• The aim of this study was to explore the role of target tissue biotransformation in OM-selective toxicity and the metabolic basis of the species differences in coumarin toxicity. (aspetjournals.org)
  • This study thus highlights the potential environmental significance of microbial processes for the mobility and toxicity of selenium in future repositories, which in turn contribute to their safe implementation. (ugr.es)
  • Co-Exposure of Phenanthrene and the cyp-Inducer 3-Methylchrysene Leads to Altered Biotransformation and Increased Toxicity in Fish Egg and Larvae. (uib.no)
  • New research suggests that diets rich in phytonutrients (nutrients from plant-based foods) may offset toxicity from pollutants and reduce disease risks associated with environmental toxicity. (alive.com)
  • Removal, biotransformation and toxicity variations of climbazole by freshwater algae Scenedesmus obliquus. (bvsalud.org)
  • Moreover, the toxicity of biotransformation products was much lower than its corresponding precursor compound (CBZ). (bvsalud.org)
  • There are two opinions to address the problem related to mercury toxicity: the risk of human contamination and the risk of environmental contamination. (bvsalud.org)
  • Environmental Science & Technology Letters 2023 , 10 (3) , 214-221. (acs.org)
  • For doing so, the in vitro biotransformation data inserted by the user are automatically extrapolated to the corresponding in vivo rates (in vitro-in vivo extrapolation) and then used in the BCF prediction model. (ufz.de)
  • Besides in vitro biotransformation data, information on the modelled fish and information on the partition properties of the chemical of interest are required as input. (ufz.de)
  • Krause, S. and K.-U. Goss, 2020, Comparison of a simple and a complex model for BCF prediction using in vitro biotransformation data. (ufz.de)
  • Dr Mohamed Abdallah has wide experience in applying mass spectrometric techniques for analysis of trace levels of environmental pollutants in biotic and abiotic matrices including different human tissues. (birmingham.ac.uk)
  • During his PhD studies, Dr. Abdallah published 19 papers in high-impact peer-reviewed journals investigating environmental behaviour, fate, human exposure and risk assessment of persistent organic pollutants (POPs). (birmingham.ac.uk)
  • ALTERNATIVE?s proof-of-concept validation will be performed on well-known mixtures of pollutants, affecting different environmental compartments, and selected via epidemiological, toxicological and modelling expertise. (europa.eu)
  • Detoxification Support - Xenobiotics, including environmental pollutants and medications, must undergo biotransformation into molecules that can be easily excreted from the body. (acuatlanta.net)
  • The results of this study revealed that S. obliquus might have a great impact on the environmental fates of CBZ and could be further applied to remove organic pollutants in aquatic environment . (bvsalud.org)
  • My expertise lies in answering questions about how environmental pollutants interact with organisms on a molecular level. (lu.se)
  • The main objective of research in my laboratory is to understand how environmental pollutants interfere with and change biological processes in organisms from natural, wild populations. (lu.se)
  • How the high number of gene copies is involved in the complicated life histories of salmonids and affect the displayed high sensitivity to environmental pollutants seen in these species is currently unknown. (lu.se)
  • The use of tadalafil (sales data Sweden 2020) has been considered to result in insignificant environmental risk. (janusinfo.se)
  • Fass environmental information for Cialis (tadalafil) from Lilly (downloaded 2020-04-13). (janusinfo.se)
  • Applied and Environmental Microbiology Lab. (gist.ac.kr)
  • Applied and Environmental Microbiology , 74(6), 1914-1921. (matis.is)
  • Applied and Environmental Microbiology , 77(15), 5505-5512. (matis.is)
  • Applied and Environmental Microbiology 71: 7279-7284. (sisef.it)
  • Environmental Microbiology, 17, 2018-2034. (hutton.ac.uk)
  • Environmental Microbiology, 17, 2064-2075. (hutton.ac.uk)
  • Environmental Microbiology, 16, 1441-1451. (hutton.ac.uk)
  • Environmental Microbiology 15, 2173-2186. (hutton.ac.uk)
  • To describe biotransformation in earthworms, a TK model is going to be developed, and metabolites identified by analytical instruments will explain the main metabolic pathways involved in the degradation of a certain chemical. (sense.nl)
  • Biotransformation is accomplished through myriad metabolic detoxification pathways that take place in every tissue and organ, even the lungs and brain. (alive.com)
  • Since our regular food choices affect the activity of detoxification pathways to assist with toxin biotransformation, they also affect the body's sensitivity to toxic substances. (alive.com)
  • It is clear that the complex biotransformation pathways arsenic undergoes produces several chemical forms of arsenic that vary greatly in their toxicological potency. (nih.gov)
  • The more complex model considers blood flow limitation as well as the potential first-pass effect in the gills following chemical uptake via ventilation and the sequential order of GIT and liver biotransformation while the simple model neglects these specific features (for more details please refer to our corresponding paper). (ufz.de)
  • So far, few studies have analyzed biotransformation in soil invertebrates, and yet there are no available predictive models to estimate the metabolites of a given chemical in these organisms. (sense.nl)
  • PhD in Civil, Environmental and Chemical Engineering, RMIT University. (edu.au)
