Enzyme 13 chromosomes human pair 13. Medical search. Frequent questions

1992) demonstrated that genes for 12-lipoxygenase and 15-lipoxygenase are located on human chromosome 17, whereas the most unrelated lipoxygenase (5-lipoxygenase) was mapped to chromosome 10. (wikipedia.org)
Thirteen of these genes provide instructions for making enzymes involved in oxidative phosphorylation. (medlineplus.gov)
The mitochondrial genes associated with cytochrome c oxidase deficiency provide instructions for making proteins that are part of a large enzyme group (complex) called cytochrome c oxidase (also known as complex IV). (medlineplus.gov)
Using a combination of miRNA hairpin predictions and co-mapping with miRBase entries, we identified a highly conserved cluster of miRNA genes on the X chromosome in the tammar and a total of 94 other predicted miRNA producing genes. (biomedcentral.com)
Mapping all miRNAs to the tammar genome and comparing target genes among tammar, mouse and human, we identified 163 conserved target genes. (biomedcentral.com)
An additional nine genes were identified in tammar that do not have an orthologous miRNA target in human and likely represent novel miRNA-regulated genes in the tammar. (biomedcentral.com)
The characterization of new miRNA target genes and a unique profile for crasiRNAs has allowed for insight into multiple RNA mediated processes in the tammar, including gene regulation, species incompatibilities, centromere and chromosome function. (biomedcentral.com)
In this process, maternal and paternal versions of each chromosome pair up and swap sections of their DNA through a process known as homologous recombination-a "reshuffling" that gives rise to chromosomes with new combinations of maternal and paternal genes. (nyu.edu)
The yeast ML01 was modified using a shuttle vector containing a chromosome integration cassette with genes for malolactic enzyme, malate transporter (permease), regulatory genes and a sequence directing homologous recombination at a chromosomal locus (not specified in the FDA report), and the antibiotic phleomycin gene was used as a selectable marker via another plasmid. (i-sis.org.uk)
The protein coding genes produce multiple enzymes that are used within C. mastitidis' metabolic pathways such as esterase, esterase lipase, catalase, and urease [7]. (kenyon.edu)
Human telomere biology disorders (TBD)/short telomere syndromes (STS) are heterogeneous disorders caused by inherited loss-of-function mutations in telomere-associated genes. (bvsalud.org)
The inactivation of MMR genes, usually hMSH2 or hMLH1, is associated with human colorectal cancers and is responsible for the characteristic microsatellite instability (MSI)+ phenotype of these tumors. (aacrjournals.org)
In the absence of strong functional candidate genes, several genome-wide scans in families with affected sib-pairs have been conducted. (helpforibs.com)
Interindividual differences observed in the metabolism of xenobiotics may be due to polymorphisms of genes encoding the detoxification enzymes. (springeropen.com)
Xenobiotic-metabolizing enzymes ( XME ), coded by a family of xenobiotic-metabolizing genes ( XMG ), have a major role in elimination of many xenobiotics or environmental chemical compounds from the body. (springeropen.com)
Because researchers use different approaches to genome annotation , their predictions of the number of genes on each chromosome varies (for technical details, see gene prediction ). (wikipedia.org)
So CCDS's gene number prediction represents a lower bound on the total number of human protein-coding genes. (wikipedia.org)
The following is a partial list of genes on human chromosome 9. (wikipedia.org)
Using this system, the researchers showed that they could deliver genes as long as 36,000 DNA base pairs to several types of human cells, as well as to liver cells in mice. (sflorg.com)
In this study, the researchers showed that they could use PASTE to insert genes into several types of human cells, including liver cells, T cells, and lymphoblasts (immature white blood cells). (sflorg.com)
In the process of transcription in prokaryotes 1) rRNA is specified by exons in DNA 2) mRNA is formed as coded by introns 3) the base sequence of DNA is copied into tRNA 4) a str and of mRNA is for med with base sequences complementar y to those of DNA 5) a polypeptide is formed as specified by the genes in a chromosomes 13. (studyres.com)
Multiple miRNA-mRNA prediction databases were searched by differentially expressed genes (DEGs) to obtain pairs of a miRNA-DEG regulatory network. (frontiersin.org)
Human genetics is the study of the human genome and the transmission of genes from one generation to the next. (amboss.com)
Chromosomes are structures within cells that contain a person's genes. (msdmanuals.com)
Genes are contained in chromosomes, which are in the cell nucleus. (msdmanuals.com)
A chromosome contains hundreds to thousands of genes. (msdmanuals.com)
Protein synthesis is controlled by genes, which are contained on chromosomes. (msdmanuals.com)
Humans have about 20,000 to 23,000 genes. (msdmanuals.com)
Chromosomes Genes are segments of deoxyribonucleic acid (DNA) that contain the code for a specific protein that functions in one or more types of cells in the body or the code for functional ribonucleic. (msdmanuals.com)
A chromosome contains many genes. (msdmanuals.com)

