• human
  • To confirm and extend these observations, we examined the effect of engaging, cross-linking, or expressing PECAM-1 on NF-κB activation in a variety of human cells. (jimmunol.org)
  • mechanism
  • Since metastases are rarely cleared by blood-borne cells from the immune system, we asked whether the tumor may escape host defense by interfering with the mechanism of effector cell extravasation. (rupress.org)
  • We propose that the downregulation of VCAM-1 is a mechanism by which vascularized melanoma and carcinoma avoid invasion by cytotoxic cells of the immune system. (rupress.org)
  • However, the mechanism by which PECAM-1, and specifically endothelial PECAM-1, is protective against exaggerated inflammation is poorly understood. (jimmunol.org)
  • function
  • Prevents phagocyte ingestion of closely apposed viable cells by transmitting 'detachment' signals, and changes function on apoptosis, promoting tethering of dying cells to phagocytes (the encounter of a viable cell with a phagocyte via the homophilic interaction of PECAM1 on both cell surfaces leads to the viable cell's active repulsion from the phagocyte. (uniprot.org)