  • Increasing nitrate concentrations and total abundance of nitrifying taxa occur in parallel with precursor biotransformation. (uri.edu)
  • Further elucidation of interrelationships between precursor biotransformation and nitrogen cycling in ecosystems would help inform site remediation efforts. (uri.edu)
  • Isomer-specific biotransformation rates of a perfluorooctane sulfonate (PFOS) precursor by cytochrome P450 isozymes and human liver microsomes. (cdc.gov)
  • TK includes processes of uptake, elimination, internal distribution, and biotransformation of chemicals, whereas TD studies the processes leading to toxic effects. (sense.nl)
  • iv) After fulfilling these three criteria, the product must be biosafe: not produce mammalian toxins that affect users and consumers, and have a host range that does not include crops and beneficial organisms, and in most cases that it will not spread from application sites or have environmental residues beyond those needed to control the target pest. (weizmann.ac.il)
  • Hence, it is important to develop sound predictive TK models to estimate the time needed to start biotransformation and the metabolites that are formed afterward. (sense.nl)
  • This project fully characterizes the genetic variability of all known genes involved in arsenic biotransformation in a diverse group of ethnically defined, globally collected human samples of arsenic-exposed individuals. (nih.gov)
  • Levels of Hexabromocyclododecane in harbor porpoises and common dolphins from Western European seas, with evidence for stereoisomer-specific biotransformation by cytochrome P450. (elsevierpure.com)
  • To test if biotransformation by the cytochrome P450 system could explain the observed compositional difference with technical HBCD mixtures, a number of in vitro assays with microsomal preparations of liver were carried out. (elsevierpure.com)
  • This confirms the process of cytochrome P450 mediated biotransformation. (elsevierpure.com)
  • Although rat and harbor seal belong to different families of the mammalia than the cetaceans, we propose that biotransformation by the cytochrome P450 system is also the most likely process to explain the exclusive accumulation of alpha-HBCD in harbor porpoise and common dolphin. (elsevierpure.com)
  • Dive into the research topics of 'Levels of Hexabromocyclododecane in harbor porpoises and common dolphins from Western European seas, with evidence for stereoisomer-specific biotransformation by cytochrome P450. (elsevierpure.com)
  • Arsenic: Environmental health aspects with special reference to ground water in South Asia. (cdc.gov)
  • Thus, it is reasonable to expect that human biotransformation of arsenic is key to its toxic effects. (nih.gov)
  • Arsenic biotransformation appears to have a considerable degree of inter-individual variability that has the characteristics of being heritably determined, suggested by a number of studies, including reports of familial aggregation of urinary arsenic metabolite levels. (nih.gov)
  • Third National Report on Human Exposure to Environmental Chemicals. (cdc.gov)
  • In environmental risk assessment, the fish bioconcentration factor (BCF) has been established as an assessment criterion for estimating the bioaccumulation potential of chemicals. (ufz.de)
  • CICADs join the Environmental Health Criteria documents (EHCs) as authoritative documents on the risk assessment of chemicals. (inchem.org)
  • But the most serious fact is that it can undergo a process known as biotransformation, when the metallic mercury is converted into an organic form by the action of algae and bacteria. (bvsalud.org)
  • The current soil risk assessment procedure follows a tiered approach, where a Tier 1 analysis is based on standard laboratory test results and estimates risks for the worst-case environmental scenarios. (sense.nl)
  • Workers in industries that use these agents may have occupational exposure, whereas other individuals may have environmental exposures if they live near industrial installations and/or have contact with contaminated water, soil, air, or food. (medscape.com)
  • In recent years, various environmental issues have aroused a concern on the pollution of pesticides in rivers and in their various intercompartments. (springer.com)
  • Environmental Pollution 147 (1): 231-237. (sisef.it)
  • I am interested in evolutionary history as well as gene expression dynamic of hormone receptors and how gene activities are influenced by anthropogenic factors (e.g. environmental pollutant and sewage treatment plant effluents) throughout the life cycle. (lu.se)
  • Persistence: 'Tadalafil disappeared from water sediment systems with half-lives of 70 and 117 days and there was evidence of biotransformation and mineralization. (janusinfo.se)
  • Molecular analyses can reveal changes that affect important system such as reproduction and biotransformation processes. (lu.se)
  • Glutathione S-transferases are phase II biotransformation enzymes that play a role in detoxifying a wide range of exogenous agents including carcinogens but also anticarcinogenic drugs. (nih.gov)
  • This family of enzymes is involved in the metabolism of pharmaceuticals, hormones, environmental toxicants, ketones, and fatty acids. (alive.com)
  • NIEHS research uses state-of-the-art science and technology to investigate the interplay between environmental exposures, human biology, genetics, and common diseases to help prevent disease and improve human health. (nih.gov)
  • However, the biotransformation rate at which the parent compound is degraded limits the overall bioaccumulation of the toxicant. (sense.nl)
