• Particularly in yeast, an organism where gluconeogenesis and glycolytic activity are intermittently coordinated, the multi-subunit GID E3 ligase complex specifically targets the surplus of gluconeogenic enzymes, including the conserved Fructose-1,6-bisphosphatase 1 (Fbp1), for proteasomal degradation. (elifesciences.org)
  • To better understand the roles of genes involved in mannan degradation in filamentous fungi, in this study we searched, identified, and characterized one putative GH5 endo-β-mannanase (GH5-7) and two putative GH2 mannan-degrading enzymes (GH2-1 and GH2-4) in Neurospora crassa . (megazyme.com)
  • The mechanisms of L-glutamine hydrolysis, ammonia transfer and fructose-6P conversion into D-glucosamine-6P are analyzed with the E. coli enzyme in light of recent X-ray structures. (shengsci.com)
  • In enzymology, a fructose 5-dehydrogenase (EC 1.1.99.11) is an enzyme that catalyzes the chemical reaction D-fructose + acceptor ⇌ {\displaystyle \rightleftharpoons } 5-dehydro-D-fructose + reduced acceptor Thus, the two substrates of this enzyme are D-fructose and acceptor, whereas its two products are 5-dehydro-D-fructose and reduced acceptor. (wikipedia.org)
  • Other names in common use include fructose 5-dehydrogenase (acceptor), D-fructose dehydrogenase, and D-fructose:(acceptor) 5-oxidoreductase. (wikipedia.org)
  • 25] D-Fructose dehydrogenase from Gluconobacter industrius, membrane-bound. (wikipedia.org)
  • If genomics involves the study of genes and proteomics deals with proteins, glycomics examines the role of carbohydrates, which are organic molecules composed of carbon, hydrogen and oxygen. (fapesp.br)
  • Proteomics is the culmination of advances in chemistry, physics, bioinformatics, and molecular biology that allow the study of thousands of proteins simultaneously. (stanford.edu)
  • Enzymatic studies on the oxidation of sugar and sugar alcohol. (wikipedia.org)
  • In the present study, we considered the simulation of the main metabolic pathways such as glycolysis, TCA cycle, pentose phosphate (PP) pathway, and the anapleorotic pathways using enzymatic reaction models of E. coli . (biomedcentral.com)
  • Invented dynamic combinatorial chemistry, combining ideas from molecular evolution, enzymology, analytical chemistry, and organic chemistry to generate a strategy to discover small molecule therapeutic leads. (thewestheimerinstitute.org)
  • From Lobry de Bruyn to enzyme-catalyzed ammonia channelling: molecular studies of D-glucosamine-6P synthase. (shengsci.com)
  • Although maltose is an important building block of acarbose, the maltose/maltodextrin metabolism has not been studied in Actinoplanes sp. (frontiersin.org)
  • Mutations in GFPT1 (glutamine-fructose-6-phosphate transaminase 1), a gene encoding an enzyme involved in glycosylation of ubiquitous proteins, cause a limb-girdle congenital myasthenic syndrome (LG-CMS) with tubular aggregates (TAs) characterized predominantly by affection of the proximal skeletal muscles and presence of highly organized and remodeled sarcoplasmic tubules in patients' muscle biopsies. (nih.gov)
  • Histological studies confirmed an increase in insulin level is due to stimulation of injured pancreatic β-cells. (uni-mysore.ac.in)
  • 1) Al-Attas O.S., Comparative studies on the major feature of insulin receptors in mammalian and non-mammalian liver membranes. (biochemistry4all.com)
  • Established paleomolecular biology, where researchers resurrect ancestral proteins from extinct organisms for study in the laboratory, The strategy allows scientists to connect chemistry to function in biology, which is defined by an organism's fitness in a complex and changing environment. (thewestheimerinstitute.org)
  • Previous studies have reported the therapeutic properties of A. iwayomogi on obesity, hyperlipidemia, and liver fibrosis [ 7 , 8 ]. (hindawi.com)
  • The obtained results supplement our fundamental knowledge in biochemistry-enzymology, as well as the biodiversity of microorganisms expressing exoinulinase. (bvsalud.org)
  • Conclusion The results of the study suggested that N-Trisaccharide possesses propitious effect on STZ-NA induced type 2 diabetes, indicating its usefulness in diabetes management. (uni-mysore.ac.in)
  • The results from this study suggest that ACE has the pharmaceutical potential reducing the metabolic abnormalities in an animal model. (hindawi.com)
  • In this study we evaluated the effect of the water extract of a mixture of A. iwayomogi and C. longa (ACE) on high-fat diet-induced metabolic syndrome in a mouse model. (hindawi.com)
  • A previous cohort study reported a strong relationship between metabolic syndrome and an increased risk of mortality [ 2 ]. (hindawi.com)
  • However, to date, no study has evidenced the combined effect of A. iwayomogi and C. longa (ACE) on metabolic syndrome. (hindawi.com)
