• Bifunctional
  • D0PAH7_BRUSS Bifunctional uridylyltransferase/uridylyl-removing enzyme OS=Brucella suis bv. (uniprot.org)
  • Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. (uniprot.org)
  • This bifunctional enzyme has two main domains, an orotate phosphoribosyltransferase (OPRTase, EC 2.4.2.10) subunit and an orotidine-5'-phosphate decarboxylase (ODCase, EC 4.1.1.23) subunit. (wikipedia.org)
  • Fusion events between OPRTase and ODCase, which have led to the formation of the bifunctional enzyme UMPS, have occurred distinctly in different branches of the tree of life. (wikipedia.org)
  • genome
  • Bacteriophages (viruses infecting bacteria) belonging to the families Tectiviridae and Corticoviridae have a lipid bilayer membrane inside the icosahedral protein capsid and the membrane surrounds the genome. (wikipedia.org)
  • The regulation of this gene is more complex than most other genes in the E. coli genome, as FIS is an important protein which regulates expression of other genes. (wikipedia.org)
  • Bacteriophages are composed of proteins that encapsulate a DNA or RNA genome, and may have relatively simple or elaborate structures. (wikipedia.org)
  • inhibitors
  • p>Describes annotations that are concluded from looking at variations or changes in a gene product such as mutations or abnormal levels and includes techniques such as knockouts, overexpression, anti-sense experiments and use of specific protein inhibitors. (uniprot.org)
  • binds
  • p>This subsection of the 'Function' section indicates at which position the protein binds a given metal ion. (uniprot.org)
  • The oxidized form of this factor specifically binds to the promoters of constituent genes of OxyR regulon, including katG (hydroperoxidase-catalase HPІ), gorA (glutathione reductase), grxA (glutaredoxin 1), trxC(thioredoxin 2), ahpCF (alkyl hydroperoxide reductase), dps (nonspecific DNA binding protein) and oxyS (a small regulatory RNA). (wikipedia.org)
  • The deamination rate of 5mC is approximately three times that of C. MBD4 protein binds preferentially to fully methylated CpG sites and to their deamination derivatives G:U and G:T base pairs. (wikipedia.org)
  • MBD4 protein binds strongly to the MMR protein MLH1. (wikipedia.org)
  • bacteria
  • This is the first demonstration that the cell separation event is post-translationally controlled through a direct interaction between cell separation enzymes and a specific novel inhibitor in bacteria. (biomedsearch.com)
  • The TraA gene is usually found on megaplasmids in bacteria, and it is somewhat conserved among different bacterial species. (wikipedia.org)
  • There are four enzymes that provide the bulk of protection against deleterious reactions involving active oxygen in bacteria: SODs (superoxide dismutases encoded by sodA and sodB), catalases (katE and katG), glutathione synthetase (gshAB) and glutathione reductase (gor). (wikipedia.org)
  • In bacteria, it was shown that ClpP is capable to cleave full-length proteins without being associated with ClpA but the degradation is at a much slower rate. (wikipedia.org)
  • novel
  • A novel cell surface protein, IseA, inhibits the cell wall lytic activities of these d,l-endopeptidases in vitro, and IseA negatively regulates the cell separation enzymes at the post-translational level. (biomedsearch.com)
  • coli
  • In E.coli, negative autoregulation of SoxS protein serves as a dampening mechanism for the soxRS redox stress response. (wikipedia.org)
  • fis is the E. coli gene encoding FIS protein. (wikipedia.org)
  • The Fis nucleoid protein is differentiated by its fast increase in synthesis rates following nutrient upshifts and its abundance in rapidly growing E. coli cells. (wikipedia.org)
  • regulon
  • This protein is a positive regulator for the phosphate regulon. (uniprot.org)
  • Oxidized SoxR then induces the expression of SoxS protein, which in turn activates the transcription of structural genes of the SoxRS regulon. (wikipedia.org)
  • Regulation of the soxRS regulon occurs by a two-stage process: the SoxR protein is first converted to an oxidized form that enhances soxS transcription, and the increased level of SoxS protein in turn activates the expression of the regulon. (wikipedia.org)
  • The structural genes under this regulon include sodA (Mn-superoxide dismutase(SOD)), zwf (glucose-6-phosphate dehydrogenase(G6PDH)), acnA (aconitase A), nfsA (nitrate reductase A), fumC (fumarase C) and nfo (endonuclease IV) among others. (wikipedia.org)
  • SoxRS regulon genes can be regulated by additional factors. (wikipedia.org)
