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  • polypeptide
  • This general reaction is: (5-L-glutamyl)-peptide + an amino acid ⇌ {\displaystyle \rightleftharpoons } peptide + 5-L-glutamyl amino acid In prokaryotes and eukaryotes, it is an enzyme that consists of two polypeptide chains, a heavy and a light subunit, processed from a single chain precursor by an autocatalytic cleavage. (wikipedia.org)
  • serum
  • Serum gamma glutamyl transferes. (alliedacademies.org)
  • Measurement of GGT enzyme activity in serum appears to be a sensitive index with low specificity in the diagnosis of alcoholics with hepatitis when correlated clinically. (alliedacademies.org)
  • Changes in serum enzyme levels following ketamine infusions. (hkmj.org)
  • However, determination of high levels of total serum GGT activity is not specific to alcohol intoxication, and the measurement of selected serum forms of the enzyme offer more specific information. (wikipedia.org)
  • The more common clinical manifestations include: Fatigue Malaise Joint and bone pain Liver cirrhosis (with an increased risk of hepatocellular carcinoma) Liver disease is always preceded by evidence of liver dysfunction including elevated serum enzymes specific to the liver, clubbing of the fingers, leuconychia, asterixis, hepatomegaly, palmar erythema and spider naevi. (wikipedia.org)
  • metabolic
  • Your body produces thousands of types of metabolic and digestive enzymes. (livestrong.com)
  • After your stomach and bowels complete absorption of alcohol, it is carried to your liver for further metabolic breakdown, where it is met by alcohol and aldehyde dehydrogenase enzymes. (livestrong.com)
  • ENZYME-SPECIFIC PROFILES for metabolic pathway prediction. (ebi.ac.uk)
  • The product of this initial metabolic step, 15(S)-hydroperoxyeicosatetraenoic acid, is then converted to a series of eoxins by the same enzymes that metabolize the 5-lipoxygenase product of arachidonic acid metabolism, i.e. 5-hydroperoxy-eicosatetraenoic acid to a series of leukotrienes. (wikipedia.org)
  • These metabolic transformations are similar to and therefore thought to be mediated by the same enzymes that metabolize the 5-hydroperoxyeicosatetraenoci acid of arachidonic acid (i.e. 5(S)-HpETE) to the peptide-leukotriens, LTA4, LTC4, LTD4, and LTE4. (wikipedia.org)
  • elevation
  • The degree of elevation of urinary gamma-GT activity was greater when the initial creatinine clearance was lower, and it is therefore suggested that those patients with pre-existing renal dysfunction should be monitored particularly carefully for signs of nephrotoxicity from these antibiotics. (bmj.com)
  • Cholestasis can be suspected when there is an elevation of both 5'-nucleotidase and ALP enzymes. (wikipedia.org)
  • Complex
  • Most people with PBC (>90%) have anti-mitochondrial antibodies (AMAs) against pyruvate dehydrogenase complex (PDC-E2), an enzyme complex that is found in the mitochondria. (wikipedia.org)
  • primarily
  • It is primarily based on the recommendations of the Nomenclature Committee of the International Union of Biochemistry and Molecular Biology (IUBMB) and it describes each type of characterized enzyme for which an EC (Enzyme Commission) number has been provided. (ebi.ac.uk)
  • levels
  • Enzymes converge with other substances in your body to speed up chemical reactions, making your body work at optimal levels. (livestrong.com)
  • The enzyme is elevated in some forms of liver disease, so physicians use GGT levels to detect liver damage and alcohol abuse. (medicalnewstoday.com)
  • Among all men, the risk of cardiovascular death was 28 percent higher for those with moderately high GGT, compared to men with normal levels of the enzyme, and rose to 64 percent for those with highly elevated GGT. (medicalnewstoday.com)
  • Multivariate logistic regression analysis is conducted to determine the associations between the levels of various liver enzymes and clustered components of MetS. (mdpi.com)
  • Unwanted side effects include dizziness, reversible cholestatic jaundice, pseudoallergic reaction, and elevated levels of liver enzymes (transaminases and gamma-glutamyltransferase). (wikipedia.org)
  • toxic
  • These two enzymes are responsible for breaking down the toxic properties of alcohol for later elimination from your body. (livestrong.com)
  • help
  • Although the majority of alcohol is metabolized by your liver, a small percentage of alcohol is not, which constitutes the alcohol that reaches your brain with the help of the cytochrome enzymes and the catalase enzyme. (livestrong.com)
  • Arachidonic
  • These cells produce the eoxins by initially metabolizing arachidonic acid, an omega-6 (ω-6) fatty acid, via any enzyme possessing 15-lipoxygenase activity. (wikipedia.org)
  • The product of this initial metabolic step, 15(S)-hydroperoxyeicosatetraenoic acid, is then converted to a series of eoxins by the same enzymes that metabolize the 5-lipoxygenase product of arachidonic acid metabolism, i.e. 5-hydroperoxy-eicosatetraenoic acid to a series of leukotrienes. (wikipedia.org)
  • These metabolic transformations are similar to and therefore thought to be mediated by the same enzymes that metabolize the 5-hydroperoxyeicosatetraenoci acid of arachidonic acid (i.e. 5(S)-HpETE) to the peptide-leukotriens, LTA4, LTC4, LTD4, and LTE4. (wikipedia.org)
  • Cells make eoxins by metabolizing arachidonic acid with a 15-lipoxygenase enzyme to form 15(S)-hydroperoxyeicosapentaenoic acid (i.e. 15(S)-HpETE). (wikipedia.org)
  • acid
  • Although these accumulations may be tiny, the bacteria in them produce chemicals, such as degradative enzymes, and toxins, such as lipopolysaccharide (LPS, otherwise known as endotoxin) or lipoteichoic acid (LTA), that promote an inflammatory response in the gum tissue. (wikipedia.org)
  • levels
  • The levels of this enzyme in the blood depend on factors such as age, gender, blood type and whether an individual is pregnant or not. (wikipedia.org)
  • class
  • As of late 2007, two structures have been solved for this class of enzymes, with PDB accession codes 2PN7 and 2RBH. (wikipedia.org)
  • found
  • The enzyme is found across a multitude of organisms, prokaryotes and eukaryotes alike, with the same general function but in different structural forms suitable to the environment they function in. (wikipedia.org)
  • drug
  • The drug blocks several enzymes involved in the immune system and can minimize joint damage associated with rheumatoid arthritis (RA) . (labtestsonline.org)
  • specific
  • In effect, along with the concomitant compound the phosphate was bound to, this enzyme yields pure inorganic phosphate which can be ultimately targeted by the phosphate-specific transport system (Pst system) for translocation into the cytosol. (wikipedia.org)