus and tonsils, but EGFR protein expression was detected in the majority of the cases. (biomedcentral.com)
  • EGFR amplification was seen in tonsil but not in anal canal carcinomas. (biomedcentral.com)
  • This indicates that EGFR and K-RAS mutation analysis is not useful as a screening test for sensitivity to anti-EGFR therapy in anal canal and tonsil squamous cell carcinoma. (biomedcentral.com)
  • Epidermal growth factor receptor (EGFR) has been validated as a therapeutic target in several human tumours, including colorectal cancer (CRC), non-small cell lung cancer (NSCLC) and squamous cell carcinoma of the head and neck (HNSCC). (biomedcentral.com)
  • Background: In this study, we intend to determine the immunohistochemical expression of EGFR in cases of head and neck squamous cell carcinoma and its association with prognostic clinico-pathologic features. (aku.edu)
  • therefore, EGFR expression can help as a prognostic biomarker in head and neck squamous cell carcinoma. (aku.edu)
  • On the other hand, we suggest that molecular studies should be performed in squamous cell carcinoma of head and neck in our setup to identify patients that can avail response from anti-EGFR therapy. (aku.edu)
  • The hybrid protein was specifically cytotoxic to A431, an EGFR overexpressing squamous carcinoma cell line, with an IC 50 of ~10 -7 M. In contrast, recombinant hpRNase1 had an IC 50 higher than 10 -4 M. A mixture of free hEGF and free hpRNase1 was not more cytotoxic than hpRNase1 alone and no cytotoxicity was detected in EGFR-deficient control cells. (elsevierpure.com)
  • Taken together, these data suggest that this construct might be useful for targeted therapy of esophageal, lung and other squamous cell carcinomas and also breast cancers overexpressing EGFR, which correlate with a poor prognosis and cannot be cured by surgery alone. (elsevierpure.com)
  • The ErbB family of proteins contains four receptor tyrosine kinases, structurally related to the epidermal growth factor receptor (EGFR), its first discovered member. (wikipedia.org)
  • The ErbB protein family consists of 4 members ErbB-1, also named epidermal growth factor receptor (EGFR) ErbB-2, also named HER2 in humans and neu in rodents ErbB-3, also named HER3 ErbB-4, also named HER4 v-ErbBs are homologous to EGFR, but lack sequences within the ligand binding ectodomain. (wikipedia.org)
  • EGFR signal transactivation in cancer cells. (mpg.de)
  • The present study evaluated the prognostic value of the epidermal growth factor receptor (EGFR) mutation status, and excision repair cross-complementation group 1 (ERCC1) and thymidylate synthase (TS) expression following intercalated tyrosine kinase inhibitor (TKI) therapy and platinum- and pemetrexed-based chemotherapies (subsequent second-line treatment) for patients with adenocarcinoma non-small-cell lung cancer (AC-NSCLC). (medsci.org)
  • The standard therapies for lung adenocarcinoma include epidermal growth factor receptor (EGFR) mutation targeted therapy and conventional chemotherapy, such as platinum- and pemetrexed-based chemotherapies. (medsci.org)
  • Long noncoding RNA EGFR-AS1 mediates epidermal growth factor receptor addiction and modulates treatment response in squamous cell carcinoma. (nccs.com.sg)
  • nonetheless, previous studies pointed out that GC may reduce the efficacy of chemotherapy on cancer cells, especially in epidermal growth factor receptor (EGFR)-targeted therapy of head and neck squamous cell carcinoma (HNSCC) remaining to be elucidated. (techscience.com)
  • It and the gene for the epidermal growth factor receptor ( EGFR ) are involved in cell signaling. (medscape.com)
  • To date, cetuximab is the only anti‑epidermal growth factor receptor (EGFR) monoclonal antibody (mAb) approved for the targeted therapy of head and neck squamous cell carcinoma (HNSCC). (spandidos-publications.com)
  • Bossi P, Resteghini C, Paielli N, Licitra L, Pilotti S and Perrone F: Prognostic and predictive value of EGFR in head and neck squamous cell carcinoma. (spandidos-publications.com)
  • Cassell A and Grandis JR: Investigational EGFR-targeted therapy in head and neck squamous cell carcinoma. (spandidos-publications.com)
  • This study explored the expression of Ln5 and the role of its relationships with PTEN, phospho-EGFR (p-EGFR) and phospho-Akt (p-Akt) in the prognosis of patients with non-small cell lung cancer (NSCLC). (spandidos-publications.com)
