Ephrin receptor protein tyrosine kinases. Medical search. Frequent questions

Preclinical studies confirmed ephrin type-B receptor 4 (EphB4) as a potential therapeutic target based on the efficacy of human serum albumin-conjugated soluble EphB4 in mice bearing orthotopic xenografts. (ppbhg.org)

They can be classified into two classes (EphA and EphB), according to their extracellular sequences, which largely correspond to binding preferences for either GPI-anchored ephrin-A ligands or transmembrane ephrin-B ligands. (umbc.edu)
Eph receptors represent the largest known family of receptors tyrosine kinases and are broadly divided into subclasses, EphA and EphB. (medsci.org)
The Eph family of receptor tyrosine kinases (comprising EphA and EphB receptors) has been implicated in synapse formation and the regulation of synaptic function and plasticity6. (betalifesci.com)
Eph receptors are subdivided into two subclasses, termed EphA and EphB, based on sequence similarity and their preference for binding a particular subclass of ephrins. (silverchair.com)
There are 14 Eph receptors in the human genome, which can be subdivided into EphA and EphB subclasses. (aging-us.com)

The EphA receptors (A1-A9) bind to EphrinA ligands, a group of glycosyl phosphatidylinositol-linked membrane proteins and EphB receptors (B1-B6) interact with EphrinB ligands [ 9 ]. (medsci.org)
Typically, EphA receptors bind to glycosylphosphatidylinositol anchor (GPI)-linked ephrin A proteins and EphB receptors bind to transmembrane ephrin B proteins. (silverchair.com)
Based on sequence homology, Eph and ephrin have been classified into EphA/EphrinA and EphB/EphrinB class of families [ 2 ]. (genominfo.org)

This gene belongs to the ephrin receptor subfamily of the protein-tyrosine kinase family. (wikipedia.org)
Receptors in the EPH subfamily typically have a single kinase domain and an extracellular region containing a Cys-rich domain and 2 fibronectin type III repeats. (wikipedia.org)
EphRs comprise the largest subfamily of receptor tyr kinases (RTKs). (umbc.edu)
The EPH subfamily is the biggest group of receptor protein kinases and they take part in vital nervous system function and development. (prospecbio.com)
The ephrins and EPH-related receptors comprise the largest subfamily of receptor protein-tyrosine kinases and have been implicated in mediating developmental events, especially in the nervous system and in erythropoiesis. (creative-biolabs.com)
Erythropoietin-producing hepatocellular A2 (EphA2) is a member of the Eph subfamily with tyrosine kinase activity, plays a key role in the regulation of signaling pathways related to the malignant phenotype of various tumor cells, but its specific regulatory mechanism in colorectal cancer needs to be further clarified. (aging-us.com)

Ephrin receptors are components of cell signalling pathways involved in animal growth and development, forming the largest sub-family of receptor tyrosine kinases (RTKs). (betalifesci.com)
Eph receptors constitute the largest family of receptor tyrosine kinases (RTKs). (silverchair.com)
Receptor tyrosine kinases (RTKs) play an important role in a variety of cellular processes in cancer [ 3 ]. (hindawi.com)
Ephrins, also known as ephrin ligands, and Eph receptors (Ephs), which are RTKs, are key regulators of physiological and pathological processes involved in development and disease, such as cellular motility, cell repulsion, and cell adhesion [ 4 ]. (hindawi.com)
Receptor tyrosine kinase (RTKs), a sub-class of tyrosine kinase, regulates numerous physiological events such as cell growth, division, metabolism, and motility. (genominfo.org)
Mutations reported in different functional domains of RTKs are linked to the kinase constitutive expression, ligand-independent signaling, and drug sensitivity [ 1 ]. (genominfo.org)
Structurally Eph receptors are similar to RTKs, comprises extracellular region, a ligand binding and fibronectin repeat domain, whereas intracellular has a juxtamembrane, kinase, and SAM domain. (genominfo.org)