  • XthA (exonuclease III, a DNA repair enzyme) and KatE (catalase) are known to play important roles in the defense against oxidative stress but interestingly KatF regulon genes are not induced by oxidative stress. (wikipedia.org)
  • antimicrobial
  • Some studies suggest that antimicrobial hand soaps containing triclosan provide a slightly greater bacterial reduction on the hands compared to plain soap. (wikipedia.org)
  • genetic
  • This enzyme plays a central role in cellular defense against genetic mutation caused by the spontaneous deamination of 5-methylcytosine and cytosine. (wikipedia.org)
  • homologous
  • However, a homologous IIC protein from Listeria monocytogenes has been shown to be required for D-arabitol fermentation. (wikipedia.org)
  • RAD51 family members are homologous to the bacterial RecA, Archaeal RadA and yeast Rad51. (wikipedia.org)
  • In humans, RAD51 is a 339-amino acid protein that plays a major role in homologous recombination of DNA during double strand break repair. (wikipedia.org)
  • cancers
  • Many cancers have epigenetic deficiencies in various DNA repair genes (see Frequencies of epimutations in DNA repair genes in cancers), likely causing increased unrepaired DNA damages. (wikipedia.org)
  • While other DNA repair genes, such as MGMT and MLH1, are often evaluated for epigenetic repression in many types of cancer, epigenetic deficiency of MBD4 is usually not evaluated, but might be of importance in such cancers as well. (wikipedia.org)
  • In colorectal cancers with mutations in MMR genes, co-occurrence of MBD4 mutations were found in 27% of cancers. (wikipedia.org)
  • mitochondrial
  • The protein is transported into mitochondrial matrix and is associated with the inner mitochondrial membrane. (wikipedia.org)
  • ClpP protease is a major contributor for mitochondrial protein quality control system and removing damaged or misfolded proteins in mitochondrial matrix. (wikipedia.org)
  • mutations
  • Further, MBD4 gene mutations are detected in tumors with primary microsatellite instability (MSI), a form of genomic instability associated with defective DNA mismatch repair, and MBD4 gene meets 4 of 5 criteria of a bona fide MIS target gene. (wikipedia.org)
  • Mutations in the MBD4 gene (especially expansions/deletions in the polyadenine regions of the MBD4 gene) increase the genomic instability phenotype of a subset of MMR-defective tumors in mice, specifically contributing to elevated G:C to A:T transitions. (wikipedia.org)
  • For example, nearly 50% of somatic mutations of the tumor suppressor gene p53 in colorectal cancer are G:C to A:T transitions within CpG sites. (wikipedia.org)
  • transcriptional
  • This small, basic, DNA-bending protein has recently been shown to function in many other reactions including phage lambda site-specific recombination, transcriptional activation of rRNA and tRNA operons, repression of its own synthesis, and oriC-directed DNA replication. (wikipedia.org)
  • catalyzes
  • section describes the catalytic activity of an enzyme, i.e. the chemical reaction it catalyzes. (uniprot.org)
  • Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). (uniprot.org)
  • amino
  • Human MBD4 protein has 580 amino acids with a methyl-CpG-binding domain at amino acids 82-147 and a C-terminal DNA glycosylase domain at amino acids 426-580. (wikipedia.org)
  • The N-terminal 97 amino acid segment of LACTB does not form part of the conserved penicillin-binding protein domain and may therefore be responsible for organelle targeting. (wikipedia.org)
  • phenotype
  • Gene inactivation in the zebrafish also causes a cardiac arrhythmia phenotype and defective skeletal muscle development. (wikipedia.org)
  • cell
  • Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. (uniprot.org)
  • Immunofluorescence microscopy indicated that the IseA-3xFLAG fusion protein was specifically localized at cell separation sites and poles on the vegetative cell surface in a similar manner of the d,l-endopeptidases. (biomedsearch.com)
  • The bacterial cell cycle is divided into three stages. (wikipedia.org)
  • expression
  • Protein expression occurs after monocytes differentiate into dendritic cells. (wikipedia.org)
  • A fully mature, active enzyme is produced following lipopolysaccharide expression in mature dendritic cells. (wikipedia.org)
  • It has been found LACTB could cause obesity through gene co-expression analysis based on data integrated from multiple sources. (wikipedia.org)
  • describes
  • p>An evidence describes the source of an annotation, e.g. an experiment that has been published in the scientific literature, an orthologous protein, a record from another database, etc. (uniprot.org)