• mutations
  • Severe diseases such as scurvy can result from defects in this hydroxylation, e.g., mutations in the enzyme prolyl hydroxylase or lack of the necessary ascorbate (vitamin C) cofactor. (wikipedia.org)
  • chirality
  • H. Tabata, "Chemistry of Amide-based Axial Chirality: Elucidation of the Active Conformation Recognized by Enzymes and Receptors", YAKUGAKU ZASSHI , vol. 133, pp. 857-866, 2013. (imperial.ac.uk)
  • secondary
  • The exceptional conformational rigidity of proline affects the secondary structure of proteins near a proline residue and may account for proline's higher prevalence in the proteins of thermophilic organisms. (wikipedia.org)