• synthase
  • A novel low molecular weight enzyme was cloned and named lysophospholipase II, which also contained the GXSXG motif and belonged to the esterase family as Lysophospholipase I. In collaboration with Michel, we showed that lysophospholipase I mediates the depalmitoylation of NO synthase, suggesting a role of the enzyme in the regulation of NO synthesis. (nii.ac.jp)
  • protein
  • Protein kinase C enzymes can be divided into three classes: conventional, novel, and atypical. (asahq.org)
  • Phosphorylation usually results in a functional change of the target protein by changing enzyme activity, cellular location, or association with other proteins. (embl.de)
  • The enzyme is stimulated by calcium and phosphatidylserine and phosphorylated by protein kinase C. This domain is always associated with IPR001206 . (embl.de)
  • The molecular identification of genes encoding enzymes that catalyze steps in TAG biosynthesis from glycerol 3-phosphate has revealed an unexpected number of protein isoforms of the glycerol phosphate acyltransferase (GPAT), acylglycerolphosphate acyltransferase (AGPAT), and lipin (phosphatidate phosphatase) families that appear to catalyze similar biochemical reactions. (physiology.org)
  • This review will focus on the roles of three protein families in triglyceride biosynthesis: the GPAT, AGPAT, and lipin (PAP) enzymes. (physiology.org)
  • Protein kinase C, commonly abbreviated to PKC (EC 2.7.11.13), is a family of protein kinase enzymes that are involved in controlling the function of other proteins through the phosphorylation of hydroxyl groups of serine and threonine amino acid residues on these proteins, or a member of this family. (wikipedia.org)
  • however, subsequent studies have suggested that the protein may cross-react with a monoclonal antibody that recognizes the phosphatidylserine receptor and does not directly function in the clearance of apoptotic cells. (wikipedia.org)
  • These enzymes can activate a transmembrane protein if it is a receptor (e.g. (wikipedia.org)
  • Tumor necrosis factor alpha converting enzyme (TACE) is a sheddase protein that has been observed in many types of cancer and could serve as an important Biomarker (medicine) used in the detection of cancer. (wikipedia.org)
  • dementia
  • Good supplements for brain health: vitamins E and C, taken together, ginko biloba, alpha lipoic acid, wine (1-2 glasses, 2-3 times a week), co-enzyme Q10, phosphatidylserine and, if family history of dementia or hysterectomy with ovary removal, take estrogen. (mailtribune.com)
  • In May, 2003 the Food and Drug Administration gave "qualified health claim" status to phosphatidylserine thus allowing labels to state "consumption of phosphatidylserine may reduce the risk of dementia and cognitive dysfunction in the elderly" along with the disclaimer "very limited and preliminary scientific research suggests that phosphatidylserine may reduce the risk of cognitive dysfunction in the elderly. (wikipedia.org)
  • thrombin
  • TF serves as a cellular receptor and cofactor for plasma FVIIa, the enzyme initiating the coagulation protease cascade, leading ultimately to the generation of thrombin and fibrin. (biochemsoctrans.org)
  • When circulating platelets encounter the site of an injury, collagen and thrombin -mediated activation causes externalization of phosphatidylserine (PS) from the inner membrane layer, where it serves as a pro-coagulant surface. (wikipedia.org)
  • Inositol
  • Inositol phosphates and phosphoinositides activate insulin-degrading enzyme, while phosphoinositides also mediate binding to endosomes. (nih.gov)
  • cellular
  • However, recent studies expose additional controls and consequences for PKD1 activation loop and C-terminal phosphorylation as well as additional autophosphorylation reactions and trans- phosphorylations (by PKC and other cellular enzymes) that contribute to the spatiotemporal control of PKD1 signaling in cells. (aspetjournals.org)
  • The deadly Ebola virus incorporates a cellular enzyme into its virus particles, facilitating the infection to the target cells, according to new research published in the journal PLOS Pathogens . (news-medical.net)
  • As phosphatidylserine is located entirely on the inner monolayer surface of the plasma membrane (and of other cellular membranes) and it is the most abundant anionic phospholipids. (hmdb.ca)
  • molecules
  • LA JOLLA, CA--January 12, 2015--A team led by scientists at The Scripps Research Institute (TSRI) has identified an enzyme that produces a class of inflammatory lipid molecules in the brain. (eurekalert.org)
