Enzyme lipoprotein high hyperlipidemias. Medical search. Frequent questions

Instead, it is transported in the bloodstream by lipoproteins that are water-soluble and carry cholesterol and triglycerides internally. (wikipedia.org)
Lipolysis is a process of breaking down of triglycerides to glycerol and fatty acids, the process is done by hydrolysis by inducing some hormones like epinephrine, nor-epinephrine, cortisol, testosterone, etc. to release the compounds like High density lipoproteins (HDL), Low density lipoproteins (LDL) and Very low density lipoproteins (VLDL) [ 12 - 18 ]. (omicsonline.org)
By inhibiting the production of LDL and VLDL the risk factors for the hyperlipidemia can be controlled, Bile acid sequestrants like Cholestyramine, Colestipol and Colesevelam are used to regulate high serum levels by binding the bile acid which is secreting from liver to metabolize the triglycerides [ 20 - 24 ]. (omicsonline.org)
2018). The blood lipids measurements in NHANES include total cholesterol, high-density lipoprotein cholesterol (HDL-C), low-density lipoproteins cholesterol (LDL-C), and triglycerides. (cdc.gov)
Hyperlipidemia comprises a heterogeneous group of disorders, characterized by high levels in one or more lipids and/or lipoproteins [atherogenic free fatty acids (FA), triglycerides (TG) (hypertriglyceridemia), small dense low-density lipoprotein cholesterol (LDL-C) (hypercholesterolemia), and apolipoprotein (apo) B], and/or low level in antiatherogenic high density lipoprotein cholesterol (HDL-C), in the circulation [ 1 - 3 ]. (hindawi.com)
Interestingly, the group with the highest percentage of saturated fatty acid and trans-fat exhibited the highest PCSK9 levels, along with the highest increase in plasma cholesterol, triglycerides, and platelet activation parameters. (bvsalud.org)
The disease is suspected on clinical presentation of hepatomegaly, elevated transaminases, total cholesterol, low-density lipoprotein, and triglycerides, and low high-density lipoprotein. (orpha.net)
a very large lipoprotein that contains 90% triglycerides and 5% cholesterol. (ashp.org)
Diabetic dyslipidemia is characterized by increasing concentrations of low-density triglycerides and lipoproteins and a decrease in high-density lipoproteins HDL-cholesterol (HDL-c). (jabonline.in)
These patients generally present a pattern characterized by high concentrations of triglycerides and low-density lipoproteins (LDL) LDL-cholesterol (LDL-c) and a reduction in high-density lipoproteins (HDL) HDL-cholesterol (HDL-c) called atherogenic dyslipidemia [ 2 , 5 ]. (jabonline.in)
Due to this insulin resistance, there is a greater release of free fatty acids from adipocytes, which in the liver induce an increase in the synthesis of triglycerides and stimulate the production of apolipoprotein B. An increase in the production of triglyceride-rich very low-density lipoprotein (VLDL) particles is also observed, which increases the concentration of triglycerides in the blood [ 5 , 6 ]. (jabonline.in)
Reduce elevated total cholesterol (total-C), low-density lipoprotein cholesterol (LDL-C), apolipoprotein B (Apo B), and triglycerides (TG), and to increase high-density lipoprotein cholesterol (HDL-C) in patients with primary hyperlipidemia (Fredrickson type IIa, heterozygous familial and nonfamilial) or mixed dyslipidemia (Fredrickson type IIb). (druglib.com)
The Bezafibrate functions primarily by stimulating the action of two enzymes that break down triglycerides. (scopeheal.com)
Stimulating these enzymes increases the breakdown of triglycerides in the blood. (scopeheal.com)
2009. Beyond low-density lipoprotein cholesterol: respective contributions of non-high-density lipoprotein cholesterol levels, triglycerides, and the total cholesterol/high-density lipoprotein cholesterol ratio to coronary heart disease risk in apparently healthy men and women. (agrifoodscience.com)
Using data from the second phase (1991-1994) of the Third National Health and Nutrition Examination Survey (NHANES III), we examined associations between 22 polymorphisms in 13 candidate genes and four serum lipids: high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), total cholesterol (TC), and triglycerides (TG). (cdc.gov)

