• induces
  • This induces long-range allostery via protein domain dynamics, causing the structure to be destabilized, resulting in the opening up of the SH3, SH2 and kinase domains and the autophosphorylation of the residue tyrosine 416. (wikipedia.org)
  • MAPK
  • Additionally, activated Brx also recruits and physically interacts with JIP4, a p38 MAPK-specific scaffold protein. (wikipedia.org)
  • The addition of a p38 MAPK inhibitor was found to correlate with decreased NFAT5 expression, even in the presence of osmotic stress signals. (wikipedia.org)
  • transmembrane
  • Full length human M-CSF transcripts encode a 522 amino acid (aa) type I transmembrane (TM) protein with a 464 aa extracellular region, a 21 aa TM domain, and a 37 aa cytoplasmic tail that forms a 140 kDa covalent dimer. (rndsystems.com)
  • selectively
  • We have reported that UCN-01 (7-hydroxystaurosporine) abrogates DNA damage-induced S and G 2 arrest and enhances cytotoxicity selectively in p53 mutant cells, thus providing a potential, tumor-targeted therapy. (aacrjournals.org)
  • We have previously identified the compound cambinol, an inhibitor of the human sirtuins SIRT1 and SIRT2, which is selectively toxic to Burkitt's lymphoma cells. (washington.edu)
  • Cyclic
  • Uniaxial cyclic strain (1 Hz, 20%) of cells cultured on elastic membranes induced a 2-fold increase in both PAR-1 mRNA and protein levels. (ahajournals.org)
  • Cyclic strain (20%) induced PAR-1 mRNA expression, leading to an increase in surface PAR-1 protein and an increase in cell proliferation in response to thrombin. (ahajournals.org)
  • heat shock pr
  • Once ruptured, particles and substances are released, including: (1) high mobility group B-1 (HMGB1) (2) heat shock proteins and (3) various other proteases. (wikipedia.org)
  • degradation
  • Activated IKKs phosphorylate the inhibitory proteins, IκBα and IκBβ, leading to their degradation and release of NF-κB transcription factors into the nucleus ( 8 , 14 , 15 ). (jimmunol.org)
  • mediate
  • Src contains at least three flexible protein domains, which, in conjunction with myristoylation, can mediate attachment to membranes and determine subcellular localization. (wikipedia.org)
  • This provides docking sites for 14-3-3 proteins, which mediate the export of HDAC5 out of the nucleus. (wikipedia.org)
  • enzymes
  • These methods allowed her to characterize UGT1A1, the gene coding for an enzyme in this family that processes the protein bilirubin, a breakdown product of hemoglobin, and to identify 12 other previously unknown and independent UGT enzymes. (wikipedia.org)
  • Owens' research group also identified that UGT enzymes must be activated before they can detoxify foreign chemicals and that in some cases suppressing these enzymes could enhance the effects of therapeutic drugs. (wikipedia.org)
  • This is useful for control of cellular signaling because the di-phosphorylated phosphoinositide PIP2 is only phosphorylated by the family of enzymes, PI 3-kinases (phosphoinositide 3-kinase or PI3-K), and only upon receipt of chemical messengers which tell the cell to begin the growth process. (wikipedia.org)
  • gene
  • We have synthesized analogues of these compounds, identifying more selective sirtuin inhibitors and more potent calmodulin-dependent protein kinase inhibitors.The sirtuins are a family of NAD+-dependent deacetylases that regulate cellular aging and gene silencing in simple organisms and appear to play important regulatory roles in human cells that make them attractive anti-cancer targets. (washington.edu)
  • G1/S-specific cyclin-D2 is a protein that in humans is encoded by the CCND2 gene. (wikipedia.org)
  • The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. (wikipedia.org)
  • Sprouty homolog 2 (Drosophila), also known as SPRY2, is a protein which in humans is encoded by the SPRY2 gene. (wikipedia.org)
  • This gene encodes a protein belonging to the sprouty family. (wikipedia.org)
  • Two transcript variants encoding the same protein have been found for this gene. (wikipedia.org)
  • performed showed that chronic cocaine use induced upregulation of the NK1 receptor protein in HDAC5 knockout mice, which is associated with hyperacetylation of H3 at the NK1R gene promoter. (wikipedia.org)
  • The NK1R gene promoter has been associated with enhanced response to cocaine reward, meaning HDAC5 in normal genomes may decrease cocaine reward with chronic cocaine exposure. (wikipedia.org)
  • Phospholamban, also known as PLN or PLB, is a protein that in humans is encoded by the PLN gene. (wikipedia.org)
  • Proteins belonging to this family play a central role in inducible gene transcription during the immune response. (wikipedia.org)
  • Peroxiredoxin-1 is a protein that in humans is encoded by the PRDX1 gene. (wikipedia.org)
  • dependent
  • Exocytosis is, as expected, Ca2+ dependent and appears to be under a negative control involving protein phosphorylations. (jci.org)
  • As a probable mechanism, we found that sDPP-4 caused dose-dependent increases in the expression levels of toll-like receptor 4 (TLR4) and TLR2 in RAW264.7 cells, and that these alterations were inhibited by vildagliptin, M6P, or bisindolylmaleimide II, a protein kinase C inhibitor. (gopubmed.org)
  • Exposure of the bag cell neurons of Aplysia to activators of protein kinase C, such as phorbol esters, enhances electrically evoked action potentials by increasing the voltage-dependent calcium current. (jneurosci.org)
