Loading...
  • reactivity
  • We, therefore, sought to determine the mechanism of this enhanced vasoconstrictor reactivity by assessing vasoconstriction and VSM Ca2+ responses to the endothelium-derived vasoconstrictor peptide endothelin-1 (ET-1). (unm.edu)
  • Given evidence that Rho kinase (ROK), PKC and reactive oxygen species (ROS) contribute to the development of PH, we addressed their respective contributions to augmented pulmonary vasoconstrictor reactivity to ET-1 following E-IH. (unm.edu)
  • type
  • About one third of patients with type 1 diabetes develops kidney disease. (physiology.org)
  • The endothelin system has recently been demonstrated to regulate oxygen availability in the diabetic kidney via a pathway involving endothelin type A receptors (ETA-R). These receptors mainly mediate vasoconstriction and tubular sodium retention, and inhibition of ETA-R improves intrarenal oxygenation in the diabetic kidney. (physiology.org)
  • Endothelin type B receptors (ETB-R) can induce vasodilation of the renal vasculature and also regulate tubular sodium handling. (physiology.org)
  • 2000
  • Pulmonary fibrosis and chronic lung inflammation in ET-1 transgenic mice," American Journal of Respiratory Cell and Molecular Biology , vol. 23, no. 1, pp. 19-26, 2000. (hindawi.com)
  • potent
  • A single oral dose (3 to 10 mg/kg) of J-104132 (L-753 037), a potent, orally active mixed endothelin A and B (ET A /ET B ) receptor antagonist, reduced blood pressure to normotensive levels in DS rats with high salt intake, and its action was maintained for ≥24 hours. (ahajournals.org)
  • Endothelin-1 (ET-1) is known to have not only potent vasoconstrictive action but also mitogenic action on smooth muscle. (ahajournals.org)
  • renal
  • To explore these mechanisms, we examined the effects of a highly selective ET B antagonist (A-192621.1), a calcium channel blocker (verapamil), a nitric oxide synthase inhibitor ( N -nitro- l -arginine methyl ester [L-NAME]), and a cyclooxygenase inhibitor (indomethacin) on the systemic and renal actions of big ET-1 in anesthetized rats. (ahajournals.org)
  • Glomerular filtration rate and renal plasma flow significantly decreased only at the highest dose of big ET-1. (ahajournals.org)
  • Moreover, A-192621.1 potentiated the decline in glomerular filtration rate and renal plasma flow and the increase in mean arterial blood pressure produced by the low doses of big ET-1. (ahajournals.org)
  • Unlike verapamil and L-NAME, only indomethacin administration was associated with significant natriuretic/diuretic responses and did not influence the pressor effect and renal actions of big ET-1. (ahajournals.org)
  • experimental
  • In this project the investigators aim to study the effects of ET-1 on the human brain, to investigate aura-inducing effects of ET-1 in patients and to develop a safe and reliable method for the experimental induction of migraine aura using ET-1. (clinicaltrials.gov)
  • This mini-review surveys epidemiological and experimental air pollution studies focused on ET-1 dysregulation as a plausible mechanism underlying the development of cardiovascular disease. (springer.com)
  • concentrations
  • Plasma irET-1 concentrations in young (6-week-old) and mature (18-week-old) SHR did not differ from those of age-matched Wistar-Kyoto (WKY) rats. (ahajournals.org)
  • Plasma irET-1 concentrations were not increased in the 2K1C rats. (ahajournals.org)
  • Serial quantitative measurements of plasma pro-endothelin-1 concentrations in very preterm infants. (clinicaltrials.gov)
  • amino acids
  • Studies suggest that this antibody binds to an epitope in the region of ET-1 represented by amino acids 8-16. (abcam.com)
  • vitro
  • Big Endothelin-1 can be hydrolyzed by chymase to generate endothelin 1 (1-21) in vitro. (anaspec.com)
  • This review assessed these in vitro findings, with a specific focus toward elucidating the mechanism underlying the NO-mediated negative regulation of ET-1-dependent increased arterial pressure, as demonstrated after acute NOS inhibitor in vivo. (ahajournals.org)
  • Bosentan
  • Bosentan was injected as an intravenous bolus (3 mg/kg) followed by a 1-hour infusion at a rate of 7 mg · kg −1 · h −1 . (ahajournals.org)
  • Plasma endothelin-1 levels, similar under basal conditions in healthy and hypertensive dogs, increased 30-fold with bosentan ( P =.0001). (ahajournals.org)