Phase 3, 12-week, randomized, double-blind, placebo- and ezetimibe-controlled trial (N=1,896) in patients with primary hyperlipidemia (including 526 who had ASCVD) on maximum dose statin therapy. (repatha.ca)
In adults with primary hyperlipidemia. (nih.gov)
It may be a useful medication for treating primary hyperlipidemia. (agrifoodscience.com)

After a meal, some of the fatty acids taken up by the liver is converted into very low density lipoproteins (VLDL) and again secreted into the blood. (wikipedia.org)
The liver converts unburned food metabolites into very low density lipoproteins (VLDL) and secretes them into plasma where they are converted to intermediate-density lipoproteins(IDL), which thereafter are converted to low-density lipoprotein (LDL) particles and non-esterified fatty acids, which can affect other body cells. (wikipedia.org)
3 Statins lower LDL (low-density lipoproteins) and VLDL (very-low-level lipoproteins), and they increase HDL (high-density lipoproteins). (rdhmag.com)
Reduce elevated TG and VLDL-C in patients with primary dysbetalipoproteinemia (Fredrickson type III hyperlipidemia). (druglib.com)
Al lomicrons, low-density lipoproteins (LDL), Muhtaseb's study of Arab women indi- very-low-density lipoproteins (VLDL) and cated an incidence of 50% of lipid disorders high-density lipoproteins (HDL). (who.int)

Hyperlipidemia is the presence of elevated or abnormal levels of lipids and/or lipoproteins in the blood, and is a major risk factor for cardiovascular disease. (wikipedia.org)
In pregnancy as mentioned earlier the lipid concentration in blood increases, if the concentration of the lipids in the blood is not controlled it results in the increase in the concentration of the lipid in the perinatals and may be leads obesity and/or hyperlipidemia [ 25 - 31 ]. (omicsonline.org)
USPI recommendation for lipids: at 12 weeks and thereafter according to hyperlipidemia guidelines. (rinvoqhcp.com)
In this study, we examined the effects of two commonly consumed forms of Pu-erh tea, fermented and unfermented, on weight gain, serum levels of lipids and lipoprotein, lipid oxidation, and blood antioxidant enzymes in a rat hyperlipidemia model. (purepuer.com)
however, more than 50% of American adults have hyperlipidemia or elevated (inappropriately high) levels of lipids in their bloodstreams. (ashp.org)

Repatha ® is indicated as an adjunct to diet and standard of care therapy (including moderate- to high-intensity statin therapy alone or in combination with other lipid-lowering therapy), to reduce the risk of myocardial infarction, stroke, and coronary revascularization in adult patients with atherosclerotic cardiovascular disease (ASCVD) by further lowering low-density lipoprotein cholesterol (LDL-C) levels. (repatha.ca)
The combination of low-dose, high-potency statin with ezetimibe can be equivalent to high-dose statin monotherapy and, with better tolerability, promote therapy adherence. (bvsalud.org)
In patients with CAD, efforts should be made to lower the low-density lipoprotein (LDL) level (eg, with a statin). (medscape.com)
Conventional treatment for high cholesterol usually involves costly statin drugs, which reduce LDL (low-density lipoprotein) cholesterol. (healthy.co.nz)
Furthermore, statin drugs inhibit Co-Q10 production, which can lead to congestive heart failure, high blood pressure and low energy. (healthy.co.nz)
For patients that require a high-intensity statin or are unable to achieve their LDL-C goal receiving simvastatin 40 mg daily, prescribe alternative LDL-C lowering treatment. (nih.gov)

The drugs which are used lower the low density lipoproteins (LDL) in the blood by preventing the conversion of them from high density lipoproteins by interrupting the various steps during lipolysis [ 6 - 11 ]. (omicsonline.org)

Higher total cholesterol (TC) levels and low-density lipoprotein cholesterol (LDL-C) help immensely foster an atherosclerotic plaque in the coronary artery. (hindawi.com)
Fortunately, natural supplements such as red yeast rice have been shown to not only lower total cholesterol, but also raise HDL cholesterol levels and lower lipoprotein(a) a damaging blood fat similar to LDL cholesterol. (healthy.co.nz)
The serum levels of total cholesterol (TC), triglyceride (TG), high-density lipoprotein cholesterol (HDL-C), and low-density lipoprotein cholesterol (LDL-C) in patients were detected by biochemistry. (amegroups.org)
Previous reports from the Framingham Heart Study suggested a strong positive relationship between coronary heart disease and elevated levels of total cholesterol (TC) and low-density lipoprotein cholesterol (LDL-C) levels, in addition to an inverse relationship between the disease and high-density lipoprotein cholesterol (HDL-C) levels [ 5 - 8 ]. (cdc.gov)

