• kinase
  • Methods/Results -Using five different monoclonal antibodies (E29/anti-EMA, DF3, 139H2, VU-4H5, and SM3) that distinguish between various MUC1 glycoforms, high MUC1 expression (50-95% of tumour cells positive) was found in 13 of 17 anaplastic lymphoma kinase (ALK) positive systemic nodal ALCLs, and in one of 20 cases of classic HD. (bmj.com)
  • 1 In 30-50% of cases, a chromosomal aberration such as the t(2;5)(p23;q35) translocation gives rise to expression of the anaplastic lymphoma kinase (ALK) protein, 2 identifying a subgroup of patients with systemic ALCL with excellent prognosis. (bmj.com)
  • Advanced ALK-rearranged non-small cell lung cancer (NSCLC) patients will develop acquired resistance after anaplastic lymphoma kinase (ALK) inhibitors therapies. (springeropen.com)
  • Histological subtyping to maximise treatment efficacy and avoid toxicity has marked the beginning of the revolution, opening the way to molecular characterisation to guide genomically driven treatments with targeted agents, led by an Epidermal Growth Factor Receptor (EGFR) and Anaplastic Lymphoma Kinase (ALK) inhibitors. (ecancer.org)
  • Not to be confused with anaplastic lymphoma kinase (ALK) ) ALK4 is ACVR1B, ALK7 is ACVR1C, and ALK5 is [part of] the TGF-β type I receptor. (wikipedia.org)
  • numerous tyrosine kinase cell signaling proteins are responsible for the growth and proliferation of eosinophils {see clonal eosinophilia}), methotrexate and Hydroxycarbamide (both are chemotherapy and immunosuppressant drugs), and Alemtuzumab (a antibody that binds to the CD52 antigen on mature lymphocytes thereby marking them for destruction by the body). (wikipedia.org)
  • tumor cells
  • Similarly to other galectins, Gal-9 performs a role in cell aggregation and adhesion and in the apoptosis of tumor cells ( 10 , 11 ). (spandidos-publications.com)
  • The tumor cells primarily grow within the blood vessel lumina but may cause minimal extravascular infiltration around the involved vessels in some patients. (histopathology-india.net)
  • They include engagement of the B-cell receptor (BCR) by self or microbial antigens ( 6 ), influences mediated by T cells activated by microbial pathogens ( 7 ), host inflammatory responses ( 8 - 10 ), and the interface between tumor cells and stromal elements such as collagen interactions with integrins and other receptors ( 11 , 12 ). (aacrjournals.org)
  • In such cases, the goal is to excise as much of the mass (tumor cells) and as much of the tumor margin as possible without endangering vital functions or other important cognitive abilities. (wikipedia.org)
  • malignant
  • The importance of the malignant cell environment to its growth and survival is becoming increasingly apparent, with dynamic cross talk between the neoplastic cell, the leukocyte infiltrate and the stroma. (biomedcentral.com)
  • Almost all cancers are accompanied by leukocyte infiltration, the significance of which has recently come under increasing scrutiny as to whether these cells work to eradicate the malignant cell, or whether they act to support it. (biomedcentral.com)
  • IVLBCL was first described by Pfleger and Tappeiner [ 3 ] in 1959 and is characterized by the proliferation of malignant B-cells in small- and medium-size vessels. (biomedcentral.com)
  • Among the malignant brain cancers, gliomas of the brainstem and pons, glioblastoma multiforme, and high-grade (highly anaplastic) astrocytoma are among the worst. (wikipedia.org)
  • ALCL
  • 25% of tumour cells) was seen in two additional ALK positive systemic ALCLs, two additional classic HD cases, and in three of 20 cases of ALK negative systemic nodal ALCL. (bmj.com)
  • 7, 10, 12, 13 Morphologically, these lymphomas may closely resemble systemic ALCL, being also characterised by CD30 positive tumour cells with abundant cytoplasm, large irregular nuclei, and a prominent single nucleolus or multiple nucleoli. (bmj.com)
  • Several markers can be used in the differential diagnosis of ALCL and other CD30 positive lymphomas. (bmj.com)
