Endothelial cells muscle smooth vascular. Medical search. Frequent questions

Endothelial progenitor cells (EPCs) are cells derived from the bone marrow which differentiate into endothelial cells to help support the vascular endothelium and create new blood vessels. (wikipedia.org)
48: 1538-1547 Bouvier, C.A., Gaynor, E., Clintron, J.R. et al (1970) Circulating endothelium as an indicator of vascular injury. (wikipedia.org)
Atherosclerosis starts with dysfunctional changes in the endothelium induced by disturbed shear stress which can lead to endothelial and platelet activation, adhesion of monocytes on the activated endothelium, and differentiation into proinflammatory macrophages, which increase the uptake of oxidized LDL (oxLDL) and turn into foam cells, exacerbating the inflammatory signalling. (hindawi.com)
Therefore, with the aim to summarize the current knowledge on the initiation of the atherosclerotic process, in this paper, we review the early markers of atherosclerosis and we address the main therapeutic targets for preventing atheroma formation at its very initial stages focusing on inflammation, oxidative stress, endothelial dysfunction, and the interaction between platelets and endothelium. (hindawi.com)
The vascular endothelium modulates contractile responses to 5-HT and ET-1 in human subcutaneous resistance arteries but this effect is lost in patients with NPG, indicating a selective defect in agonist mediated release of endothelium derived vasodilators. (bmj.com)
9 Impaired systemic vascular function has been demonstrated in patients with NPG in whom blood flow in the fingers is reduced 10, 11 (both under basal conditions and following cold provocation) and endothelium dependent vasodilatation in the forearm is impaired. (bmj.com)
YAP was localized in the vascular endothelium within the CNV site. (molvis.org)
9. Chan CK, Vanhoutte PM. Hypoxia, vascular smooth muscles and endothelium Acta Pharmaceutica Sinica B. 2013;3(1):1-7. (scielo.br)
Cerebral endothelium is a one cell layer on the inner wall of the vessels and as such is a difficult subject to image. (hindawi.com)
Normally, the endothelium forms an integral cellular barrier to regulate vascular homeostasis. (surrey.ac.uk)

Endothelial cells normally line blood vessels to maintain vascular integrity and permeability, but when these cells enter into the circulation, this could be a reflection of vascular dysfunction and damage. (wikipedia.org)
CECs are known to express endothelial markers such as the blood glycoprotein von Willebrand factor (vWF) which is involved in platelet aggregation and adhesion, CECs also express the cell surface protein CD146 which is the most commonly known endothelial marker found in CECs and plays an important role in permeability, cell-cell cohesion and signalling. (wikipedia.org)
Endothelial cells are highly metabolically active and play an important role in many physiological functions, including the control of vasomotor tone, blood cell trafficking, haemostatic balance, permeability, proliferation, and immunity. (hindawi.com)
2-5 These mechanisms reduce inflammatory cellular response, vascular permeability, fibrin exudation, and scar formation. (dovepress.com)
vasculogenesis and vascular permeability and has been implicated in the pathogenesis of pre-eclampsia. (who.int)
Belik J. The contribution of arterial versus venous vascular permeability in peritoneal fluid formation. (bvsalud.org)
peritoneal fluid accumulation is a common finding in many children with abdominal disorders and its generation secondary to increased vascular permeability. (bvsalud.org)
The purpose of the present study as to evaluate the effect of changes in intravascular pressure and the inflammatory mediator bradykinin on rat mesenteric arterial and venous vascular permeability. (bvsalud.org)
Vascular permeability to dextran was determined at 100, 200 and 300 % of physiological pressures. (bvsalud.org)
vascular permeability was present at all measurements for both vessels and its magnitude directly proportional to the intravascular pressure. (bvsalud.org)
Changes in vascular permeability are lial cells tethered together by junctional proteins commonly present in certain clinical diseases such as tight and adherens junctions. (bvsalud.org)

