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  • kinase
  • Methods/Results -Using five different monoclonal antibodies (E29/anti-EMA, DF3, 139H2, VU-4H5, and SM3) that distinguish between various MUC1 glycoforms, high MUC1 expression (50-95% of tumour cells positive) was found in 13 of 17 anaplastic lymphoma kinase (ALK) positive systemic nodal ALCLs, and in one of 20 cases of classic HD. (bmj.com)
  • 1 In 30-50% of cases, a chromosomal aberration such as the t(2;5)(p23;q35) translocation gives rise to expression of the anaplastic lymphoma kinase (ALK) protein, 2 identifying a subgroup of patients with systemic ALCL with excellent prognosis. (bmj.com)
  • Advanced ALK-rearranged non-small cell lung cancer (NSCLC) patients will develop acquired resistance after anaplastic lymphoma kinase (ALK) inhibitors therapies. (springeropen.com)
  • Histological subtyping to maximise treatment efficacy and avoid toxicity has marked the beginning of the revolution, opening the way to molecular characterisation to guide genomically driven treatments with targeted agents, led by an Epidermal Growth Factor Receptor (EGFR) and Anaplastic Lymphoma Kinase (ALK) inhibitors. (ecancer.org)
  • Not to be confused with anaplastic lymphoma kinase (ALK) ) ALK4 is ACVR1B, ALK7 is ACVR1C, and ALK5 is [part of] the TGF-β type I receptor. (wikipedia.org)
  • numerous tyrosine kinase cell signaling proteins are responsible for the growth and proliferation of eosinophils {see clonal eosinophilia}), methotrexate and Hydroxycarbamide (both are chemotherapy and immunosuppressant drugs), and Alemtuzumab (a antibody that binds to the CD52 antigen on mature lymphocytes thereby marking them for destruction by the body). (wikipedia.org)
  • tumor cells
  • The latter mechanisms could be important to reduce the development of drug resistance by tumor cells. (springer.com)
  • Circulating tumor cells (CTCs) are cancer cells shed from primary or metastatic solid tumors into peripheral blood, whereas circulating endothelial cells (CECs) are derived from endothelial cells (ECs) of blood vessels into circulation. (mdpi.com)
  • Detection of circulating rare cells (CRCs), including both CTCs and CECs, is the most representative of liquid biopsy due to its unique availability of frequent and non-invasive detecting tumor cells in carcinoma patients. (mdpi.com)
  • IL-33 also induced an identical maturation into TNF-α- and IFN-γ-producing Th1 effector memory cells, and IL-33-stimulated cells showed an equivalent cytotoxicity for various tumor cells in vitro. (jimmunol.org)
  • These so-called unconventional T lymphocytes respond selectively to various non-peptide phosphoantigens (PAgs), which are metabolites from two distinct biosynthesis pathways, namely the prokaryotic methyl erythritol phosphate pathway in microbial pathogens ( 1 ) and the eukaryotic mevalonate pathway in tumor cells ( 2 ). (jimmunol.org)
  • Similarly to other galectins, Gal-9 performs a role in cell aggregation and adhesion and in the apoptosis of tumor cells ( 10 , 11 ). (spandidos-publications.com)
  • The tumor cells primarily grow within the blood vessel lumina but may cause minimal extravascular infiltration around the involved vessels in some patients. (histopathology-india.net)
  • They include engagement of the B-cell receptor (BCR) by self or microbial antigens ( 6 ), influences mediated by T cells activated by microbial pathogens ( 7 ), host inflammatory responses ( 8 - 10 ), and the interface between tumor cells and stromal elements such as collagen interactions with integrins and other receptors ( 11 , 12 ). (aacrjournals.org)
  • New methods of tumor imaging are being developed to specifically tag or label tumor cells so they may be visualized in the operating room. (medscape.com)
  • In such cases, the goal is to excise as much of the mass (tumor cells) and as much of the tumor margin as possible without endangering vital functions or other important cognitive abilities. (wikipedia.org)