  • Tyrosine kinase inhibitors (TKIs) targeting epidermal growth factor receptor (EGFR), including gefitinib and erlotinib, have become the standard first-line therapy for patients with advanced non-small cell lung cancers (NSCLCs) harboring activating EGFR mutations ( 4 , 5 ). (spandidos-publications.com)
  • It is a tri-specific monoclonal antibody, acts by targeting epidermal growth factor receptor (EGFR) and hepatocyte growth factor receptor (c Met) (EGFR/cMET/cMET). (pharmaceutical-technology.com)
  • In the phase II randomized CONCERT-1 trial, patients with unresected, locally advanced squamous cell carcinoma of the head and neck were randomly assigned 2:3 to concurrent chemoradiation without or with added panitumumab (Vectibix), an antibody to epidermal growth factor receptor (EGFR). (ascopost.com)
  • Epidermal growth factor receptor (EGFR) inhibitors are part of an emerging class of anticancer medicines known as "targeted therapy," which target pathways more specific to neoplastic proliferation than traditional chemotherapeutic agents. (medscape.com)
  • The epidermal growth factor receptor (EGFR) is expressed in epithelial tissues as well as hair follicles. (medscape.com)
  • in contrast, EGFR inhibitors (EGFRIs) target pathways more specific to survival of neoplastic cells, thus belonging to a new class of chemotherapeutic agents - so-called "targeted therapy. (medscape.com)
  • [ 3 , 4 ] These antibodies are approved for the treatment of advanced EGFR-expressing colorectal cancer, and cetuximab is also approved for treatment of squamous cell carcinoma of the head and neck. (medscape.com)
  • There are also combination therapies that affect multiple receptors such as lapatinib (approved for human epidermal growth factor receptor 2-positive [HER2+] breast cancer) and afatinib (approved for non-small cell lung cancer), which inhibit both the EGFR and HER2 receptors, and vandetanib (approved for advanced medullary thyroid cancer), which inhibits EGFR, vascular endothelial growth factor (VEGFR), and rearranged during transfection (RET) activities. (medscape.com)
  • People with lung cancer who have never smoked may have a DNA mutation, such as a mutation in the epidermal growth factor receptor (EGFR) gene or other genes. (cdc.gov)
  • Focal acantholytic dyskeratosis is also observed in diseases such as Darier disease, linear epidermal nevus, actinic keratosis, and Grover disease. (cdlib.org)
  • Typically, the histologic examination of linear epidermal nevus reveals marked hyperkeratosis, papillomatosis, and acanthosis with rete ridge elongation in a psoriasiform pattern. (medscape.com)
  • Nervous system changes may also occur in patients with linear epidermal nevus syndrome. (medscape.com)
  • These include linear sebaceous nevus, linear nevus comedonicus (NC), linear epidermal nevus (LEN), and inflammatory linear verrucous epidermal nevus (ILVEN). (medscape.com)
  • Linear epidermal nevus syndrome is a congenital neurocutaneous disorder characterized by linear epidermal nevus with significant involvement of the nervous, ophthalmologic, and/or skeletal systems. (medscape.com)
  • Waltz KM, Helm KF, Billingsley EM: The spectrum of epidermal nevi: a case of verrucous epidermal nevus contiguous with nevus sebaceus. (karger.com)
  • Histologic examination of inflammatory linear verrucous epidermal nevus reveals a similar psoriasiform hyperplasia of the epidermis, alternating parakeratosis without a granular layer, and orthokeratosis with a thickened granular layer. (medscape.com)
  • Inflammatory linear verrucous epidermal nevus is a linear, persistent, pruritic plaque, usually first noted on a limb in early childhood. (medscape.com)
  • [ 3 ] delineated inflammatory linear verrucous epidermal nevus as a distinct entity in 25 patients. (medscape.com)
  • They coined the name inflammatory linear verrucous epidermal nevus, labeling it a clinical and histopathologic type of linear verrucous nevus that is often inflammatory or psoriasiform. (medscape.com)
  • Inflammatory linear verrucous epidermal nevus accounts for approximately 5% of patients with epidermal nevi and has been described in a mother and daughter. (medscape.com)
  • These individual apoptotic keratinocytes are often referred to as "sunburn" cells and are seen histologically in the epidermis of skin overexposed to sunlight or UV radiation. (medscape.com)
  • When SCC is confined to the epidermis, it is called squamous cell carcinoma in-situ, sometimes referred to as Bowen's disease. (family-health-information.com)