Atherosclerosis is a chronic vascular inflammatory disease associated to oxidative stress and endothelial dysfunction. (hindawi.com)
Factors such as anatomic stresses (eg, coarctation of the aorta) that contribute to an increased afterload (end-systolic wall stress), as well as neurohormonal factors that increase systemic vascular resistance, also lead to systolic dysfunction. (medscape.com)
Causes of primary diastolic dysfunction include an anatomic obstruction that prevents ventricular filling (eg, pulmonary venous obstruction), a primary reduction in ventricular compliance (eg, cardiomyopathy, transplant rejection), external constraints (eg, pericardial effusion), and poor hemodynamics after the Fontan procedure (eg, elevated pulmonary vascular resistance). (medscape.com)
Recently, endothelial dysfunction (ED) has been demonstrated in these patients, but the mechanisms remain elusive. (mdpi.com)
Conclusions: This study has identified dysfunction of the systemic vascular endothelial cell in patients with normal pressure glaucoma. (bmj.com)
It has been proposed that vascular dysfunction contributes to the pathogenesis of glaucoma and, in particular, NPG as this condition is associated with the presence of widespread cerebrovascular and systemic cardiovascular disease. (bmj.com)
The mechanisms of vascular dysfunction have been investigated in a number of conditions, including hypertension 13 and diabetes, 14 using subcutaneous arteries isolated from biopsies of gluteal fat. (bmj.com)
This approach has the advantage of studying vascular dysfunction directly in arteries from patients (rather than animal models) and uses resistance arteries which contribute significantly to maintenance of blood pressure. (bmj.com)
One of the causes of erectile dysfunction is the inability of the penile smooth muscle to relax. (cssbasics.com)
In erectile dysfunction, impaired nitric oxide occurs when the penile smooth muscle does not function properly. (cssbasics.com)
Cerebral endothelial dysfunction is mentioned in the pathophysiology of several neurological diseases. (hindawi.com)
Janowska J, Chudek J, Olszanecka-Glinianowicz M, Semik-Grabarczyk E, Zahorska-Markiewicz B. Interdependencies among Selected Pro-Inflammatory Markers of Endothelial Dysfunction, C-Peptide, Anti-Inflammatory Interleukin-10 and Glucose Metabolism Disturbance in Obese Women. (medsci.org)
We have studied the relationship between clinical and biochemical parameters and C-peptide and anti-inflammatory IL-10, as well as selected markers of inflammation and endothelial dysfunction such as: CCL2, CRP, sICAM-1, sVCAM-1 and E-selectin in obese women with various degree of glucose metabolism disturbance. (medsci.org)
Disturbed lipid and carbohydrate metabolism are manifested by enhanced inflammation and endothelial dysfunction in patients with simply obesity. (medsci.org)
Pulmonary arterial hypertension (PAH) is a progressive disease characterized by lung endothelial cell dysfunction and vascular remodeling. (surrey.ac.uk)
This microvascular dysfunction is associated with adherence of polymorphonuclear leukocytes and generation of reactive species at the vessel walls, and resultant scavenging of nitric oxide secreted from dilator-stimulated endothelial cells. (cdc.gov)
Neutrophil depletion or antioxidants partially reverse this vascular dysfunction.There also appears to be a neurogenic component to these cardiovascular changes, since inhibition of pulmonary sensory neurons or neuronal input to the arteriolar smooth muscle partially reverses these effects. (cdc.gov)

Circulating endothelial progenitor cells, vascular function, and cardiovascular risk. (wikipedia.org)
Circulating endothelial progenitor cells and cardiovascular outcomes. (wikipedia.org)
Human endothelial progenitor cells (hEPCs) are adult stem cells, located in the bone marrow and peripheral blood. (intechopen.com)
Different phenotypes and subtypes of endothelial progenitor cells (EPCs), such as early and late EPCs, have been described according to their functionality. (intechopen.com)
Likewise, these cells give rise to progenitor cells committed to a particular cell lineage, and play a crucial role in tissue repair and homeostasis. (bvsalud.org)

Sphingosine 1-phosphate (Sph-1-P), a bioactive lysophospholipid capable of inducing a wide spectrum of biological responses, acts as an intercellular mediator, through interaction with the endothelial differentiation gene (EDG)/S1P family of G protein-coupled receptors. (nih.gov)
Does not induce differentiation of vascular smooth muscle cells or endothelial cells. (tocris.com)
BMPs are involved in a host of cellular functions including osteogenesis , cell growth and cell differentiation . (wikidoc.org)
BMPR2 is expressed on both human and animal granulosa cells, and is a crucial receptor for bone morphogenetic protein 15 (BMP15) and growth differentiation factor 9 (GDF 9). (wikidoc.org)
At these sites, which are a compound of stromal cells, extracellular matrix and soluble factors, complex molecular interactions that maintain the essential properties of stem cells occur, such as self-renewal and differentiation into multiple lineages, according to the organism's needs. (bvsalud.org)