  • squamous
  • Importantly, the increased bleeding risk was associated with squamous cell histology and this observation led to the subsequent development of bevacizumab exclusively in nonsquamous NSCLC. (ecancer.org)
  • This stratified squamous epithelium is maintained by cell division within the stratum basale, in which differentiating cells slowly displace outwards through the stratum spinosum to the stratum corneum, where cells are continually shed from the surface. (wikipedia.org)
  • metastasis
  • Comprehensive co-detecting observable aneuploid CTCs and CECs by SE-iFISH, along with applicable genomic and/or proteomic single cell molecular profiling, are anticipated to facilitate elucidating how those disparate categories of aneuploid CTCs and CECs cross-talk and functionally interplay with tumor angiogenesis, therapeutic drug resistance, tumor progression, and cancer metastasis. (mdpi.com)
  • Nonetheless, how those diverse types of aneuploid malignant cells cross-talk and inter-play in tumor formation and metastasis remains to be further investigated. (mdpi.com)
  • Although cerebrospinal fluid analysis is not part of the diagnosis of astrocytoma, it may help in ruling out other possible diagnoses, such as metastasis, lymphoma, or medulloblastoma. (medscape.com)
  • ALCLs
  • 25% of tumour cells) was seen in two additional ALK positive systemic ALCLs, two additional classic HD cases, and in three of 20 cases of ALK negative systemic nodal ALCL. (bmj.com)
  • Antibodies detecting hypoglycosylated MUC1 were found to be absent in all lymphomas (SM3) or present in only six of 15 ALK positive ALCLs (VU-4H5). (bmj.com)
  • gene
  • An important gene associated with Primary Cutaneous Anaplastic Large Cell Lymphoma is NPM1 (Nucleophosmin 1), and among its related pathways/superpathways are NF-kappaB Signaling and Tyrosine Kinases / Adaptors . (malacards.org)
  • Accordingly, a novel strategy integrating subtraction enrichment and immunostaining-fluorescence in situ hybridization (SE-iFISH), independent of cell size variation and free of hypotonic damage as well as anti-EpCAM perturbing, has been demonstrated to enable in situ phenotyping multi-protein expression, karyotyping chromosome aneuploidy, and detecting cytogenetic rearrangements of the ALK gene in non-hematologic CRCs. (mdpi.com)
  • This suggested that collagen XIII might normally function as a novel tumor suppressor gene for intestinal microbe-dependent lymphomas. (aacrjournals.org)
  • patients
  • However, the stringent dependence of such strategies on the inherently toxic IL-2 has raised safety concerns for patients, justifying a search for alternative methods for inducing γδ T cell stimulation. (jimmunol.org)
  • Recently, the FDA has approved four drugs for patients with relapsed/refractory PTCL over the past 5 years, and if one counts the recent Japanese approval of the anti-CCR4 monoclonal antibody for patients with adult T-cell leukemia/lymphoma, five drugs have been approved worldwide. (aacrjournals.org)
  • In 2002, the Eastern Oncology Cooperative Group (ECOG) published in the New England Journal of Medicine the results of a landmark randomised phase III trial comparing four chemotherapy platinum-based doublets in patients with untreated advanced non-small cell lung cancer (NSCLC) [ 1 ]. (ecancer.org)
  • The aim of this study was to perform proteomic analysis of serum from pediatric patients with B-cell acute lymphoblastic leukemia (B-ALL) to identify candidate biomarker proteins, for use in early diagnosis and evaluation of treatment. (biomedcentral.com)
  • The symptom of episodic angioedema in lymphocyte-variant hypereosinophilia resembles that occurring in Gleich's syndrome, a rare disease that is accompanied by secondary hypereosinophilia plus a sub-population of CD3(-), CD4(+) T cells and therefore proposed, at least in many patients, a subtype of lymphocyte-variant hypereosiophilia. (wikipedia.org)