  • Furthermore, anaplastic large-cell lymphoma (ALCL) ALK−positive (ALK+) is now recognized as a distinct entity from the ALCL ALK-negative (ALK−) lymphomas, which occurs in an older population, and which bears a far worse prognosis [ 5 ]. (hindawi.com)
  • squamous
  • Importantly, the increased bleeding risk was associated with squamous cell histology and this observation led to the subsequent development of bevacizumab exclusively in nonsquamous NSCLC. (ecancer.org)
  • This stratified squamous epithelium is maintained by cell division within the stratum basale, in which differentiating cells slowly displace outwards through the stratum spinosum to the stratum corneum, where cells are continually shed from the surface. (wikipedia.org)
  • receptor
  • Analogous to the role of the germinal center in B-cell ontogeny, the thymus represents the site of T-cell receptor gene rearrangement, and is the reference point that differentiates the pre- and post-thymic T-cell neoplasms. (aacrjournals.org)
  • Previous studies have uncovered additional mechanisms by which T cell immunoglobulin mucin-3, a receptor for Gal-9, negatively regulates T cell responses by promoting CD8+ T cell exhaustion and inducing the expansion of myeloid-derived suppressor cells ( 14 , 15 ). (spandidos-publications.com)
  • This gene encodes a type I cell-surface receptor for the TGF-beta superfamily of ligands. (wikipedia.org)
  • Basigin has been shown to be an essential receptor on red blood cells for the human malaria parasite, Plasmodium falciparum. (wikipedia.org)
  • Basigin interacts with the fourth C-type lectin domain in the receptor Endo180 to form a molecular epithelial-mesenchymal transition suppressor complex that if disrupted results in the induction of invasive prostate epithelial cell behavior associated with poor prostate cancer survival. (wikipedia.org)
  • In many clinical settings, however, studies on the T cell receptor and IL-5 are not available and therefore not routine parts of the diagnostic work-up or criteria for the disease. (wikipedia.org)
  • Pathology
  • The pathology advances with time leading to erosive dermatitis which is inflamed with a mixed infiltrate involving activated CD8+ T-cells, CD4+ T-cells including CD4+/CD25+/FoxP3+ Treg cells, mast cells and neutrophils. (biomedcentral.com)
  • The crucial role of mature T- and/or B-lymphocytes in the advancing pathology is demonstrated by their elimination, which precludes mast cell infiltration and limits the pathology to an early, benign stage. (biomedcentral.com)
  • With the initiation of an inflammatory programme, leukocyte recruitment follows which then itself contributes to the progressing pathology in these transgenic mice, with a pivotal role for B-and/or T-cells in the process. (biomedcentral.com)
  • patients
  • In 2002, the Eastern Oncology Cooperative Group (ECOG) published in the New England Journal of Medicine the results of a landmark randomised phase III trial comparing four chemotherapy platinum-based doublets in patients with untreated advanced non-small cell lung cancer (NSCLC) [ 1 ]. (ecancer.org)
  • Due to the low prevalence of this disease, diagnosis and optimal treatment of patients have not been studied prospectively in large randomized trials. (hindawi.com)
  • The symptom of episodic angioedema in lymphocyte-variant hypereosinophilia resembles that occurring in Gleich's syndrome, a rare disease that is accompanied by secondary hypereosinophilia plus a sub-population of CD3(-), CD4(+) T cells and therefore proposed, at least in many patients, a subtype of lymphocyte-variant hypereosiophilia. (wikipedia.org)
  • Follicular thyroid cancer (10% to 20% of cases) - occasionally seen in patients with Cowden syndrome Medullary thyroid cancer (5% to 8% of cases) - cancer of the parafollicular cells, often part of multiple endocrine neoplasia type 2. (wikipedia.org)
  • immune response
  • The data indicate that activity of the humoral (cryoglobulinaemia, RF, autoantibodies) and cellular (sIL2r, sICAM-1, sCD30) immune response and endothelial damage (sICAM-1) are found in HCV associated CV. (bmj.com)