  • The studied exoinulinase exhibits activity at salinity of the medium and can potentially be used in the biotechnology of inulin bioconversion into bioproducts under alkaline conditions. (bvsalud.org)
  • 9. Derouiche S, Degachi O, Gharbi K. Phytochemistry analysis and modulatory activity of Portulacae oleracea and Aquilaria malaccensis extracts against High-fructose and high-fat diet induced immune cells alteration and heart lipid peroxidation in Rats. (ajrconline.org)
  • These authors recognized that defects in the enzymology of hepatic glycogen-storage disease may cause a heterogeneous group of disorders. (medscape.com)
  • The aim of the current study is to evaluated the effect of drinking Water in Djamaa region on kidney function in rats. (ajrconline.org)
  • Aim of the study The present investigation was designed to study the effect of N-Trisaccharide (a new compound isolated from the fruit of C. prophetarum (L.)) on hyperglycemia in streptozotocin (STZ)-nicotinamide (NA) induced type 2 diabetic rats. (uni-mysore.ac.in)
  • Electrolyte Analysis of drinking water of Djamaa (Algeria) region and study its effect on the kidneys in Wistar rats. (ajrconline.org)
  • Aims: In this parallel randomized controlled trial study, an energy-restricted healthy diet and two dietary challenges were used to assess the effect of weight loss on phenotypic flexibility. (westminster.ac.uk)
  • As shown in our previous study, KGM-modified SiO 2 nanoparticles (KSiNPs) effectively activate macrophages to differentiate into the M2-type phenotype by inducing mannose receptor (MR) clustering on the cell surface. (megazyme.com)
  • 16. Zobeidi A, Leila M. Physico-chemical quality of drinking water in the south of Algeria (Case of El-Oued region) study of excess minerals. (ajrconline.org)
  • Also, the repertoire of Cryptococcus neoformans may represent a better model fungal system within which to study the functions of the PPIases as its genome size and genetic tractability are equal to those of Saccharomyces cerevisiae , whilst its repertoires exhibits greater orthology to that of humans. (biomedcentral.com)
  • Glucokinase regulatory protein (GKRP), found in the hepatic nucleus, is a well-established inhibitor, enhanced by fructose-6-P and counteracted by glucose and fructose-1-P (hence the stimulation of hepatic glycolysis by low fructose, the substrate of fructokinase-1). (medscape.com)
  • In this study, the effect of 1,25(OH)2 D3treatment on oxidative stress parameters and AGEs levels together with hepatic histopathology was investigated in high fructose (HFr) or ethanol (EtOH)-treated rats. (trdizin.gov.tr)
  • These authors recognized that defects in the enzymology of hepatic glycogen-storage disease may cause a heterogeneous group of disorders. (medscape.com)
  • In enzymology, a fructose 5-dehydrogenase (EC 1.1.99.11) is an enzyme that catalyzes the chemical reaction D-fructose + acceptor ⇌ {\displaystyle \rightleftharpoons } 5-dehydro-D-fructose + reduced acceptor Thus, the two substrates of this enzyme are D-fructose and acceptor, whereas its two products are 5-dehydro-D-fructose and reduced acceptor. (wikipedia.org)
  • An enzyme that catalyzes the synthesis of fructose-6-phosphate plus GLUTAMINE from GLUTAMATE plus glucosamine-6-phosphate. (lookformedical.com)
  • in the USA before returning to the UK to learn about the enzymology of protein kinases in Dundee. (ed.ac.uk)
  • Gareth Jenkins (Glasgow) is the UK lead representative on this Chinese-led study into the role of the 'Tolerant to Chilling and Freezing 1' (TCF1) protein. (garnetcommunity.org.uk)
  • Paul Jarvis (Oxford) is an expert on the mechanisms that control protein import into the chloroplast and this study looks at the interaction of the TOC translocon apparatus with ubiquitin-proteasome system. (garnetcommunity.org.uk)
  • Protein chemistry - Insect biochemistry - Studies on lipids, lipoproteins and their correlation with antioxidants - Diabetes research. (biochemistry4all.com)
  • He obtained his PhD in Biochemistry from Northwestern University in 2008 where he studied protein structure-based drug design of novel chemotherapeutic agents. (chi-peptalk.com)
  • To identify a new inhibitor against CHIKV infection, this study constructed a subgenomic RNA replicon expressing the secretory Gaussia luciferase (Gluc) based on the CHIKV SL11131 strain. (bvsalud.org)
  • This set her on a path as an enzymologist and she subsequently won a Broodbank Fellowship to study the regulation of pyrophosphate-fructose-6-phosphate 1-phosphotransferase in the laboratory of Prof Tom ap Rees at the University of Cambridge. (ed.ac.uk)
  • Whilst in Dundee Kathryn was awarded first a Project Grant and then a CRUK Senior Cancer Research Fellowship to establish her own group studying the post-translational regulation of the growth regulator p21WAF1. (ed.ac.uk)