Kelavkar and Badr (1999) described experiments yielding data that supported the hypothesis that loss of the TP53 gene, or gain-of-function activities resulting from the expression of its mutant forms, regulates ALOX15 promoter activity in human and in mouse, albeit in directionally opposite manners. (wikipedia.org)
In humans, it is encoded by the ALOX15 gene located on chromosome 17p13.3. (wikipedia.org)
This 11 kilobase pair gene consists of 14 exons and 13 introns coding for a 75 kiloDalton protein composed of 662 amino acids. (wikipedia.org)
To our knowledge, angiotensin converting enzyme ( ACE ) gene I/D polymorphisms have not yet been investigated in AS patients in Turkish population.This study was conducted in Turkish patients with AS to determine the frequency of I/D polymorphism genotypes of angiotensin converting enzyme gene. (molvis.org)
As a result of our study, angiotensin converting enzyme gene I/D polymorphism DD genotype could be a genetic marker in ankylosing spondylitis in a Turkish study population. (molvis.org)
Small RNAs play important roles in many aspects of pre- and post-transcriptional gene regulation, epigenetic modifications, chromosome segregation and genome structure. (biomedcentral.com)
The first class of small RNAs identified were the micro RNAs (miRNAs), which are small (~22 nt) non-coding RNAs that regulate gene expression by base pairing to mRNAs where they direct either mRNA cleavage or repress translation [ 8 ]. (biomedcentral.com)
MicroRNA (miRNA) molecules, a series of single-stranded non-coding RNA chains measuring 20-25 nucleotides in length, regulate gene expression at the transcriptional level by complementary pairing with target gene mRNA ( 5 ). (spandidos-publications.com)
The strain included a gene for malolactic enzyme from the bacterium Oenococcus oeni and a malate permease gene from the fission yeast Schizosaccharomyces pombe . (i-sis.org.uk)
The yeast released for commercial wine production, ML01, was found to be only somewhat substantially equivalent to unmodified wine yeast, as a cytochrome p450 enzyme protein appeared to have been altered from the parental strain based on a comprehensive analysis of the yeast cell proteins, and a number of codon changes were observed in the inserted malolactic gene cassette, but those changes were not considered significant. (i-sis.org.uk)
The fate of yeast and plant DNA, as monitored by yeast chitinase gene and the plant chlorophyll a/b binding protein gene and micro-satellite markers showed that large DNA markers were present in must (the starting fermentation mixture of mainly yeast and grape juice), while the 250 base pair micro-satellites were present in both must and young wine for up to six months [9]. (i-sis.org.uk)
DMD is an X-chromosome linked recessive disorder caused by a loss of function of the dystrophin gene of 2.3 million base pairs, which results in progressive weakness and atrophy of the skeletal and cardiac muscles. (nature.com)
The CYP1A1 gene is located on 15q22-q24 [ 8 ], contains 7 exons and 6 introns and spans 5810 base pairs. (springeropen.com)
The CYP1A1 3801T/C (also named MspI polymorphism, *2A or m1), results from a replacement of thymine by a cytosine at the 3801st base pair in the 3' flanking region of the gene [ 9 , 10 ]. (springeropen.com)
These are some of the gene count estimates of human chromosome 9. (wikipedia.org)
The ABO gene , which determines ABO blood type , is located on the long arm of this chromosome. (wikipedia.org)
The CRISPR-Cas9 gene editing system consists of a DNA-cutting enzyme called Cas9 and a short RNA strand that guides the enzyme to a specific area of the genome, directing Cas9 where to make its cut. (sflorg.com)
When a gene is switched on, an enzyme called RNA polymerase attaches to the start of the gene. (boards.net)
c) For production of every enzyme there is a gene. (jbrconsultant.com)
All homologous chromosome pairs contain two variant forms of the same gene , called " alleles ," which are passed down from parent to offspring. (amboss.com)
The MDH1 gene maps within the RP28 arRP linkage interval and encodes cytoplasmic malate dehydrogenase, an enzyme functionally related to IDH3B. (molvis.org)
Chromosome fusion - Gene fusion or chromosome fusion is when two chromosomes are spliced together. (rationalwiki.org)
[ 5 ] The factor XIII A chain gene is found on chromosome 6. (medscape.com)
Lateral gene transfers resulted in different linkages between the ospC gene and loci of the chromosome or other plasmids. (cdc.gov)

