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CholesterolCholesterol, DietaryCholesterol, HDLCholesterol, LDLCholesterol EstersEnzymesCholesterol OxidaseCholesterol 7-alpha-HydroxylaseBiocatalysisCholesterol, VLDLLipidsKineticsLipoproteinsTriglyceridesHypercholesterolemiaCatalysisAnticholesteremic AgentsMethylmalonate-Semialdehyde Dehydrogenase (Acylating)Substrate SpecificityDithioerythritolSterol O-AcyltransferaseLipoproteins, HDLSterolsHydroxymethylglutaryl CoA ReductasesApolipoprotein A-IBile Acids and SaltsBiosynthetic PathwaysAcyltransferasesModels, MolecularBileSitosterolsbeta-CyclodextrinsATP Binding Cassette Transporter 1LiverMolecular Sequence DataModels, ChemicalLipoproteins, LDLLipid MetabolismHydroxycholesterolsOxidation-ReductionS-AdenosylmethioninePhospholipidsPhytosterolsCyclodextrinsAmino Acid SequenceEsterificationPhosphatidylcholine-Sterol O-AcyltransferaseHyperlipidemiasDietary FatsPyridoxal PhosphateMolecular StructureATP-Binding Cassette TransportersAcyl Coenzyme AApolipoproteinsPhosphatidylcholinesCholestyramine ResinDesmosterolCholesterol Ester Transfer ProteinsLovastatinMevalonic AcidReceptors, LDLFilipinCatalytic DomainApolipoproteins BBiological TransportHydroxymethylglutaryl-CoA Reductase InhibitorsArteriosclerosisApolipoproteins EIntestinal AbsorptionOxidoreductasesSterol EsteraseCholestanolMembrane MicrodomainsBinding SitesCholelithiasisAzetidinesModels, BiologicalLanosterolHydrolysisHydrogen-Ion ConcentrationAndrostenesSphingomyelinsDiet, AtherogenicOrphan Nuclear ReceptorsDehydrocholesterolsEmbolism, CholesterolHypolipidemic AgentsLipoproteins, VLDLIron-Sulfur ProteinsProtein ConformationProtein Structure, TertiaryMembrane LipidsScavenger Receptors, Class BCholesterol Side-Chain Cleavage EnzymeFatty AcidsFree RadicalsNiemann-Pick DiseasesFoam CellsSimvastatinCrystallography, X-Ray

Oxidative StressMethodsHepatic2019Oxidase from StreptomycesLipidsMolecularDefectsConverselyOleicFatsLower cholesterolDisruptionProteinFattyPreparationMembraneCellularConcentrationEventsStudyProductionPlasmaGroupMetabolismHigh density lipRatsImmunologySynthesisAlpha-hydroxylaseTriglyceridesCoronary arteryEnzymeComparativeBiosynthesisMiceCellsDerivativesBiochemistryCellular cholesterolToxicityGeneBloodIncludeLevelsReduceActivityReview

Oxidative Stress1

• ACE significantly reduced the body and peritoneal adipose tissue weights, serum lipid profiles (total cholesterol and triglycerides), glucose levels, hepatic lipid accumulation, and oxidative stress markers. (hindawi.com)

Methods4

• Methods in Enzymology, 3, 392- 394. (scirp.org)
• Enzymology congress 2019 mainly emphasizes on methods such as Biochemical processes, Bio molecular engineering, Immunoassays for protein detection, Mass spectroscopy & protein profiling, Membrane-lipid therapy and Polyunsaturated fatty acids (PUFA). (biochemistryconferences.com)
• In: Methods in Enzymology: Oxygen Radicals in Biological Systems, J. N. Abelson and M. I. Simon, eds. (brucenames.org)
• In: Methods in Enzymology: Oxygen Radicals in Biological Systems, Part B: Oxygen Radicals and Antioxidants, L. Packer and A. Glazer, eds. (brucenames.org)

Hepatic3

• Little is known about the effects of the vitamin D receptor (VDR) on hepatic activity of human cholesterol 7α-hydroxylase (CYP7A1) and cholesterol metabolism. (nih.gov)
• Activation of the VDR represses hepatic SHP to increase levels of mouse and human CYP7A1 and reduce cholesterol. (nih.gov)
• These authors recognized that defects in the enzymology of hepatic glycogen-storage disease may cause a heterogeneous group of disorders. (medscape.com)