  • Biotransformation was the predominant way to remove CBZ in the culture solution , whereas the contribution of bioaccumulation and bioadsorption were negligible. (bvsalud.org)
  • More commonly known as metabolic detoxification, biotransformation is the normal physiologic process of converting toxicants from the environment and from the body itself into compounds that can be safely mobilized and excreted from the body. (alive.com)
  • He subsequently took up the post of Lecturer at Birmingham in 2016, where he continues his research on emerging environmental contaminants. (birmingham.ac.uk)
  • RDX and HMX are widely used energetic materials and they are recognized as environmental contaminants at numerous locations. (mcmaster.ca)
  • Environmental Science & Technology 2016, 50 (6), 2908-20. (massbank.jp)
  • Nikoleris, L. , 2016 , Centre for Environmental and Climate Research (CEC) and Department of Biology, Faculty of Science, Lund University . (lu.se)
  • In other environmental species, long chain aliphatic alcohols are formed as part of fatty acid breakdown in aquatic invertebrates and vertebrates. (europa.eu)
  • Species has specific environmental requirements for the optimal growth. (scirp.org)
  • My thesis investigated how different genotypes contribute to biotransformation capacity in wild populations of Atlantic salmon (Salmo salar) carrying high loads of PCBs in their tissues. (lu.se)
  • 1 This research was supported in part by Grant ES-07462 from the National Institute of Environmental Health Sciences, National Institutes of Health. (aspetjournals.org)
  • Subsequently, He took a job as a lecturer in Assiut University, Egypt, where he continued his research in the environmental health field, and established collaborations with various international research groups via a Marie-Curie Staff Exchange Scheme. (birmingham.ac.uk)
  • If you are giving a presentation about an environmental health topic or just looking for general information about environmental health research or the institute, this page will help. (nih.gov)
  • NIEHS is committed to conducting the most rigorous research in environmental health sciences, and to communicating the results of this research to the public. (nih.gov)
  • NIEHS offers a broad range of job opportunities, career enhancement programs, and research training grants and programs in environmental health sciences and administration. (nih.gov)
  • I am now employed at the Center for Environmental and Climate Research (CEC) and have my research group at the Department of Biology in the Ecology Building. (lu.se)
  • Phytoplankton samples, water samples and in situ environmental parameters were collected during dry and wet seasons. (scirp.org)
  • This observation was confirmed by all methods and the examination of the impact of geological conditions on the biotransformation process was facilitated by the unique combination of the applied methods. (lu.se)
  • Not all smokers develop lung cancer, indicating that genetic variations and other environmental factors may play an important role in its development. (nih.gov)
  • The environmental fate of the major constituents of Alcohols, C9-11-branched and linear is summarised as follows. (europa.eu)
  • The environmental fate of docosan-1-ol is summarised as follows. (europa.eu)
  • School of Earth Sciences and Environmental Engineering Gwangju Institute of Science and Technology, 61005, korea Tel. +82-62-715-2455, 2472 Fax. (gist.ac.kr)
  • The Institute offers graduate studies in M.S. and Ph.D. levels in the fields of Environmental Sciences and Environmental Technology. (boun.edu.tr)
  • The National Institute of Environmental Health Sciences (NIEHS) is expanding and accelerating its contributions to scientific knowledge of human health and the environment, and to the health and well-being of people everywhere. (nih.gov)
  • Environmental Monitoring and Assessment, 30, 105-112. (springer.com)
  • Environmental Monitoring and Assessment, 98, 381-389. (springer.com)
  • The U.S. Environmental Protection Agency (EPA) recently published its draft Perc assessment (U.S. EPA, 2009). (who.int)
  • Together, these data provide multiple lines of evidence supporting microbially limited biotransformation of C6 sulfonamido precursors involving ammonia-oxidizing archaea ( Nitrososphaeria ) and nitrite-oxidizing bacteria ( Nitrospina ). (uri.edu)
  • In B-compass fish, biotransformation data from in vitro assays with cells or S9 fraction can be used for BCF prediction. (ufz.de)
  • Journal of Exposure Science and Environmental Epidemiology. (cdc.gov)
  • Journal of exposure science & environmental epidemiology 2019 Jun 29 (4): 539-547. (cdc.gov)
  • Do environmental pharmaceuticals affect the composition of bacterial communities in a freshwater stream? (umu.se)
  • Environmental Health Perspectives Vol 110, number 7, 729-733. (cdc.gov)
  • Bulletin Environmental Contamination and Toxicology, 66, 171-177. (springer.com)
  • Polish Journal of Environmental Studies, 13 (2), 133-138. (springer.com)
  • Students with an engineering background receive an M.S. or Ph.D. in Engineering upon completion of the M.S. or Ph.D. program in Environmental Technology. (boun.edu.tr)
  • Environmental engineering requires sound knowledge and understanding of fundamental principles, but also an aptitude for creative thinking. (edu.au)
  • PhD in Environmental Engineering, University of New South Wales. (edu.au)
  • Environmental Science and Technology, 39 , 3464-3473. (springer.com)
  • Environmental Science and Technology, 38 , 5290-5296. (springer.com)
  • Environmental Science and Technology, 38, 3551-3557. (springer.com)
  • Environmental Science and Technology. (uib.no)