  • Oxidative and nitrosative stress caused by drug metabolism may be a trigger for keratinocyte apoptosis in the epidermis seen in toxic epidermal necrolysis (TEN) and Stevens Johnson syndrome (SJS). (e-ijd.org)
  • In addition, NFκB immunostaining was performed on 89 sections and the intensity of staining was evaluated in the epidermis, basal cells, and the lymphocytes. (e-ijd.org)
  • A search was conducted in PubMed utilizing the combination of 'LSD1' with keywords such as 'epidermis,' 'squamous cell carcinoma,' or 'skin. (nih.gov)
  • HB-EGF (Heparin-Binding EGF-like growth factor), also known as DTR, is produced by bronchial epithelium, visceral and vascular smooth muscle, CD4+ T cells, cardiac muscle, glomerular podocytes, keratinocytes, and IL-10-secreting regulatory macrophages. (rndsystems.com)
  • Regulation of cyclooxygenase-2 by interferon γ and transforming growth factor α in normal human epidermal keratinocytes and squamous carcinoma cells. (houstonmethodist.org)
  • Basal cell carcinomas arise from keratinocytes near the basal layer, which are. (msdmanuals.com)
  • Hafner C, van Oers JM, Vogt T, et al: Mosaicism of activating FGFR3 mutations in human skin causes epidermal nevi. (karger.com)
  • Squamous carcinogenesis: Potential truncal mutations Tang H, Seykora J, Ko C . Squamous carcinogenesis: Potential truncal mutations. (yale.edu)
  • These energetic light waves can produce mutations in the DNA of skin cells, which in turn can lead to skin cancer. (emedicinehealth.com)
  • This condition is related to squamous cell carcinoma of the skin and is often described as a precursor or early form of squamous cell carcinoma in situ, although most actinic keratoses will not progress to invasive squamous cell carcinoma. (medscape.com)
  • The scanning power view of squamous cell carcinoma in situ (SCCIS) reveals epidermal alteration (Figure 1). (dermnetnz.org)
  • Cystic fibrosis transmembrane conductance regulator is helpful in the distinction of extra-mammary Paget's disease from squamous cell carcinoma in situ (Bowen's disease). (dermnetnz.org)
  • Al-Arashi MY, Byers HR. Cutaneous clear cell squamous cell carcinoma in situ : clinical, histological and immunohistochemical characterization. (dermnetnz.org)
  • Patients are unable to reject their lesions, and cutaneous Bowen carcinomas in situ and invasive squamous cell carcinomas develop in about half of them, mainly on sun-exposed areas. (lu.se)
  • The cancer is called squamous cell carcinoma in situ. (medlineplus.gov)
  • Squamous cell cancer in situ can occur on any part of the body. (medlineplus.gov)
  • A cutaneous horn is a mass of dead skin cells. (emedicinehealth.com)
  • LSD1: a viable therapeutic target in cutaneous squamous cell carcinoma? (nih.gov)
  • In clinical samples, expression of ANXA1 and PD-L1 was significantly higher in breast cancer, non-small cell lung cancer, and skin cutaneous melanoma compared with corresponding normal tissues and positively correlated in cancer tissues. (bvsalud.org)
  • sEVs were isolated from different clinical samples of head and neck squamous cell carcinoma (HNSCC) patients, the level and cellular origins of PD-L1-positive sEVs were assessed. (nature.com)
  • PD-L1-positive sEVs in HNSCC patients had various cellular origins, including tumor cell, T cell, B cell, dendritic cell and monocyte/macrophage. (nature.com)
  • HNSCC cell lines (HSC-3, SCC-25, SCC-9, and H-400) and the human oral keratinocyte (HOK) cell lines were assessed for GC receptor (GR) expression. (techscience.com)
  • GC increased the proliferation of HNSCC cells in a GR-dependent manner and promoted AKT/mTOR signaling. (techscience.com)
  • Head and neck squamous cell carcinoma (HNSCC) is a type of cancer that originates in the squamous cells lining the mucous membranes of the head and neck region. (advfn.com)
  • Head and neck cancer most commonly is of the squamous cell carcinoma type (HNSCC) and includes cancers of the oral cavity, oropharynx, hypopharynx, larynx, sinonasal tract, and nasopharynx. (cdc.gov)
  • Distinct ADAM metalloproteinases regulate G protein-coupled receptor-induced cell proliferation and survival. (mpg.de)
  • TACE cleavage of proamphiregulin regulates GPCR-induced proliferation and motility of cancer cells. (mpg.de)
  • Lysophosphatidic acid-induced squamous cell carcinoma cell proliferation and motility involves epidermal growth factor receptor signal Transactivation. (mpg.de)