  • Follicular thyroid cancer (10% to 20% of cases) - occasionally seen in patients with Cowden syndrome Medullary thyroid cancer (5% to 8% of cases) - cancer of the parafollicular cells, often part of multiple endocrine neoplasia type 2. (wikipedia.org)
  • immune response
  • The data indicate that activity of the humoral (cryoglobulinaemia, RF, autoantibodies) and cellular (sIL2r, sICAM-1, sCD30) immune response and endothelial damage (sICAM-1) are found in HCV associated CV. (bmj.com)
  • proteins
  • With respect to detecting the full spectrum of highly heterogeneous circulating rare cells (CRCs), including CTCs and circulating endothelial cells (CECs), it is imperative to develop a strategy systematically coordinating all tri-elements of nucleic acids, biomarker proteins, and cellular morphology, to effectively enrich and comprehensively identify CRCs. (mdpi.com)
  • incidence
  • The studies to be presented here were prompted by the unanticipated findings that mice heterozygous for the Col13a1 del allele developed T-cell-rich, histiocyte-rich B-cell lymphomas appearing in mesenteric lymph nodes (MLN) and that the incidence of lymphomas was significantly reduced in mice raised under specific pathogen-free (SPF) conditions. (aacrjournals.org)
  • lymphoid
  • In the skin the blood vessels in the dermis and the subcutis are almost completely occluded by atypical lymphoid cells. (histopathology-india.net)
  • High level expression of miR-17 family members induces cell proliferation, whereas deletion of the miR-17~92 cluster, in mice, is lethal and causes lung and lymphoid cell developmental defects. (wikipedia.org)
  • protein
  • white blood cells (WBCs)), or those unique carcinoma cells with double positive expression of surface epithelial cell adhesion molecule (EpCAM) for isolation, and intracellular structural protein cytokeratins (CKs) for identification. (mdpi.com)
  • lesion
  • The lesion is characterised by an accumulation of large atypical lymphocytes within the lumens of small to intermediate-sized blood vessls of the affected tissue. (histopathology-india.net)
  • Like low-grade astrocytomas, anaplastic astrocytomas may appear as low-density lesions or inhomogeneous lesions, with areas of both high and low density within the same lesion. (medscape.com)
  • vitro
  • In conclusion, Gal‑9 may suppress the growth of human pancreatic cancer cells in vitro. (spandidos-publications.com)
  • DNMT3B in vitro knocking-down is able to reverse embryonal rhabdomyosarcoma cell phenotype through inhibition of proliferation and induction of myogenic differentiation. (pubfacts.com)
  • lymphocytes
  • The availability of specific stimuli to induce the anticancer cytotoxicity of human TCRVγ9-expressing T lymphocytes has allowed the development of γδ T cell-based cancer immunotherapies. (jimmunol.org)
  • Epithelial cells of mucosal surfaces are critical for maintaining immune homeostasis by aiding in the discrimination of pathogenic and commensal microorganisms and modulating the activities of antigen-presenting cells and lymphocytes. (aacrjournals.org)
  • Because of the effect on immune cells (especially lymphocytes), chemotherapy drugs often find use in a host of diseases that result from harmful overactivity of the immune system against self (so-called autoimmunity). (wikipedia.org)
  • Lymphocyte-variant hypereosinophila, also termed lymphocyte variant eosinophilia, is a rare disorder in which eosinophilia or hypereosinophilia (i.e. a large or extremely large increase in the number of eosinophils in the blood circulation) is caused by aberrant population of lymphocytes. (wikipedia.org)
  • These aberrant lymphocytes function abnormally by stimulating the proliferation and maturation of bone marrow eosinophil-precursor cells termed colony forming unit-Eosinophils or CFU-Eos. (wikipedia.org)
  • tumour cells