She is particularly known for her work on mechanisms of vascular endothelial eicosanoid generation and recent studies have identified biological roles for novel fatty acid metabolites in vascular repair and angiogenesis. (rvc.ac.uk)
Genomic actions involve the regulation of target genes, and suppress most of the vascular elements of inflammation and angiogenesis in the airway. (ersjournals.com)
Transcriptional coactivator Yes-associated protein (YAP) can promote the proliferation of multiple cancer cells, corneal endothelial cells, and vascular smooth muscle cells, which participate in angiogenesis. (molvis.org)
TIMP-1 also protects against apoptosis in B cells, stimulates erythropoiesis and BFU-E expansion, both stimulates and inhibits tumor growth, inhibits angiogenesis, and stimulates gonadal steroidogenesis in conjuction with Cathepsin L. (rndsystems.com)
While the general molecular principles of angiogenesis and peripheral nerve development have been described, how these two processes are coordinated to form the intranervous vascular system is virtually unknown. (elifesciences.org)
These cells can be differentiated into mature endothelial cells, which are involved in processes of angiogenesis and vessel regeneration. (intechopen.com)
This chapter provides an overview of the key role of hEPC in promoting angiogenesis and their potential use for cell therapy. (intechopen.com)

The atherosclerotic process is accelerated by a myriad of factors, such as the release of inflammatory chemokines and cytokines, the generation of reactive oxygen species (ROS), growth factors, and the proliferation of vascular smooth muscle cells. (hindawi.com)
BMPR2 functions to inhibit the proliferation of vascular smooth muscle tissue. (wikidoc.org)

The group uses in vitro, ex vivo and in vivo cell and molecular approaches to delineate the signalling pathways controlling gene expression and functional responses of human and murine large vessel and microvascular endothelial cells.Caroline was an associate editor of the Biochemical Journal for over 10 years and is a founder member of the European Vascular Biology Organisation and of the London Vascular Biology Forum. (rvc.ac.uk)

There are many factors involved in the process of creating CECs, including: reduced interaction between the endothelial cells and basement membrane proteins, damaged endothelial cellular adhesion molecules, mechanical injury, decreased survival of cytoskeletal proteins, and inflammation. (wikipedia.org)
King's College London) fuelled her interest in vascular cellular signalling and her subsequent post-doctoral position with Professor Jeremy Pearson at King's College London (KCL) allowed her to pursue this interest in human endothelial cells. (rvc.ac.uk)
Recent advances in the understanding of the cellular mechanisms responsible for these vascular abnormalities may ultimately lead to new therapeutic approaches for the treatment of asthma. (ersjournals.com)
Immunofluorescent double staining was used to detect YAP cellular localization with CD31 (an endothelial cell marker) antibody. (molvis.org)
To learn about basic mitochondrial and cellular biology, understand mechanisms of disease, and develop drugs, cell culture is indispensable. (brocku.ca)
Recently, we have focused on understanding how standard cell culture approaches, which fail to replicate in vivo conditions, affect various cellular functions. (brocku.ca)
Because age-related cellular senescence and type 2 diabetes (T2D) have been recognised as risk factors for CRC development, the recent finding that type 2 diabetic patients present an elevated circulating volume of senescent cells raises the question whether type 2 diabetes facilitates the process of CRC tumorigenesis by inducing premature cell senescence. (frontiersin.org)
The increased resistance observed for the non-endothelial cell types was accompanied by an increased rate of cellular attachment, even though spontaneous migration was comparable to the control, i.e., to the standard cultivation surface. (nature.com)
Among numerous physiological tasks, the vascular network transports oxygen and nutrients and eliminates waste products, all critical for organ survival and cellular homeostasis. (elifesciences.org)
Rejuvenation therapies aim to reverse or repair age-related cellular changes such as molecular waste, calcification , tissue stiffening , loss of stem cell function , genetic alterations, and impaired energy production . (fightaging.org)

It appears that the hormones estrogen and follicle stimulating hormone (FSH) have roles in regulating expression of BMPR2 in granulosa cells. (wikidoc.org)
HN - 2008 BX - Von Ebner's Glands MH - Cumulus Cells UI - D054885 MN - A05.360.319.114.630.535.200.500 MN - A06.407.312.497.535.300.500 MN - A11.436.300.500 MS - The granulosa cells of the cumulus oophorus which surround the OVUM in the GRAAFIAN FOLLICLE. (bvsalud.org)
HN - 2008 BX - Granulosa Cells, Cumulus MH - Coronary Sinus UI - D054326 MN - A07.231.908.194.500 MS - A short vein that collects about two thirds of the venous blood from the MYOCARDIUM and drains into the RIGHT ATRIUM. (bvsalud.org)

In fact, several studies have shown that T2D induces senescence in multiple types of cells, including fibroblasts and endothelial cells ( 11 , 12 ). (frontiersin.org)
Clinical Manifestations and Diagnosis The clinical presentation of AAC is usually nonspecific, but tradihg in differ- entiated cells, induces transcription factors that profitabe vate stress response strateggy [Witt et al. (forextrading-madeeasy.com)