  • The PD-L1 on tumor cell-derived small extracellular vesicles (sEVs) can suppress the proliferation and cytokine production of T cells. (nature.com)
  • It activates both the EGF R/ErbB1 and ErbB4 receptors and has been linked to many cellular processes including proliferation, apoptosis, cell migration/invasion, differentiation, morphogenesis, and development. (rndsystems.com)
  • This process is mediated by 2 mutually exclusive programs of gene expression: 1) an undifferentiated program supporting proliferation by stem cells within the basal layer and 2) a differentiation program instructing growth arrest and differentiation-associated programmed cell death in suprabasal layers. (stanford.edu)
  • MTT assay was performed to determine the proliferation of cancer cells. (techscience.com)
  • In addition, overexpression of ZYX in hepatoma cell lines (PLC/PRF/5, HCCLM3) enhanced their proliferation, migration and invasion, whereas ZYX knockdown had the opposite effects (SK HEP-1, Huh-7). (techscience.com)
  • It is involved in the proliferation, invasion, apoptosis and epithelial mesenchymal transformation of malignant tumor cells. (techscience.com)
  • It contributes to epidermal proliferation, differentiation, and hair growth. (medscape.com)
  • Rosenquist K, Wennerberg J, Schildt EB, Bladström A, Göran Hansson B, Andersson G. Oral status, oral infections and some lifestyle factors as risk factors for oral and oropharyngeal squamous cell carcinoma. (medscape.com)
  • A growing body of research shows that human papillomavirus (HPV) is a common and increasing cause of oropharyngeal squamous cell carcinoma (OSCC). (cdc.gov)
  • We focus on the role of HPV in the increased incidence of oropharyngeal squamous cell carcinoma (OSCC), the head and neck cancer in which HPV is most commonly found ( 4 ). (cdc.gov)
  • Oxidative and osmotic stress signaling in tumor cells is mediated by ADAM proteases and heparin-binding epidermal growth factor. (mpg.de)
  • However, PD-L1 can also be expressed by non-tumor cells. (nature.com)
  • Fig. 3: Different clinical significance between tumor cell- and immunocyte-derived PD-L1-positive sEVs. (nature.com)
  • Tumor-associated B7-H1 promotes T-cell apoptosis: a potential mechanism of immune evasion. (nature.com)
  • I am also interested in mechanisms of carcinogenesis, particularly as they relate to squamous cell carcinoma of the skin and a spontaneously regressing tumor called keratoacanthoma. (yale.edu)
  • Imatinib failed to activate EGF receptor signals in other tumor types, suggesting that COX-2 induction in imatinib-treated cells is mediated through release of autocrine factors expressed or activated in squamous tumors. (oldcitypublishing.com)
  • Laminin 5 (Ln5) is an extracellular matrix protein that plays an important role in cell migration and tumor invasion. (spandidos-publications.com)
  • and GB223, a RANKL (receptor activator of NF-kappaB ligand) monoclonal antibody to treat giant-cell tumor of bone (GCTB). (pharmaceutical-technology.com)
  • There are two main routes by which tumor cells disseminate, through blood vessels (hematogenous spread) and through lymphatic vessels (lymphogenous spread). (harvard.edu)
  • In vitro, SEMA3F inhibits tumor cell adhesion to fibronectin by inhibiting beta 1 integrin levels, inhibits tumor cell motility, and inhibits tumor cell invasion through matrigel. (harvard.edu)
  • Together these results indicate that SEMA3F is a potent metastasis inhibitor that targets both tumor and stromal cells and raise the possibility of SEMA3F having therapeutic potential. (harvard.edu)
  • EXPERT OPINION: Given the ability of LSD1 inhibitors to promote epidermal differentiation and enhance anti-tumor immune responses, LSD1 inhibitors may offer a highly effective therapeutic approach for the prevention and treatment of these ubiquitous cancers. (nih.gov)
  • The capability to enhance the T cell-mediated tumor cell killing activity and antitumor effect of A11 via suppressing tumor immune evasion were investigated. (bvsalud.org)
  • Functionally, A11 promotes T cell ability of killing cancer cells in vitro, inhibits tumor immune evasion in mice via increasing the population and activation of CD8+ T cells in tumor microenvironment, and A11 and PD-1 mAb possess synergistic antitumor effect in mice. (bvsalud.org)