20192

• Enzymology Conference 2019 has a strong emphasis on support and inspiration for the next generation of scientists, along with early-career researchers, a Young Researchers Forum, and activities to encourage interaction with peers and experts. (biochemistryconferences.com)
• Altogether Enzymology Conference 2019 aims to be an extraordinary cross discipline gathering in the enzymology life sciences for research presentations, discussions, learnings, inspirations and encouragement with participants leaving with new research knowledge and ideas, and perhaps the beginnings of international collaborations and associations. (biochemistryconferences.com)

Oxidase from Streptomyces1

• Cholesterol Oxidase from Streptomyces sp. (moleculardepot.com)

Lipids2

• Lipids also encompass molecules such as fatty acids and their derivatives (including tri- , di- , and monoglycerides and phospholipids ), as well as other sterol -containing metabolites such as cholesterol . (wikidoc.org)
• Lipids, predominantly phospholipids, cholesterol and small amounts of glycolipids found in membranes including cellular and intracellular membranes. (edu.au)

Molecular2

• In addition a range of special sessions aims to engage participants on broader issues such as teaching in the enzymology and molecular biology research. (biochemistryconferences.com)
• Molecular enzymology is that branch of biochemistry which encircles or deals with the functional as well as the structural characteristics of the enzymes within a molecular level. (biochemistryconferences.com)

Defects1

• These growth defects were rescued by addition of exogenous cholesterol. (microbialcell.com)

Conversely2

• Conversely, bacterial growth within cholesterol-leaden macrophages was enhanced. (microbialcell.com)
• Conversely, production of cholesterol and triglycerides increases. (biomedcentral.com)

Oleic1

• At the top is oleic acid and cholesterol . (wikidoc.org)

Fats1

• Fish are frequently cited as a good source of essential fatty acids, but the high amounts of other fats, cholesterol and toxins (like mercury) mean fish are a bad catch. (greendinnertable.co.nz)

Lower cholesterol1

• 1993. Stabilized Rice Bran and Oat Bran Lower Cholesterol in Human. (jurnalpangan.com)

Disruption1

• Here we investigated the link between cellular cholesterol and L. pneumophila intracellular replication and discovered that disruption of cholesterol biosynthesis or cholesterol trafficking lowered bacterial replication in infected cells. (microbialcell.com)

Protein1

• 1980. Lateral diffusion of M-13 coat protein in mixtures of phosphatidylcholine and cholesterol . (wisc.edu)

Fatty1

• Cholesterol does not count since it inserts itself into the hydrophobic fatty acid chains of the lipid. (encapsula.com)

Preparation1

• Stadtman, T.C. (1957) [63] Preparation and assay of cholesterol and ergosterol. (scirp.org)

Membrane2

• One membrane component that is often subverted by vacuolar bacteria is cholesterol - an abundant lipid that mammalian cells produce de novo at the endoplasmic reticulum (ER) or acquire exogenously from serum-derived lipoprotein carriers. (microbialcell.com)
• Collectively, we provide experimental evidence that cellular cholesterol promotes L. pneumophila replication within a membrane bound organelle in infected macrophages. (microbialcell.com)

Cellular2

• Importantly, the growth benefit of cholesterol was observed strictly in cellular infections and L. pneumophila growth kinetics in axenic cultures did not change in the presence of cholesterol. (microbialcell.com)
• Recent evidence suggests that sera from patients with glycogen-storage disease Ia are able to more efficiently promote scavenger receptor class B type I-mediated cellular cholesterol efflux and that an increased antioxidant effect of these sera is directly related to the increased urate concentration. (medscape.com)

Concentration1

• 1972) Estimation of the concentration of low density lipoprotein cholesterol in plasma, without use of preparative ultracen-trifuge. (scirp.org)

Events1

• expended with events by download cholesterol. (sliotarmusic.com)

Study1

• Enzymology deals with the study of enzymes, their kinetics, structure, and function, as well as their relation to each other. (biochemistryconferences.com)

Production1

• From within a unique ER-derived vacuole L. pneumophila promotes host lipogenesis and experimental evidence indicates that cholesterol production might be one facet of this response. (microbialcell.com)