EphB4 is a membrane-bound receptor tyrosine kinase (RTK) commonly over-produced by many epithelial cancers but with low to no expression in most normal adult tissues. (oncotarget.com)
Peptide exclusion was used to identify the epitope targeted by this antibody within the cysteine-rich region of the EphB4 protein, a sequence defined as a potential ligand interacting interface. (oncotarget.com)
Addition of antibody to cancer cells resulted in phosphorylation and subsequent degradation of the EphB4 protein, suggesting a mechanism that is ligand mimetic and tumour suppressive. (oncotarget.com)
EphB4 is a member of the largest family of receptor tyrosine kinases and is an important regulator of fundamental physiological and pathophysiological processes such as tissue patterning during development, angiogenesis and tumour progression [ 1 ]. (oncotarget.com)
Despite significant promiscuity between other Eph family members and the ephrin ligands, the single physiologically-relevant ligand of the EphB4 receptor is ephrin-B2 [ 2 ]. (oncotarget.com)
In summary, we present a comprehensive landscape of Diazepam-Binding Inhibitor Fragment, human tyrosine phosphoproteome with EphB4 Diazepam-Binding Inhibitor Fragment, human as a promising Diazepam-Binding Inhibitor Fragment, human therapeutic target in pancreatic ductal adenocarcinoma. (ppbhg.org)

They exclusively bind membrane-tethered ligands known as ephrin proteins. (silverchair.com)

CF stands for Carrier Free (CF). We typically add Bovine Serum Albumin (BSA) as a carrier protein to our recombinant proteins. (rndsystems.com)
Adding a carrier protein enhances protein stability, increases shelf-life, and allows the recombinant protein to be stored at a more dilute concentration. (rndsystems.com)
In general, we advise purchasing the recombinant protein with BSA for use in cell or tissue culture, or as an ELISA standard. (rndsystems.com)
EPHA2 MS Standard C13 and N15-labeled recombinant protein (NP_004422) with a C-terminal MYC/DDK tag, was expressed in HEK293 cells. (creativebiomart.net)
It has been estimated that the biological activity of 50 million PODS® co-crystals generates the same peak dose as 3.3 µg of standard recombinant protein. (cellgs.com)
The recombinant proteins are stable for up to 1 year from date of receipt at -70°C. (betalifesci.com)

EFNA1 belongs to the ephrin (EPH) family. (prospecbio.com)

Ephrin-A1 is widely expressed on endothelial and epithelial cells, particularly in the lung, intestine, liver, and skin. (cellgs.com)

Ephrin-A ligands are structurally related to the extracellular domains of the transmembrane Ephrin-B ligands. (cellgs.com)

PTKs catalyze the transfer of the gamma-phosphoryl group from ATP to tyrosine (tyr) residues in protein substrates. (umbc.edu)
The cytoplasmic domain contains a juxtamembrane motif with two tyrosine residues, which are the major autophosphorylation sites, a kinase domain, and a conserved sterile alpha motif (SAM) (5). (rndsystems.com)
At the center of protein-protein interactions are the binding surfaces, or interfacial residues which form contacts between binding partners and stabilize protein complexes. (biomedcentral.com)
FN2 is followed by a transmembrane (TM) helix, and an intracellular part consisting of a juxtamembrane (JM) region with several conserved tyrosine (Y) residues, a tyrosine kinase domain, a sterile-α motif (SAM) protein-protein interaction domain, and a C-terminal Psd-95, Dlg and ZO1 domain (PDZ)-binding motif ( Pasquale, 2008 ). (silverchair.com)
The cytoplasmic region contains a juxtamembrane motif with two tyrosine residues which are the major autophosphorylation sites, a kinase domain, and a conserved sterile alpha motif (SAM) in the carboxy tail which contains one conserved tyrosine residue. (rndsystems.com)
Residues that compose the RNA-binding surface are conserved in a subgroup of SAM domain-containing proteins, suggesting that the function of the domain is conserved from yeast to humans. (embl.de)

Receptor tyrosine kinase which binds promiscuously GPI-anchored ephrin-A family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. (affbiotech.cn)

CusabioProtein Description: Extracellular DomainAlternative Name (s) : CD137;ILA;TNFRSF9;4-1BB ligand receptor;CDw137;T-cell antigen. (joplink.net)

The Eph receptor family is the largest family of receptor tyrosine kinases and is a key regulator of cell growth, differentiation and motility [ 6 - 8 ]. (aging-us.com)
Ephs belong to the largest family of receptor tyrosine kinase and are highly conserved both sequentially and structurally. (genominfo.org)