  • Cyclins function as regulators of cyclin-dependent kinases. (wikipedia.org)
  • cellular
  • Another cellular enzyme, RNAse L-also induced by interferon action-destroys RNA within the cells to further reduce protein synthesis of both viral and host genes. (wikipedia.org)
  • synthesis
  • the phosphorylated eIF-2 forms an inactive complex with another protein, called eIF2B, to reduce protein synthesis within the cell. (wikipedia.org)
  • Inhibited protein synthesis destroys both the virus and infected host cells. (wikipedia.org)
  • While certain templates of programmed cell death have been known to rely on de novo protein synthesis, paraptotic cell death induced by IGFIR-IC in 293T cells is deterred by actinomycin D and cycloheximide, thus demonstrating a dependence on transcription and translation. (wikipedia.org)
  • agonist
  • Thus, activators of PKA, such as the beta-adrenergic agonist epinephrine (released by sympathetic stimulation), may enhance the rate of cardiac myocyte relaxation. (wikipedia.org)
  • Additionally
  • Additionally, research found that caspase inhibitors (zVAD.fmk, p53, BAF), x-chromosome-linked inhibitor (xiap), and Bcl-xL( from the Bcl-2 family) did not prevent cell death in 293T cells when induced by IGFIR-IC. (wikipedia.org)
  • Expression
  • In addition, treatment of cells with antioxidants or an NADPH oxidase inhibitor blocked strain-induced PAR-1 expression. (ahajournals.org)
  • One of these inhibitors, the p.o. active ZD1839, has marked effects against the growth of the A431 tumor, which exhibits high levels of expression of EGFR. (aacrjournals.org)
  • Treatment with a protein kinase C inhibitor partially decreased losartan-mediated RGS2 mRNA expression. (gopubmed.org)
  • Chk1 must inactivate in order for the cell to transition from the G2 phase into mitosis, Chk1 expression levels are mediated by regulatory proteins. (wikipedia.org)
  • The proteins in this family are expressed in nearly every tissue in the body and are known transcriptional regulators in cytokine and immune cell expression. (wikipedia.org)
  • homology
  • citation needed] Akt possesses a protein domain known as a PH domain, or Pleckstrin Homology domain, named after Pleckstrin, the protein in which it was first discovered. (wikipedia.org)
  • Like the other Rel proteins, NFAT5 contains the Rel homology domain, a conserved DNA-binding domain. (wikipedia.org)
  • tumor cells
  • These observations demonstrate selectivity for enhancing toxicity in cells with mutated p53 (many tumor cells), whereas cells with wild-type p53 (normal cells) are spared. (aacrjournals.org)
  • Interferons (IFNs) are a group of signaling proteins made and released by host cells in response to the presence of several pathogens, such as viruses, bacteria, parasites, and also tumor cells. (wikipedia.org)
  • chromatin
  • In apoptosis, HMGB1, a chromatin protein, is retained within the nucleus to result in formations of apoptotic bodies, while in paraptosis HMGB1 is released. (wikipedia.org)
  • induce
  • In addition, interferons induce production of hundreds of other proteins-known collectively as interferon-stimulated genes (ISGs)-that have roles in combating viruses and other actions produced by interferon. (wikipedia.org)
  • shown
  • In a phase 2 multicenter study, sotrastaurin, a protein kinase C inhibitor, has shown promise in preserving renal graft function but lacks potency as an immunosuppressive agent. (gopubmed.org)
  • This protein may play a role in alveoli branching during lung development as shown by a similar mouse protein. (wikipedia.org)
  • The neurite outgrowth instigated by bucladesine in cell cultures has been shown to be enhanced by nardosinone. (wikipedia.org)
  • Recent studies have shown that administering HDAC inhibitors can help reduce the craving for cocaine in rats. (wikipedia.org)
  • cell
  • In general, we advise purchasing the recombinant protein with BSA for use in cell or tissue culture, or as an ELISA standard. (rndsystems.com)
  • The isozyme protein kinase C (PKC) β is involved in several processes that are deregulated in different retinal cell types by hyperglycemia. (gopubmed.org)
  • The height and width of electrically evoked action potentials in bag cell neurons can also be enhanced by cAMP analogs or agents that elevate cAMP. (jneurosci.org)
  • We have found that microinjection of a protein inhibitor of cAMP-PK (PKA-I) into isolated bag cell neurons prevents and reverses the effect of the adenylate cyclase activator forskolin on action potentials of these cells. (jneurosci.org)
  • An inhibitor of several protein kinases, tesevatinib (XL647, KD019) entered Phase II clinical trial for certain indications of non-small cell lung cancer. (wikipedia.org)
  • c-Src is a widely studied member of non-receptor tyrosine kinases which are not associated with a cell-surface receptor. (wikipedia.org)
  • Therefore, paraptosis was concluded to differ from apoptosis (cell death type 1) in being unaffected by inhibitors of apoptosis. (wikipedia.org)
  • molecules
  • IFNs belong to the large class of proteins known as cytokines, molecules used for communication between cells to trigger the protective defenses of the immune system that help eradicate pathogens. (wikipedia.org)