• Increased antioxidant enzyme activities (SOD, APX, and CAT) and upregulation of ROS pathway genes (CAT, APX, GR, and DHAR) were observed in PGPR inoculated okra plants under salinity stress. (hindawi.com)
  • ACC deaminase-containing PGPR can reduce the deleterious effects of environmental stress and can enhance stress tolerance of plants by a variety of mechanisms such as the synthesis of phytohormones, mineral solubilization, nutrient uptake, increased leaf area, increased chlorophyll and soluble protein content, and antioxidant enzyme activities [ 20 ]. (hindawi.com)
  • Contain isothiocyanates, which help activate the antioxidant enzyme glutathione, which has anticarcinogenic properties. (stack.com)
  • Contain copper, which helps produce antioxidant enzyme superoxide dismutase. (stack.com)
  • Superoxide dismutase (SOD) is an important antioxidant enzyme present in all oxygen-metabolizing cells. (scirp.org)
  • The SOD1 gene provides instructions for making an enzyme called superoxide dismutase, which is abundant in cells throughout the body. (medlineplus.gov)
  • About half of all Americans with ALS caused by SOD1 gene mutations have a particular mutation that replaces the amino acid alanine with the amino acid valine at position 5 in the enzyme, written as Ala5Val or A5V. (medlineplus.gov)
  • However, on April 25, 2023, the FDA granted accelerated approval to tofersen (Qalsody), an antisense oligonucleotide, indicated to treat patients with ALS associated with a mutation in the SOD1 (superoxide dismutase 1) gene. (uspharmacist.com)
  • The first familial ALS pathogenic gene, the SOD1 (superoxide dismutase 1) gene, was discovered in 1993. (uspharmacist.com)
  • The catalytic mechanism is analogous to highly efficient "ping-pong" mechanism of copper-zinc superoxide dismutase, where O− 2 alternately reduces and oxidizes the nickel cofactor. (wikipedia.org)
  • This enzyme attaches (binds) to molecules of copper and zinc to break down toxic, charged oxygen molecules called superoxide radicals. (medlineplus.gov)
  • Valentine JS, Doucette PA, Zittin Potter S. Copper-zinc superoxide dismutase and amyotrophic lateral sclerosis. (medlineplus.gov)
  • 1 This gene is involved in the production of the enzyme copper-zinc superoxide dismutase 1. (uspharmacist.com)
  • RÉSUMÉ Les informations concernant les bénéfices d'une supplémentation en zinc chez l'enfant asthmatique sont contradictoires. (who.int)
  • L'étude a examiné les effets d'une supplémentation en zinc chez des enfants asthmatiques suivis dans un service de consultations externes à Sari (République islamique d'Iran). (who.int)
  • Dans un essai clinique randomisé d'une durée de 8 semaines, en double aveugle et contrôlé contre placebo, 284 enfants sous corticostéroïdes inhalés ont été répartis entre un groupe recevant une supplémentation en zinc (50 mg/jour) (n = 144) et un groupe sous placebo (n = 140). (who.int)
  • Les cas comme les témoins présentaient des concentrations sériques en zinc initiales faibles [61,8 (E.T. 7,3) µg/dL et 60,9 (E.T. 4,3) µg/dL]. (who.int)
  • However, there seems to be no detailed information about the extent to which these factors can affect superoxide dismutase 1 gene expression in female athletes, especially in incremental exercises. (ac.ir)
  • Therefore, the aim of the present study was to investigate the correlation between superoxide dismutase 1 gene expression with lactate dehydrogenase (LDH) and free radicals in female athletes after an incremental intensity exercise. (ac.ir)
  • Most of these mutations change one of the protein building blocks (amino acids) in the superoxide dismutase enzyme. (medlineplus.gov)
  • Extract from a desert-growing succulent plant that provides multi-beneficial vitamins, minerals, enzymes, amino acids, and natural sugars. (lanikaibathandbody.com)
  • Just normal barley is a well known nutritional food which contains numerous enzymes, amino-acids, anti-oxidants, carbohydrate, vitamins and minerals. (organicnutrition.co.uk)
  • Can someone guide me on the references of spectrophotometer methods used to measure enzymes or proteins newly discovered in the blood serum? (researchgate.net)
