Enzyme nad p h dehydrogenase quinone. Medical search. Frequent questions

The systematic name of this enzyme class is NAD(P)H:quinone oxidoreductase. (wikipedia.org)
The systematic name of this enzyme class is NADPH:NAD+ oxidoreductase ( Re / Si -specific). (wikipedia.org)
NAD(P)H:quinone oxidoreductase (NQO) is a flavoenzyme that is implicated in the detoxication of quinones, including those formed during L-Dopa autooxidation. (amsterdamumc.org)
NAD(P)H:quinone acceptor oxidoreductase 1 (NQO1) is a widely-distributed FAD-dependent flavoprotein that promotes obligatory 2-electron reductions of quinones, quinoneimines, nitroaromatics, and azo dyes, at rates that are comparable with NADH or NADPH. (dundee.ac.uk)
The enzyme is therefore called malate:quinone oxidoreductase, abbreviated to Mqo. (rhea-db.org)
Characterization of the Threshold for NAD(P)H:quinone Oxidoreductase A" by Robert D. Bongard, Gary S. Krenz et al. (marquette.edu)
sulf-treated) increased cell-lysate NAD(P)H:quinone oxidoreductase (NQO1) activity by 5.7 ± 0.6 (mean ± SEM)-fold, but intact-cell NQO1 activity by only 2.8 ± 0.1-fold compared to control cells. (marquette.edu)
G SNP, a marker of oxidative stress (NAD[P]H quinone oxidoreductase mRNA) and homeostasis model assessment of insulin resistance. (diabetesjournals.org)
Casutt MS, Huber T, Brunisholz R, Tao M, Fritz G & Steuber J. Localization and function of the membrane-bound riboflavin in the Na+-translocating NADH:quinone oxidoreductase (Na+-NQR) from Vibrio cholerae. (uzh.ch)
Tao, M., Casutt, M. & Steuber, J. Oxidant-induced formation of a neutral flavosemiquinone in the Na(+)-translocating NADH:Quinone oxidoreductase (Na(+)-NQR) from Vibrio cholerae. (uzh.ch)
Tao, M., Fritz, G. & Steuber, J. The Na+ -translocating NADH:quinone oxidoreductase (Na+ -NQR) from Vibrio cholerae enhances insertion of FeS in overproduced NqrF subunit. (uzh.ch)
Vgenopoulou, I., Gemperli, A. C. & Steuber, J. Specific modification of a Na+ binding site in the NADH:quinone oxidoreductase (NDH-1) from Klebsiella pneumoniae with dicyclohexylcarbodiimide. (uzh.ch)
Steuber, J. The Na+ -translocating NADH:quinone oxidoreductase (NDH I) from Klebsiella pneumoniae and Escherichia coli: implications for the mechanism of redox-driven cation translocation by complex I. (uzh.ch)
An enzyme of the oxidoreductase class that catalyzes the reaction between catechol and oxygen to yield benzoquinone and water. (lookformedical.com)
For example, polymorphisms of NAD(P)H:quinone oxidoreductase (NQO1), an enzyme that metabolizes benzene derivatives, are associated with an increased risk of AML. (medscape.com)

The MDR superfamily with ~350-residue subunits contains the classical liver alcohol dehydrogenase (ADH), quinone reductase, leukotriene B4 dehydrogenase and many more forms. (researchgate.net)
For detailed information about NADH:quinone reductase (non-electrogenic), go to the full flat file . (brenda-enzymes.info)
In pathway V, the racemase alr forms D-lysine, which is oxidized to 6-amino-2-oxo-hexanoate, spontaneously decarboxylates to 1-piperideine-2-carboxylate, a reductase forms L-pipecolate, an oxidase forms 1-piperideine-6-carboxylate, and a dehydrogenase forms L-2-aminoadipate. (lbl.gov)
NADPH cytochrome P450 reductase activity, an enzyme implicated in bio-reductive activation of MMC, did not differ significantly in these cells. (elsevierpure.com)

This enzyme belongs to the family of oxidoreductases, specifically those acting on NADH or NADPH with a quinone or similar compound as acceptor. (wikipedia.org)
Biochemical and genetic characterization of the membrane-associated malate dehydrogenase (acceptor) from Corynebacterium glutamicum. (rhea-db.org)
In addition to a cytoplasmic, NAD-dependent malate dehydrogenase (EC 1.1.1.37), Corynebacterium glutamicum possesses a highly active membrane-associated malate dehydrogenase (acceptor) (EC 1.1.99.16). (rhea-db.org)
NAD is not an acceptor and the natural direct acceptor for the enzyme is most likely a quinone. (rhea-db.org)
In general, enzymes using NADH or NADPH to reduce a substrate are classified according to the reverse reaction, in which NAD+ or NADP+ is formally regarded as an acceptor. (lookformedical.com)
This subclass includes only those enzymes in which some other redox carrier is the acceptor. (lookformedical.com)

