• MDS was found to be related to genetic mutations or epigenetic modifications, which lead to abnormal autophagy, apoptosis of mature cells, chromosomal abnormalities, and a high level of inflammation in the bone marrow microenvironment ( 4 - 8 ). (frontiersin.org)
  • Early pregnancy loss is caused most commonly by fetal chromosomal abnormalities, which account for more than two-thirds of all early pregnancy loss between 6 and 10 weeks of gestation. (cdc.gov)
  • neither the etiology of sperm abnormalities nor the cause of sister-chromatid exchange in spontaneous abortions has been established (11,12). (cdc.gov)
  • For example, the detection of rare outcomes, such as birth defects, requires the study of several thousand pregnancies, and retrospective studies are subject to problems of recall and misclassification, both of reproductive events and of exposures (20,21). (cdc.gov)
  • The prevalence of anemia in population studies of healthy people (excluding pregnant women) depends on the hemoglobin concentration selected as the lower limit of normal. (eistria.com)
  • The Chemotherapy Induced Anemia market is expected to surge due to the disease's increasing prevalence and awareness during the forecast period. (beststockmarketnews.com)
  • An analysis of eight studies conducted in Thailand, France, Italy, and Brazil found that the combined prevalence of hypertensive emergency and hypertensive urgency in EDs was roughly 1.2%, with hypertensive urgency being significantly more common than hypertensive emergency, though prevalence varied across studies. (nursingcenter.com)
  • 7 (2008) studied prevalence of oral mucosal lesions in patient aged 2-80 years. (bvsalud.org)
  • However, numerous studies have demonstrated that light to moderate alcohol consumption (ie, 1-2 drinks per d or 3-9 drinks per wk) decreases the risk of cardiac events such as myocardial infarction. (medscape.com)
  • monitor with electrocardiograms (ECGs) if concomitant electrolyte abnormalities, cardiac failure or arrhythmias, or use of other QT prolonging drugs. (nih.gov)
  • The inactivating ALDH2 rs671 polymorphism, present in up to 8% of the global population and in up to 50% of the East Asian population, is associated with increased risk of cardiovascular conditions such as coronary artery disease, alcohol-induced cardiac dysfunction, pulmonary arterial hypertension, heart failure and drug-induced cardiotoxicity. (cdc.gov)
  • The diagnosis of brain hemorrhage typically requires a combination of clinical findings, medical history assessments, and numerous confirmatory studies. (imarcgroup.com)
  • The objective of the present paper is to conduct a semi-structured literature review on epidemiology, clinical characteristics, diagnosis, and treatment of GPP. (springer.com)
  • The current study provides a detailed analysis of the clinical characteristics of a homogenous group of 61 patients with computer tomography (CT)-defined CPFE, thus leading to the individualisation of a characteristic entity, and further shows that the presence of pulmonary arterial hypertension (PAH) at diagnosis is a critical determinant of prognosis in these patients. (ersjournals.com)
  • Patients with connective tissue disease at the time of the diagnosis of CFPE were excluded from the study, as well as patients with a diagnosis of other interstitial lung diseases, such as drug-induced interstitial lung disease, pneumoconiosis, hypersensitivity pneumonitis, sarcoidosis, pulmonary histiocytosis, lymphangioleiomyomatosis and eosinophilic pneumonia 4 . (ersjournals.com)
  • 1977. Metabolism of haloforms to carbon monoxide: I. In vitro studies. (cdc.gov)
  • CMV infection has been shown to induce transient abnormalities of in vitro cellular-immune function in otherwise healthy human hosts (2,3). (cdc.gov)
  • In contrast, macrocytic anemias most commonly originate from abnormalities that impair erythroid precursors' maturation in the bone marrow. (eistria.com)
  • Chemotherapy-induced anemia (CIA) is a consequence of malignant invasion of normal tissue leading to blood loss, bone marrow infiltration with disruption of erythropoiesis, and functional iron deficiency as a consequence of inflammation. (beststockmarketnews.com)
  • 8 Damage subsequently results from autoimmunity-induced inflammation or tissue deposition of immune complexes. (lww.com)