  • 7, 10, 12, 13 Morphologically, these lymphomas may closely resemble systemic ALCL, being also characterised by CD30 positive tumour cells with abundant cytoplasm, large irregular nuclei, and a prominent single nucleolus or multiple nucleoli. (bmj.com)
  • Neurological manifestations are primarily caused by varying degrees of ischemia due to intravascular tumour cells. (histopathology-india.net)
  • amplification
  • IL-33 was as potent as IL-2 in allowing the proliferative amplification of Vγ9 T cells isolated from PBMC following activation by the synthetic phosphoantigen bromohydrin pyrophosphate. (jimmunol.org)
  • Blood
  • This results in the most common side-effects of chemotherapy: myelosuppression (decreased production of blood cells, hence also immunosuppression), mucositis (inflammation of the lining of the digestive tract), and alopecia (hair loss). (wikipedia.org)
  • metastatic
  • Thyroid cancer is usually found in a euthyroid patient, but symptoms of hyperthyroidism or hypothyroidism may be associated with a large or metastatic well-differentiated tumor. (wikipedia.org)
  • tissues
  • The lymphomas did not express the mutant collagen XIII, indicating that its influence on tumorigenesis was B-cell extrinsic and likely to be associated with collagen XIII-positive tissues drained by the MLN. (aacrjournals.org)
  • The overly stimulated CFU-Eos cells mature to apparently normal eosinophils, enter the circulation, and may accumulate in, and severely damage, various tissues. (wikipedia.org)
  • Human
  • Therefore, we investigated its ability to support the stimulation of human TCRVγ9 + γδ T cells. (jimmunol.org)
  • Drugs
  • Many of the side effects of chemotherapy can be traced to damage to normal cells that divide rapidly and are thus sensitive to anti-mitotic drugs: cells in the bone marrow, digestive tract and hair follicles. (wikipedia.org)
  • Melanoma
  • In addition, treatment with recombinant Gal-9 prolonged survival in a murine melanoma model, not only by increasing the numbers of CD8 cytotoxic T cells (CTLs) but also by increasing the number of natural killer (NK) cells and macrophages ( 13 ). (spandidos-publications.com)
  • malignancies
  • It is well established that these B-cell-intrinsic molecular changes are not sufficient to fully induce transformation ( 5 ) and that secondary genetic mutations and other factors have important roles in the pathogenesis of B-cell malignancies. (aacrjournals.org)
  • lung
  • Non-small cell lung cancer treatment (r)evolution: ten years of advances and more to come. (ecancer.org)
  • Diagnostic and treatment algorithms in non-small cell lung cancer (NSCLC) are evolving at a never-before-seen pace. (ecancer.org)
  • In fact, in 2002, identification of NSCLC histological subtypes was considered irrelevant, with pathologists being required to discriminate only between NSCLC and small-cell lung cancer (SCLC), the latter following a peculiar treatment algorithm. (ecancer.org)
  • relatively
  • Finally, the degree of MUC1 glycosylation in lymphomas is relatively high, compared with the aberrant hypoglycosylation found in adenocarcinomas. (bmj.com)
  • neoplasms
  • T-cell neoplasms: organ of origin or involvement and associated chromosomal and genetic alterations. (aacrjournals.org)
  • The last 20 years have witnessed remarkable progress in understanding the cellular origins and molecular mechanisms involved in the development of B-cell lineage neoplasms. (aacrjournals.org)
  • markers
  • Therefore, although MUC1 could be used in a panel of markers for CD30 positive lymphomas, it is probably not a valuable tool to differentiate between ALK negative CD30 positive large cell lymphomas. (bmj.com)
  • disease
  • It is a disease in which cells grow abnormally and have the potential to spread to other parts of the body. (wikipedia.org)
  • cytotoxic
  • Traditional chemotherapeutic agents are cytotoxic by means of interfering with cell division (mitosis) but cancer cells vary widely in their susceptibility to these agents. (wikipedia.org)