In enzymology, a NAD(P)H dehydrogenase (quinone) (EC 1.6.5.2) is an enzyme that catalyzes the chemical reaction NAD(P)H + H+ + a quinone ⇌ {\displaystyle \rightleftharpoons } NAD(P)+ + a hydroquinone The 4 substrates of this enzyme are NADH, NADPH, H+, and quinone, whereas its 3 products are NAD+, NADP+, and hydroquinone. (wikipedia.org)
Thus, the two substrates of this enzyme are NADPH and NAD + , whereas its two products are NADP + and NADH . (wikipedia.org)
Glucose-6-phosphate dehydrogenase (G-6-PDH) inhibition partially blocked NQO1 activity in control and sulf-treated cells, but G-6-PDH overexpression via transient transfection with the human cDNA alleviated neither the restriction on intact sulf-treated cell NQO1 activity nor the impact on the NADPH/NADP + ratios. (marquette.edu)

NQO1 ELISA kit applies the competitive enzyme immunoassay technique utilizing an anti- NQO1 antibody and an NQO1 -HRP conjugate. (elisakit.cc)
NQO1 is a highly-inducible enzyme that is regulated by the Keap1/Nrf2/ARE pathway. (dundee.ac.uk)
NQO1 is an enzyme produced by the Nrf2 pathway that functions as an antioxidant, is important for detoxification and to increase NAD+ levels ( 1 ). (selfhack.com)
NQO1 is employed in the removal of a quinone from biological systems as a detoxification reaction: NAD(P)H + a quinone → NAD(P) + hydroquinone [ 1 ]. (selfhack.com)
NQO1 increases the enzyme (Ornithine decarboxylase) for polyamine synthesis (like spermidine) [ 1 ]. (selfhack.com)
For instance, binding from the p53 downstream p21 to Nrf2 inhibits Nrf2 degradation [26], whereas binding from the Nrf2 downstream NAD(P)H dehydrogenase quinone 1 (NQO1) to p53 prevents p53 degradation [27]. (researchtoactionforum.org)

FLAVOPROTEIN containing siroheme and can utilize both NAD and NADP as cofactors. (lookformedical.com)

The other 2 genes encoded phase 2 enzymes [NAD(P)H-quinone oxidoreductase1and aldehyde dehydrogenase family 3, subfamily A1]. (thieme-connect.com)

Zinc binding to the peptide replica and analogs to residues 93-115 of horse liver alcohol dehydrogenase (ADH) was examined by competition of the peptides and the chromophoric chelator 4-(2- pyridylazo)resorcinol for zinc and X-ray absorption fine structure analysis of the zinc ligands. (researchgate.net)

Glycerol 3-phospate may then be converted by dehydrogenation to dihydroxyacetone phosphate (DHAP) by the enzyme glycerol-3-phosphate dehydrogenase. (hmdb.ca)

Short-chain dehydrogenases/reductases (SDRs) constitute a large family of NAD(P)(H)-dependent oxidoreductases, sharing sequence motifs and displaying similar mechanisms. (researchgate.net)

The electron carriers are found within four membrane-bound enzyme-complexes, which are imbedded in the inner mitochondrial membrane. (drugstorepdfsearch.com)
Reduced coenzyme Q passes the electrons to cytochrome b and releases 2H+ into the mitochondrial matrix The oxidation of ubiquinol involves the successive action of 2 enzymes: a) - Ubiquinol (coenzyme Q) dehydrogenase which transfers electrons to cytochrome c. (drugstorepdfsearch.com)
The enzymes of the electron transport chain are organized in the inner mitochondrial membrane in the form of four enzyme complexes. (drugstorepdfsearch.com)
[ 12 ] The activity of key mitochondrial enzymes of the tricarboxylic acid cycle, β-oxidation, and the electron transport system, conversely, were unchanged, [ 12 ] leaving many unanswered questions regarding the effects of CR on muscle-specific mitochondrial function in humans. (medscape.com)

Steffen W, Gemperli AC, Cvetesic N & Steuber J. Organelle-specific expression of subunit ND5 of human complex I (NADH dehydrogenase) alters cation homeostasis in Saccharomyces cerevisiae. (uzh.ch)

