LyasesEnzymesGlycoside hydrolaseEnzymeMolecularGlycobiologyMethodsBiochemistryFattyLife sciencesSequenceKnowledgeResearchTypeMembersPRODUCTMetabolismMicrosomal epoxide hFumarylacetoacetate hydrolaseOxidoreductasesInhibitorsLysosomalPeptideSubstratesChemistryDegradationProteinsCleavageMolecular biologyHydrolysisBiosynthesisEnzymaticCellsEffectsFunctionAspects
Lyases1
- There are 6 main classes of enzymes: oxydoreductases (E.C.1), transferases (E.C.2), hydrolase (E.C.3), lyases (E.C.4), isomerases (E.C.5) and ligases (E.C.6). (proteogenix.science)
Enzymes3
- Examples of hydrolase enzymes are carbonic anhydrase , metallo phosphatases , and metalloproteinases . (cloudfront.net)
- His main interest for carbohydrate-active enzymes as biocatalysts for chemo-enzymatic synthesis of glycoconjugates led him to the creation of the research group named Enzymology and Glycobiochemistry. (glycodiag.com)
- The research focus is within the area "enzymes of extremophilic microorganisms", especially concerning thermostable glycoside hydrolases (including representatives from GH-family 1, 3, 10, 12 and 13). (lu.se)
Glycoside hydrolase2
- 2016) Construction of the first thermostable β-glucosynthase derived from glycoside hydrolase family 3. (lu.se)
- Here, the structural characterization of a novel endo-α(1,4)-fucoidanase, Mef1, from the marine bacterium Muricauda eckloniae is presented, showing sequence similarity to members of glycoside hydrolase family 107. (bvsalud.org)
Enzyme7
- In enzymology, a pantetheine hydrolase (EC 3.5.1.92) is an enzyme that catalyzes the chemical reaction (R)-pantetheine + H2O ⇌ {\displaystyle \rightleftharpoons } (R)-pantothenate + 2-aminoethanethiol Thus, the two substrates of this enzyme are (R)-pantetheine and H2O, whereas its two products are (R)-pantothenate and 2-aminoethanethiol. (wikipedia.org)
- This enzyme belongs to the family of hydrolases, those acting on carbon-nitrogen bonds other than peptide bonds, specifically in linear amides. (wikipedia.org)
- Pig lactase/phlorizin hydrolase was shown to have the same quaternary structure as the human enzyme, i.e., built up of two polypeptides of the same molecular weight (160000). (nih.gov)
- The candidate should have good knowledge of Biochemistry (enzymology, enzyme reactors) and Chemistry (organic synthesis). (bio.net)
- In the enzymology, the palmitoyl - co a hydrolase is said to the enzyme that hydrolase the fatty acid. (journalcra.com)
- This enzyme belongs to the family of hydrolases , specifically those glycosylases that hydrolyse N-glycosyl compounds. (alchetron.com)
- This enzyme is also called 1-methyladenosine hydrolase . (alchetron.com)
Molecular1
- Under the mentorship of Dr. Federico Sabbadin and Prof. Katherine Denby at the University of York, you'll gain hands-on experience with advanced molecular biology, plant pathology, and enzymology techniques. (findaphd.com)
Glycobiology1
- Enzymology and the glycosciences field (coupling glycochemistry and glycobiology) inspire many and varied academic and industrial innovations. (capacites.fr)
Methods2
- Methods in Enzymology. (wikipedia.org)
- Through advanced RNAseq and proteomics methods, we've pinpointed several previously unknown families of these CWDEs that become highly active during infections, potentially functioning as oxygenases, esterases, and hydrolases. (findaphd.com)
Biochemistry1
- The obtained results supplement our fundamental knowledge in biochemistry-enzymology, as well as the biodiversity of microorganisms expressing exoinulinase. (bvsalud.org)
Fatty1
- BACKGROUND: Combined fatty acid amide hydrolase (FAAH) and cyclooxygenase (COX) inhibition is a promising approach for pain-relief. (cnr.it)
Life sciences1
- right]] Dr. '''Toma Kashima''' (https://twitter.com/TKcaramel_sugar) is an Assistant Professor at the [http://enzyme13.bt.a.u-tokyo.ac.jp/index-e.html Laboratory of Enzymology], Department of Biotechnology, Graduate School of Agricultural and Life Sciences, the University of Tokyo, Japan. (cazypedia.org)
Sequence1