As demonstrated on LF fibroblasts, the resistance to trypsin was similar in serum-supplemented and serum-free media, i.e., medium without cell adhesion-mediating proteins. (nature.com)
Based on all the results, the increased resistance to trypsinization of C2C12, LF, HaCaT, and VSMC cells on amine PPs can be explained most probably by a non-specific cell adhesion such as electrostatic interaction between the cells and amine groups on the material surface, rather than by the receptor-mediated adhesion through serum-derived proteins adsorbed on the PPs. (nature.com)
Hyperglycemia contributes to glycosylation of proteins and lipids, increases the production of reactive oxygen species, stimulates the synthesis and secretion of pro-inflammatory cytokines and acute phase proteins in various tissues, promoting thus inflammation processes in the vascular wall [ 2 , 3 ]. (medsci.org)
Induced EndoMT cells exhibited up-regulation of mesenchymal markers, including collagen type I and α-smooth muscle actin, and a reduction in endothelial cell and junctional proteins, including von Willebrand factor, CD31, occludin, and vascular endothelial-cadherin. (surrey.ac.uk)

Our previously-obtained impressive results of highly increased C2C12 mouse myoblast adhesion to amine plasma polymers (PPs) motivated current detailed studies of cell resistance to trypsinization, cell proliferation, motility, and the rate of attachment carried out for fibroblasts (LF), keratinocytes (HaCaT), rat vascular smooth muscle cells (VSMC), and endothelial cells (HUVEC, HSVEC, and CPAE) on three different amine PPs. (nature.com)

Activation of the VEGFA/VEGFR2 signaling and expression of blood vascular endothelial cell (BEC) markers, such as NRP1 and EphrinB2, further differentiate these precursor cells into BECs, which then form the hierarchical network of blood vessels 4 . (nature.com)
The compound relaxes the inner muscles of blood vessels, allowing a constant supply of nutrients and oxygen to every organ. (cssbasics.com)
Although Stathmin is widely expressed throughout the body, it has been found to be highly abundant within cells that are associated with blood vessels. (prospecbio.com)
These cells are referred to as tone-like because they are able to control the diameter of blood vessels, which helps regulate the blood pressure within the body. (prospecbio.com)
We show that, while the axon guidance molecule Netrin-1 promotes nerve invasion by blood vessels via the endothelial receptor UNC5B during embryogenesis, myelinated Schwann cells negatively control intra-nervous vascularization during post-natal period. (elifesciences.org)
To become functional, blood vessels mature and specialize by recruitment of mural cells and form a network of arteries, capillaries, and veins. (elifesciences.org)
Thus, it has been shown that early EPCs release cytokines that promote tissue regeneration and neovasculogenesis, whereas late EPC and endothelial colony forming cells (ECFCs) contribute to the formation of blood vessels and stimulate tube formation. (intechopen.com)
hEPCs have been used for cell-based therapies due to their capacity to contribute in the re-endothelialization of injured blood vessels and neovascularization in ischemic tissues. (intechopen.com)

Cardiac stem and progenitor cell identification: different markers for the same cell? (nih.gov)

The left ventricle (LV) must generate a relatively high-pressure gradient to overcome the high systemic vascular resistance (SVR), whereas the RV needs to generate a lower pressure gradient to overcome the lower pulmonary vascular resistance (PVR). (medscape.com)

In the present study, we focus on the proliferation of human arterial smooth muscle cells (SMCs) from NIDDM patients (DM-SMCs) to clarify the reactivity to the growth factor(s) in fetal calf serum (FCS) and the factors) secreted by T-cells. (diabetesjournals.org)
Endothelial function is not uniform throughout the arterial system. (hindawi.com)
It functions by promoting the survival of pulmonary arterial endothelial cells, therefore preventing arterial damage and adverse inflammatory responses. (wikidoc.org)
It also inhibits pulmonary arterial proliferation in response to growth factors, which prevents the closing of arteries by proliferating endothelial cells. (wikidoc.org)
the abdominal fluid accumulation related to bowel inflammatory disease is more likely to be secondary to venous, as opposed to arterial vascular leakage. (bvsalud.org)
o acúmulo de líquido abdominal relacionado à doença inflamatória intestinal é mais prová- vel de ser secundária a venosa, em oposição à fuga vascular arterial. (bvsalud.org)

Cardiovascular (CV) risk factors such as hypercholesterolemia, hyperglycaemia, obesity, hypertension, smoking, and aging promote vascular inflammation and endothelial activation [ 7 - 9 ]. (hindawi.com)
lipid- and inflammation-mediated insulin resistance in skeletal muscle and vasculature. (rvc.ac.uk)
Over lifetime, due to the action of several stressors such as DNA damage and telomere shortening, senescent cells accumulate in the organism and release a variety of pro-inflammatory cytokines responsible for low-grade inflammation. (frontiersin.org)