  • CONCLUSION: Our results reveal that A11 competes with USP7 to bind and degrade PD-L1 in cancer cells, A11 exhibits obvious antitumor effects and synergistic antitumor activity with PD-1 mAb via inhibiting tumor immune evasion and A11 can serve as an alternative strategy for ICIs therapy in multiple cancers. (bvsalud.org)
  • COX-2 induction by imatinib in squamous tumors derived from the head and neck region is unique with respect to other target-specific agents and may represent one of the unintended toxic effects of imatinib described in some patients. (oldcitypublishing.com)
  • GB-263 is under development for the treatment of non-small cell lung cancer, gastric cancer, esophageal cancer, head and neck squamous cell carcinoma, metastatic colorectal cancer and other solid tumors. (pharmaceutical-technology.com)
  • Nasopharyngeal carcinoma (NPC) is a rare disease and one of the most common types of malignancies that appear in the nasopharynx, which is the narrow tube passage behind the nasal cavity and one of the malignancies associated with the Epstein-Barr virus (EBV) and is considered one of the malignant and rare tumors in most parts of the world and is distinguished by distribution geographical and ethnic [ 1 ]. (intechopen.com)
  • Rarely, tumors, such as apocrine carcinoma and porocarcinoma, may appear with more metastatic potential. (medscape.com)
  • An 84-year-old Chinese man with stage IV non-small cell lung cancer was initiated on pembrolizumab, an anti-programmed cell death (PD)-1 monoclonal antibody, 4 times. (annals.edu.sg)
  • I am studying skin cancer, particularly squamous cell carcinoma and keratoacanthoma. (yale.edu)
  • Free radicals cause damage to the DNA double helix, changing the way cells replicate and naturally die, which is how cancer develops. (emedicinehealth.com)
  • Bladder Cancer Extracellular Vesicles Elicit a CD8 T Cell-Mediated Antitumor Immunity. (rochester.edu)
  • Assessing the Magnitude of Immunogenic Cell Death Following Chemotherapy and Irradiation Reveals a New Strategy to Treat Pancreatic Cancer. (rochester.edu)
  • Ten to forty years can pass between the time of sun exposure and the development of a squamous cell skin cancer. (family-health-information.com)
  • It has been classified histologically into two major groups: small-cell lung cancer and non-small-cell lung cancer (NSCLC). (medsci.org)
  • Influence of the KDM4A rs586339 polymorphism on overall survival in Asian non-small-cell lung cancer patients. (nccs.com.sg)
  • Changes in these and other oncogenes can disrupt cell growth control, ultimately leading to the uncontrolled growth of cancer. (medscape.com)
  • H- ras was one of the oncogenes that first caught the attention of molecular biologists interested in cell signaling, cell growth control, and cancer. (medscape.com)
  • Squamous cell carcinoma is a common type of skin cancer. (trustedhealthproducts.com)
  • Squamous cell carcinoma can be a more serious type of cancer than basal cell carcinoma and generally needs appropriate skin cancer treatments . (trustedhealthproducts.com)
  • GB-263 is under clinical development by Genor BioPharma and currently in Phase II for Head And Neck Cancer Squamous Cell Carcinoma. (pharmaceutical-technology.com)
  • According to GlobalData, Phase II drugs for Head And Neck Cancer Squamous Cell Carcinoma have a 26% phase transition success rate (PTSR) indication benchmark for progressing into Phase III. (pharmaceutical-technology.com)
  • If you have Actinic Keratoses, it indicates that you have sustained sun damage and could develop any kind of skin cancer - not just Squamous Cell Carcinoma. (skcin.org)
  • Inhibition of Wnt signaling in colon cancer cells via an oral drug that facilitates TNIK degradation. (harvard.edu)
  • Fruits and seed extracts of Annona montana have significant cytotoxic potential in several cancer cells. (techscience.com)
  • This study evaluates the effect of A. montana leaves hexane extract on several signaling cascades and gene expression in metastatic breast cancer cells upon insulin-like growth factor-1 (IGF-1) stimulation. (techscience.com)
  • Fra-1 is highly expressed in gastric cancer (GC), affects the cycle distribution and apoptosis of GC cells, and participates in GC occurrence and development. (techscience.com)
  • Here, we reported that mammalian target of rapamycin complex 2 (mTORC2) kinase is overexpressed in pancreatic cancer tissues and promotes pancreatic cancer cell growth and invasion. (techscience.com)