- Organophosphorus hydrolase, containing a genetically introduced hexahistidine sequence (His 6 -OPH), attracts the attention of researchers by its promiscuous activity in hydrolytic reactions with various substrates, such as organophosphorus pesticides and chemical warfare agents, mycotoxins, and N -acyl homoserine lactones. (mdpi.com)
Knowledge1
- Recent work has allowed a considerable increase in the knowledge of the enzymology of non-substituted and acetylated polysaccharides, thus illuminating the biodegradation mechanism. (springer.com)
Research2
- This Topical Collection entitled "Feature Papers in Enzymology" aims to collect high-quality research articles, review articles, and communications on all aspects of enzymology. (mdpi.com)
- We aim to represent our section as an attractive open-access publishing platform for the enzymology research field. (mdpi.com)
Type1
- Enzymology of type IV macromolecule secretion systems: the conjugative transfer regions of plasmids RP4 and R388 and the cag pathogenicity island of Helicobacter pylori encode structurally and functionally related nucleoside triphosphate hydrolases. (sjtu.edu.cn)
Members1
- It will be comprised of a selection of exclusive papers from the Editorial Board Members (EBMs) of the Enzymology Section, as well as invited papers from relevant experts. (mdpi.com)
PRODUCT1
- The reduced specificity for the product and the high initial transferase/hydrolase ratio of betaF24A resulted in high yields in acyl transfer reactions. (hanze.nl)
Metabolism2
- The metabolism of tryptophan was assessed by measurement of the production of 14CO2 after the administration of [methylene-14C]tryptophan to estimate the activity of kynureninase (L-kynurenine hydrolase, EC 3.7.1.3) and [benzene ring U-14C]tryptophan to estimate the activity of picolinate carboxylase (aminocarboxymuconate semialdehyde decarboxylase, EC 4.1.1.45). (ucl.ac.uk)
- Since the first introduction of drug metabolism as a scientific discipline six decades ago, the studies of DMEs have influenced many aspects of biology and medicine, including drug metabolism, enzymology, pharmacology, toxicology, cancer research, drug development, and risk assessment (A Personal and Historical Perspective on Drug Metabolism). (cdc.gov)
Microsomal epoxide h4
- It has been suggested that affected individuals may have a genetically-determined defect of microsomal epoxide hydrolase. (nih.gov)
- The technique of polymerase chain reaction single-strand conformation polymorphism analysis (PCR-SSCP) was used to screen for mutations in all nine exons of the microsomal epoxide hydrolase gene. (nih.gov)
- There was a higher frequency of mutations in the hypersensitive group when compared with the controls, but there was no consistent mutation (or pattern of mutations) in the microsomal epoxide hydrolase gene which was common to the hypersensitive group. (nih.gov)
- Polymorphisms of N-acetyltransferases, glutathione S-transferases, microsomal epoxide hydrolase and sulfotransferases: influence on cancer susceptibility. (cdc.gov)
Fumarylacetoacetate hydrolase3
- Expression and purification of fumarylacetoacetate hydrolase domain-containing proteins is described with examples (expression in E. coli , FPLC). (jove.com)
- Fumarylacetoacetate hydrolase (FAH) domain-containing proteins (FAHD) are identified members of the FAH superfamily in eukaryotes. (jove.com)
- Prokaryotic and eukaryotic fumarylacetoacetate hydrolase (FAH) superfamily members, sharing conserved regions that form the so-called FAH-domain, catalyze a remarkable variety of reactions. (nih.gov)
Oxidoreductases1
- Of the more than 40 hydrolases, oxidoreductases, transferases, and lyases identified in human and animal urine, only ten or so are being used as diagnostic indicators. (powells.com)
Inhibitors2
- Design of covalent inhibitors for ubiquitin proteasome system through computational enzymology. (uwm.edu)
- Arjun Saha, Amy Shih, Tara Mirzadegan and Mark Seierstad* " Predicting the Binding of Fatty Acid Amide Hydrolase Inhibitors by Free Energy Perturbation " Journal of Chemical Theory and Computation , 2018 , 14 , 5815. (uwm.edu)
Lysosomal3