  • Hence, it is intrinsically difficult to 'isolate' dietary risk factors in epidemiological studies. (nature.com)
  • It contains descriptions and evaluations of toxicological studies and epidemiological investigations and provides conclusions, where possible, on the relevance of toxicity and toxicokinetic data to public health. (cdc.gov)
  • 1 The incidence and severity of cytopenias correlate directly with the degree of immunosuppression, while isolated haematological abnormalities, particularly anaemia and thrombocytopenia, may be the initial presentation of HIV infection. (scielo.org.za)
  • 2 HIV infection should be considered when assessing patients presenting with any cytopenia, although the causes of haematological abnormalities in HIV infection are often multifactorial. (scielo.org.za)
  • Mpox (formerly known as monkeypox) is an orthopoxvirus based zoonotic infection that induces a smallpox-like human illness. (bvsalud.org)
  • Maternal exposure after conception may result in death of the fetus or structural and functional abnormalities in the newborn. (cdc.gov)
  • Care, treatment and follow-up in psychiatric and epileptic pregnant women were compared with women inquiring Czech Teratology Information Service (CZTIS) due to other exposure to drugs during pregnancy. (nel.edu)
  • Exposure to certain drugs may induce a lupus-like illness or exacerbate SLE. (lww.com)
  • There are no standardized diagnostic criteria for drug-induced lupus erythematosus, but in such cases there must have been continuous exposure to a pharmacological trigger for at least a month, with resolution after discontinuation of the drug. (lww.com)
  • Concomitant THC and stress adolescent exposure induces impaired fear extinction and related neurobiological changes in adulthood. (upf.edu)
  • Maternal illnesses like diabetes mellitus, conditions such as iodine and folic acid deficiency, and exposure to medicinal and recreational drugs including alcohol and tobacco, certain environmental chemicals, and high doses of radiation are other factors that cause birth defects. (who.int)
  • When an erythrocyte becomes infected with P. falciparum , it induces erythrocyte alterations and microcirculatory abnormalities. (sjrhem.ca)
  • prevention of radiation-induced nausea and vomiting (greater than or equal to 2%) are: headache, constipation, and diarrhea. (nih.gov)
  • In women with high pre-gestational BMI and twin pregnancy, our aims were to explore the biochemical and hematological parameters and to study the rate of obstetric adverse outcomes. (mdpi.com)
  • Anemia is the most common and persistent hematological abnormality in oncology patients. (beststockmarketnews.com)
  • Lead- (Pb-) induced hypertension has been shown in humans and experimental animals and cardiovascular effects of hydrogen sulfide (H 2 S) have been reported previously. (hindawi.com)
  • Furthermore, the inflating adoption of effective drugs, including diuretics, antihypertensive agents, antiepileptics, etc., for reducing the disease symptoms is acting as another significant growth-inducing factor. (imarcgroup.com)
  • The clinical manifestations of drug-induced lupus erythematosus are generally milder with arthralgias and serositis being the predominant symptoms, and major organ involvement is usually absent. (lww.com)
  • Serotonin syndrome ( SS ) is a group of symptoms that may occur with the use of certain serotonergic medications or drugs . (wikipedia.org)
  • [6] (Many of these symptoms may be side effects of the drug or drug interaction causing excessive levels of serotonin rather than an effect of elevated serotonin itself. (wikipedia.org)
  • Histone deacetylases inhibitor trichostatin A reverses anxiety-like symptoms and memory impairments induced by maternal binge alcohol drinking in mice (In press). (upf.edu)
  • 3) no intoxication--patients whose symptoms or ECG abnormalities were clearly explained by other associated clinical illnesses and persisted after withdrawal of digoxin. (nih.gov)
  • prevention of chemotherapy-induced (greater than or equal to 5%) are: headache, malaise/fatigue, constipation, diarrhea. (nih.gov)
  • This report aims to inform the discussion on birth defects, including definition, epidemiology, burden of disease and interventions for prevention and care, as well as indications of how these interventions might be integrated into existing health services. (who.int)