Unified nomenclature for Eph family receptors and their ligands, the ephrins. (wikipedia.org)
The PTKc family is part of a larger superfamily that includes the catalytic domains of other kinases such as protein serine/threonine kinases, RIO kinases, and phosphoinositide 3-kinase (PI3K). (umbc.edu)
EphA5, also known as Ehk1, Bsk, Cek7, Hek7, and Rek7, is a member of the Eph receptor tyrosine kinase family which binds members of the Ephrin ligand family (1 - 4). (rndsystems.com)
The β and γ chains of the IL-2R are members of the type I cytokine receptor family. (transcriptionfactor.org)
Ephrin-A1 is a member of Ephrin-A family, and it is also known as B61 and LERK-1. (cellgs.com)
Ephrin type-A receptor 2 (EphA2) is a member of the tyrosine receptor kinases, a family of membrane proteins recognized as potential anticancer targets. (bvsalud.org)
Receptor for members of the ephrin-A family. (abcam.com)
Ephrin receptors make up the largest subgroup of the receptor tyrosine kinase (RTK) family. (cancer.gov)
The activities of the ephrin family in breast cancer (BrCa) are complex. (hindawi.com)
Family A receptors (EPHA) and ligands (EFNA) can act as oncogenes or tumor suppressors and are implicated in chemoresistance. (hindawi.com)
The Ephrin family consists of multiple Ephs and ephrins. (hindawi.com)
Ephrin family A includes ten receptors named EPHA (1-10) and five ligands designated as EFNA (1-5) [ 6 ]. (hindawi.com)
Several Ephrin A (EPHA/EFNA) family members are overexpressed or downregulated in a variety of tumors, suggesting that they act as oncogenes or as tumor suppressors according to the cellular context [ 9 ]. (hindawi.com)
Ephrin family members receptor tyrosine kinases are mediators of angiogenesis that may also regulate endothelial barrier function in the lung. (biospraysehatalami.com)
This represents a new function for the SAM domain family, which is well characterized for mediating protein-protein interactions. (embl.de)
Eph receptor belongs to the largest family of RTK. (genominfo.org)
Eph-ephrin as a family is ubiquitously expressed in different tissues [ 4 ]. (genominfo.org)
Our lab seeks to understand how the protein kinase family organises complex intracellular communication networks. (edu.au)

These events are influenced by and activate other molecular pathways, including phosphatidylinositol 3-kinase (PI3K), mammalian target of rapamycin (mTOR), and mitogen-activated protein kinase (MAPK),[2] and therapies are now available that target these pathocellular processes. (cancernetwork.com)

The resulting downstream signals occur bidirectionally in both EphR-expressing cells (forward signaling) and ephrin-expressing cells (reverse signaling). (umbc.edu)
The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. (affbiotech.cn)
Ligand-mediated activation of Ephs induce various important downstream effects and Eph receptors have been studied for their potential roles in the development of cancer. (betalifesci.com)
Moreover, Eph/ephrin signalling can be bi-directional, with intracellular pathways operating downstream of both the Eph receptor (forward signalling) and the ephrin ligand (reverse signalling) ( Kullander and Klein, 2002 ). (silverchair.com)
Downstream effectors of the EPHA8 signaling pathway include FYN which promotes cell adhesion upon activation by EPHA8 and the MAP kinases in the stimulation of neurite outgrowth (By similarity). (wuxibiortus.com)
Eph-ephrin regulates many downstream pathways that lead to physiological events such as cell migration, proliferation, and growth. (genominfo.org)

Soluble monomeric ligands bind the receptor but do not induce receptor autophosphorylation and activation (2). (rndsystems.com)
In HV rats EphA2 antagonism with either the soluble decoy receptor EphA2/Fc or with monoclonal anti-EphA2 antibody decreased albumin extravasation and histological proof edema development ( (biospraysehatalami.com)

EPH receptor A1 (ephrin type-A receptor 1) is a protein that in humans is encoded by the EPHA1 gene. (wikipedia.org)
Expression system for standard: EPH receptor A4 (ephrin type-A receptor 4) is a protein that in humans is encoded by the EPHA4 gene. (innov-research.com)
This gene encodes a protein that binds ephrin-A ligands. (creativebiomart.net)
Protein-protein interactions play important functional roles in almost all biological activities, including, but not restricted to, signal transduction, gene regulation, catalytic enzymatic activities and structural roles [ 1 ]. (biomedcentral.com)
The protein encoded by this gene binds to ephrin-B2 and plays an essential role in vascular development. (cancer.gov)

Anteroposterior patterning in Drosophila melanogaster is dependent on the sequence-specific RNA-binding protein Smaug, which binds to and regulates the translation of nanos (nos) mRNA. (embl.de)
Eph/ephrin signaling is a cell-to-cell communication pathway, which regulates cell migration and proliferation. (5dok.org)

This antibody is not suitable for use in a Reverse Phase Protein Array format as described in SOP M-105. (cancer.gov)