- Their outer membrane then fuses with the LYSOSOME (forming the AUTOLYSOSOME) and the inner membrane and contents are digested by lysosomal HYDROLASES. (bvsalud.org)
- Effect of ghrelin on activities of some lysosomal hydrolases in rabbits. (nel.edu)
- In each disorder, a deficiency of a lysosomal hydrolase is inherited, which leads to lysosomal accumulation of the enzyme's specific sphingolipid substrate. (medscape.com)
Peptide2
- This enzyme belongs to the family of hydrolases, those acting on carbon-nitrogen bonds other than peptide bonds, specifically in linear amides. (wikipedia.org)
- 1986). Peptide hydrolases have also tidases from senescing wheat leaves. (123dok.net)
Substrates3
- In enzymology, a pantetheine hydrolase (EC 3.5.1.92) is an enzyme that catalyzes the chemical reaction (R)-pantetheine + H2O ⇌ {\displaystyle \rightleftharpoons } (R)-pantothenate + 2-aminoethanethiol Thus, the two substrates of this enzyme are (R)-pantetheine and H2O, whereas its two products are (R)-pantothenate and 2-aminoethanethiol. (wikipedia.org)
- α-galactosidase (α-GAL) and α-N-acetylgalactosaminidase (α-NAGAL) are two glycosyl hydrolases responsible for maintaining cellular homeostasis by regulating glycan substrates on proteins and lipids. (aber.ac.uk)
- Our results could be very useful to guide how much enzyme is needed for a biomass degradation process or determine what aspects of an enzyme to try to modify and what substrates are relevant to test activity on, where small model compounds do not properly mimic the more complex cell wall," said Johan Larsbrink, study researcher and associate professor of molecular enzymology at Chalmers University of Technology in Sweden. (lu.se)
Chemistry1
- In 2003, he was the recipient of the Repligen Corporation Award in Chemistry for Biological Processes from the Division of Biological Chemistry of the American Chemical Society His research interests are in mechanistic enzymology. (illinois.edu)
Degradation1
- Differential Roles of Three Different Upper Pathway meta Ring Cleavage Product Hydrolases in the Degradation of Dibenzo-p-Dioxin and Dibenzofuran by Sphingomonas wittichii Strain RW1. (nih.gov)
Proteins1
- Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd. (wikipedia.org)
Cleavage2
- Previous work by others (P. V. Bunz, R. Falchetto, and A. M. Cook, Biodegradation 4:171-178, 1993, https://doi/org/10.1007/BF00695119) identified two upper pathway meta cleavage product hydrolases (DxnB1 and DxnB2) active on the DBF upper pathway metabolite 2-hydroxy-6-oxo-6-(2-hydroxyphenyl)-hexa-2,4-dienoate. (nih.gov)
- For example, we are elucidating the mechanisms of the reactions catalyzed by dihydroxynaphthoyl CoA synthase and 2-ketocyclohexanecarboxyl CoA hydrolase that catalyze the formation and cleavage of carbon-carbon bonds, respectively. (illinois.edu)
Molecular biology1
- Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd. (wikipedia.org)
Hydrolysis1
- Cytosolic broad-specificity ß-glucosidase and lactase phlorizin hydrolase, as well as intestinal flora, participated in the hydrolysis of EG. (bvsalud.org)
Biosynthesis1
- His PhD was at the University of London (UCL and QMUL) researching the enzymology of a key step in tetrapyrrole biosynthesis. (portlandpress.com)
Enzymatic1
- In the discussion of this work, the identified enzymatic mechanisms of FAHD1 are outlined to describe its hydrolase and decarboxylase bi-functionality in more detail. (jove.com)
Cells1
- cytochemical detection of hydrolases in fungus cells. (liverpool.ac.uk)
Effects1
- 5. Rather, MY, Nordberg Karlsson E, Adlercreutz P. ( 2015 ) Complexation of alkyl glycosides with α-cyclodextrin can have drastically different effects on their conversion by glycoside hydrolases. (lu.se)
Function1
- Thus, the DxnB1 and DxnB2 hydrolases function in the DBF but not the DXN catabolic pathway, and the SWIT0190 hydrolase functions in the DXN but not the DBF catabolic pathway. (nih.gov)
Aspects1
- The purpose of this study was to investigate the interaction of TSG with EMD in the aspects of enzymology, pharmacokinetics, and hepatotoxicity. (bvsalud.org)