Plasma1

• Plasma and tissue samples were collected and levels of Vdr, Shp, Cyp7a1, Cyp24a1, and rodent fibroblast growth factor (Fgf) 15 expression, as well as levels of cholesterol, were measured. (nih.gov)

Group1

• Group 2 (MC) received a normal rabbit diet with 1% methionine plus 0.5% cholesterol. (austin.org.au)

Metabolism2

• Introduction to Cholesterol Metabolism. (promotionalceramics.eu)
• We investigated the regulation of this enzyme in the hamster, a suitable animal model for studying cholesterol metabolism. (omeka.net)

High density lip2

• The lipid abnormalities, which include hypercholesterolemia (decreased high-density lipoprotein [HDL] cholesterol and increased low-density lipoprotein [LDL] cholesterol), together with the characteristic hypertriglyceridemia do not cause premature atherosclerotic lesions in affected individuals. (medscape.com)
• The present study was intended to evaluate the effects of Paeonia emodi rhizome extracts on serum triglycerides (TGs), total cholesterol (TC), low density lipoprotein cholesterol (LDL-c), high density lipoprotein cholesterol (HDL-c), atherogenic index (AI), superoxide dismutase (SOD), and glutathione peroxidase (GPx). (hindawi.com)

Rats2

• Protection against carbon tetrachloride-induced hepatotoxicity by pretreating rats with the hemisuccinate esters of tocopherol and cholesterol. (nih.gov)
• Two cholesterol 7 alpha-hydroxylase isozymes were purified from liver microsomes of cholestyramine-treated female rats by using anion exchange high performance liquid chromatography. (omeka.net)

Immunology1

• It integrates new advances in modern medical science like pathology, toxicology, biology, enzymology, and immunology with homeopathic principles of treatment. (eradicatortechnologies.com)

Synthesis2

• NADP, in contrast, enables anabolic reactions, such as the synthesis of cholesterol and fatty acids, and plays a critical role in maintaining cellular antioxidant function. (nih.gov)
• The gene encoding cholesterol 7 alpha-hydroxylase (CYP7A), the rate-limiting enzyme in bile acid synthesis, is transcriptionally regulated by bile acids and hormones. (omeka.net)

Alpha-hydroxylase10

• Regulation of cholesterol 7 alpha-hydroxylase in the liver. (omeka.net)
• Cloning, sequencing, and regulation of cholesterol 7 alpha-hydroxylase mRNA. (omeka.net)
• Monospecific antibody against purified rat liver cholesterol 7 alpha-hydroxylase cytochrome P-450 was used to screen a lambda gt11 cDNA library constructed from immuno-enriched polysomal RNA of cholestyramine-treated female rat liver. (omeka.net)
• Purification of cholesterol 7 alpha-hydroxylase and the immunochemical evidence for the induction of cholesterol 7 alpha-hydroxylase by cholestyramine and circadian rhythm. (omeka.net)
• Cholesterol 7 alpha-hydroxylase plays a crucial role in cholesterol homeostasis. (omeka.net)
• Transcriptional regulation of the human cholesterol 7 alpha-hydroxylase gene (CYP7A) in HepG2 cells. (omeka.net)
• A stable HepG2 cell line harboring a human cholesterol 7 alpha-hydroxylase (CYP7A) minigene/luciferase reporter gene construct was selected for studying transcriptional regulation of CYP7A gene promoter. (omeka.net)
• The opposing effects of retinoic acid and phorbol esters converge to a common response element in the promoter of the rat cholesterol 7 alpha-hydroxylase gene (CYP7A). (omeka.net)
• Genomic cloning, sequencing, and analysis of the hamster cholesterol 7 alpha-hydroxylase gene (CYP7). (omeka.net)
• Cholesterol 7 alpha-hydroxylase is the rate limiting enzyme in bile acid biosynthesis and plays an important role in cholesterol homeostasis. (omeka.net)

Triglycerides1

• The basis for the divergent opinions is the lack of evidence from definitive studies that test these diets in a single trial and that assess the impact of these diets on the major, diet-related CVD risk factors [blood pressure and the plasma lipids, LDL-cholesterol (LDL-C), HDL-cholesterol (HDL-C), and triglycerides]. (nih.gov)