  • and (iii) inhibits cancer immune escape in immune-competent mice via downregulating PD-L1 expression and increasing the number and killing activity of CD8+ T cells. (bvsalud.org)
  • Specifically, binding of ANXA1 to PARP1 decreased PARP1's binding to Stat3, which reduced poly(ADP-ribosyl)ation and dephosphorylation of Stat3 and thus, increased Stat3's transcriptional activity, leading to transcriptionally upregulated expression of PD-L1 in multiple cancer cells. (bvsalud.org)
  • RESULTS: A11 decreases PD-L1 protein stability and levels by ubiquitin proteasome pathway in breast cancer, lung cancer and melanoma cells. (bvsalud.org)
  • Moreover, expression levels of both USP7 and PD-L1 are significantly higher in breast cancer, non-small cell lung cancer and skin melanoma tissues than those in their corresponding normal tissues and are positively correlated in cancer tissues, and both proteins for predicting efficacy of PD-1 mAb immunotherapy and patient prognosis are superior to individual protein. (bvsalud.org)
  • [ 3 , 4 ] Both gefitinib and erlotinib are approved for the treatment of non-small cell lung cancer, and erlotinib in combination with gemcitabine is approved for the treatment of advanced pancreatic cancer. (medscape.com)
  • About 50% to 60% of lung cancers found in people who never smoked are adenocarcinomas (cancer that begins in the cells that line the lung's tiny air sacs and make substances such as mucus). (cdc.gov)
  • About 10% to 20% are squamous cell carcinomas (cancer that forms in the thin, flat cells lining the inside of the lungs). (cdc.gov)
  • Adenocarcinomas and squamous cell carcinomas are two types of non-small cell lung cancer. (cdc.gov)
  • A few (6% to 8%) are small cell lung cancers, and the rest are other types of lung cancer. (cdc.gov)
  • Epidermal nevi(EN)represent a heterogeneous group of mosaic skin lesions frequently following the lines of Blaschko. (karger.com)
  • The evaluation of squamous intraepithelial lesions (SILs) was performed in 21 cases. (scielo.br)
  • Predisposing factors associated with squamous cell carcinoma include overexposure to the sun's ultraviolet rays, radiation therapy, ingestion of herbicides containing arsenic, chronic skin irritation and inflammation, exposure to local carcinogens (such as tar and oil), hereditary diseases (such as xeroderma pigmentosum and albinism), and the presence of premalignant lesions (such as actinic keratosis or Bowen's disease). (family-health-information.com)
  • Although the risk of an AK transforming into squamous cell carcinoma (SCC) is very low, the risk increases over time and with larger number of lesions. (skcin.org)
  • These hyperpigmented, scaly lesions on the earlobe were diagnosed as squamous cell carcinoma on biopsy. (msdmanuals.com)
  • The term organoid nevus may be used to emphasize the admixture of epidermal cells often evident in individual lesions of epidermal nevi. (medscape.com)
  • The lesions may transform into malignant carcinomas, usually after age 30 years. (lu.se)
  • Happle R, Rogers M: Epidermal nevi. (karger.com)
  • Solomon LM, Esterly NB: Epidermal and other congenital organoid nevi. (karger.com)
  • Histologic examination of the four types of epidermal nevi is variable. (medscape.com)
  • In this review, 4 distinct epidermal nevus syndromes, recognizable by the different types of associated epithelial nevi, are described. (medscape.com)
  • Six different syndromes with epidermal nevi as part of them have been delineated. (medscape.com)
  • Epidermal nevi, neoplasms, and cysts. (medlineplus.gov)
  • AC is also known as actinic keratosis (AK) of the lip and is considered a potentially malignant disorder likely to develop into invasive squamous cell carcinoma (SCC) as in the case of AK (4). (medicaljournals.se)
  • Malignant degeneration, usually of the superficial basal cell type, is frequent. (lu.se)
  • Paller AS, Syder AJ, Chan YM, et al: Genetic and clinical mosaicism in a type of epidermal nevus. (karger.com)
  • Clinical photograph of the oral cavity of a cat with sublingual squamous cell carcinoma. (merckvetmanual.com)
  • Blaszczak W, Barczak W, Wegner A, Golusinski W and Suchorska WM: Clinical value of monoclonal antibodies and tyrosine kinase inhibitors in the treatment of head and neck squamous cell carcinoma. (spandidos-publications.com)
  • The clinical differential diagnoses includes hypertrophic actinic keratosis and squamous cell carcinoma. (cdlib.org)