  • What are the main references (book or research) for one or more, that specify methods for measuring newly discovered enzymes or proteins, in which simple manual methods are used. (researchgate.net)
  • Once the seed starts to germinate and sprout a root and stem it is extremely active at a molecular level and releases numerous proteins, minerals, vitamins, enzymes and many other nutrients which science is only just beginning to understand. (organicnutrition.co.uk)
  • Pathogenicity is related to production of lipopolysaccharides containing a poly N-formyl perosamine O chain, Cu-Zn superoxide dismutase, erythrulose phosphate dehydrogenase, stress-induced proteins related to intracellular survival, and adenine and guanine monophosphate inhibitors of phagocyte functions. (cdc.gov)
  • Superoxide is a reactive oxygen species that is produced in large amounts during photosynthesis and aerobic cellular respiration. (wikipedia.org)
  • The enzyme protects the cell against dangerous levels of highly reactive superoxide . (emf-portal.org)
  • Superoxide dismutase is a metalloenzyme that plays an important role in protecting cells from oxidative damage, by catalyzing the conversion of the superoxide radical to H 2 O 2 [ 15 , 16 ]. (hindawi.com)
  • Manganese superoxide dismutase (MnSOD), an enzyme that catalyzes superoxide radical quenching, is hypothesized to protect against premature aging. (cdc.gov)
  • Astringent that reduces lysosomal enzyme activity to encourage healthy circulation. (lanikaibathandbody.com)
  • 12q14 (Sanfilippo syndrome): The diagnosis requires a specific lysosomal enzyme assay for glucosamine ( N -acetyl)-6-sulfatase (GNS) activity. (medscape.com)
  • We evaluated the effects of two insecticides (fipronil, sulfluramid) and metallic insecticide complex (magnesium complex [Mg(hesp)2(phen)] (1)) on the superoxide dismutase (SOD), glutathione (GSH) and the overall antioxidant capacity using two different methodologies: total radical-trapping potential (TRAP) and oxygen radical absorbance capacity (ORAC). (springer.com)
  • The effect of 200 and 400 mg/kg body weight of 80% ethanolic extract of the fresh leaves of Lawsonia inermis were examined on drug metabolizing phase-I and phase-II enzymes, antioxidant enzymes, glutathione content, lactate dehydrogenase and lipid peroxidation in the liver of 7 weeks old Swiss albino mice. (nih.gov)
  • In some cases of familial ALS the enzyme superoxide dismutase has been found to be defective. (nih.gov)
  • The activity of the biotransformation enzyme gluthatione-S-transferase did not change during exposure. (scielo.br)
  • GLA promoted the expression of biotransformation enzymes (cypb5, gst) in the hepatopancreas. (bvsalud.org)
  • Superoxide is an extremely destructive free radical that can cause massive damage to cells and tissues when left unchecked. (nationalnutrition.ca)
  • Catalytically perfect enzymes have the maximum catalytic efficiency with high turnover numbers, k cat , and strong affinities for their substrates, K M . (jove.com)
  • Substrates must diffuse within the cell to interact with their enzymes. (jove.com)
  • Some enzymes have achieved catalytic perfection through electrostatic forces that attract and guide substrates into their active site. (jove.com)
  • Our primary findings reveal the 'duel-acting' nature of henna leaf as deduced from its potential to induce only the phase-II enzyme activity, associated mainly with carcinogen detoxification in liver of mice and inhibit the phase I enzyme activities. (nih.gov)
  • Modeling superoxide dismutase immobilizing a Cu-Zn complex in porous matrices and activity testing in H202 decomposition / by: Hernádi Klára, et al. (u-szeged.hu)
  • In this study, we characterized plant growth-promoting rhizobacteria (PGPR) containing 1-aminocyclopropane-1-carboxylate (ACC) deaminase and examined their effect on salinity stress tolerance in okra through the induction of ROS-scavenging enzyme activity. (hindawi.com)
  • Lead also interferes with the activity of other antioxidant enzymes including superoxide dismutase and catalase. (medscape.com)