  • Cancer Epidemiology, Biomarkers & Prevention 2003, 12:1227-1233). (justia.com)
  • Birth defects can be defined as structural or functional abnormalities, including metabolic disorders, which are present from birth. (who.int)
  • The alcohol-induced defects include pre- and post-natal growth deficiencies, minor facial abnormalities, and damage to the developing central nervous system (CNS). (asu.edu)
  • Despite antimicrobial drug therapy with linezolid, the patient died 19 days after reintubation. (cdc.gov)
  • If SCLE is drug-induced, withdrawal of the culprit medication in conjunction with medical therapy is often necessary for disease control. (medscape.com)
  • Drug discontinuation and therapy reconciliation remain the mainstay in patent's management to minimize occurrence of acute liver failure. (wjgnet.com)
  • Antipsychotic-Induced Dopamine Supersensitivity Psychosis: Pharmacology, Criteria, and Therapy. (nih.gov)
  • The American Academy of Ophthalmology has not designated any agent because the drug of alternative for initiation of glaucoma therapy. (atpobtvs.com)
  • Laser trabeculoplasty is often an intermediate step between drug therapy and trabeculectomy. (atpobtvs.com)
  • Long-term studies demonstrate these agents are protected, efficacious, and nicely tolerated in glaucoma therapy. (atpobtvs.com)
  • This study confirms that insulin resistance affects treatment outcome, and thus HOMA-IR testing before initiation of therapy may be a cost-effective tool. (who.int)
  • Olanzapine (Zyprexa), an FDA-approved antipsychotic, effectively controlled chemotherapy-induced nausea and vomiting (CINV) in patients who failed to respond to guideline-recommended antiemetic therapy in a phase III trial presented at the ASCO Annual Meeting. (ascopost.com)
  • In advanced melanoma, combination therapy with two investigational drugs-one targeting BRAF and the other the MEK pathway-achieved a median progression-free survival of 7.4 months, which rose to 10.8 months in patients who were optimally dosed, reported Jeffrey S. Weber, MD, PhD , Director of the. (ascopost.com)
  • Drug therapy for hypertensive emergency is influenced by end-organ involvement, pharmacokinetics, potential adverse drug effects, and patient comorbidities. (nursingcenter.com)
  • The present study was undertaken to highlight the nature of oral mucosal alterations and lesions among 4-14-year-old children and to study the influence of age and gender on oral mucosal lesions. (bvsalud.org)
  • Studies of occupational reproductive hazards to date have consisted mainly of epidemiologic surveys of pregnancy outcomes following maternal exposures. (cdc.gov)
  • Studies of adverse outcomes of pregnancy, however, are subject to several methodologic limitations. (cdc.gov)
  • Using this drug for a long time during pregnancy may lead to withdrawal in the newborn baby. (drugs.com)
  • In addition to this, the rising incidence of several associated risk factors, such as drug abuse, traumatic brain injury, arteriovenous malformations, vascular abnormalities, use of blood-thinning medications, etc., is also propelling the market growth. (imarcgroup.com)
  • In perhaps as many as 30% of patients with SCLE, drugs may exacerbate or induce their disease. (medscape.com)
  • In animal studies, PUUV induces production of proinflammatory cytokines, such as interleukin (IL)-6 and IL-10 ( 3 ). (cdc.gov)
  • Over many years, several theories have arisen based on clinical and scientific data obtained in human and animal studies, including oxidative stress, apoptosis, mitochondrial dysfunction, derangements of fatty acid metabolism/transport, and accelerated protein catabolism. (medscape.com)
  • Oxidative stress can denature lipids and proteins [ 10 , 12 - 14 ], as well as induce DNA and RNA fragmentation [ 15 - 17 ], leading to cell dysfunction, injury, and death. (hindawi.com)
  • Proposed molecular mechanisms of oxidative stress-induced Nrf2 activation. (hindawi.com)
  • Therefore, H 2 S pathway may be involved in Pb-induced hypertension and treatment with NaHS exerts antihypertensive effect, promotes non-NO-mediated relaxation, and decreases oxidative stress in rats with Pb-induced hypertension. (hindawi.com)
  • 2] In addition, the literature reports alcohol withdrawal being associated with takotsubo, or stress-induced, cardiomyopathy. (medscape.com)