A new inhibitor of cholesterol absorption, ezetimibe, in a dose of 10 mg/d, can reduce low-density lipoprotein (LDL) cholesterol levels and has small triglyceride-lowering effects. (medscape.com)
This study included 189 patients with elevated cholesterol levels of 116 mg/dL or higher while on a stable dose of simvastatin (Zocor) or atorvastatin (Lipitor). (second-opinions.co.uk)

3 Erythromycin, clarithromycin, and grapefruit juice inhibit the liver enzyme that metabolizes statins. (rdhmag.com)
Carriers of p.E40K, a variant that abolishes ANGPTL4 ability to inhibit lipoprotein lipase, have lower odds of T2D (odds ratio 0.89, 95% confidence interval 0.85-0.92, p = 6.3 × 10 −10 ), lower fasting glucose, and greater insulin sensitivity. (nature.com)
The finished product, red yeast rice, contains important substances known as monacolins, which have the ability to inhibit HMG-CoA reductase - an enzyme responsible for cholesterol synthesis in the liver. (healthy.co.nz)
Reishi Mushroom Triterpenoids such as ganoderic acid A and ganoderic acid B can inhibit angiotensin-converting enzyme and increase the capillary loop density, diameter and red blood cell flow rate, reduce blood viscosity, and improve the microcirculation. (ganoherb.com)

Results of this Long-Term Extension (LTE) of the SELECT-COMPARE study show that RINVOQ plus MTX maintained higher levels of clinical response, including remission compared to adalimumab plus MTX, through week 72. (pharmiweb.com)
However, little is known about this specific mechanism, particularly how nutrition affects platelet activation and PCSK9 levels in hyperlipidemia conditions. (bvsalud.org)
The results showed that high-fat diet-induced hypercholesterolemia and hypertriglyceridemia significantly increased the plasma levels of ß-thromboglobulin (ß-TG), p-selectin, and platelet factor 4 (PF-4). (bvsalud.org)
Serum low density lipoprotein-cholesterol (LDL-C) and triglyceride levels were significantly lowered by tea extract compared to the control group. (purepuer.com)
Conversely, levels of high density lipoprotein-cholesterol (HDL-C) were elevated in the groups given daily doses of tea extract (p (purepuer.com)
a lipid used in the production of hormones, bile salts, and cell membranes that contributes to atherosclerotic plaque formation when levels are high. (ashp.org)
elevated levels of one or more lipoproteins in the blood. (ashp.org)
Patients with diabetes mellitus are at high risk of cardiovascular events because of abnormal lipid levels status. (heraldopenaccess.us)
About half of the studied T2DM patients have high serum cholesterol level (52.5%), while 22.5% had low serum HDL- C levels and 39.2% had high serum triglyceride level, most of patients had serum LDL-C levels above normal range (67.5%), so the common patterns of dyslipidemia in this study were LDL-C followed by cholesterol. (heraldopenaccess.us)
Angiopoietin-like 4 (ANGPTL4) is an endogenous inhibitor of lipoprotein lipase that modulates lipid levels, coronary atherosclerosis risk, and nutrient partitioning. (nature.com)
The lipoprotein lipase (LPL) pathway has emerged as an attractive therapeutic target for reducing lipid levels and cardiovascular risk. (nature.com)
Human investigations suggest that fenugreek can be beneficial as an adjunct in controlling high blood glucose and lipid levels in people with diabetes. (lww.com)
Patients with established CAD and low HDL levels are at high risk for recurrent events and should be targeted for aggressive nonpharmacologic and pharmacologic treatment. (medscape.com)
Individuals with high plasma levels of lipo-protein(a) have a 10 times greater risk for heart disease than individuals with elevated LDL levels. (healthy.co.nz)
Frequent monitoring in people taking statins can help detect high blood sugar levels. (medicalnewstoday.com)
The overall effect is to reduce "bad fats" and the high "good fats" levels in the blood. (scopeheal.com)
They suggested that, if a patient came to his doctor with high cholesterol, the first thing that should be checked was his thyroid levels. (second-opinions.co.uk)
BALANCE - Balances acid and alkaline levels in your digestive system, while enhancing immunity - remember ulcer is as a result of high acidity in the intestine. (skyhealthcaregh.com)
post-menopausal women with a higher serum FSH (≥78.3 IU/L) had higher serum TC and LDL-C levels than those with relatively lower FSH levels (40-78.3 IU/L), and ovariectomized mice had higher serum FSH and lipid levels and reduced hepatic LDL receptor expression. (nature.com)
The genetic basis for elevation in lipid levels is not well understood, but substantial heritability has been demonstrated in twin [ 9 ] and family-based [ 10 - 12 ] studies, which have estimated that approximately 43% to 83% of the variance in blood lipid and lipoprotein levels is attributable to genetic factors. (cdc.gov)