  • BACKGROUND: Immune checkpoint inhibitors (ICIs) therapy targeting programmed cell death 1 (PD-1)/programmed cell death ligand 1 (PD-L1) shows promising clinical benefits. (bvsalud.org)
  • A clinical entity called epidermal nevus syndrome should be more precisely defined and distinguished by clinical, histopathologic, and genetic criteria. (medscape.com)
  • In our investigated panel, only one mutation in the K-RAS gene of a tonsil squamous cell carcinoma was identified. (biomedcentral.com)
  • The gene encoding human pancreatic ribonuclease 1 (hpRNase1) was fused with a gene encoding human epidermal growth factor (hEGF). (elsevierpure.com)
  • We are currently pursuing studies of the dominant signaling and gene regulatory networks that control this process, including the Ras/MAPK cascade, which is required for stem cell-mediated self-renewal and the p53 transcription factor family member, p63, which is required for epidermal differentiation. (stanford.edu)
  • Epigenetic control of gene expression lasts through multiple cell divisions without alterations in primary DNA sequence and can occur via mechanisms that include histone modification and DNA methylation. (stanford.edu)
  • Oral squamous cell carcinoma gene patterns connected with RNA methylation for prognostic prediction. (cdc.gov)
  • A functional polymorphism in the poly(ADP-ribose) polymerase-1 gene increases the risk of endometrial carcinoma. (cdc.gov)
  • Combined impacts of histamine receptor H1 gene polymorphisms and an environmental carcinogen on the susceptibility to and progression of oral squamous cell carcinoma. (cdc.gov)
  • In stratified epithelia proliferative basal cells adherent to the underlying basement membrane undergo cell cycle arrest then outward migration and terminal differentiation. (stanford.edu)
  • The function of histone modifying epigenetic regulators and noncoding RNA as central mediators of epithelial stem cell renewal and differentiation represent major emerging areas of study in the lab. (stanford.edu)
  • Abstract Fos-related antigen 1 (Fra-1) is a nuclear transcription factor that regulates cell growth, differentiation, and apoptosis. (techscience.com)
  • Abstract Hepatocellular carcinoma (HCC) is a common malignancy that is driven by multiple genes and pathways. (techscience.com)
  • The base which generates the horn can be an actinic keratosis, a squamous cell carcinoma, or a benign keratosis. (emedicinehealth.com)
  • Plasma cell cheilitis (PCC) is a rare, idiopathic, and benign inflammatory mucosal condition characterised by dense polyclonal plasma cell infiltrates within the mucosa (1). (medicaljournals.se)
  • Multiple G-protein-coupled receptor signals converge on the epidermal growth factor receptor to promote migration and invasion. (mpg.de)
  • It was verified that co-expression of CD80 disrupted the binding of sEV PD-L1 to its receptor PD-1 on T cells and attenuated the immunosuppression mediated by sEV PD-L1 both in vitro and in vivo. (nature.com)
  • Hydration effects on the efficacy of the Epidermal growth factor receptor kinase inhibitor afatinib. (nccs.com.sg)
  • Chapman CH, Saba NF and Yom SS: Targeting epidermal growth factor receptor for head and neck squamous cell carcinoma: Still lost in translation? (spandidos-publications.com)
  • COX-2 induction by imatinib was initiated through epidermal growth factor (EGF) receptor kinase activation and downstream signaling through mitogenic-activated protein kinase. (oldcitypublishing.com)
  • Vulvar squamous cell carcinomas (VSCCs) in cattle were retrospectively studied regarding the prevalence, epidemiology, clinicopathological, and immunohistochemical aspects. (scielo.br)
  • The control of this transition from epithelial stem cell to differentiated corneocyte, which is abnormal in epidermal cancers, is not well understood. (stanford.edu)
  • Skin malignancies, including epidermal squamous cell carcinoma (SCC), alone account for nearly as many cancers as all other tissues combined. (stanford.edu)
  • Unfortunately, there is no way to know which actinic keratoses are precursors of squamous cell carcinoma. (skcin.org)
  • Propidium iodide staining and flow cytometry analysis of Annexin V binding was utilized to measure the progression of the cell cycle and the induction of apoptosis. (techscience.com)