Glucocorticoids bind steroid receptors in the cytoplasm, alter DNA expression and inhibit formation of inflammatory mediators such as interleukin-6 (IL-6), IL-8, prostaglandins, and vascular endothelial growth factor (VEGF). (dovepress.com)
Thanks to the expression of specific receptors, tip cells can sense the microenvironment, and respond to guidance cues to lead the angiogenic sprout. (elifesciences.org)

In particular, it plays a vital role in the physiological and pathological activities of the three important cells, Endothelial cells, macrophages and vascular smooth muscle cells. (wjgnet.com)
In conclusion CVR-L-Arg is a promising noninvasive research method that could provide means for evaluation of cerebral endothelial function in physiological and pathological conditions. (hindawi.com)

The product decreases oxidative stress in the region of smooth muscles giving you impressive stamina and endurance during lovemaking. (cssbasics.com)
The bioactive components of Red Boost enhance the performance of smooth muscle and reduce oxidative stress by producing adequate nitric oxide. (cssbasics.com)

Context-dependent regulation of endothelial cell metabolism: differential effects of the PPARβ/δ agonist GW0742 and VEGF-A. Sci Rep. 2020 May 12;10(1):7849. (rvc.ac.uk)
YAP expression increased following laser exposure, in accordance with vascular endothelial growth factor (VEGF) expression. (molvis.org)
Among them, VEGF-A can promote the division and proliferation of vascular endothelial cells and neovascularization and maintain the survival of new vessels. (molvis.org)
Its receptor binding site is VEGF-A, which is known to promote vascular generation and leakage and to cause nAMD. (molvis.org)
ABSTRACT We evaluated the prognostic value of serum endostatin and vascular endothelial growth factor (VEGF) for diagnosis of pre-eclampsia. (who.int)
RÉSUMÉ Nous avons évalué la valeur pronostique de l'endostatine et du facteur de croissance endothéliale vasculaire (VEGF) dans le sérum pour le diagnostic de la prééclampsie. (who.int)

During early stages of embryogenesis, by a process called vasculogenesis, a part of the mesoderm differentiates into endothelial cells, forms a lumen, and deposits a basal lamina to create a vascular plexus de novo. (elifesciences.org)
During embryogenesis endothelial cells exhibit substantial plasticity that contribute to cardiac development by undergoing endothelial-to-mesenchymal transition (EndoMT). (surrey.ac.uk)

Neutrophil migration in response to factors secreted by the treated endothelial cells was then assessed. (bl.uk)
The genesis of an inappropriate oxidative burst by the neutrophil upon exposure to endothelial chemoattractants and adhesion molecules was also measured. (bl.uk)
Neutrophil adhesion to ECV304 cells, which had been hypoxic for 4 hours and then reoxygenated for 30 minutes, was significantly increased. (bl.uk)
ROS generation in turn caused the release of a soluble factor (s) which induced a conformational change on the neutrophil surface allowing it to bind to the intercellular adhesion molecule 1 (ICAM-1) on the endothelial cell. (bl.uk)
Soluble factor (s) from hypoxia/reoxygenated endothelial cells also had a powerful neutrophil chemoattractant ability. (bl.uk)

Proliferating cell nuclear antigen (PCNA) expression in CNV mice without or with YAP siRNA intravitreal injection and the colocalization of PCNA and CD31 were measured with western blotting and immunofluorescent double staining, respectively. (molvis.org)

Icariin, as an antiapoptotic, inhibits such cell death. (cssbasics.com)

Vascular calcification is commonly observed in chronic kidney disease. (spandidos-publications.com)
The mechanism of how the calcification signal from endothelial cells is transmitted to vascular smooth muscle cells (VSMCs) remains unknown. (spandidos-publications.com)
Ren SC, Mao N, Yi S, Ma X, Zou JQ, Tang X and Fan JM: Vascular calcification in chronic kidney disease: An update and perspective. (spandidos-publications.com)
Nelson AJ, Raggi P, Wolf M, Gold AM, Chertow GM and Roe MT: Targeting vascular calcification in chronic kidney disease. (spandidos-publications.com)
Yamada S and Giachelli CM: Vascular calcification in CKD-MBD: Roles for phosphate, FGF23, and Klotho. (spandidos-publications.com)