Coronary artery1

• Specifically, although there is widespread agreement that saturated fat and cholesterol intake increases LDL cholesterol and contributes to coronary artery disease (ATP III, 2001), there is less agreement about the nutrient that is an optimal replacement for saturated fat. (nih.gov)

Enzyme3

• This, in turn, correlated with increased expression of the cholesterol catabolic enzyme cholesterol 24-hydroxylase. (nih.gov)
• She also discovered the enzyme used to measure blood cholesterol. (nih.gov)
• In enzymology, an ATP citrate synthase (EC 2.3.3.8) is an enzyme that catalyzes the chemical reaction. (siderac.com)

Comparative1

• 10. Inhibition of pancreatic lipase by black tea theaflavins: Comparative enzymology and in silico modeling studies. (nih.gov)

Biosynthesis2

• Cholesterol biosynthesis occurs in the endoplasmic reticulum (ER). (nih.gov)
• This antibody reacts with Human, Mouse, Rat … TATA Acetyl-CoA is a vital building block for the endogenous biosynthesis of fatty acids and cholesterol and is involved in isoprenoid-based protein modifications. (siderac.com)

Mice3

• Because reduced levels of cholesterol and increased expression of choleseterol-24-hydroxylase were also observed in the hippocampus of aged mice, changes in cellular cholesterol content may be used to modulate receptor activity strength in vivo, autonomously or as a way to complement the natural decay of neurotrophin production. (nih.gov)
• Mice were fed a hypercholesterolemic diet (1 g cholesterol/100 g over 7 days). (fdocument.org)
• The hypercholesterolemic mice whose diets were supplemented with microwave-dehydrated mango powder showed a significant decrease (P ≤ 0.05) in total serum cholesterol compared to the hypercholesterolemic mice and the mice fed with conventional dehydrated mango powder. (fdocument.org)

Cells1

• While most lipids found in foam cells are triglyceride and cholesterol, these cells accumulate several other lipids with bioactive properties, such as vitamin A and carotenoids. (illinois.edu)

Derivatives1

• As observed with the tocopherol derivatives, pretreatment with unesterified cholesterol or CA demonstrated no protective ability. (nih.gov)

Biochemistry1

• In 1956, Singer joined the Laboratory of Biochemistry NIAMS, and in 1975, she moved to NCI as chief of the Nucleic Acid Enzymology Section in the Laboratory of Biochemistry. (nih.gov)

Cellular cholesterol1

• Recent evidence suggests that sera from patients with glycogen-storage disease Ia are able to more efficiently promote scavenger receptor class B type I-mediated cellular cholesterol efflux and that an increased antioxidant effect of these sera is directly related to the increased urate concentration. (medscape.com)

Toxicity1

• To test this hypothesis, the hepatoprotective capacity of cholesteryl hemisuccinate (CS), unesterified cholesterol, and cholesteryl acetate (CA) was examined against CCl4 toxicity. (nih.gov)

Gene1

• Anticancer activity of the cholesterol exporter ABCA1 gene. (rochester.edu)

Blood1

• The CARB diet has been shown to reduce blood pressure and LDL-cholesterol substantially, and is currently recommended by policy makers. (nih.gov)

Include1

• Mechanisms involved and under study include novel conformation dependant sorting signals, sorting receptors and cholesterol-rich lipid microdomains (rafts). (nih.gov)

Levels1

• Direct cause-effect, cholesterol loss-high TrkB activity was demonstrated by pharmacological means and by manipulating the levels of cholesterol 24-hydroxylase. (nih.gov)

Reduce1

• 12. Theaflavins from black tea, especially theaflavin-3-gallate, reduce the incorporation of cholesterol into mixed micelles. (nih.gov)

Activity1

• Age-associated increase in TrkB activity correlated with a mild yet progressive loss of cholesterol. (nih.gov)

Review1

• Here, we review recent structures of three key cholesterol biosynthetic enzymes: Squalene epoxidase (SQLE), NAD(P)-dependent steroid dehydrogenase-like (NSDHL), and 3β-hydroxysteroid Δ 8 -Δ 7 isomerase termed EBP. (nih.gov)