  • For patient education information, see the Mental Health Center, as well as Alcoholism, Alcohol Intoxication, Drug Dependence and Abuse, and Substance Abuse. (medscape.com)
  • Some studies have suggested that a genetic vulnerability exists to the myocardial effects of alcohol consumption. (medscape.com)
  • Digital health interventions have also been proven to reduce alcohol use in adolescents in long-term studies. (cdc.gov)
  • Motivated by our conduct of a literature review on social exposures and accelerated aging as measured by a growing number of epigenetic "clocks" (which estimate age via DNA methylation patterns (DNAm)), we report on three different approaches - 1 incorrect and 2 correct - in the epidemiologic literature on treatment of age in these and other studies using other common exposures (i.e., body mass index and alcohol consumption). (cdc.gov)
  • It is well established that acetaldehyde is the culprit in hangovers and in alcohol-induced facial flushing, and it is the principal suspect in alcohol-associated cancers as well vide infra. (justia.com)
  • Several studies have shown that the presence of ADH2*2 alleles, which encode hyper-active forms of alcohol dehydrogenase (W. F. Bosron, T. K. Li, Hepatology, 1986 6:502-510), also contributes to alcohol flushing and a predisposition to esophageal cancer (A. Shibuya et al. (justia.com)
  • Our current knowledge of choline in human milk is proscribed to comparatively few studies, largely from high-income international locations the place maternal animal source food consumption is likely greater than that of counterparts from low-income nations. (cpanet.com)
  • Reported with 5-HT 3 receptor antagonists alone but particularly with concomitant use of serotonergic drugs. (nih.gov)
  • Out of 29 liver tissue sections examined, 14 had a low level of expression of insulin receptor type 1 by immunohistochemical studies. (who.int)
  • It would be interesting to carry out more studies to elucidate precisely the different pathophysiological mechanisms of these diseases. (who.int)
  • 13 Aberrant epigenetic regulation including DNA methylation, histone modifications and microRNA-mediated regulation may contribute to the complex array of immune abnormalities and disease manifestations in SLE. (bmj.com)
  • 15 The key role of aberrant B cell autoreactivity in SLE was revealed in a landmark murine study using a knockout gene mutation to prevent lupus mice from developing B cells, which resulted in a lack of autoantibody formation and clinical manifestations (nephritis or vasculitis). (bmj.com)
  • Inhibition of ALDH by the drug disulfuram creates a similar sensitivity in people having an otherwise normally-acting enzyme. (justia.com)
  • The use of aqueous shunts or valves to manage glaucoma has been rising, and the outcomes of a current study have demonstrated improved security and efficacy of those devices. (atpobtvs.com)
  • Past studies showed that in the socially stressed mice model BDNF levels were increased and BDNF-TrkB signaling contributed to depressive-like outcomes ( 21 , 22 ). (frontiersin.org)
  • CDH was no longer considered a primarily surgical disease but, rather, a disease associated with pulmonary hypoplasia , pulmonary hypertension , pulmonary immaturity, and an increased susceptibility of the lungs to ventilation-induced lung injury. (medscape.com)
  • Combined pulmonary fibrosis and emphysema (CPFE) has been mentioned in passing in series of patients with IPF or has been the subject of case reports or short series 1 - 3 , but has not hitherto been specifically studied in a large cohort of patients. (ersjournals.com)
  • 200 physicians dedicated to the study of rare (so-called "orphan") pulmonary diseases. (ersjournals.com)
  • Serotonin syndrome is typically caused by the use of two or more serotonergic medications or drugs. (wikipedia.org)
  • Norpropoxyphene is a major metabolite of the opioid analgesic drug dextropropoxyphene, and is responsible for many of the side effects associated with use of this drug, especially the unusual toxicity seen during dextropropoxyphene overdose. (wikipedia.org)
  • Misuse or abuse of this drug can lead to overdose and death. (drugs.com)