  • Actinic keratosis is a precancer which indicates sun damage and can lead to Squamous Cell Carcinoma which if left untreated has the potential to spread to organs and be fatal. (skcin.org)
  • The copy number variation of GSTM1 as a promising prognostic factor of oral squamous cell carcinoma. (cdc.gov)
  • Integrative analysis of lysine acetylation-related genes and identification of a novel prognostic model for oral squamous cell carcinoma. (cdc.gov)
  • The image below shows an early oral squamous cell carcinoma (SCC) on the midlateral border of the tongue, previously diagnosed as a lichenoid reaction to amalgam. (medscape.com)
  • Oral squamous cell carcinoma on the midlateral border of the tongue. (medscape.com)
  • Oral squamous cell carcinoma in the most common intraoral site, lateral tongue, initially reported as a chronic leukoplakia, which had become ulcerated and indurated at the time diagnosis was confirmed. (medscape.com)
  • Identification of genetic instability in peripheral blood lymphocyte of oral squamous cell carcinoma patients assess by comet assay. (cdc.gov)
  • Whole genome duplication in oral squamous cell carcinoma in patients younger than 50?years: implications for prognosis and adverse clinicopathological factors. (cdc.gov)
  • Connexin 43, Bcl-2, Bax, Ki67, and E-cadherin patterns in oral squamous cell carcinoma and its relationship with GJA1 rs12197797 C/G. (cdc.gov)
  • The B7 family molecules in oral squamous cell carcinoma: a systematic review. (cdc.gov)
  • The Association of Epidermal Growth Factor Variant with Oral Squamous Cell Carcinoma. (cdc.gov)
  • One series of 155 cases of linear sebaceous nevus with clinicopathologic correlation could not identify any cases of authentic basal cell carcinoma or other malignancies, whereas several examples of primitive follicular induction and trichoblastomas were evident. (medscape.com)
  • Squamous cell carcinomas that arise in association with actinic keratosis typically have a low risk for metastasis. (medscape.com)
  • Solid organ transplant patients are at increased risk for actinic keratosis and squamous cell carcinoma. (medscape.com)
  • To estimate oxidative damage in the serum and to examine the role of nitric oxide in mediating epidermal damage in patients with TEN and SJS. (e-ijd.org)
  • In the randomized phase III DeCIDE trial, patients with N2/N3 locally advanced squamous cell carcinoma of the head and neck were assigned to two cycles of induction chemotherapy-docetaxel, cisplatin, and fluorouracil (TPF)-followed by concurrent chemoradiation, or to chemoradiation alone. (ascopost.com)
  • The randomized phase III PARADIGM trial also compared chemoradiation alone vs TPF induction chemotherapy followed by chemoradiation in patients with locally advanced stage III or IV squamous cell carcinoma of the head and neck. (ascopost.com)
  • Mall V, Heinen F, Uhl M, Wellens E, Korinthenberg R. CNS lipoma in patients with epidermal nevus syndrome. (medscape.com)
  • Suprabasal clefts, acantholysis with villous formation, luminal keratin plugs, dyskeratotic cells, and a few corps ronds were observed (Fig. 2). (cdlib.org)
  • In nevus comedonicus, rudimentary hair follicles are dilated to form epidermal invaginations, which are filled with keratin in concentric lamellae. (medscape.com)
  • Methods: A total of 115 cases of head and neck squamous cell carcinoma treated at Liaquat National Hospital, Karachi, Pakistan, were included in the study. (aku.edu)
  • Johnson DE, Burtness B, Leemans CR, Lui VWY, Bauman JE and Grandis JR: Head and neck squamous cell carcinoma. (spandidos-publications.com)
  • As per DelveInsight analysis, the head and neck squamous cell carcinoma market is expected to grow positively at a significant CAGR during the study period (2019-2032). (advfn.com)
  • The head and neck squamous cell carcinoma epidemiology section provides insights into the historical and current head and neck squamous cell carcinoma patient pool and forecasted trends for individual seven major countries. (advfn.com)
  • Lack of Schwann cell maturation leads to degeneration of motor and sensory neurons. (wikipedia.org)
  • The research conducted by central investigators is quite broad, ranging from cell and molecular biology to tissue engineering, biophysics and nanobiology/medicine. (upenn.edu)
  • The latter encompass human skin regenerated on immune deficient mice as well as organotypic constructs with epithelial and stromal cells embedded within architecturally faithful mesenchyma in vitro. (stanford.edu)