  • Kathryn moved her group to the University of Edinburgh in 2004 to take up a Readership and to set-up a cross-disciplinary programme of research that uses Biophysics and Chemistry as well as Biochemistry and cell systems to study IRF-1 regulation and the mechanism of ubiquitination by E3-ubiquitin ligases. (ed.ac.uk)
  • After receiving her degree Kathryn moved to the Biochemistry Department at the University of Leeds and decided to do a PhD that combined her interests by studying the mechanism by which the enzyme lipoprotein lipase was degraded. (ed.ac.uk)
  • Materials and methods: Rats were treated with fructose (30%) or ethanol (5-20%) in drinking water with and without 1,25(OH)2 D3 treatment (5 µg/kg two times a week) for 8 weeks. (trdizin.gov.tr)
  • 10 rats were fed a normal basal diet (Cr), 30 rats fed a high-fat diet (HFD) for 14 weeks during the entire study. (biomedcentral.com)
  • Enzymatic studies on the oxidation of sugar and sugar alcohol. (wikipedia.org)
  • studies on the oxidation of aromatic compounds by Pseudomonas fluorescens» Recent work has shown that polyhydroxy aromatic compounds are involved in. (nih.gov)
  • NMR Studies of the Mechanism of Enzyme Action (A. S. Mildvan & D. C. (ellibs.com)
  • The present study was conducted to evaluate the antiulcerogenic effect and recognize the basic mechanism of action of Tabernaemontana divaricata (L.) R. Br. (hindawi.com)
  • In continuation to our research on pharmacological assessment of the gastroprotective potential of T. divaricata flowers, the present study was conducted to understand its mechanism of action in chemically induced gastric ulcers. (hindawi.com)
  • The role of the Trichoderma harzianum endochitinase (Ech42) in mycoparasitism was studied by genetically manipulating the gene that encodes Ech42, ech42. (lookformedical.com)
  • Prospective study of predictors of vitamin D status and survival in patients with colorectal cancer. (drbriffa.com)
  • Dr. AlAzzam was also the CMC lead for developing several unique radio labelled products for PET imaging clinical studies. (chi-peptalk.com)
  • Wheat germ was utilized for improvement in quality and nutritive value of date syrup in the present study. (scialert.net)
  • Studies of some physicochemical and antioxidant properties of date syrup as affected by wheat germ addition were conducted on October, 2010 till December 2011 at Food Science and Human Nutrition Department, Agriculture and Veterinary Medicine College, Qassim University, Qassim, Saudi Arabia. (scialert.net)
  • The first of these studies was published this month in the British Journal of Cancer, and focused on the relationship between vitamin D levels and colon cancer [1]. (drbriffa.com)
  • Individuals with the highest levels of vitamin D were found to be at half the risk of dying from colon cancer during the study than individuals with the lowest levels. (drbriffa.com)
  • In the second study, researchers assessed the relationship between vitamin D levels and malignant melanoma [2]. (drbriffa.com)
  • The cohort study tests this hypothesis, providing evidence that higher 25-hydroxyvitamin D3 levels, at diagnosis, are associated with both thinner tumors and better survival from melanoma, independent of Breslow thickness. (drbriffa.com)
  • In the 19th century, when studying the fermentation of sugar to alcohol by yeast , Louis Pasteur came to the conclusion that this fermentation was catalyzed by a vital force contained within the yeast cells called " ferments ", which were thought to function only within living organisms. (wikidoc.org)
  • In 1897 Eduard Buchner began to study the ability of yeast extracts that lacked any living yeast cells to ferment sugar. (wikidoc.org)
  • This study is expanded to show that SP1 plays an important role in the response to abiotic stress with sp1 mutants being hypersensitive to salt, osmotic, and oxidative stresses whereas the opposite is true in SP1 OX plants. (garnetcommunity.org.uk)
  • Forget the fact, for example, that a recent study of 15 pharmacies and 5 hospital drug dispensaries in Sierra Leone discovered the widespread and unconscionable use of beta-lactam antibiotics. (nomorefakenews.com)
  • Results from the retrospective study were consistent with a role for vitamin D in melanoma outcome. (drbriffa.com)
  • The role of surface proteins in Vibrio cholerae attachment to chitin particles in vitro was studied. (lookformedical.com)
  • Our study is unique in using the native brain tissues obtained from HIV+ individuals at autopsy for a detailed proteomic analysis. (biomedcentral.com)
  • 2023 , ""Hit" to lead optimization and chemoinformatic studies for a new series of Autotaxin inhibitors. (fleming.gr)