This multiscale model includes single-scale models for stent deployment, blood flow and tissue growth in the stented vessel, including smooth muscle cell (SMC) proliferation and extracellular matrix (ECM) production. (springer.com)
43 Therefore, cell sheets with enhanced thickness and mechanical properties obtained through appropriate cyclic mechanical stimulation possess great potential for bone tissue engineering applications. (researchgate.net)
Cell sheet-based scaffold-free technology holds promise for tissue engineering applications and has been extensively explored during the past decades. (researchgate.net)
Findings from this study reveal that thermo-responsive elastomer, together with mechanical conditioning, can potentially be applied to prepare high-quality cell sheets for bone tissue engineering. (researchgate.net)
Low dose lithium supplementation promotes adipose tissue browning and SERCA uncoupling in muscle. (brocku.ca)
Therefore, many laboratories try with great effort to develop resorbable tissue scaffolds that could support the patient´s cells. (nature.com)
ECM provides mechanical support for cells and also determines the shape of tissue 9 . (nature.com)
Finally to appraise how tissue function might be affected by endothelial cell hypoxia the contractility of vascular smooth muscle was examined. (bl.uk)
Niches are special microenvironments in tissue where stem cells are located. (bvsalud.org)
Likewise, the knowledge of stem cell biology is crucial to the development of stem cell therapies, based on tissue engineering applied to dentistry, seeking the regeneration of dental tissues damaged or lost by caries, trauma or genetic diseases. (bvsalud.org)

Methods were initially developed to examine the adhesion of neutrophils to monolayers of a cultured endothelial cell line (ECV304) after periods of hypoxia and reoxygenation. (bl.uk)
The secretory products from hypoxia/reoxygenated endothelial cells also affected smooth muscle contractility having an anti-vasoconstrictor or relaxation property, similar to that exerted by PAF. (bl.uk)
Histologic assessment of patients with systemic sclerosis-associated PAH and the hypoxia/SU5416 mouse model identified the presence von Willebrand factor/α-smooth muscle actin-positive endothelial cells in up to 5% of pulmonary vessels. (surrey.ac.uk)

Researchers are hoping that the HD-CEC test will be used to predict cardiovascular diseases such as acute MI, angina and heart failure and analyze vascular damage. (wikipedia.org)
C. Characterize the interaction between the microbiome, host health and nutrition to modify physiology and promote health and development (skeleton, gastrointestinal and hepatic tissues, immune system, cardiovascular, and muscle, e.g. (usda.gov)
Dietary Factors and Physical Activity Effects on Health, Development and Function of Organ Systems (skeleton, gastrointestinal and hepatic tissues, immune system, cardiovascular, and muscle, e.g. (usda.gov)
Therapies based on the application of stem cells have great potential in the prevention and treatment of several diseases, such as cancer, diabetes, cardiovascular disease, spinal cord injuries, neurological diseases such as Parkinson's and Alzheimer's, and in the regeneration of various tissues and organs. (bvsalud.org)

She co-ordinated the Comparative Physiology and Medicine reserach programme for 3 years (2009-2012) Caroline's major research interest is in endothelial cell signalling. (rvc.ac.uk)
My research in cell physiology focuses on mitochondrial biology in the context of health, aging, and disease. (brocku.ca)
These morphological changes affect cell physiology and are therefore important to measure and understand. (brocku.ca)
American Journal of Physiology - Cell Physiology. (brocku.ca)
check the tag ADOLESCENCE HN - 2008 BX - Nutrition in Adolescence FX - Adolescent Nutrition Physiology MH - Peritoneal Stomata UI - D054048 MN - A01.047.025.600.700 MN - A10.810 MS - Natural openings in the subdiaphragmatic lymphatic plexus in the PERITONEUM, delimited by adjacent mesothelial cells. (bvsalud.org)

Using mouse genetic models, the authors show that Schwann cells regulate vascularization of the sciatic nerve and are required for a decrease in vascular density postnatally. (elifesciences.org)

In this study, the effects of JTE-013, a specific antagonist of the migration-inhibitory receptor EDG-5, on Sph-1-P-elicited responses were examined in human umbilical vein endothelial cells (HUVECs) and vascular smooth muscle cells (SMCs), which expressed EDG-5 protein weakly and abundantly, respectively. (nih.gov)
17 Since it is formed by growth and proliferation of smooth muscle cells (SMCs) in the vessel wall, the composition of a restenotic lesion is different from the initial lesion: a restenotic lesion mainly consists of SMCs and the extracellular matrix (ECM) they produce. (springer.com)
T-cells increased DNA synthesis of SMCs, and DM-SMCs strikingly reacted to T-cells. (diabetesjournals.org)

Caroline is a Professor of Vascular Cell Biology and is Head of Comparative Biomedical Sciences. (rvc.ac.uk)
Caroline was appointed to a Lectureship position at the Royal Veterinary College in late 1997 and now holds a personal Chair in Vascular Cell Biology. (rvc.ac.uk)
Caroline is an internationally recognised expert in vascular cell signalling and biology with 20 years' experience in the field. (rvc.ac.uk)
Cell Biology and Toxicology. (brocku.ca)
However, further studies are required to gain complete understanding of stem cell biology, which is fundamental for the development of successful cell-based therapies 1-3 . (bvsalud.org)