BMC Ophthalmol, 2023 Jan 13. (nih.gov)

Through a series of manipulations, in which the researchers inhibited the activity of individual proteins, they found two enzymes that were necessary for meiosis: Mec1, which is similar to ATR, known to suppress tumors in humans, and DDK, which is a vital coordinator of chromosome reshuffling. (nyu.edu)
Complexes containing a pair of structural maintenance of chromosomes (SMC) family proteins are fundamental for the three-dimensional (3D) organization of genomes in all domains of life. (nature.com)
Each chromosome contains a long strand of DNA tightly packaged around proteins called histones. (boards.net)
Enzymes are complex proteins that control and carry out nearly all chemical processes and reactions within the body. (msdmanuals.com)

Most cells in an organism contain two sets of chromosomes, one inherited from the mother and the other from the father. (nyu.edu)
This means that they also need to copy all of their DNA and then deliver identical sets of chromosomes to each new cell. (elifesciences.org)
Animal cells use structures called centrioles to help them divide their sets of chromosomes accurately. (elifesciences.org)

In particular, G band analysis usually does not show the chromosomal origin of small marker chromosomes or of a small amount of extra material detected on otherwise normal chromosomes. (bmj.com)
Chromosomal identification of marker chromosomes and extra bands on chromosomes through molecular techniques is always of clinical interest. (bmj.com)
One member of each chromosomal pair comes from your mother, and the other comes from your father. (howstuffworks.com)
Down Syndrome (DS), defined as the trisomy of chromosome 21, is the most frequent chromosomal abnormality that causes intellectual disability 1 . (bvsalud.org)
Down Syndrome (DS) is the most common chromosomal aberration resulting from trisomy of the chromosome 21. (bvsalud.org)

The term 'homologous chromosomes' A) means a pair of chromosomes of the same kind, such as sex chromosomes B) is another name for sister chromatids C) must be haploid D) refers to replications of the same chromosome 1) only D is valid 2) only B is valid 3) none (A-D) is valid 4) B, C are valid 5) only A is valid 21. (studyres.com)
The human genome consists of 23 pairs of chromosomes ( 22 pairs of homologous chromosomes and one pair of sex chromosomes ). (amboss.com)
Each human cell contains 23 pairs of homologous chromosomes (corresponding in structure and genetic information, i.e., 23 chromosomes are inherited from each parent). (amboss.com)
The two homologous chromosomes contain identical alleles at a given locus . (amboss.com)
The two homologous chromosomes contain different alleles at a given locus . (amboss.com)

eukaryotic topoisomerase I and topoisomerase V). These enzymes are primarily responsible for relaxing positively and/or negatively supercoiled DNA, except for reverse gyrase, which can introduce positive supercoils into DNA. (embl.de)
Telomeres are nucleoprotein complexes at the ends of eukaryotic chromosomes. (biomedcentral.com)
The eukaryotic SMC complexes cohesin and condensin are thought to fold interphase and mitotic chromosomes, respectively, into large loop domains, although the underlying molecular mechanisms have remained unknown. (nature.com)