HMG-CoA Reductase inhibitors like statins (atorvastatin, lovastatin, simvastatin) acts on the cells which absorbs the lipoproteins by inhibiting the enzyme (HMG CoA reductase) which regulates the cholesterol. (omicsonline.org)
Hyperlipidemia can be reduced by lipid-lowering drugs (eg, 3-hydroxy-3-methylglutaryl coenzyme A [HMG-CoA] reductase inhibitors, fibric acid derivatives). (medscape.com)
Lipitor competitively blocks HMG-CoA reductase, an enzyme that converts substrates into cholesterol precursors. (insulin-store.com)

The disease is due to mutations in the gene LIPA (10q23.2-q23.3) encoding the enzyme lysosomal acid lipase (LAL). (orpha.net)
These are called lipoprotein lipase (found in muscle and adipose tissue) and hepatic lipase (found in the liver). (scopeheal.com)

Hyperlipidemia, characterized by the abnormal blood lipid profiles, is one of the dominant factors of many chronic diseases such as diabetes, obesity, and cardiovascular diseases (CVD). (hindawi.com)
Apart from CVD, hyperlipidemia is also closely associated with diabetes, insulin resistance, and obesity [ 10 ]. (hindawi.com)

Reduce elevated TG in patients with hypertriglyceridemia (Fredrickson type lV hyperlipidemia). (druglib.com)

High prevalence of dyslipidemia among type 2 diabetes mellitus in Mukalla city were observed and so the common patterns of dyslipidemia is LDL-C followed by cholesterol. (heraldopenaccess.us)
Diabetes mellitus is a common secondary cause of hyperlipidemia, particularly if glycemic control is poor, which in-turn is an important risk factor for atherosclerosis and coronary heart disease [12,13]. (heraldopenaccess.us)
By studying diabetic dyslipid- in diabetes mellitus because insulin resist- aemia among a group of our patients we ance or deficiency affects key enzymes hoped to draw attention of the medical com- and pathways in lipid metabolism [ 1 ]. (who.int)

The prevalence of hyperlipidemia has dramatically increased worldwide due to a sedentary lifestyle and consumption of high fat diets [ 1 , 2 ]. (biomedcentral.com)
In those subjects with a higher prevalence of known risk factors for MACE and malignancy (e.g., older age, smoking), a higher occurrence of events was seen across all treatment groups. (pfizer.com.sg)
Six countries in the Middle East are rated among the top 10 countries in the world with the highest prevalence of diabetes [5]. (heraldopenaccess.us)
In addition, the prevalence of hypercholesterolemia is significantly higher in peri-menopausal women than that in pre-menopausal women. (nature.com)

Differential diagnosis includes familial hypercholesterolemia, non-alcoholic fatty liver disease, cryptogenic cirrhosis, and combined hyperlipidemia, as well as other lysosomal storage disorders. (orpha.net)
Moreover, blocking FSH signaling by anti-FSHβ antibody or ablating the FSH receptor ( FSHR ) gene could effectively prevent hypercholesterolemia induced by FSH injection or high-cholesterol diet feeding. (nature.com)

Plasma FABP3 concentrations were measured by an enzyme-linked immunosorbent assay. (medsci.org)
As a consequence, these cells have high concentrations of intracellular glucose during hyperglycaemia. (madridge.org)
Results from our study contribute to a growing body of literature identifying key determinants of plasma lipoprotein concentrations and could provide insight into the biological mechanisms underlying serum lipid and cholesterol concentrations. (cdc.gov)