  • Trichoderma reesei superoxide dismutase (TrSOD) is a well characterized enzyme being stable between 30 and 90°C for 1 h with activity at pH between 2.6 and 9.0. (pimac.org)
  • Activity of superoxide dismutase enzyme. (who.int)
  • The turnover of these molecules depends on their subsequent internalization by endocytosis, their delivery to the lysosomes, and their digestion by lysosomal enzymes. (medscape.com)
  • If histidine is not a ligand in the reduced enzyme, the nickel(II) cofactor would be square planar. (wikipedia.org)
  • H+ is most likely carried into the active site by the substrate, meaning that superoxide enters the enzyme in its protonated form (HO2). (wikipedia.org)
  • For catalytically perfect enzymes, this value ranges from 10 8 to 10 9 per molar substrate per second. (jove.com)
  • The reaction rates of catalytically perfect enzymes are limited only by the speed of substrate diffusion into or product release from the active site. (jove.com)
  • In catalytically perfect enzymes, every enzyme-substrate collision yields an intermediate that quickly transforms into products. (jove.com)
  • These enzymes are also called 'diffusion-controlled' as the only rate-limiting step in the catalysis is that of the substrate diffusion into the active site. (jove.com)
  • Most enzymes achieve catalytic perfection due to the charged groups present on their surface that orient and steer the substrate into the active site. (jove.com)
  • There has been increasing evidence that deranged superoxide dismutase (SOD) activities might be a risk factor for schizophrenia and/or tardive dyskinesia (TD). (nature.com)
  • The enzyme deficiencies lead to the accumulation of mucopolysaccharides in the lysosomes of the cells in the connective tissue and to an increase in their excretion in the urine. (medscape.com)
  • 16q24.3 (Morquio syndrome): The deficiency of enzymes in Morquio syndrome type A or type B leads to the accumulation of keratan sulfate and chondroitin-6-sulfate in the connective tissue, the skeletal system, and the teeth. (medscape.com)
  • S. Slathia, A. Sharma and S. Choudhary, "Influence of Exogenously Applied Epibrassinolide and Putrescine on Protein Content, Antioxidant Enzymes and Lipid Peroxidation in Lycopersicon esculentum under Salinity Stress," American Journal of Plant Sciences , Vol. 3 No. 6, 2012, pp. 714-720. (scirp.org)
  • Superoxide dismutase supplements have not been shown to confer any health benefits. (mskcc.org)
  • Mucopolysaccharidoses (MPSs) are a group of lysosomal storage diseases, each of which is produced by an inherited deficiency of an enzyme involved in the degradation of acid mucopolysaccharides, now called glycosaminoglycans (GAGs). (medscape.com)
  • Haemoglobin is a serious problem during purification and analysis of antioxidant enzymes from red blood cells. (researchgate.net)
  • Superoxide dismutase (SOD) is an enzyme found in all cells of the human body. (mskcc.org)
  • This work aimed to clone, express, purify and evaluate the protective effect antioxidant of this enzyme on skin cells when fused to transactivator of transcription (TAT) protein transduction domain of HIV-1 and Abalone (Ab) peptides to allow cell penetration. (pimac.org)
  • The 3T3 cells were exposed to the oxidant agent tert-butyl hydroperoxide (tBH) and evaluated for ROS generation, in the presence or not of the recombinant enzymes. (pimac.org)
  • In addition, a number of nutrient substances, vitamins, and minerals have been shown to contribute to a. functions, generally by serving as co-factors or co-enzymes. (theodora.com)
  • Because it contains numerous low glycemic carbohydrates, vitamins, minerals, protein and enzymes it will greatly increase your chances of successfully losing weight. (organicnutrition.co.uk)
  • GoodCarbs™ will benefit any diet because it contains vital nutrients and enzymes your body needs. (organicnutrition.co.uk)
  • This in conjunction with the thousands of enzymes built in means that the body can easily digest and absorb it. (organicnutrition.co.uk)