During synapsis A) sister chromatids pair at the centromeres B) homologues pair all along their length C) homologues repel each other except at the ends D) sister chromatids pair all along their length 1) only C is valid 2) only B is valid 3) none (A-D) is valid 4) only A is valid 5) only D is valid 12. (studyres.com)

To do so, they examined budding yeast--a model organism in cell biology because its chromosome replication and regulation are similar to that of humans. (nyu.edu)
Talking about the "aging" of a single-celled organism such as yeast, and drawing conclusions about the aging of multicellular organisms and humans, from events in the life of yeast, is meaningful only to people who subscribe to the Hayflick doctrine, and who deny the reality of stem cells in mammals and other complex organisms. (doctorsaredangerous.com)

The mature miRNA is then loaded onto an Argonaute protein (Ago2 in humans) where it then interacts with and regulates the mRNA target. (biomedcentral.com)
The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. (nih.gov)
This study aimed to find out more candidate miRNA-mRNA pairs involved in the osteogenic differentiation of MC3T3-E1 cells. (frontiersin.org)
There were 7 overlapped miRNA-mRNA pairs identified during osteogenic differentiation of MC3T3-E1 cells, including mmu-miR-204-5p-Arhgap11a, mmu-miR-211-5p-Arhgap11a, mmu-miR-24-3p-H2afx, mmu-miR-3470b-Chek2, mmu-miR-3470b-Dlgap5, mmu-miR-466b-3p-Chek1, and mmu-miR-466c-3p-Chek1. (frontiersin.org)

In phase I, cytochrome P450 enzymes play an important role in the metabolism of estrogen and polycyclic aromatic hydrocarbons (PAHs). (springeropen.com)

Although most DNA is packaged in chromosomes within the nucleus, mitochondria also have a small amount of their own DNA. (medlineplus.gov)
In each human cell, there is a structure called the nucleus. (boards.net)
DNA (deoxyribonucleic acid) is the cell's genetic material, contained in chromosomes within the cell nucleus and mitochondria. (msdmanuals.com)
Except for certain cells (for example, sperm and egg cells and red blood cells), the cell nucleus contains 23 pairs of chromosomes. (msdmanuals.com)

These enzymes target specific genome sequences known as attachment sites, which function as "landing pads. (sflorg.com)
CGH has been widely applied to detect gains and losses of DNA sequences on specific chromosomes in the study of solid tumours, 1 but has not been extensively used to study unbalanced constitutional karyotypes. (bmj.com)
Despite the intrinsic complexity of human genome sequences, reads were easily mapped and analyzed, and all algorithms used provided the same results. (molvis.org)

Human leukocyte antigen B27 ( HLA-B27 ) is the major genetic susceptibility marker in AS. (molvis.org)
The major component of the genetic predisposition to CD resides in the HLA region of chromosome 6. (helpforibs.com)
Although no additional susceptibility loci have been clearly identified thus far, there is some evidence of a genetic risk factor on chromosomes 5q and 11p11. (helpforibs.com)
The new tool combines the precise targeting of CRISPR-Cas9, a set of molecules originally derived from bacterial defense systems, with enzymes called integrases, which viruses use to insert their own genetic material into a bacterial genome. (sflorg.com)

In humans, mitochondrial DNA spans about 16,500 DNA building blocks (base pairs), representing a small fraction of the total DNA in cells. (medlineplus.gov)
Once considered an academic backwater, mitochondrial biology is deemed to play a fundamental role in human health and aging. (longevityfacts.com)
They aren't hard to find as there are over ten million billion mitochondrial witnesses in every human body. (longevityfacts.com)
Mitochondrial DNA is circular, differing significantly from the DNA in our chromosomes. (longevityfacts.com)
Mitochondrial enzymes for oxidative metabolism are 1) on or within the surface of cr istae 2) in mitochondrial lysosomes 3) floating freely in intermembrane space 4) in the matrix 5) located on the outer membrane 20. (studyres.com)

Topoisomerases are nuclear enzymes that modify the topological state of DNA and participate in fundamental metabolic processes such as replication, transcription, repair, recombination, and chromosome segregation (1) . (aacrjournals.org)