  • incidence
  • The studies to be presented here were prompted by the unanticipated findings that mice heterozygous for the Col13a1 del allele developed T-cell-rich, histiocyte-rich B-cell lymphomas appearing in mesenteric lymph nodes (MLN) and that the incidence of lymphomas was significantly reduced in mice raised under specific pathogen-free (SPF) conditions. (aacrjournals.org)
  • gene
  • An important gene associated with Primary Cutaneous Anaplastic Large Cell Lymphoma is NPM1 (Nucleophosmin 1), and among its related pathways/superpathways are NF-kappaB Signaling and Tyrosine Kinases / Adaptors . (malacards.org)
  • This suggested that collagen XIII might normally function as a novel tumor suppressor gene for intestinal microbe-dependent lymphomas. (aacrjournals.org)
  • FDG-PET emerges as an increasingly important tool in diagnosis, gene-expression signatures may aid with prognostication in the future, and novel therapies are currently being studied to improve outcomes in T-cell lymphomas. (hindawi.com)
  • lymphoid
  • Pre-thymic/thymic T-cell neoplasms represent malignancies of immature T cells and arise in central lymphoid organs (green), whereas mature T-cell and NK-cell neoplasms arise via oncogenic transformation of post-thymic T- and NK cells in peripheral lymphoid organs (blue). (aacrjournals.org)
  • The classification of T-cell and natural-killer- (NK-) cell lymphomas has been updated in the 4th edition of the World Health Organization (WHO) classification of tumors of the haematopoietic and lymphoid tissue published in 2008. (hindawi.com)
  • High level expression of miR-17 family members induces cell proliferation, whereas deletion of the miR-17~92 cluster, in mice, is lethal and causes lung and lymphoid cell developmental defects. (wikipedia.org)
  • Clinical
  • T-cell lymphomas, however, represent a heterogeneous group of diseases with variations in clinical characteristics, prognosis and response to treatment. (hindawi.com)
  • phenotype
  • Affiliated tissues include t cells , skin and bone , and related phenotype is neoplasm . (malacards.org)
  • DNMT3B in vitro knocking-down is able to reverse embryonal rhabdomyosarcoma cell phenotype through inhibition of proliferation and induction of myogenic differentiation. (pubfacts.com)
  • Thyroid
  • Computed tomography scans revealed that the left lobar thyroid was occupied by a large, slightly lower density mass (5.8 × 4.7 × 8.4 cm). (biomedcentral.com)
  • There are four main types - papillary thyroid cancer, follicular thyroid cancer, medullary thyroid cancer, and anaplastic thyroid cancer. (wikipedia.org)
  • Thyroid cancer is usually found in a euthyroid patient, but symptoms of hyperthyroidism or hypothyroidism may be associated with a large or metastatic well-differentiated tumor. (wikipedia.org)
  • Environmental exposure to ionizing radiation from both natural background sources and artificial sources is suspected to play a significant role, and there are significant increased rates of thyroid cancer in those exposed to mantlefield radiation for lymphoma, and those exposed to iodine-131 following the Chernobyl, Fukushima, Kyshtym, and Windscale nuclear disasters. (wikipedia.org)
  • Poorly differentiated thyroid cancer Anaplastic thyroid cancer (less than 5% of cases) is not responsive to treatment and can cause pressure symptoms. (wikipedia.org)
  • proliferation
  • Therefore, the present study evaluated the effects of Gal‑9 on the proliferation of human pancreatic cancer cells and examined the microRNAs that are associated with the antitumor effects of Gal‑9. (spandidos-publications.com)
  • Gal‑9 suppressed the proliferation of multiple pancreatic cancer cell lines. (spandidos-publications.com)
  • These aberrant lymphocytes function abnormally by stimulating the proliferation and maturation of bone marrow eosinophil-precursor cells termed colony forming unit-Eosinophils or CFU-Eos. (wikipedia.org)
  • precursor
  • To eliminate redundancy, precursor T-lymphoblastic lymphoma/leukaemia has lost its "precursor" prefix as the term "lymphoblastic" implies this. (hindawi.com)
