The resultant product is no longer sensitive to aminoglycoside-modifying enzymes, a strategy that antibiotic-producing species employ to counter drug resistance in competing species. (hokudai.ac.jp)
Requires2
Bryan and Van den Elzen, 1976 ), is thought to be essential for the bactericidal activity of aminoglycosides, and requires respiration ( Bryan and Van den Elzen, 1976 ). (elifesciences.org)
N-Formimidoylation/-iminoacetylation modification in aminoglycosides requires FAD-dependent and ligand-protein NOS bridge dual chemistry. (hokudai.ac.jp)
Class2
Aminoglycosides are a potent class of translation inhibitor antibiotics with a broad activity spectrum. (elifesciences.org)
Antibiotics in the aminoglycoside class, such as gentamicin and tobramycin, may produce cochleotoxicity through a poorly understood mechanism. (wikipedia.org)
Drug2
It is widely accepted that membrane voltage potentiates aminoglycoside activity, which is ascribed to voltage-dependent drug uptake. (elifesciences.org)
In this paper, we measured the response of Escherichia coli treated with aminoglycosides and discovered that the bactericidal action arises not from the downstream effects of voltage-dependent drug uptake, but rather directly from dysregulated membrane potential. (elifesciences.org)
Effects1
In the absence of voltage, aminoglycosides are taken into cells and exert bacteriostatic effects by inhibiting translation. (elifesciences.org)
Essential1
By this approach to enzyme modification and characterization, we will contribute to bridge the gap between disciplines such as Bio-Organic Chemistry, Biochemistry and Bio-informatics that are all essential to the further development of modern enzymology. (umontreal.ca)