In humans, telomeric DNA consists mainly of non-coding t-type (TTAGGG) repeats. (biomedcentral.com)
The genome of the isolate consists of 2,264,319 base pairs. (kenyon.edu)

Germ cells only carry one-half of a somatic cell's chromosomes . (amboss.com)

Chromosome 9 spans about 150 million base pairs of nucleic acids (the building blocks of DNA ) and represents between 4.0 and 4.5% of the total DNA in cells . (wikipedia.org)

Humans normally have two copies of this chromosome, as they normally do with all chromosomes. (wikipedia.org)
This phenomenon occurs during spermatogenesis, resulting in three copies of the chromosome 21. (bvsalud.org)

2022. Pronounced sequence specificity of the TET enzyme catalytic domain guides its cellular function . (cardiff.ac.uk)

Mediates attachment of the chromosome to the meiotic or mitotic spindle . (amboss.com)

In the majority of cases, people affected by DS present free or simple trisomy 21, in which all cells in the body have a third chromosome of pair 21 3,4 . (bvsalud.org)
The remaining cases are due translocation, mosaicism and partial trisomy of the chromosome 21. (bvsalud.org)

Adenine and thymine always bond together as a pair, and cytosine and guanine bond together as a pair. (howstuffworks.com)
In the steps, adenine is paired with thymine and guanine is paired with cytosine. (msdmanuals.com)

Following a complex process of miRNA transcription, processing, and nuclear export, miRNAs are further processed by the RNaseIII enzyme, Dicer, and its cofactor TRBP. (biomedcentral.com)
The present study aimed to identify the probable anti‑Condyloma acuminata (CA) mechanism of microRNA‑375 (miRNA‑375) in human papillomavirus (HPV). (spandidos-publications.com)
The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. (nih.gov)
MiRNA-93: a novel signature in human disorders and drug resistance. (nih.gov)

However, as the enzymes maintaining the epigenetic states are responsive to various parameters, epigenetic signatures are also dynamic in nature, thus providing transcriptional plasticity in response to environmental stimuli and intrinsic and extrinsic cellular stress. (cardiff.ac.uk)

Specifically, they found that Mec1 senses when chromosomes are being replicated and transmits a molecular "wait" signal to DDK. (nyu.edu)
The recent emergence of the human-pathogenic Vibrio vulnificus in Israel was investigated by using multilocus genotype data and modern molecular evolutionary analysis tools. (cdc.gov)
We investigated this outbreak by combining a multilocus sequence typing approach ( 13 ) with molecular evolutionary analyses. (cdc.gov)
12 Similar to patients, the dystrophin mutant mdx mice do not express dystrophin 13 and have been widely used as a model system to study DMD and to make important advances in understanding therapeutic strategies as well as the molecular processes and underlying causes of the disease. (nature.com)

In this way, Mec1 acts like a traffic cop that allows chromosome replication to finish without interruption, before giving DDK the ok to begin the reshuffling. (nyu.edu)

A famous example of this is the L-gulonolactone oxidase that synthesizes vitamin C . All simians, including humans , share one pseudogene of inactivated L-gulonolactone oxidase, but the guinea pig has a different pseudogene indicating a different mutation. (rationalwiki.org)

if too many or too few centrioles are built, cell division errors can occur that lead to the generation of new cells with abnormal numbers of chromosomes. (elifesciences.org)
We have used comparative genomic hybridisation to analyse 19 constitutional chromosome abnormalities detected by G band analysis, including seven deletions, five supernumerary marker chromosomes, two interstitial duplications, and five chromosomes presenting with abnormal terminal banding patterns. (bmj.com)

Glutathione S - transferases ( GSTs ) involve a superfamily of multifunctional and ubiquitous phase II metabolic enzymes. (springeropen.com)
1997. Metabolic activation of aromatic amines by human pancreas. (cdc.gov)
icologic and metabolic data that explain the nasal and major differences are 4- to 10-fold more ring-oxidation lung differences and their relevance for human risk and phenylacetaldehyde pathways in mice compared assessment. (cdc.gov)