EPHA1, EPHA2, EFNA3, and EFNA4 mRNA expression was significantly higher in human epidermal growth factor receptor 2- (HER2-) positive tumors than in HER2-negative tumors. (hindawi.com)

This domain occurred 367 times on human genes ( 852 proteins). (umbc.edu)
This domain occurred 324 times on human genes ( 748 proteins). (umbc.edu)
To better understand the molecular changes associated with AD, genome-wide association studies (GWAS) have identified hundreds of candidate genes linked to the disease, like the receptor tyrosine kinase EphA1. (sdbonline.org)
In the online version, these sections contain links to more information about proteins encoded by over 17,000 known or predicted human genes. (cshlpress.com)

In vivo , the ligands and receptors display reciprocal expression (3). (rndsystems.com)
The interaction between ligands and receptors via bidirectional signaling and its involvement in cancer biology are mediated by complex processes [ 7 , 8 ]. (hindawi.com)

Smaug, a protein that helps to establish a morphogen gradient in Drosophila embryos by repressing the translation of nanos (nos) mRNA, binds to the 3' untranslated region (UTR) of nos mRNA via two similar hairpin structures. (embl.de)
The Nanos protein gradient in Drosophila, required for proper abdominal segmentation, is generated in part via translational repression of its mRNA by Smaug. (embl.de)
Utilising fly genetics, this study generated the first Drosophila model of human wild-type and P460L mutant EphA1 and tested the effects of Eph /ephrin signalling on AD-relevant behaviour and neurophysiology. (sdbonline.org)
A role for a Drosophila Eph receptor tyrosine kinase (Eph) in the control of photoreceptor axon and cortical axon topography in the developing visual system is described. (sdbonline.org)

The sterile alpha motif (SAM) domain is a putative protein interaction module present in a wide variety of proteins [ ( PUBMED:9007998 ) ] involved in many biological processes. (embl.de)
Crystal structure of the putative cell-wall lipoglycan biosynthesis protein LmcA from Mycobacterium smegmatis. (edu.au)

There are ten vertebrate EphA receptors (EphA1-10), which display promiscuous interactions with six ephrin-A ligands. (umbc.edu)
EphA1 mis-expression did not cause neurodegeneration, shorten lifespan or affect memory but flies mis-expressing the wild-type or mutant receptor were hyper-aroused, had reduced sleep , a stronger circadian rhythm and increased clock neuron activity and excitability. (sdbonline.org)

Ephrin/EphR signaling is important in neural development and plasticity, cell morphogenesis and proliferation, cell-fate determination, embryonic development, tissue patterning, and angiogenesis. (umbc.edu)
Ephrin/EphR interaction mainly results in cell-cell repulsion or adhesion, making it important in neural development and plasticity, cell morphogenesis, cell-fate determination, embryonic development, tissue patterning, and angiogenesis. (umbc.edu)
Growth factors such as fibroblast growth factor (FGF), vascular endothelial cell growth factor (VEGF), and angiopoietin-1 (Ang1) are upregulated to stimulate angiogenesis, while downregulation of endogenous protein inhibitors (thrombospondin 1 and interferon) disrupts the balance of physiologic angiogenesis. (cancernetwork.com)
The ephrin/Eph families also appear to play a role in angiogenesis (3). (rndsystems.com)

Vertebrates have ten EphA and six EhpB receptors, which display promiscuous ligand interactions within each class. (umbc.edu)
These observations reveal a conserved role for Eph kinases as determinants of topographic map formation in vertebrates and invertebrates (Dearborn, 2002). (sdbonline.org)

Eph-Ephrin interactions are widely involved in the regulation of cell migration, tissue morphogenesis, and cancer progression. (cellgs.com)
Eph receptors lie functionally at the interface between pattern formation and morphogenesis. (silverchair.com)

This allows ephrin/EphR dimers to form, leading to the activation of the intracellular tyr kinase domain. (umbc.edu)
constituting the extracellular ligand binding domain, a fibronectin domain followed by intracellular juxtamembrane kinase, and SAM domain. (genominfo.org)
The overall domain organization of EphAs and EphBs are similar, however, ephrin A is GPI anchored to the membrane, whereas ephrin B has an intracellular PDZ binding domain. (genominfo.org)
The intracellular domains of the EphB6 and EphA10 receptor tyrosine pseudokinases function as dynamic signalling hubs. (edu.au)
Cell surface proteins that bind signalling molecules external to the cell with high affinity and convert this extracellular event into one or more intracellular signals that alter the behavior of the target cell (From Alberts, Molecular Biology of the Cell, 2nd ed, pp693-5). (bvsalud.org)

