CDDs are slowly metabolized in mammalian tissues via oxidation and reductive dechlorination reactions catalyzed by cytochrome P450 enzymes, followed by conjugation to more polar molecules such as glutathione and glucuronic acid (ATSDR 1998). (cdc.gov)
Genes13
A new study shows that an enzyme involved in appropriately repressing sets of neuronal genes in non-neuronal cells is also a target for certain monoamine oxidase inhibitors used to treat depression. (sciencedaily.com)
In 2005, professor Ramin Shiekhattar, Ph.D., at The Wistar Institute and his colleagues reported details about an enzyme involved in appropriately repressing sets of neuronal genes in non-neuronal cells. (sciencedaily.com)
Because the primary role of the enzyme is to repress sets of related genes, many other areas of potential influence for the monoamine oxidase inhibitors are possible too, according to Shiekhattar. (sciencedaily.com)
In the body's scheme for safely storing genes away until needed, DNA is tightly looped around the histones, kept secure by enzymes similar to the ones studied by the Wistar team until made accessible by the activity of other enzymes responsible for gene expression. (sciencedaily.com)
His main research interests concern the identification of genes and enzymes involved in this pathway, the regulation of this metabolism, the mode of action of antibiotics and bacteriocins interfering with this pathway and the corresponding resistance mechanisms, as well as the molecular bases for the recognition of bacterial cell-wall peptidoglycan by host innate immunity mechanisms. (degruyter.com)
Both genes are involved in transcriptional repression and we speculate their involvement in FXN gene silencing. (frontiersin.org)
In general, the methylation of H3K9 leads to transcriptional repression of the affected target genes. (enzyme-database.org)
Ionic liquid pretreatment of straw led to a dynamic induction and repression of genes, which was correlated with the higher levels of pentose sugars saccharified from the ionic liquid-pretreated straw. (nottingham.ac.uk)
Hydrothermal pretreatment of straw led to reduced levels of transcripts of genes encoding carbohydrate-active enzymes as well as the derived proteins and enzyme activities. (nottingham.ac.uk)
Both pretreatments abolished the expression of a large set of genes encoding pectinolytic enzymes. (nottingham.ac.uk)
These characteristics are caused by selective pressure of mutations in chromosomal genes that lead to ampC hyperexpression, repression or inactivation of oprD , and overexpression of efflux pumps ( 2 ). (cdc.gov)
MBL genes are normally encoded in class 1 integrons along with other resistance determinants, such as the aminoglycoside-modifying enzymes. (cdc.gov)
A very natural place to study gene detecting and metabolizing lactose, it is known that the overall regulation is in the metabolism of the cell, and then specifically in effect of expressing the lac genes in vain is a drop in the growth rate the regulation of genes that code for enzymes and transporter of as much as 5% [1,6]. (lu.se)
Inhibit2
A defect in splicing can occur as a result of mutation(s) in the guanylyltransferase, which can inhibit enzyme activity, preventing the formation of the cap. (wikipedia.org)
One member of this family of drugs in particular, called tranylcypromine (brand name Parnate®, manufactured by GlaxoSmithKline), was seen to inhibit the enzyme most strongly. (sciencedaily.com)
Ligases4
The capping enzyme is part of the covalent nucleotidyl transferases superfamily, which also includes DNA ligases and RNA ligases. (wikipedia.org)
The NTase domain, conserved in capping enzymes, DNA and RNA ligases, is made up 5 motifs, I, III, IIIa, IV and V. Motif I or KxDG is the active site where the covalent (lysyl)-N-GMP intermediate is formed. (wikipedia.org)
Her main research interests have been the study of Mur ligases from different bacterial species and the search for inhibitors of these enzymes. (degruyter.com)
The synthesis of the peptide stem of bacterial peptidoglycan involves four enzymes, the Mur ligases (MurC, D, E and F). Among them, MurD is responsible for the ATP-dependent addition of d -glutamic acid to UDP-MurNAc- l -Ala, a reaction which involves acyl-phosphate and tetrahedral intermediates. (degruyter.com)
Biosynthesis2
For more than 30 years, his main research interests have been the functional and structural study of the enzymes of peptidoglycan biosynthesis, the determination of the structure of peptidoglycan from certain bacterial species, and the search for peptidoglycan biosynthesis inhibitors that could act as antibacterial agents. (degruyter.com)
Like most enzymes of peptidoglycan biosynthesis, MurD constitutes an attractive target for the design and synthesis of new antibacterial agents. (degruyter.com)
Compounds2
To understand the mechanism of action of these compounds, we probed the kinetic properties of the active and inactive inhibitors, and found that only compounds that target HDACs 1 and 3 exhibited a slow-on/slow-off mechanism of action for the HDAC enzymes. (frontiersin.org)
Crop plants take up sulphur (S) mainly in the form of sulphate and assimilate it into many compounds such as cysteine, methionine, glutathione (GSH), co-enzymes and vitamins. (biomedcentral.com)
