• An enzyme that catalyses the phosphorylation of proteins using ATP and therefore causes changes in their functions. (emf-portal.org)
  • Specific activities of the phase I enzymes, ethoxyresorufin-O-deethylase (EROD), microsomal and cytosolic epoxide hydrolase (mEH and cEH), aldehyde dehydrogenase (ALDH) and DT-diaphorase, and the phase II enzymes, gamma-glutamyltransferase (gamma-GT), glutathione transferase (GST) and uridine diphosphoglucuronyl transferase (UDPGT) were measured. (nih.gov)
  • Ethanol-induced HepG2/CYP2E1 cells were treated with the compounds at various concentrations, and the results showed that there was a dose-dependent decrease of gamma-glutamyl transpeptidase (GGT) activity and increase of glutathione (GSH) in the culture media with an increase in cell viability. (hindawi.com)
  • Ethanol-induced oxidative stress leads to a decrease in intracellular antioxidative capacity of the liver cells including small molecular antioxidants and antioxidant enzymes such as superoxide dismutase (SOD) and glutathione (GSH). (hindawi.com)
  • He was among the first to use nanosized complexes of polycations and later, cationic block copolymers for the delivery of nucleic acids into a cell (known today as "polyplexes") and developed core-shell polyelectrolyte complexes for the therapeutic drug delivery of polypeptides such as antioxidant enzymes and scavengers of organophosphate poisons. (wikipedia.org)
  • Histochemical analyses showed the induction of ALDH, gamma-GT, DT-diaphorase and UDPGdH, and the depression of cytochrome P450IA1 in hepatic neoplasms. (nih.gov)
  • Nonutility of measurement of serum gamma-glutamyl transpeptidase activities in diagnosis of myocardial disease. (nih.gov)
  • Serum enzymes and isoenzymes in the diagnosis and differential diagnosis of myocardial ischemia and necrosis. (nih.gov)
  • The changes of immune function, pulmonary function, myocardial enzymology indexes, MCP-4, IL-1ß, IFN-γ, and TNF-α were noticed in the groups before and after treatment. (bvsalud.org)
  • CONCLUSIONS: The treatment of andrographolide sulfonate in children with MPP can enhance the therapeutic effect, ameliorate the immune function and lung function of children, and reduce inflammation and myocardial enzymes. (bvsalud.org)
  • His early work was in the field of enzyme catalysis in surfactant aggregates in organic media, where he developed methods using reverse micelles as nanoscale reactors for modification of proteins, controllable assembly of oligomeric enzymes and tailoring protein-polymer conjugates for bioengineering applications. (wikipedia.org)
  • Primary changes occur on the level of metabolic ways of the cells of the pancreas and liver: redistribution of mitochondrial and microsomal processes of oxidation with possible synthesis of new isoenzymatic forms of important metabolic enzymes, disturbance of synthesis of regulatory proteins and, as a result, degenerative changes in the cellular structure (lysis, necrosis and apoptosis). (ijpsr.com)
  • alkaline phosphatase (ALP), gamma glutamyl transferase (GGT), total bilirubin were estimated. (biomedcentral.com)
  • In addition, marker enzyme histochemistry of neoplasms revealed heterogeneous populations of hepatocytes and absence of necrotic areas. (nih.gov)
  • Cryostat sections of tumor and surrounding liver from the same cohorts were analyzed immunohistochemically for cytochrome P450IA1 and histochemically for ALDH (benzaldehyde and hexanal), DT-diaphorase, gamma-GT and uridine diphosphoglucuronyl dehydrogenase (UDPGdH). (nih.gov)
  • Increases in other enzymes ranged from 1.26 to 2.84 times that of control liver, except EROD, which decreased, and cEH and mEH, which were unchanged. (nih.gov)
  • In tumor tissues, the largest biochemical changes were found with benzaldehyde dehydrogenase, where activity increased from undetectable levels to 7.4 nmol/min/mg protein, and gamma-GT, where activity increased 12-fold over controls. (nih.gov)
  • Reference values for selected enzyme activities and protein concentrations in serum and plasma derived from cord-blood specimens. (nih.gov)
  • Cardiac biopsy or episodes of cardiac rejection did not usually alter serum enzyme activities. (nih.gov)
  • Serum gamma-glutamyltransferase activities were intermittently, and inexplicably, increased for months after the transplant. (nih.gov)