Inflammatory cytokines and growth factors via RSK AKT and Protein Kinase A (PKA) induce phosphorylation of EphA2 Ser897. (aging-us.com)

Eph-ephrin signalling can be bi-directional and controls actin cytoskeleton dynamics, thereby leading to changes in cellular shape. (silverchair.com)

In general, class EphA receptors bind GPI-anchored ephrin-A ligands. (umbc.edu)
EphB2 has been shown to bind ephrin-B1, ephrin-B2, and ephrin-B3 (2, 3). (rndsystems.com)
The receptors are also categorized as A or B according to the type of ligand they bind to. (hindawi.com)

Eph/ephrin signal transduction occurs not only in the receptor-expressing cell but also in the ligand-expressing cell via bidirectional signaling [ 5 ]. (hindawi.com)
In EPH-related tyrosine kinases, appears to mediate cell-cell initiated signal transduction via the binding of SH2-containing proteins to a conserved tyrosine that is phosphorylated. (embl.de)

Based on their structures and sequence relationships, ephrins are divided into the ephrin-A (EFNA) class, which are anchored to the membrane by a glycosylphosphatidylinositol linkage, and the ephrin-B (EFNB) class, which are transmembrane proteins. (creative-biolabs.com)
The ligands can have a glycosylphosphatidylinositol anchor (A type) or a membrane-spanning protein domain (B type). (hindawi.com)

EphA5: EPH receptor A5. (affbiotech.cn)
Among GPI-anchored ephrin-A ligands, EFNA5 most probably constitutes the cognate/functional ligand for EPHA5. (creativebiomart.net)

Activation of kinase activity occurs after membrane-bound or clustered ligand recognition and binding. (rndsystems.com)
The recruitement of VAV2, VAV3 and PI3-kinase p85 subunit by phosphorylated EPHA2 is critical for EFNA1-induced RAC1 GTPase activation and vascular endothelial cell migration and assembly (By similarity). (abcam.com)
Eph receptor-mediated signaling, which is triggered by ephrins7, probably modifies the properties of synapses during synaptic activation and remodeling. (betalifesci.com)
Activation of kinase activity occurs after ligand recognition and binding. (rndsystems.com)
Both receptors and ligands are membrane-bound proteins that require direct cell-cell interaction for activation. (hindawi.com)
Significantly we discovered that strategies to stop EphA2 activation decrease markers of lung damage including protein drip in to the distal lung and histological proof edema. (biospraysehatalami.com)
The mass spectrometric analysis revealed widespread and heterogeneous activation of both receptor and non-receptor tyrosine kinases. (ppbhg.org)
The non-classical pathway refers to EphA2 ligands and tyrosine kinase non-dependent activation and phosphorylation. (aging-us.com)
The juxtamembrane domain has two highly conserved tyrosine that regulate activation of catalytic core of the receptor. (genominfo.org)
Finally, we have studied the role of nanoarchitecture of ephrin ligands in Eph receptor activation. (5dok.org)

It has been found that nearly all the receptors and ligands are expressed in developing and adult neural tissue (3). (rndsystems.com)
The establishment of neural circuits depends on the ability of axonal growth cones to sense their surrounding environment en route to their target. (biologists.com)

Eph and ephrin are membrane-bound and thus regulate cell-cell interaction, migration, partitioning, and cell adhesion [ 3 ]. (genominfo.org)

Characterization and classification of protein-protein interactions would allow us to organize information in protein-protein interaction networks, to make predictions on their function, as well as to facilitate drug design targeted at interfering with those disease-associated protein-protein interactions. (biomedcentral.com)
Trans interactions of Eph receptors with ephrins at cell-cell interfaces promote a variety of cellular responses, including repulsion, attraction and migration. (silverchair.com)
Thirty-two mutations predicted to be pathogenic using SIFT, Polyphen-2, PROVEAN, SNPs&GO, PMut, iSTABLE, and PremPS in-silico tools were found located either in critical functional regions or encompassing interactions at the binding interface of Eph-ephrin. (genominfo.org)

The classical mode means that EphA2 inhibits positive signaling of ligands and tyrosine kinases, thereby suppressing tumorigenesis. (aging-us.com)
Therefore, considering the importance of Eph-ephrin class of protein in tumorigenesis, 7,620 clinically reported missense mutations belonging to the class of variables of unknown significance were retrieved from cBioPortal and evaluated for pathogenicity. (genominfo.org)