Cancers 13(10), article number: 2455. (cardiff.ac.uk)
Cancers at these sites can differ anatomically and histologically and might have different causal factors, such as tobacco use, alcohol use, and infection with human papillomavirus (HPV) (1). (cdc.gov)

It turned out that cells in human fibroblast culture live for a limited time under good conditions and are able to double approximately 50±10 times, and this number was called the Hayflick limit [6, 7]. (vechnayamolodost.ru)

Uridine diphosphate-glucuronosyltransferases (UGTs) are phase 2 conjugation enzymes mainly located in the endoplasmic reticulum (ER) of the liver and many other tissues, and can be recovered in artificial ER membrane preparations (microsomes). (mdpi.com)

Mapping By PCR analysis of a human-hamster somatic hybrid DNA panel, Funk et al. (wikipedia.org)

The crystal structures of human topoisomerase I comprising the core and carboxyl-terminal domains in covalent and noncovalent complexes with 22-base pair DNA duplexes reveal an enzyme that 'clamps' around essentially B-form DNA. (embl.de)
For this study, the researchers focused on serine integrases, which can insert huge chunks of DNA, as large as 50,000 base pairs. (sflorg.com)
This allows them to target any site in the genome for insertion of the landing site, which contains 46 DNA base pairs. (sflorg.com)
These nucleotides exist as base pairs that link together like the rungs in a ladder. (howstuffworks.com)
While the majority of DNA doesn't differ from human to human, some 3 million base pairs of DNA (about 0.10 percent of your entire genome) vary from person to person. (howstuffworks.com)

The core domain and the first eight residues of the carboxyl-terminal domain of the enzyme, including the active-site nucleophile tyrosine-723, share significant structural similarity with the bacteriophage family of DNA integrases. (embl.de)
and PGTsr, which involves specifically screening for a structural rearrangment of chromosomes such as balanced translocations. (medscape.com)
Although the structural chromosome abnormalities in these cases were too small to identify the origin of the extra genomic material based on banding pattern, none of the abnormalities described by these authors can be considered to be subtle or cryptic. (bmj.com)

Human ALOX15 was initially named arachidonate 15-lipoxygenase or 15-lipoxygenase but subsequent studies uncovered a second human enzyme with 15-lipoxygenase activity as well as various non-human mammalian Alox15 enzymes that are closely related to and therefore orthologs of human ALOX15. (wikipedia.org)

Uhlmann, F. SMC complexes: from DNA to chromosomes. (nature.com)

Orthologs of ALOX15, termed Alox15, are widely distributed in animal and plant species but commonly have different enzyme activities and make somewhat different products than ALOX15. (wikipedia.org)
Additionally, related Corynebacterium species have been found in granulomatous lobular mastitis in humans [6]. (kenyon.edu)
If the two species share a common ancestor, scientists should be able to figure out what happened to that chromosome. (rationalwiki.org)
A related, often sympatric species is Borrelia bissettii , but this species has not been associated with human disease. (cdc.gov)

However, in order for normal development to occur, chromosomes must be replicated prior to their reshuffling. (nyu.edu)
Mutations occur rarely, and in order for a cell to become cancerous - this is calculated for human fibroblasts - about 100 divisions must occur (this number of divisions usually occurs in a person at about the age of 40) [5]. (vechnayamolodost.ru)

C. mastitidis is an irregular bacterium within the genus that works as an opportunistic pathogen in immunocompromised animals as well as an important microbe on the ocular surface of mice [2] and humans [3]. (kenyon.edu)
C. mastitidis also has a role in the microbiome of the ocular surface in both mice [2] and humans [3]. (kenyon.edu)
Relevant of mutagenicity and clastogenici- angiosarcomas of the liver, which carcinogens discussed in this chap- ty, including the induction of sister are rare tumours, were identified in ter do not include pharmaceutical chromatid exchange (SCE), chro- humans, rats, and mice exposed to drugs classified in Group 1, which mosomal aberrations (CA), and mi- vinyl chloride. (who.int)
or each of these agents, carcinogenicity in rats and/or mice, els, differences in exposure con- there was sufficient evidence of car- for example for the liver (aflatoxins, ditions between studies in animals cinogenicity from studies in rats and/ trichloroethylene [TCE], and vinyl and in humans, or limitations in Part 1 · Chapter 1. (who.int)

