• The transcription factor CCAAT/enhancer binding protein beta (C/EBPβ) is expressed in Pax7 + satellite cells of healthy muscle and is downregulated during myoblast differentiation. (biomedcentral.com)
  • CCAAT/enhancer binding proteins (C/EBPs) are a family of transcription factors that regulate cellular growth and differentiation, metabolism, and inflammation [ 18 ]. (biomedcentral.com)
  • CCAAT enhancer binding protein beta [So. (gsea-msigdb.org)
  • Paired box protein Pax-7 is a protein that in humans is encoded by the PAX7 gene. (wikipedia.org)
  • Guanine nucleotide exchange factor GEF115 specifically mediates activation of Rho and serum response factor by the G protein alpha subunit Galpha13. (umassmed.edu)
  • A homeobox protein and transcription factor that localizes to the cell nucleus where it activates expression of thyroid specific genes such as THYROGLOBULIN and the THYROTROPIN RECEPTOR. (bvsalud.org)
  • PAX7 functions as a marker for a rare subset of spermatogonial stem cells, specifically a sub set of Asingle spermatogonia. (wikipedia.org)
  • Lats1/2 Sustain Intestinal Stem Cells and Wnt Activation through TEAD-Dependent and Independent Transcription. (umassmed.edu)
  • pRB functions as a negative regulatory transcription factor during the G1 to S phase cell cycle transition. (medscape.com)
  • Pax-7 plays a role in neural crest development and gastrulation, and it is an important factor in the expression of neural crest markers such as Slug, Sox9, Sox10 and HNK-1. (wikipedia.org)
  • Aberrant PAX3 and PAX7 expression. (wikipedia.org)
  • Persistent expression of C/EBPβ upregulates Pax7, inhibits MyoD, and blocks myogenic differentiation. (biomedcentral.com)
  • Using genetic tools to conditionally abrogate C/EBPβ expression in Pax7 + cells, we examined the role of C/EBPβ in self-renewal of satellite cells during muscle regeneration. (biomedcentral.com)
  • Despite its cellular simplicity (five pairs of neurons), the MG exhibits conservation of transcription factor expression with the spinal cord of vertebrates. (biologists.com)
  • p53 is a transcription factor whose expression is increased by DNA damage and blocks cell division at the G1 phase of the cell cycle to allow DNA repair. (medscape.com)
  • Rapidly expanding technological innovations have led to a resurgence of interest in defining the factors that enable regenerative healing, and in coupling these factors to human therapeutic interventions. (frontiersin.org)
  • Suppression of glycogen synthase kinase activity is not sufficient for leukemia enhancer factor-1 activation. (umassmed.edu)
  • Pax7 is a transcription factor that plays a role in myogenesis through regulation of muscle precursor cells proliferation. (wikipedia.org)
  • The transcription factor Foxp3 is usually considered the master regulator for the CD4+CD25+ "Treg" lineage, which plays a key role in controlling immune and autoimmune responses, and is characterized by a unique transcriptional signature. (gsea-msigdb.org)
  • Discovery of a new class of reversible TEA domain transcription factor inhibitors with a novel binding mode. (umassmed.edu)
  • 10. PAX3-FOXO1 Establishes Myogenic Super Enhancers and Confers BET Bromodomain Vulnerability. (nih.gov)
  • Pax7 is a transcription factor that plays a role in myogenesis through regulation of muscle precursor cells proliferation. (wikipedia.org)
  • 6. Alveolar rhabdomyosarcoma-associated proteins PAX3/FOXO1A and PAX7/FOXO1A suppress the transcriptional activity of MyoD-target genes in muscle stem cells. (nih.gov)
  • 14. Pax7-FKHR transcriptional activity is enhanced by transcriptionally repressed MyoD. (nih.gov)
  • Expression of the myogenic regulatory factors required to promote differentiation, MYOD and MYOG, was downregulated in the absence of JARID2, even though decreases in the methylation of histone H3 lysine 27 (H3K27 me3 ) were observed on both promoters. (biomedcentral.com)
  • Skeletal muscle differentiation is controlled by four highly related basic helix-loop-helix proteins known as the myogenic regulatory factors (MRFs), which include MYF5, MYOD, MYOG and MYF6. (biomedcentral.com)
  • Myogenin is a member of the MyoD family of myogenic basic helix-loop-helix (bHLH) transcription factors that also includes MyoD, Myf-5, and MRF4 (also known as herculinor Myf-6). (novusbio.com)
  • MyoD family members are expressed exclusively in skeletal muscle and play a key role in activating myogenesis by binding to enhancer sequences of muscle-specific genes. (novusbio.com)
  • In addition to activating muscle specific genes, members of the MyoD family members activate their own transcription and transactivate the transcription of other MyoD family members. (novusbio.com)
  • In this context, fusions that involve fibroblast growth factor receptor 2 (FGFR2) and function as oncogenes in a subset of patients with intrahepatic CC (ICC) represent particularly attractive targets for adoptive cell therapy. (bvsalud.org)
  • Transcription factors, proteins that bind to the regulatory sequences of target genes, compose the largest class of oncogenes identified in pediatric tumors. (medscape.com)
  • A homeobox protein and transcription factor that localizes to the cell nucleus where it activates expression of thyroid specific genes such as THYROGLOBULIN and the THYROTROPIN RECEPTOR . (nih.gov)
  • Proteína homeótica y factor de transcripción que se localiza en el núcleo celular donde activa la expresión de genes tiroideos específicos como el de la TIROGLOBULINA y el RECEPTOR DE TIROTROPINA. (bvsalud.org)
  • HN - 2006(1998) MH - Activating Transcription Factor 1 UI - D051697 MN - D12.776.260.108.61.500 MN - D12.776.930.127.61.500 MS - An activating transcription factor that regulates expression of a variety of genes including C-JUN GENES and TRANSFORMING GROWTH FACTOR BETA2. (nih.gov)
  • The methylation of H3K27 by PRC2 requires the presence of one of the enhancer of Zeste proteins, EZH1 or EZH2. (biomedcentral.com)
  • HN - 2006(1981) BX - Actin-Capping Proteins MH - Actin Depolymerizing Factors UI - D051339 MN - D5.750.78.730.212 MN - D12.776.220.525.212 MS - A family of low MOLECULAR WEIGHT actin-binding proteins found throughout eukaryotes. (nih.gov)
  • The Sox6 transcription factor is a key regulator of fast-twitch muscle fiber differentiation in the zebrafish, a role similar to that ascribed to its murine ortholog. (biomedcentral.com)
  • Differential requirements for different subfamilies of the mammalian SWI/SNF chromatin remodeling enzymes in myoblast cell cycle progression and expression of the Pax7 regulator. (umassmed.edu)
  • e.g. they bind selectively to DNA, stimulate transcription resulting in tissue-specific RNA synthesis and undergo specific changes in response to various hormones or phytomitogens. (umassmed.edu)
  • PAX7 functions as a marker for a rare subset of spermatogonial stem cells, specifically a sub set of Asingle spermatogonia. (wikipedia.org)
  • pRB functions as a negative regulatory transcription factor during the G1 to S phase cell cycle transition. (medscape.com)
  • PAX7 may also function in the recovery in spermatogenesis. (wikipedia.org)