The GPI-anchored ephrin-A EFNA2, EFNA3, and EFNA5 are able to activate EPHA8 through phosphorylation. (wuxibiortus.com)

The ephrin receptors are divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. (wikipedia.org)
The extracellular domain facilitates binding to ephrin. (genominfo.org)

Catalytic domain of Ephrin Receptor Protein Tyrosine Kinases. (umbc.edu)
Eph receptor signalling: from catalytic to non-catalytic functions. (edu.au)

The main effect of ephrin/EphR interaction is cell-cell repulsion or adhesion. (umbc.edu)
In the majority of cases, Eph forward signalling causes cell repulsion away from the ephrin-expressing cell, although adhesive responses have been described. (silverchair.com)

Widespread domain in signalling and nuclear proteins. (embl.de)

Eluted peptides were lyophilized and subjected to immunoaffinity purification of tyrosine-phosphorylated peptides. (ppbhg.org)
Immunoaffinity Purification of Tyrosine Phosphopeptides Immunoaffinity purification (IAP) of tyrosine-phosphorylated peptides was carried out as previously described [11]. (ppbhg.org)
Liquid Chromatography-Tandem Mass Spectrometry LC-MS/MS analysis of the enriched tyrosine-phosphorylated peptides was carried out using a reversed-phase liquid chromatography system (Ultimate 3000 RSLCnano, Thermo Scientific, San Jose, CA, USA) connected online to an Orbitrap Fusion Lumos mass spectrometer (Thermo Scientific, San Jose, CA, USA). (ppbhg.org)

Ephrin receptors and their ligands, the ephrins, mediate numerous developmental processes, particularly in the nervous system. (cancer.gov)

EphRs contain an ephrin binding domain and two fibronectin repeats extracellularly, a transmembrane segment, and a cytoplasmic tyr kinase domain. (umbc.edu)
There are two classes of receptors, designated A and B. Both the A and B class receptors have an extracellular region consisting of a globular domain, a cysteine-rich domain, and two fibronectin type III domains. (rndsystems.com)

To further define which neurons express Eph, antibodies were generated to the cytoplasmic portion of the Eph protein. (sdbonline.org)
for hormone receptors in general coord HORMONES (IM) and RECEPTORS, CELL SURFACE (IM) or RECEPTORS, CYTOPLASMIC AND NUCLEAR (IM), for receptors of specific hormones, coord specific hormone or hormone group (IM) and precoord hormone receptor (e.g. (bvsalud.org)

Mechanistically, Eph/ephrin signalling controls local cytoskeletal dynamics and thereby allows cellular shape changes that underlie repulsive or migratory responses. (silverchair.com)
Furthermore, the kinase and SAM domains allow the binding of other cellular proteins. (genominfo.org)

Receptor tyrosine kinases have important roles in the development and progression of human tumors [ 8 ]. (medsci.org)

Here, we employed high-resolution mass spectrometry combined with immunoaffinity purification using anti-phosphotyrosine antibodies to profile tyrosine phosphoproteome across 13 pancreatic ductal adenocarcinoma PDX models. (ppbhg.org)

Anatomy19

Organisms7

Diseases3

Chemicals and Drugs169

Analytical, Diagnostic and Therapeutic Techniques and Equipment14

Phenomena and Processes40

Disciplines and Occupations1

Information Science3

Type-B receptor1

EphA and EphB5

EphB3

Subfamily6

RTKs7

EphB46

Known as ephrin1

Recombinant6

Belongs to the ephrin1

Epithelial1

Transmembrane ephrin-B ligands1

Residues6

Binds promiscuously1

Antigen1

Largest family of receptor2

Family18

Phosphatidylinositol 3-kina1

Downstream6

Soluble2

Gene5

Regulates2

Antibody1

Epidermal growth f1

Genes4

Ligands and receptors2

Drosophila4

Putative2

Epha12

Angiogenesis4

Vertebrates2

Morphogenesis2

Intracellular5

Induce1

Actin1

Bind3

Signal transduction2

Glycosylphosphatidylinositol2

EphA52

Activation10

Neural2

Cell adhesion1

Interactions3

Tumorigenesis2

EFNA51

Extracellular domain2

Catalytic2

Repulsion2

Nuclear proteins1

Peptides3

Mediate1

Fibronectin2

Cytoplasmic2

Cellular2

Roles in the development1

Antibodies1