  • In this cohort study, cross-sectional and longitudinal multimodal secondary analyses involving a combined 15?928 individuals indicated that endorsement of criteria empirically designated as representing greater severity of AUD was significantly associated with 2-fold increased likelihood of progression from mild-to-moderate AUD to severe AUD, even after accounting for total criterion count. (cdc.gov)
  • 1. Viara M, Menicanti V, Nebiolo M, Michos N, Sarchi C. Double-blind placebo-controlled study of the efficacy and tolerability of suprofen suppositories in patients with osteoarthritic pain. (drugs.com)
  • A case-control study of gastrointestinal and urinary tract cancer mortality and drinking water chlorination. (cdc.gov)
  • Lymphocyte studies were not performed on the other 2 patients. (cdc.gov)
  • SCLE may occur in patients with systemic lupus erythematosus (SLE), Sjögren syndrome , deficiency of the second component of complement (C2d), or it may be drug-induced. (medscape.com)
  • One study demonstrated that patients with SCLE, as well as those with discoid lupus erythematosus, but not those with lupus tumidus, have elevated levels of type I interferon-regulated genes in their blood. (medscape.com)
  • If concomitant use of ZOFRAN with other serotonergic drugs is clinically warranted, patients should be made aware of a potential increased risk for serotonin syndrome. (nih.gov)
  • The current authors conducted a retrospective study of 61 patients with both emphysema of the upper zones and diffuse parenchymal lung disease with fibrosis of the lower zones of the lungs on chest computed tomography. (ersjournals.com)
  • All patients admitted into these beds during a 3-month period in 2008/2009 who received a transfusion with blood or blood products were enrolled in the study. (scielo.org.za)
  • Simple descriptive statistics (Microsoft Excel, SPSS and STATISTICA) were used to interpret data and draw inferences about the patients studied. (scielo.org.za)
  • Patients responding to however intolerant of initial remedy could additionally be switched to one other drug. (atpobtvs.com)
  • For patients failing to respond to an preliminary drug, a change to another agent must be considered. (atpobtvs.com)
  • The value of the targeted agent crizotinib (Xalkori) may not be restricted to the 5% of patients with non-small cell lung cancer who have abnormalities in the ALK gene. (ascopost.com)
  • There were conflicting results on the comparison of brain-derived neurotrophic factor (BDNF) levels between poststroke depression (PSD) patients and stroke patients without PSD among previous studies. (frontiersin.org)
  • Multiple genetic susceptibility loci have been identified in genomic studies, and specific major histocompatibility complexes are also linked to lupus. (lww.com)
  • Diazoxide is the first-line drug for controlling hypoglycemia in HI, but it is ineffective in some genetic forms (KATP-HI, GK-HI). (medscape.com)
  • No age group seems to be exempt from depression, and studies have found that depression appears in infants as young as 6 months old who have been separated from their mothers. (wikipedia.org)
  • A severe and sometimes deadly problem called serotonin syndrome may happen if you take this drug with certain other drugs. (drugs.com)
  • In the US, however, 163 cases of acute flank pain syndrome were reported from approximately 700,000 persons using the drug. (drugs.com)
  • 11 , 12 Thirty-one susceptibility loci for SLE have been identified by genome-wide association studies and other gene mapping studies. (bmj.com)
  • 3 Immunohistochemical studies of an animal model with retinal vasculitis disclosed immune complex deposition within the vessel walls, which ultimately caused vaso-occlusion in the eye. (bmj.com)
  • Psychotic organic mental disorders resulting from the toxic effect of drugs and chemicals or other harmful substance. (nih.gov)
  • Mood disorders may also be substance induced, or occur in response to a medical condition . (wikipedia.org)
  • The tablets contain a combination of two types of ciprofloxacin drug substance, ciprofloxacin hydrochloride and ciprofloxacin betaine (base). (theodora.com)
  • The drug substance is a faintly yellowish to light yellow crystalline substance. (theodora.com)
  • Rates and Predictors of Conversion to Schizophrenia or Bipolar Disorder Following Substance-Induced Psychosis. (nih.gov)
  • Substance-induced Psychosis in Youth. (nih.gov)