Endothelial cell phenotypes are differentially regulated in space and time, giving rise to the phenomenon of endothelial cell heterogeneity. (hindawi.com)

[7] When this gene is inhibited, vascular smooth muscle proliferates and can cause pulmonary hypertension, which, among other things, can lead to cor pulmonale, a condition that causes the right side of the heart to fail. (wikidoc.org)

To facilitate this we developed the Mitochondrial Network Analysis (MiNA) toolset as a simple set of macros making use of existing ImageJ plug-ins that allows a semi-automated analysis of mitochondrial networks in cultured mammalian cells. (brocku.ca)
2022. An inexpensive 'homemade' incubator for mammalian cell culture capable of regulating O 2 , CO 2 , and temperature. (brocku.ca)

Red wine polyphenolic compounds inhibit vascular endothelial growth factor expression in vascular smooth muscle cells by preventing the activation of the p38 mitogen-activated protein kinase pathway. (igbmc.fr)

Prior to a myocardial infarction (MI or heart attack), plaque may accumulate in the coronary arteries, Some plaque formations may rupture, causing a mechanical dislodgment of endothelial cells creating CEC. (wikipedia.org)
The plaque that stays lodged in the coronary arteries may restrict blood flow to the cardiac muscle. (wikipedia.org)
Smooth muscle, as the name suggests, does not contain striations located at hollow organs such as the stomach, intestine and at, walls of arteries and veins, and in a tract of the urinary, repertory, and reproductive system. (cssbasics.com)

Glycolysis is an important metabolic pathway that generates energy in various cells of the blood vessel wall. (wjgnet.com)

During development, the blood vascular system arises from endothelial cell progenitors that differentiate from mesodermal cells, mostly through the expression of the transcription factor (TF) ETV2. (nature.com)
The structure is essential because native ECM creates space where the cells are anchored, communicate, proliferate, differentiate, and die. (nature.com)
Simultaneously, SC precursors (SCP) derive from the neural crest cells and migrate from the neural tube around embryonic day E10.5 to contact axons and differentiate into immature SC (iSC) around E15/E16 ( Woodhoo and Sommer, 2008 ). (elifesciences.org)
Dental pulp stem cells have been isolated from deciduous and permanent teeth and have the potential to self-renew and differentiate. (bvsalud.org)

PCS (n = 17), PCS/CFS (n = 13), and healthy controls (HC, n = 14) were screened for serum anti-endothelial cell autoantibodies (AECAs) and dysregulated cytokines. (mdpi.com)

Analysis of the supernatant from hypoxic/reoxygenated endothelial cell cultures and studies using inhibitors of secretion suggested platelet activating factor (PAF) may be a major component in this overall sequence of events. (bl.uk)
It may also invade and proliferate within heart and coronary artery endothelial cells, and, along with Streptococcus sanguis, it may also induce platelet aggregation associated with thrombus formation. (medscape.com)

In addition to inflammatory cell infiltration in the bronchial wall 1 , histological analysis of endobronchial biopsy specimens and new methods of blood flow measurements have revealed prominent alterations of the tracheobronchial (airway) vasculature in patients with asthma. (ersjournals.com)
Currently increasing importance is attributed to the inflammatory process as a crucial factor responsible for the progressive damage to vascular walls and progression of atherosclerosis in obese people. (medsci.org)

The vascular actions of corticosteroids contribute to controlling clinical symptoms of asthma primarily by influencing airway calibre in the lung periphery and airway hyperreactivity. (ersjournals.com)
These cell- and when occurring in the lung or brain lead to to-cell connections allow for the formation of serious consequences related to impaired gas inter-endothelial gaps through which substances exchange and cerebral function, respectively. (bvsalud.org)

Our results indicate that specific regulation of Sph-1-P-modulated migration responses in vascular cells can be achieved by EDG-5 antagonists and that manipulation of Sph-1-P biological activities by each EDG antagonist may lead to a therapeutical application to control vascular diseases. (nih.gov)

ITD 1 is also offered as part of the Tocriscreen 2.0 Max and Tocriscreen Stem Cell Library . (tocris.com)
We're thrilled to have Chad Cowan, an associate professor at Harvard University who is at the Harvard Stem Cell Institute. (medscape.com)
Chad and I have both been principal investigators on the induced pluripotent stem cell (IPSC) grant. (medscape.com)
I fell in love with the idea of human pluripotent stem cells and started surveying the United States and even Europe for who was playing in that area. (medscape.com)
At International Society for Stem Cell Research-the big stem cell meeting-Yamanaka revealed one more factor. (medscape.com)
Some adult stem cell niches have already been described, but the majority of them remain unclear, including the dental pulp stem cell niches. (bvsalud.org)
However, little is known about the exact anatomic location of these cells, and the relationship between stem cells and surrounding cells in dental pulp. (bvsalud.org)
Understanding how stem cells behave in the niche is extremely important in order to extract these cells from their natural habitat, expand them in vitro and transplant the stem cells back to the patient, to repair and/or regenerate tissues and organs, with no risks to the individual's integrity. (bvsalud.org)
Stem cells. (bvsalud.org)
that is, they have the ability to generate other stem cells and perpetuate themselves. (bvsalud.org)