  • Abnormally high levels of these molecules appear to cause a rare inherited neurodegenerative disorder, and that disorder now may be treatable if researchers can develop suitable drug candidates that inhibit this enzyme. (eurekalert.org)
  • Studies of those "PHARC mice" revealed that the ABHD12 enzyme normally breaks down immune-signaling lipid molecules called lysophosphatidylserines (lyso-PSs) in the brain. (eurekalert.org)
  • Having identified an enzyme that normally breaks down lyso-PS molecules, Cravatt and his laboratory set out, in the new study, to find an enzyme that makes lyso-PSs. (eurekalert.org)
  • To find a lyso-PS-making enzyme, Cravatt lab Research Associate Siddhesh S. Kamat led the effort to develop a sophisticated test for detecting the enzyme-mediated conversion of precursor phosphatidylserine (PS) molecules to lyso-PSs. (eurekalert.org)
  • residues
  • The pseudosubstrate region, which is present in all three classes of PKC, is a small sequence of amino acids that mimic a substrate and bind the substrate-binding cavity in the catalytic domain,lack critical serine, threonine phosphoacceptor residues, keeping the enzyme inactive. (wikipedia.org)
  • Gene
  • In 2010, PHARC was linked to gene mutations that inactivate the enzyme ABHD12. (eurekalert.org)
  • Bifunctional arginine demethylase and lysyl-hydroxylase JMJD6 is an enzyme that in humans is encoded by the JMJD6 gene. (wikipedia.org)
  • biological
  • This interaction may be of considerable relevance to the biological function of phosphatidylserine, especially during bone formation for example. (hmdb.ca)
  • The reason is that bovine brain cortex- and soy-based phosphatidylserine are different substances and might, therefore, have different biological activities. (wikipedia.org)
  • synthesize
  • When PSA-3 cells' ability to synthesize phospatidylserine was repressed, sheddase activity decreased, and the sheddase activity returned to normal levels when the cells were again able to synthesize phosphatidylserine. (wikipedia.org)
  • peptides
  • Insulin-degrading enzyme (IDE) hydrolyzes bioactive peptides, including insulin, amylin, and the amyloid β peptides. (nih.gov)
  • distinct
  • Using this test we discovered a cryptic yet distinct lyso-PS-making enzyme activity in the mouse brain," said Kamat. (eurekalert.org)
  • mechanisms
  • Due to the nature of the mechanisms and functions of sheddase enzymes, they have been studied on the basis of discovering possible uses in medicine. (wikipedia.org)
  • activity
  • A DAGKα mutant with its entire regulatory region deleted showed a much decreased activity that was not activated by Ca 2+ , but still exhibited PS (phosphatidylserine)-dependent activation. (biochemj.org)
  • In principle, such an enzyme could be targeted with compounds that inhibit its activity, to dial down lyso-PS levels in the nervous system and thus treat PHARC. (eurekalert.org)
  • THL is a known inhibitor of multiple enzymes, and the team was able to link the lyso-PS-making activity in mouse brain specifically to one of these enzymes: a previously uncharacterized enzyme called ABHD16A. (eurekalert.org)
  • While the expression of TACE does not directly correlate with particular stages of cancer, the shedding activity of the enzyme is significantly more prominent in head and neck cancer cells compared to normal cultured cells. (wikipedia.org)
  • phosphate
  • This enzyme belongs to the family of transferases, specifically those transferring non-standard substituted phosphate groups. (wikipedia.org)
  • cells
  • The enzyme expressed in COS cells was strongly dependent on PIPィイD22ィエD2, a … More nd was stimulated about two-fold by the addition of Arf. (nii.ac.jp)
  • Phosphatidylserine (PS) on the other hand is a major component of cell membranes, which aids in maintaining and repairing cells and improving their abilities to communicate with each other. (tasmanhealth.co.nz)
  • family
  • This enzyme belongs to the family of lyases, specifically the carboxy-lyases, which cleave carbon-carbon bonds. (wikipedia.org)
  • inner
  • InsPs and PtdInsPs interact with the polyanion-binding site located on an inner chamber wall of the enzyme. (nih.gov)
  • human
  • This finding is a good example of what can be gained from studying enzymes linked to rare human genetic disorders," said Benjamin F. Cravatt, chair of TSRI's Department of Chemical Physiology and member of TSRI's Skaggs Institute for Chemical Biology. (eurekalert.org)
  • Numbering based upon the human PKD1 enzyme. (aspetjournals.org)