  • lymphocytes
  • Because of the effect on immune cells (especially lymphocytes), chemotherapy drugs often find use in a host of diseases that result from harmful overactivity of the immune system against self (so-called autoimmunity). (wikipedia.org)
  • Lymphocyte-variant hypereosinophila, also termed lymphocyte variant eosinophilia, is a rare disorder in which eosinophilia or hypereosinophilia (i.e. a large or extremely large increase in the number of eosinophils in the blood circulation) is caused by aberrant population of lymphocytes. (wikipedia.org)
  • eosinophils
  • The overly stimulated CFU-Eos cells mature to apparently normal eosinophils, enter the circulation, and may accumulate in, and severely damage, various tissues. (wikipedia.org)
  • Drugs
  • Many of the side effects of chemotherapy can be traced to damage to normal cells that divide rapidly and are thus sensitive to anti-mitotic drugs: cells in the bone marrow, digestive tract and hair follicles. (wikipedia.org)
  • Blood
  • A complete blood count (CBC) test measures the following:The number of red blood cells (RBC count)The number of white blood cells (WBC count)The tota. (stlukes-stl.com)
  • Bone marrow is the soft tissue inside bones that helps form blood cells. (stlukes-stl.com)
  • This results in the most common side-effects of chemotherapy: myelosuppression (decreased production of blood cells, hence also immunosuppression), mucositis (inflammation of the lining of the digestive tract), and alopecia (hair loss). (wikipedia.org)
  • malignancies
  • It is well established that these B-cell-intrinsic molecular changes are not sufficient to fully induce transformation ( 5 ) and that secondary genetic mutations and other factors have important roles in the pathogenesis of B-cell malignancies. (aacrjournals.org)
  • cytotoxic
  • Traditional chemotherapeutic agents are cytotoxic by means of interfering with cell division (mitosis) but cancer cells vary widely in their susceptibility to these agents. (wikipedia.org)
  • lung
  • Non-small cell lung cancer treatment (r)evolution: ten years of advances and more to come. (ecancer.org)
  • Diagnostic and treatment algorithms in non-small cell lung cancer (NSCLC) are evolving at a never-before-seen pace. (ecancer.org)
  • In fact, in 2002, identification of NSCLC histological subtypes was considered irrelevant, with pathologists being required to discriminate only between NSCLC and small-cell lung cancer (SCLC), the latter following a peculiar treatment algorithm. (ecancer.org)
  • relatively
  • Finally, the degree of MUC1 glycosylation in lymphomas is relatively high, compared with the aberrant hypoglycosylation found in adenocarcinomas. (bmj.com)
  • markers
  • Therefore, although MUC1 could be used in a panel of markers for CD30 positive lymphomas, it is probably not a valuable tool to differentiate between ALK negative CD30 positive large cell lymphomas. (bmj.com)
  • Immunophenotyping is a laboratory test used to identify cells, based on the types of antigens or markers on the surface of the cell. (stlukes-stl.com)
  • The finding of T cells bearing abnormal immunophenotype cluster of differentiation markers is critical to making the diagnosis. (wikipedia.org)
  • diseases
  • Two new rare EBV-related T-cell diseases affecting children in Asia or Central/South America are recognized in this classification. (hindawi.com)
  • neoplasms
  • T-cell neoplasms: organ of origin or involvement and associated chromosomal and genetic alterations. (aacrjournals.org)
  • The last 20 years have witnessed remarkable progress in understanding the cellular origins and molecular mechanisms involved in the development of B-cell lineage neoplasms. (aacrjournals.org)
  • List of T-cell lymphomas adapted from the 2008 WHO classification of mature T-cell and NK-cell Neoplasms. (hindawi.com)
  • disease
  • It is a disease in which cells grow abnormally and have the potential to spread to other parts of the body. (wikipedia.org)