Mutations in IDH3B, an enzyme participating in the Krebs cycle, have recently been found to cause autosomal recessive retinitis pigmentosa (arRP). (molvis.org)

The new tool, PASTE (Programmable Addition via Site-specific Targeting Elements), includes a Cas9 enzyme that cuts at a specific genomic site, guided by a strand of RNA that binds to that site. (sflorg.com)

By performing cell biological and biochemical experiments using human cells, Moyer and Holland show that PLK4 interacts with a protein called STIL that is found in the central part of the centriole. (elifesciences.org)
Testing the activity of PLK4 in fruit flies revealed that it plays a similar role as in human cells. (elifesciences.org)
In human cells , DNA is tightly wrapped into 23 pairs of chromosomes. (howstuffworks.com)
Human cells contain 22 pairs of homologous autosomes. (amboss.com)
A karyotype is a picture of the full set of chromosomes in a person's cells. (msdmanuals.com)
In platelets and other cells, factor XIII lacks the B domain, existing instead as an A 2 dimer. (medscape.com)
[ 4 , 5 ] The primary site for the synthesis of subunit A in plasma factor XIII seems to exist in cells that originate in the marrow. (medscape.com)
The enzyme is very specific for monocytes and macrophages, so identification and classification of malignant diseases involving these cells can be carried out by determining whether or not factor XIII is present. (medscape.com)

Without this restraining mechanism, chromosomes can end up irreversibly broken during meiosis. (nyu.edu)

Glutathione S-transferases (GSTs), a superfamily of multifunctional enzymes, play an important role in the onset and progression of renal cell carcinoma (RCC). (cancerindex.org)

results from their study show the importance of the RAD51 nucleoprotein filament conformation for stimulating DNA pairing by BLM . (medscape.com)

this, along with their different principal product formation (e.g. 12-HETE rather than 15-HETE) has made the findings of Alox15 functions in rat, mouse, or rabbit models difficult to extrapolate to the function of ALOX15 in humans. (wikipedia.org)
Unlike Topo IA enzymes, Topo IB enzymes do not require a single-stranded region of DNA or metal ions for their function. (embl.de)
Insulin-like growth factor-1 (IGF-1), synthesized and secreted by human hepatocytes, is the primary regulator of insulin and serves an important function in regulating the growth and development of the body ( 8 ). (spandidos-publications.com)

In platelets, a nonproteolytic process activates cellular factor XIII. (medscape.com)

The variant allele was found at a frequency of 0.275 in 151970 control chromosomes in the gnomAD Genomes database, including 6918 homozygotes. (genebe.net)
In past work, scientists have found it challenging to develop these enzymes for human therapy because the landing pads are very specific, and it's difficult to reprogram integrases to target other sites. (sflorg.com)
[ 3 ] while megakaryocytes are probably responsible for synthesizing the factor XIII found in platelets. (medscape.com)

Anatomy66

Organisms9

Diseases25

Chemicals and Drugs30

Analytical, Diagnostic and Therapeutic Techniques and Equipment26

Psychiatry and Psychology2

Phenomena and Processes172

Disciplines and Occupations2

Technology, Industry, Agriculture2

Information Science4

Health Care1

Genes30

Gene24

20231

Proteins4

Sets of chromosomes3

Chromosomal5

Homologous chromosomes5

Eukaryotic3

Sister chromatids1

Organism2

MRNA4

Cytochrome1

Nucleus4

Sequences3

Genetic4

Mitochondrial5

Recombination1

Consists2

Cell's1

Spans1

Copies2

20221

Mitotic1

Trisomy2

Cytosine2

MiRNA4

Epigenetic1

Molecular4

Replication1

Pseudogene1

Abnormal2

Metabolic3

Cancers2

Fibroblast1

Conjugation1

Somatic1

Base5

Structural3

Mammalian1

Complexes1

Species4

Occur2

Mice4

Mutations1

Strand1

Cells8

Mechanism1

Superfamily1

Nucleoprotein1

Function3

Activates1

Found3