The chylomicrons are ultimately taken up by liver hepatocytes via interaction between apolipoprotein E and the LDL receptor or lipoprotein receptor-related proteins. (wikipedia.org)
The largest lipoproteins, which primarily transport fats from the intestinal mucosa to the liver, are called chylomicrons. (wikipedia.org)
ZOCOR has not been studied in conditions where the major abnormality is elevation of chylomicrons (i.e., hyperlipidemia Fredrickson types I and V). (druglib.com)

3 Because statins are metabolized by a specific enzyme system in the liver, they have many drug interactions. (rdhmag.com)
Statins work by blocking an enzyme that tells the liver to produce more cholesterol. (medicalnewstoday.com)
By blocking this enzyme, statins reduce the amount of cholesterol in the body. (medicalnewstoday.com)
Statins help lower low-density lipoprotein (LDL), or "bad," cholesterol. (medicalnewstoday.com)

Angiotensin-converting enzyme (ACE) inhibitors and angiotensin II receptor blockers (ARBs) can reduce hypertension and may also contribute to reducing proteinuria. (medscape.com)
We previously reported that mice with increased macrophage-specific angiotensin-converting enzyme, termed ACE10/10 mice, resist atherosclerosis in an adeno-associated virus-proprotein convertase subtilisin/kexin type 9 (AAV-PCSK9)-induced model. (bvsalud.org)
In patients with renal lesions, microalbuminuria can be reduced with angiotensin-converting enzyme (ACE) inhibitor therapy. (medscape.com)

Thus, prevention and treatment of hyperlipidemia are effective approaches to reduce the incident rate of chronic diseases. (hindawi.com)
Reishi Mushroom can reduce serum cholesterol, triacylglycerol, β-lipoprotein and low-density lipoprotein (LDL) to varying degrees and increase high-density lipoprotein (HDL). (ganoherb.com)
To reduce the risk of total mortality by reducing risk of coronary heart disease death, non-fatal myocardial infarction and stroke, and the need for coronary and non-coronary revascularization procedures in adults with established coronary heart disease, cerebrovascular disease, peripheral vascular disease, and/or diabetes, who are at high risk of coronary heart disease events. (nih.gov)

Temporarily discontinue simvastatin in patients experiencing an acute or serious condition at high risk of developing renal failure secondary to rhabdomyolysis. (nih.gov)

In patients with coronary heart disease (CHD) or at high risk of CHD, ZOCOR can be started simultaneously with diet. (druglib.com)

Hyperlipidemia is a group of metabolic disorders characterized by hypercholesterol and/or hypertriglyceride in blood circulation. (biomedcentral.com)
Genest J, Mora S, Libby P. Lipoprotein disorders and cardiovascular disease. (medlineplus.gov)
Lysosomal storage diseases are generally classified by the accumulated substrate and include the sphingolipidoses, oligosaccharidoses, mucolipidoses, mucopolysaccharidoses (MPSs), lipoprotein storage disorders, lysosomal transport defects, neuronal ceroid lipofuscinoses and others. (medscape.com)
Efforts are underway to develop enzyme replacement options for several other disorders. (medscape.com)

Methods: Female Wistar rats were divided into six groups: the sham, model, and Xian-Ling-Gu-Bao capsule (XLGB) groups, and the low-, medium-, and high-dose PTE groups. (researchgate.net)
Here, male Wistar rats were divided into four groups, subjected to different high-fat diets for ten weeks with varying nutrient components. (bvsalud.org)
Effect of dry garlic powder on plasma lipid profile and enzyme activities in some tissues of hypercholesterolemic rats. (agrifoodscience.com)

This study aimed to evaluate the effect of Prosopis ruscifolia on lipid profile in albino Swiss mice with hyperglycemia and hyperlipidemia. (jabonline.in)
Effect of garlic and lemon juice mixture on lipid profile and some cardiovascular risk factors in people 30-60 years old with moderate hyperlipidaemia: a randomized clinical trial. (agrifoodscience.com)

In a large, randomized, postmarketing safety study comparing another Janus kinase (JAK) inhibitor with tumor necrosis factor (TNF) blockers in rheumatoid arthritis (RA) patients ≥50 years old with at least one cardiovascular (CV) risk factor, a higher rate of all-cause mortality, including sudden CV death, was observed with the JAK inhibitor. (rinvoqhcp.com)

