• polypeptide
  • This general reaction is: (5-L-glutamyl)-peptide + an amino acid ⇌ {\displaystyle \rightleftharpoons } peptide + 5-L-glutamyl amino acid In prokaryotes and eukaryotes, it is an enzyme that consists of two polypeptide chains, a heavy and a light subunit, processed from a single chain precursor by an autocatalytic cleavage. (wikipedia.org)
  • serum
  • Serum gamma glutamyl transferes. (alliedacademies.org)
  • Measurement of GGT enzyme activity in serum appears to be a sensitive index with low specificity in the diagnosis of alcoholics with hepatitis when correlated clinically. (alliedacademies.org)
  • Changes in serum enzyme levels following ketamine infusions. (hkmj.org)
  • These include HCV genotype , testing for hepatitis A and B, full blood count (FBC) and clotting studies, liver enzyme tests (including ALT , AST , albumin and GGT ), thyroid function test (TFT), serum iron, liver autoantibodies, and liver ultrasound. (thebody.com)
  • However, determination of high levels of total serum GGT activity is not specific to alcohol intoxication, and the measurement of selected serum forms of the enzyme offer more specific information. (wikipedia.org)
  • The more common clinical manifestations include: Fatigue Malaise Joint and bone pain Liver cirrhosis (with an increased risk of hepatocellular carcinoma) Liver disease is always preceded by evidence of liver dysfunction including elevated serum enzymes specific to the liver, clubbing of the fingers, leuconychia, asterixis, hepatomegaly, palmar erythema and spider naevi. (wikipedia.org)
  • metabolism
  • The product of this initial metabolic step, 15(S)-hydroperoxyeicosatetraenoic acid, is then converted to a series of eoxins by the same enzymes that metabolize the 5-lipoxygenase product of arachidonic acid metabolism, i.e. 5-hydroperoxy-eicosatetraenoic acid to a series of leukotrienes. (wikipedia.org)
  • elevation
  • The degree of elevation of urinary gamma-GT activity was greater when the initial creatinine clearance was lower, and it is therefore suggested that those patients with pre-existing renal dysfunction should be monitored particularly carefully for signs of nephrotoxicity from these antibiotics. (bmj.com)
  • Cholestasis can be suspected when there is an elevation of both 5'-nucleotidase and ALP enzymes. (wikipedia.org)
  • abnormal
  • 3 4 Affected patients are usually asymptomatic initially, and only manifest abnormal ductal enzyme level after 1 to 2 years of recreational ketamine use, indicating that chronicity and repeated use seem to be involved. (hkmj.org)
  • activity
  • Diagnostic modalities used to evaluate hepatic damage and impaired hepatic function pre- and postaflatoxin administration included liver enzyme activity, bile acid levels, scintigraphy, and histopathologic evaluation of liver biopsy specimens. (thefreelibrary.com)
  • Changes in the activity of gamma-glutamyltransferase may signal preneoplastic or toxic conditions in the liver or kidney. (wikipedia.org)
  • These cells produce the eoxins by initially metabolizing arachidonic acid, an omega-6 (ω-6) fatty acid, via any enzyme possessing 15-lipoxygenase activity. (wikipedia.org)
  • Complex
  • Most people with PBC (>90%) have anti-mitochondrial antibodies (AMAs) against pyruvate dehydrogenase complex (PDC-E2), an enzyme complex that is found in the mitochondria. (wikipedia.org)
  • type
  • It is primarily based on the recommendations of the Nomenclature Committee of the International Union of Biochemistry and Molecular Biology (IUBMB) and it describes each type of characterized enzyme for which an EC (Enzyme Commission) number has been provided. (ebi.ac.uk)
  • The functional transcripts which have been fully characterized have been grouped and classified as type I gamma-glutamyltransferase. (wikipedia.org)
  • known
  • Arachidonate 5-lipoxygenase, also known as ALOX5, 5-lipoxygenase, 5-LOX, or 5-LO, is a non-heme iron-containing enzyme (EC 1.13.11.34) that in humans is encoded by the ALOX5 gene. (wikipedia.org)