In the present study, using primary rat astrocytes and C6 astroglioma as a model to evaluate the neuroprotective response of astroglial cells upon exposure to L-Dopa, we demonstrate that this compound, or more correctly its quinone (auto)oxidation products, up-regulates astroglial NQO in a time- and concentration-dependent way as assessed at the level of mRNA expression, protein level, and enzymatic activity. (amsterdamumc.org)
8-oxo-dGuo expressions as well as protein and mRNA expressions of DNA repair enzyme hOGG1 and antioxidant defenses (CAT, GCLC, GPx, Nrf2, and MnSOD) in nonneoplastic epidermis of control and BCC tissues were also determined. (hindawi.com)
In this study, we investigated the effects of KMS99220 on the signaling involving AMP-activated protein kinase (AMPK) and heme oxygenase-1 (HO-1), the enzymes thought to regulate inflammation. (en-journal.org)
AMP-activated protein kinase (AMPK) is an enzyme involved in the regulation of cellular homeostasis and metabolic function. (en-journal.org)

These include (1) disrupting the shikimate pathway, 2) altering the balance between pathogens and beneficial biota in the gut, (3) chelating transition metals, as well as sulfur and selenium, and (4) inhibiting cytochrome P450 enzymes. (donnieyance.com)
Characteristics of celiac disease point to impairment in many cytochrome P450 enzymes, which are involved with detoxifying environmental toxins, activating vitamin D3, catabolizing vitamin A, and maintaining bile acid production and sulfate supplies to the gut. (donnieyance.com)
Glyphosate is known to inhibit cytochrome P450 enzymes. (donnieyance.com)

The nucleotide sequence of the mqo gene was determined and is the first sequence known for this enzyme. (rhea-db.org)

The reagent comprises dehydrogenase enzyme that has specificity for the analyte, NAD, an NAD derivative, pyrrolo-quinoline quinone (PQQ), or a PQQ derivative, a tetrazolium dye precursor, a diaphorase enzyme or an analog thereof, and a nitrite salt. (patsnap.com)

The effect of 200 and 400 mg/kg body weight of 80% ethanolic extract of the fresh leaves of Lawsonia inermis were examined on drug metabolizing phase-I and phase-II enzymes, antioxidant enzymes, glutathione content, lactate dehydrogenase and lipid peroxidation in the liver of 7 weeks old Swiss albino mice. (nih.gov)

The mutant possesses normal levels of cytoplasmic NAD-dependent malate dehydrogenase. (rhea-db.org)
Functions of the membrane-associated and cytoplasmic malate dehydrogenases in the citric acid cycle of Escherichia coli. (rhea-db.org)

S -alkylation → activation of the Keap1/Nrf2 pathway → transcriptional activation → induction of phase 2 enzymes → activation of GSH metabolism → neuroprotection. (thieme-connect.com)
Nrf2 is a key transcription aspect for genes coding for antioxidants, cleansing enzymes, and multiple medication level of resistance and it confers level of resistance to anticancer medications also. (researchtoactionforum.org)

At least one compound, Dicumarol is known to inhibit this enzyme. (wikipedia.org)

It is produced by the actions of the enzyme lysyl oxidase in the extracellular matrix and is essential in the crosslink formation that stabilizes collagen and elastin. (hmdb.ca)

Enzyme Nomenclature, 1992) EC 1. (lookformedical.com)
Enzyme Nomenclature, 1992, p100) EC 1.6. (lookformedical.com)
Formally, this redox change involves a single-electron, reversible equilibrium between the Fe(II) and Fe(III) states of the central iron atom (From Enzyme Nomenclature, 1992, p539). (lookformedical.com)

This enzyme participates in nicotinate and nicotinamide metabolism . (wikipedia.org)
SDR enzymes have critical roles in lipid, amino acid, carbohydrate, cofactor, hormone and xenobiotic metabolism as well as in redox sensor mechanisms. (researchgate.net)

Our primary findings reveal the 'duel-acting' nature of henna leaf as deduced from its potential to induce only the phase-II enzyme activity, associated mainly with carcinogen detoxification in liver of mice and inhibit the phase I enzyme activities. (nih.gov)

The coenzyme of various aerobic dehydrogenases, e.g. (rcsb.org)

Cannabinoid receptors are utilized endogenously by the body through the endocannabinoid system, which includes a group of lipid proteins, enzymes, and receptors that are involved in many physiological processes. (rcsb.org)

