Indicate the pills produced with freebase DMT, synthetic harmaline, MAOi medications (such as moclobemide) and other isolated/purified compounds or extracts Evidence of Banisteriopsis caapi use in South America dates back at least 1,000 years, as demonstrated by a bundle containing the residue of the beta-carboline harmine and various other preserved psychoactive alkaloids such as bufotenin and cocaine in a cave in southwestern Bolivia, discovered in 2010. (wikipedia.org)
Harmine and harmaline are selective and reversible inhibitors of monoamine oxidase A (MAO-A), while tetrahydroharmine is a weak serotonin reuptake inhibitor (SRI). (psychonautwiki.org)
Alkaloids2
Harmala alkaloids are RIMA's which selectively and reversibly inhibit the enzyme 'Monoamine Oxidase A' (MAO-A). Because of the reversibility and selectivity RIMAs are safer than MAOI's. (dmt-nexus.me)
Ayahuasca is commonly made by the prolonged decoction of the stems of the Banisteriopsis caapi vine and the leaves of the Psychotria viridis shrub, although hundreds of species are used in addition or substitution (See "Preparation" below). (wikipedia.org)
Even though all ayahuasca vines are botanically classified as Banisteriopsis caapi, the curanderos classify them further, in reference to their effects. (ayahuascafoundation.org)
Ayahuasca5
In the cosmovision of its users, the ayahuasca is the vine that allows the spirit to wander detached from the body, entering the spiritual world, otherwise forbidden for the alive. (wikipedia.org)
As Don Jose explains, Ayahuasca, also called the Vine of the Soul, or the Vine of Death, allows us to deeply and intuitively understand the root causes for our physical and psycho-spiritual malaise and joy. (centromunay.com)
The visionary element of the experience, DMT, is not active if orally ingested without Ayahuasca because it is destroyed by the MAO enzymes in the GI tract. (centromunay.com)
However, some indigenous Amazonian cultures, like the Yahua, prepare their ceremonial brew using only the ayahuasca vine. (ayahuascafoundation.org)
Tetrahydroharmine is present in significant levels in ayahuasca, which may be responsible for some of its more profound effects. (ayahuascafoundation.org)
Monoamine oxidase1
The co-consumption of an MAOI agent is necessary for the combination to work, as the DMT molecule (which is a monoamine closely related to serotonin ) is rendered almost entirely inactive when digested by itself due to the presence of monoamine oxidase enzymes in the stomach, which rapidly degrades it. (psychonautwiki.org)
Caapi1
Of these, it most commonly consists of a DMT -containing plant source in combination with one that contains an MAOI or RIMA (typically sources like B. caapi vine or syrian rue ) to produce uniquely potent, sometimes medicinal, psychedelic effects. (psychonautwiki.org)
Produce1
The vine is cooked, usually in combination with at least one other admixture plant, to produce a brown liquid that is consumed in healing ceremonies led by Amazon healers, called ayahuasqueros. (ayahuascafoundation.org)
Monoamine3
The co-consumption of an MAOI agent is necessary for the combination to work, as the DMT molecule (which is a monoamine closely related to serotonin) is rendered almost entirely inactive when digested by itself due to the presence of monoamine oxidase enzymes in the stomach, which rapidly degrades it. (psychedelictherapyuk.com)
However, the human body naturally contains enzymes called monoamine oxidases (MAOs) which break down DMT before it can have any effect. (quantumhealingpathways.com)
Enzymes which regulate the biosynthesis or metabolism of dopamine such as aromatic L-amino acid decarboxylase (AAAD) or DOPA decarboxylase (DDC), monoamine oxidase (MAO), and catechol O -methyl transferase (COMT) may be referred to as dopaminergic as well. (wikidoc.org)