The apolipoproteins forming the surface of the given lipoprotein particle determine from what cells cholesterol will be removed and to where it will be supplied. (wikipedia.org)

While a population-wide strategy involving lifestyle changes and a high-risk strategy involving pharmacological interventions have been described, the recently proposed personalized medicine approach combining both strategies for the prevention of hypertension has increasingly gained attention. (cdc.gov)

Studies examining the role of carbohydrates in the metabolism with roughly 30 year old males in good physical condition have revealed, for instance, that even transitioning from a high glycemic index diet to a low glycemic index diet while maintaining the same ratio of carbohydrate, fat and protein can take more than four weeks. (totalhealthmagazine.com)

Intake of diets with high content of cholesterol and saturated fats (i.e. (hindawi.com)

Classically, lysosomal storage diseases encompassed only enzyme deficiencies of the lysosomal hydrolases. (medscape.com)
More recently, the concept of lysosomal storage disease has been expanded to include deficiencies or defects in proteins necessary for the normal post-translational modification of lysosomal enzymes (which themselves are often glycoproteins), activator proteins, or proteins important for proper intracellular trafficking between the lysosome and other intracellular compartments. (medscape.com)
This has led to active clinical trials evaluating the safety and efficacy of intrathecal enzyme delivery in several lysosomal storage diseases (see www.ClinicalTrials.gov ). (medscape.com)

In adults aged 30-70 with primary and moderate hyperlipidemia, the present study took place to investigate the therapeutic benefits of a polyherbal unani preparation called Garlitab. (agrifoodscience.com)

In vitro data supported the underlying mechanism and indicated that C3R might modulate postprandial glycemia by inhibiting carbohydrate digestive enzymes and decreasing glucose transport in the small intestine. (biomedcentral.com)

High-dose simvastatin for aneurysmal subarachnoid hemorrhage: multicenter randomized controlled double-blinded clinical trial. (druglib.com)
Myopathy and Rhabdomyolysis: Risk factors include age 65 years or greater, uncontrolled hypothyroidism, renal impairment, concomitant use with certain other drugs, and higher simvastatin dosage. (nih.gov)

Patients with CKD are at a high risk of cardiovascular disease and mortality and are associated with increased treatment costs [ 2 ]. (medsci.org)
A systematic review was conducted involving 4 randomized clinical trials on the lipid-lowering effects of red yeast rice in patients with hyperlipidemia. (healthy.co.nz)
Patients with a confirmed acute coronary syndrome should be admitted to a cardiac care unit or high dependency unit with continuous ECG rhythm monitoring. (bmj.com)
Patients who have had ischaemic ECG changes, or cardiac troponin release or raised CK-MB enzyme demonstrated at any time during admission, have a confirmed acute coronary syndrome. (bmj.com)
these patients are also in a category at high risk of further cardiac events. (bmj.com)
Those patients with unstable angina or non-Q wave myocardial infarction whose condition has stabilised, but who are at high risk of death or further cardiac events , should be referred for coronary angiography. (bmj.com)
Chinese patients may be at higher risk for myopathy. (nih.gov)
Patients are at greater risk for developing myopathy if they are 65 years of age or older, have uncontrolled hypothyroidism, have renal impairment, are on other drugs with myopathy risk, or are on high doses of Lipitor. (insulin-store.com)
Enzyme replacement therapy (ERT) appears safe and effective for peripheral manifestations in patients with Gaucher disease types I and III, Fabry disease, mucopolysaccharidosis I (Hurler, Hurler-Scheie, and Scheie syndromes), mucopolysaccharidosis II (Hunter syndrome), mucopolysaccharidosis VI (Maroteaux-Lamy syndrome), Pompe disease, and recently Batten disease (neuronal ceroid lipofuscinoses, CLN2). (medscape.com)
Enzyme replacement therapy (ERT) appears safe and effective for peripheral manifestations in patients with Gaucher disease types I and III, Fabry disease, mucopolysaccharidosis I (Hurler, Hurler-Scheie, and Scheie syndromes), mucopolysaccharidosis II (Hunter syndrome), mucopolysaccharidosis VI (Maroteaux-Lamy syndrome), and Pompe disease. (medscape.com)