However, it is critical to maintain conditions similar to those cells experience in vivo. (brocku.ca)
We determined the presence of EndoMT in the pulmonary vasculature in vivo and the functional effects on pulmonary artery endothelial cells (PAECs) undergoing EndoMT in vitro. (surrey.ac.uk)

Characterization of circulating endothelial cells in acute myocardial infarction. (wikipedia.org)
Controlling these factors reduces the risk of acute vascular complications and death from CVD [ 1 , 7 ]. (hindawi.com)

Aim: Vascular risk factors, and particularly vasospasm, are thought to play a part in the pathogenesis of normal pressure glaucoma (NPG). (bmj.com)

12 The relatively small number of studies to have assessed vascular reactivity and blood flow in the systemic circulation of these patients, however, prevents identification of the mechanisms underlying these abnormalities. (bmj.com)
In this review, the role of cerebrovascular reactivity to L-arginine (CVR-L-Arg) for assessment of cerebral endothelial function is discussed. (hindawi.com)
In the past few years cerebrovascular reactivity to L-arginine by means of TCD has emerged as a parameter for evaluation of cerebral endothelial function [ 3 - 7 ]. (hindawi.com)

Her major research interests are focused on the molecular control of endothelial cell function in health and disease. (rvc.ac.uk)
Her laboratory specialises in investigating the functional relevance of molecular signalling pathways in human and animal endothelial cells and a range of other vascular cell types. (rvc.ac.uk)
focus is primarily on vascular cell function with emphasis on understanding molecular control mechanisms. (rvc.ac.uk)
This study showed that YAP upregulation promoted CNV formation by upregulating the proliferation of endothelial cells, providing evidence for the molecular mechanisms of CNV and suggesting a novel molecular target for nAMD treatment. (molvis.org)

Endothelial cells in vascular smooth muscle relax by the discharge of nitric oxide. (cssbasics.com)
The product also enhances nitric oxide (NO) levels, a byproduct of nitric oxide synthase (NOS) prime factor for penile erection by relaxing cavernosal smooth muscles. (cssbasics.com)

TNF-α-activated endothelial cells promote VSMC proliferation and secretion of ICAM-1 and IL-8 by elevating IL-6 release. (geneticsmr.com)

Stathmin also has a high abundance in hypoxic cells, which are associated with regions of the body that have less oxygen. (prospecbio.com)
When neutrophils were exposed to both hypoxic/reoxygenated endothelial cells and the soluble factor (s) released by them a large oxidative burst was elicited. (bl.uk)

Circulating endothelial cells (CECs) are endothelial cells that have been shed from the lining of the vascular wall into the blood stream. (wikipedia.org)
The proliferation of choroidal endothelial cells (CECs) is one important step in the formation of new vessels. (molvis.org)

So far CVR-L-Arg has been used to study cerebral endothelial function in many pathological conditions such as stroke, migraine, etc. (hindawi.com)

Therefore, we investigated the effects of patients' sera on endothelia cells (ECs) in vitro. (mdpi.com)

Anatomy70

Organisms12

Diseases11

Chemicals and Drugs90

Analytical, Diagnostic and Therapeutic Techniques and Equipment21

Phenomena and Processes50

Disciplines and Occupations1

Information Science3

Endothelium10

Permeability11

Dysfunction17

Progenitor cells5

Differentiation5

Angiogenesis7

Proliferation of vascular smooth2

Microvascular endothelial1

Cellular10

Granulosa cells3

Induces2

Proteins4

Fibroblasts1

Blood vessels8

Markers1

Pulmonary vascular r1

Arterial6

Inflammation3

Receptors2

Physiological and pathological2

Oxidative stress2

VEGF6

Embryogenesis2

Neutrophil5

CD311

Inhibits1

Calcification5

Tissue10

Hypoxia3

Cardiovascular4

Physiology5

Regulate1

SMCs3

Biology5

Phenotypes1

Gene1

Mammalian2

Inhibit1

Arteries3

Vessel1

Differentiate4

Serum1

Platelet2

Inflammatory2

Lung2

Regulation1

Stem10

VIVO2

Acute2

Pathogenesis1

Reactivity3

Molecular4

Nitric oxide2

VSMC1

Hypoxic2

CECs2

Pathological conditions1

Vitro1