Tell your doctor and pharmacist if you are being treated with anthracycline medications for cancer such as daunorubicin (Cerubidine), doxorubicin (Doxil), epirubicin (Ellence), and idarubicin (Idamycin). (medlineplus.gov)
Anthracyclines, e. g. daunorubicin, doxorubicin, and idarubicin, consist of a tetracycline moiety linked via a glycosidic bond to a sugar residue, usually the aminosugar daunosamine. (lu.se)
In comparison to this the Epirubicin therapy contains fluorouracil/epirubicin/cyclophosphamide (FEC). (wikipedia.org)
Three large randomized studies have directly compared the epirubicin-containing regimen fluorouracil/epirubicin/cyclophosphamide (FEC) with CMF in the adjuvant setting. (wikipedia.org)
KEYNOTE-522 evaluated the combination of neoadjuvant carboplatin and paclitaxel followed by doxorubicin or epirubicin and cyclophosphamide with pembrolizumab or placebo, with completion of 1 year of pembrolizumab or placebo after surgery, in 1,174 patients with previously untreated stage II or III TNBC, Larissa Korde, MD, of the National Cancer Institute, and other members of the guideline expert panel noted in the document in the Journal of Clinical Oncology . (medpagetoday.com)
Epirubicin is an anthracycline drug used for chemotherapy. (wikipedia.org)
Epirubicin is favoured over doxorubicin, the most popular anthracycline, in some chemotherapy regimens as it appears to cause fewer side-effects. (wikipedia.org)
Doxorubicin is an anthracycline antibiotic that inhibits DNA and RNA synthesis. (medscape.com)
ON014 trade name] is given with a taxane (a type of cancer medicine such as paclitaxel or docetaxel) or if you have ever used an anthracycline (another type of cancer medicine that includes medicines called doxorubicin and epirubicin). (who.int)
Doses3
Equimolar doses of epirubicin and doxorubicin have been shown to be therapeutically equivalent in patients with metastatic breast cancer. (wikipedia.org)
With the addition of granulocytecolony-stimulating factor (G-CSF [Neupogen]) to the regimen,patients received epirubicin at clinically relevant doses after dose-escalation.Results of the topoisomerase activity will be reported with thefinal results of this phase I study. (cancernetwork.com)
Doxorubicin is suitable for use in combination with other medications. (medicalnewstoday.com)
Doctors prescribe epirubicin alongside other medications to treat breast cancer in people who have already had surgery to remove the tumor. (medicalnewstoday.com)
The recommended dose of epirubicin varies widely according to the specific condition being treated, the response to therapy, the other medications being used, and the body size of the recipient person receiving treatment. (medbroadcast.com)
Doxorubicin should only be given by health care professionals familiar with the use of chemotherapy medications used to treat cancer. (pharmasave.com)
Toxicity4
Epirubicin has a different spatial orientation of the hydroxyl group at the 4' carbon of the sugar - it has the opposite chirality - which may account for its faster elimination and reduced toxicity. (wikipedia.org)
The purpose of the study was to investigate the antitumour activity and toxicity of high dose (120 mg m-2) single agent epirubicin therapy in untreated extensive small cell lung cancer patients. (nih.gov)
The high antitumour activity and no increase in toxicity justify the incorporation of high dose epirubicin into combination therapy. (nih.gov)
The combination of irinotecan (Camptosar), epirubicin, andcapecitabine (Xeloda) has shown an acceptable toxicity profile. (cancernetwork.com)
Regimens1
Additionally the administration of more dose intensive epirubicin-containing regimens to patients with metastatic breast cancer has been associated with improved response rates, but not increased overall survival. (wikipedia.org)
Capecitabine1
In thisopen-label phase I study, irinotecan was administered IV at a fixeddose of 250 mg/m2 on day 1 in combination with capecitabine at a fixeddose of 1,500 mg/m2 for days 2 to 7 and epirubicin starting at a dose of40 mg/m2 and escalating by 10 mg/m2 in cohorts of three patients forthose with metastatic adenocarcinomas. (cancernetwork.com)
Chemotherapy1
Epirubicin monotherapy was shown to be therapeutically equivalent to doxorubicin monotherapy in patients who had to receive previous chemotherapy for advanced breast cancer. (wikipedia.org)
Topoisomerase2
Epirubicin then stabilizes the topoisomerase II-DNA complex, resulting in irreversible DNA strand breakage, leading to cell death. (wikipedia.org)
Epirubicin was reported to block DNA replication either through direct DNA damage or indirectly through inhibition of replication proteins such as topoisomerase. (nature.com)
Ovarian cancer1
Epirubicin is primarily used against breast and ovarian cancer, gastric cancer, lung cancer and lymphomas. (wikipedia.org)
Dose1
Each single-dose vial of sterile, lyophilized red powder, contains doxorubicin HCl 10 mg. (pharmasave.com)
Tamoxifen1
The combination of Epirubicin and tamoxifen lead to an increase survival in node-positive postmenopausal women with hormone receptor-positive breast tumours. (wikipedia.org)
Sterile2
Each mL of sterile, isotonic, ready-to-use, red-orange solution contains 2 mg of epirubicin hydrochloride. (medbroadcast.com)
Epirubicin is always given under the supervision of a doctor in a hospital or similar setting with access to sterile equipment for preparation. (medbroadcast.com)
Mechanism1
Thus, one mechanism of epirubicin combined TACE treatment for HCC was through induction of synergistic DNA damage. (nature.com)
Bladder2
In addition, doxorubicin should not be given directly into the bladder if tumours have penetrated the bladder wall, if blood in the urine or bladder infections are present, or if there is inflammation of the bladder. (pharmasave.com)
The aim of resection is the complete removal of the tumor manifestation, for this purpose the tumor is either resected in fractions (standard method) or dissected en bloc with tumor base from the bladder wall. (urology-textbook.com)
Lung cancer1
Phase II study of 4'-epi-doxorubicin in patients with untreated, extensive small cell lung cancer. (nih.gov)
Breast cancer1
Chae YK, Brown EN, Lei X, Melhem-Bertrandt A, Giordano SH, Litton JK, Hortobagyi GN, Gonzalez-Angulo AM, Chavez-MacGregor M. Use of ACE Inhibitors and Angiotensin Receptor Blockers and Primary Breast Cancer Outcomes. (jcancer.org)
Agent1
Epirubicin, a DNA damaging anticancer agent and CoCl 2 , which was used to imitate hypoxia condition, was applied to induce DNA damage in TIGAR knockdown HepG2 cells. (nature.com)
Treatment2
Results showed that TIGAR was increased and relocated to the nucleus after epirubicin or hypoxia treatment in cancer cells. (nature.com)
DNA damage in HepG2 cells after TIGAR knockdown with or without treatment of epirubicin or CoCl 2 was detected by Comet assay. (nature.com)
Therapy1
The aim of Epirubicin as adjuvanted therapy is to eradicate micro metastasis and prolong disease free survival. (wikipedia.org)
Patients1
Patients in the standard arm (surgery alone) will undergo large en- bloc curative intent surgery will be performed within 4 weeks following randomization. (who.int)
Cancer cells2
Epirubicin prevents the growth of cancer cells by interfering with the genetic material DNA, which is necessary for reproduction of cells. (medbroadcast.com)
As well as interfering with the genetic material DNA of cancer cells, epirubicin can interfere with some of your normal cells. (medbroadcast.com)
Drugs1
These are particularly potent drugs, with doxorubicin used most commonly in veterinary medicine. (vin.com)
Doctor1
If you miss an appointment to receive doxorubicin, contact your doctor as soon as possible to reschedule your appointment. (pharmasave.com)