Activation1
We also anticipated that our cyclic cMO strategy could be adapted to accommodate enzyme-mediated activation. (cdc.gov)
Proteins2
Proteases, also known as peptidyl-peptide hydrolases (EC 3.4.21-24 and 99), are degradative enzymes that catalyse the cleavage of peptide bonds in other proteins. (scialert.net)
Enzymes are usually proteins, however CATALYTIC RNA and CATALYTIC DNA molecules have also been identified. (bvsalud.org)
Gene expression3
A capping enzyme (CE) is an enzyme that catalyzes the attachment of the 5' cap to messenger RNA molecules that are in the process of being synthesized in the cell nucleus during the first stages of gene expression. (wikipedia.org)
Called a deacetylase, this enzyme removes acetyl groups from histones to repress gene expression. (sciencedaily.com)
Here, we describe thiamine analogs containing a central 1,2,3-triazole group to induce repression of thiM-riboswitch dependent gene expression in different E. coli strains. (strath.ac.uk)
Electron1
NfsB is a dimeric flavoprotein enzyme that has broad electron acceptor specificity 15 and has been used in conjunction with prodrugs to selectively ablate cells in vertebrates. (cdc.gov)
Clinical1
Inhibitors of that second enzyme are currently in clinical trails as cancer therapies. (sciencedaily.com)
Modifications1
The potential reversibility of epigenetic modifications renders the enzymes that are responsible for establishment of tumorigenic epigenetic changes important targets for drug development. (aacrjournals.org)
Chemistry1
Now, in a study published online today in the June 26 issue of Chemistry & Biology, Shiekhattar and his team show that the enzyme is itself a target for certain monoamine oxidase inhibitors used to treat depression. (sciencedaily.com)
Concentration1
The most promising molecule, triazolethiamine (TT), shows concentration dependent reporter gene repression that is dependent on the presence of thiamine kinase ThiK, whereas the effect of pyrithiamine (PT), a known TPP-riboswitch modulator, is ThiK independent. (strath.ac.uk)
Reactions1
These three enzymes, collectively called the capping enzymes, are only able to catalyze their respective reactions when attached to RNA polymerase II, an enzyme necessary for the transcription of DNA into pre-mRNA. (wikipedia.org)
Activity4
Moreover, inhibitors must have a long residence time on their target enzymes for this activity. (frontiersin.org)
Frataxin insufficiency leads to decreased activity of iron-sulfur cluster enzymes, mitochondrial iron accumulation, and resultant cell death, with the primary sites of pathology being the large sensory neurons of the dorsal root ganglia and the dentate nucleus of the cerebellum ( 9 ). (frontiersin.org)
The specific enzyme activity was increased by about 48.8 fold by optimizing different nutrient sources and cultivation conditions. (scialert.net)
The maximum specific enzyme activity was obtained in a medium containing 15 g L -1 lactose as the carbon source, 6 g L -1 soybean as the nitrogen source and a 5 mM mixture of Mg, Mn and Ca as trace elements, fermentation for 48 h at 37°C and agitation at 200 rpm. (scialert.net)
Specific1
In combination with transgenic organisms, such enzyme-actuated antisense tools will enable gene silencing in specific cell types, including tissues that are not amenable to optical targeting. (cdc.gov)
Cell2
Once amino acid biosynthetic enzymes start to accumulate, the cell is able to produce its own amino acids, and a new growth phase begins. (go.jp)
We envisioned that enzyme-activatable cMOs could overcome these limitations, as the triggering enzymes could be expressed in individual cell populations using cis regulatory elements. (cdc.gov)
Found2
Capping enzymes are found in the nucleus of eukaryotic cells. (wikipedia.org)
The second enzyme found in complex with BHC110/LSD1, acts in a similar way. (sciencedaily.com)
Entry1
This entry describes several enzymes that successively methylate the L -lysine 9 residue of histone H3 (H3K9), ultimately generating a trimethylated form. (enzyme-database.org)
Production1
This study indicated the significance of nutrient source and cultivation conditions on the alkaline enzyme production by Bacillus halodurans . (scialert.net)
Includes1
At the time, the scientists noted that the enzyme appeared to fit into the same extended enzyme family that includes monoamine oxidases, psychoactive enzymes that oxidize dopamine and norepinephrin. (sciencedaily.com)
Study1
11 The 4,5-dimethoxy-2-nitrobenzyl (DMNB)-containing linkers used in our previous study allowed optical MO uncaging, but cyclic cMOs could accommodate enzyme-cleavable linkers as well. (cdc.gov)
Main2
His main research interests are the structure-based design, synthesis and evaluation of small-molecule enzyme inhibitors and receptor ligands. (degruyter.com)
Alkaline proteases are the main enzymes among known proteases and constitute 60-65% of the global industrial enzyme market (Amoozegara et al . (scialert.net)
Structure1
The enzyme structure has three sub-domains referred to hinge, base and lid. (wikipedia.org)
Long1
Inhibitors of these enzymes have long been used to treat depression, certain other psychiatric and emotional disorders, and Parkinson's disease. (sciencedaily.com)