Serum elevations of ALT activity are rarely observed except in parenchymal liver disease, since ALT is a more liver-specific enzyme than asparate aminotransferase (AST). (cdc.gov)

The product of the enzyme-substrate reaction forms a blue colored complex. (elisakit.cc)
and a reaction layer containing at least pyrrolo-quinoline quinone dependent glucose dehydrogenase, formed in contact with or in the vicinity of the electrode system, and the reaction layer contains at least one kind of additive selected from the group consisting of gluconic acid and salts thereof. (patsnap.com)

This enzyme participates in biosynthesis of steroids. (wikipedia.org)

Naphthoquinones are compounds containing a naphthohydroquinone moiety, which consists of a benzene ring linearly fused to a bezene-1,4-dione (quinone). (t3db.ca)
Ubiquinones are a group of compounds containing quinone ring but vary according to number of isoprene units at the side chain. (drugstorepdfsearch.com)

Overview: Lysine degradation in GapMind is based on many metacyc pathways ( link ), including L-lysine degradation I via cadaverine ( link ), pathway IV via lysine monooxygenase ( link ), pathway V via D-lysine ( link ), pathway VI via lysine 6-aminotransferase ( link ), pathway VIII via lysine 6-dehydrogenase ( link ), and fermentation to acetate and butanoate ( link ). (lbl.gov)

An enzyme found primarily in BACTERIA and FUNGI that catalyzes the oxidation of ammonium hydroxide to nitrite. (lookformedical.com)
An enzyme that catalyzes the oxidation of nitrite to nitrate. (lookformedical.com)
The enzyme catalyzes the oxidation of o-diphenols to o-quinones without hydroxylating monophenols, the additional activity of tyrosinase. (lookformedical.com)

DT-diaphorase activity, another MMC activation enzyme, was significantly lower in the SCaBER/R cell line when compared to the SCaBER cells. (elsevierpure.com)

The autooxidation of L-Dopa, a catecholamine used in the symptomatic treatment of Parkinson's disease, generally yields reactive oxygen species and neurotoxic quinones. (amsterdamumc.org)
These reductions depress quinone levels and thereby minimize opportunities for generation of reactive oxygen intermediates by redox cycling, and for depletion of intracellular thiol pools. (dundee.ac.uk)

A transaminase forms 2-oxoadipate, a oxygenase/decarboxylase (D-2-hydroxyglutarate synthase) forms (R)-2-hydroxyglutarate, and a dehydrogenase forms 2-oxoglutarate, which is an intermediate in the TCA cycle. (lbl.gov)

In pathway VI, lysine 6-aminotransferase (lat) forms (S)-2-amino-6-oxohexanoate, which spontaenously dehydrates to 1-piperideine 6-carboxylate, and a dehydrogenase forms L-2-aminoadipate In pathway VIII, L-lysine 6-dehydrogenase (lysDH) forms (S)-2-amino-6-oxohexanoate, which spontaenously dehydrates to 1-piperideine 6-carboxylate, and a dehydrogenase forms L-2-aminoadipate. (lbl.gov)
Comment: In MetaCyc pathway glutaryl-CoA degradation ( link ), glutaryl-CoA is oxidized to (E)-glutaconyl-CoA and oxidatively decarboxylated to crotonyl-CoA (both by the same enzyme), hydrated to 3-hydroxybutanoyl-CoA, oxidized to acetoacetyl-CoA, and cleaved to two acetyl-CoA. (lbl.gov)

A group of enzymes that oxidize diverse nitrogenous substances to yield nitrite. (lookformedical.com)

Anatomy4

Organisms3

Diseases1

Chemicals and Drugs88

Analytical, Diagnostic and Therapeutic Techniques and Equipment1

Phenomena and Processes10

Information Science3

Oxidoreductase15

Reductase4

Acceptor6

NADPH3

NQO16

NADP1

Aldehyde dehydrogenase1

Alcohol dehydrogenase1

Glycerol-3-phosphate d1

Oxidoreductases1

Mitochondrial4

Subunit1

Protein4

Cytochrome3

Nucleotide1

Specificity1

Glutathione1

Malate2

Nrf22

Known to inhibit1

Oxidase1

Nomenclature3

Metabolism2

Detoxification1

Coenzyme1

Lipid1

Liver1

Reaction2

Participates1

Compounds2

Fermentation1

Oxidation3

Diaphorase1

Reactive2

Synthase1

Pathway2

Nitrogenous1