  • The increase of plasma endothelin-1 with bosentan, due either to a displacement of endothelin-1 from its receptor or to a feedback mechanism, does not prevent this blood pressure reduction. (ahajournals.org)
  • Pathways
  • 24,25 In the present study, we demonstrate that ET-1 prevents apoptosis induced by serum deprivation in cultured cardiac myocytes and investigate the signaling pathways that mediate the antiapoptotic effect of ET-1. (ahajournals.org)
  • intravenous
  • An intravenous bolus injection of incremental doses of big ET-1 (0.3, 1.0, and 3.0 nmol/kg) produced a significant hypertensive effect that was dose dependent and prolonged (from 113±7 mm Hg to a maximum of 148±6 mm Hg). (ahajournals.org)
  • exogenous
  • 1 , 2 This mechanism is essentially supported by demonstrations that NOS inhibitor enhanced the constrictor effects of exogenous ET-1 in several in vivo and ex vivo preparations. (ahajournals.org)
  • protein
  • These kits can be used to measure soluble human or rat big ET-1 protein in serum, EDTA-plasma, cell culture supernatants, or tissue extracts. (clontech.com)
  • Full length protein corresponding to Human Endothelin 1 conjugated to Keyhole Limpet Haemocyanin (KLH). (abcam.com)
  • SRL did not impair Edep vasorelaxation or increase sensitivity to vasospasm while lowering ET-1 levels and preserving eNOS protein expression. (ahajournals.org)
  • Endothelin receptor type A, also known as ETA, is a human G protein-coupled receptor. (wikipedia.org)
  • Infusion
  • Current animal evidence indicates that infusion of endothelin-1 (ET-1), a naturally occurring signaling molecule released from blood vessels, is safe and very likely to trigger migraine aura in patients. (clinicaltrials.gov)
  • 1994
  • The most cited of her peer-reviewed journal publications include: Jones TA, Schallert T "Use-Dependent Growth Of Pyramidal Neurons After Neocortical Damage" Journal of Neuroscience 14 (4): 2140-2152 Apr 1994 Times Cited: 255 Jones TA, Schallert T "Overgrowth And Pruning Of Dendrites In Adult-Rats Recovering From Neocortical Damage" Brain Research 581 (1): 156-160 May 22, 1992 Times Cited: 148 Jones TA, Chu Cj, Grande La, Et Al. (wikipedia.org)
  • human
  • These products are affinity-purified IgG antibodies that recognizes human and rat big ET-1. (clontech.com)
  • 1,2 It has been demonstrated in the myocardium from failing human hearts, 3 in patients with dilated cardiomyopathy and arrhythmogenic right ventricular dysplasia, 4,5 and in association with myocardial infarction. (ahajournals.org)
  • cardiac
  • These findings suggest that ET-1 prevents apoptosis in cardiac myocytes through the ET A receptor and the subsequent c-Src/Bcl-x L -dependent pathway. (ahajournals.org)
  • 23 In cardiac myocytes, ET-1 prevents oxidative stress- and β-adrenergic agonist-induced apoptosis. (ahajournals.org)
  • mRNA
  • PreproET-1 mRNA expression was determined by reverse transcription-polymerase chain reaction. (ahajournals.org)
  • In the kidney, expression of preproET-1 mRNA was greater in DS rats on a normal salt diet compared with DR rats of the same age. (ahajournals.org)
  • In DS rats, the level of preproET-1 mRNA expression in kidney had a significant correlation with systolic blood pressure. (ahajournals.org)
  • The expression of preproET-1 mRNA in aorta and kidney was increased by 3-week high salt intake in DS rats but not in DR rats. (ahajournals.org)
  • Expression of preproET-1 mRNA and ET-1 levels in left ventricle was exaggerated by high salt intake in DS rats. (ahajournals.org)
  • To assess the production of ET-1 in vivo, we determined the expression of preproET-1 mRNA in the aorta, heart, and kidney reverse transcription-polymerase chain reaction (PCR) and measured plasma and heart ET-1 levels in DS and Dahl salt-resistant (DR) rats with and without high-salt intake for 3 weeks. (ahajournals.org)
  • acute
  • 18,19 In patients with acute myocardial infarction, plasma ET-1 levels are elevated 20,21 and are correlated with 1-year mortality. (ahajournals.org)
  • 1 Indeed, the importance of sustained, NO inhibition of the ET-1 drive to increase tone is exemplified in vivo by the rapid, ET-1-mediated arterial pressure elevation after acute NO synthase (NOS) inhibition. (ahajournals.org)