This study aimed to assess how a high-fat diet influences platelet activation, its association with PCSK9, and the effects on blood pressure in an animal model. (bvsalud.org)

Currently, the inhibition of dietary fat digestion and absorption from the small intestine is an attractive target for the management of hyperlipidemia [ 4 , 5 ]. (biomedcentral.com)

The fate of cholesterol in the blood is highly determined by its constitution of lipoproteins, where some types favour transport towards body tissues and others towards the liver for excretion into the intestines. (wikipedia.org)

ABSTRACT To assess the risk of venous thromboembolism (VTE) associated with hyperhomocystein- aemia (hyper-Hcy) and hyperlipidaemia, we performed a case-control study. (who.int)

High-dose PTE significantly ameliorated OVX-induced estradiol (E2) deficiency. (researchgate.net)
Mean Hcy level was significantly higher in the test group. (who.int)

In fact, hyperlipidemia is one of the risk factors of CVD [ 11 ], which becomes one of the major killers around the world. (hindawi.com)
It has been reported that hyperlipidemia, a well-documented risk factors for cardiovascular diseases, tends increase platelet activation and PCSK9 expression. (bvsalud.org)
Pu-erh tea aqueous extracts lower atherosclerotic risk factors in a rat hyperlipidemia model. (purepuer.com)
Risk factors references Alcohol consumption is high in most Western countries. (merckmanuals.com)

People with decreased renal function (the dose of bezafibrate in Bezalip mono tablets is too high for people with kidney problems). (scopeheal.com)

A high Lp(a) concentration is associated with PAD progression as an independent risk factor for all atherosclerosis manifestations. (bvsalud.org)

Results: PTE reduced OVX-induced body weight gain after 6 weeks of treatment, and the high-dose exerted a significant effect. (researchgate.net)
Given the "super-size-me" diet of many Americans, coupled with sedentary lifestyles, it makes sense why four of the top 10 drugs sold in the United States are used in the treatment of gastroesophageal reflux disease (GERD), high cholesterol, hyperlipidemia, high blood pressure, and diabetes. (rdhmag.com)
Rosuvastatin -Rosuvastatin (Crestor) is used for the treatment of high cholesterol and hyperlipidemia. (rdhmag.com)
There is a growing interest in TCM treatment of hyperlipidemia. (hindawi.com)
In the last few decades, hundreds of Chinese herbal medicines in the form of compounds, extracts, single herbs, or formulae have been reported to be effective for the prevention and treatment of hyperlipidemia [ 16 ], especially those high-fat diet (HFD) induced cases. (hindawi.com)
List the classes of medications used in the treatment of hyperlipidemia and their basic mechanisms of action. (ashp.org)
Conventional treatment for high cholesterol usually involves prescription medication however this can sometimes cause abdominal discomfort, bowel irregularity and poor digestion. (healthy.co.nz)

People at high risk of diabetes may need to try other approaches to lower their cholesterol. (medicalnewstoday.com)
As noted by the researchers, their results flatly contradict decades of nutritional advice: High carbohydrate intake was associated with higher risk of total mortality, whereas total fat and individual types of fat were related to lower total mortality. (totalhealthmagazine.com)

Diseases4

Chemicals and Drugs22

Analytical, Diagnostic and Therapeutic Techniques and Equipment1

Phenomena and Processes1

Anthropology, Education, Sociology and Social Phenomena1

Information Science1

Named Groups1

Triglycerides16

Primary hyperlipidemia3

VLDL5

Lipids5

Statin6

Density lipoproteins1

Total cholesterol4

Cholesterol levels2

Inhibit4

Levels20

Reductase3

Lipase2

Obesity2

Hypertriglyceridemia1

Diabetes mellitus3

Prevalence4

Hypercholesterolemia2

Concentrations3

Chylomicrons3

Statins4

Angiotensin3

Reduce3

Secondary1

Coronary heart d1

Disorders4

Rats3

Lipid profile2

Inhibitor1

Particle1

Pharmacological1

Glycemic1

Fats1

Lysosomal3

Therapeutic1

Digestive1

Simvastatin2

Patients10

Study aimed1

Intestine1

Tissues1

Abstract1

Significantly2

Risk factors4

Renal1

Atherosclerosis1

Treatment7

Lower2