• Originally thought to behave as supporting cells for the lung epithelium and endothelium with a singular f. (researchgate.net)
  • The blood microvascular endothelium consists of a heterogeneous population of cells with regionally distinct morphologies and transcriptional signatures in different tissues and organs. (researchgate.net)
  • The walls of capillaries are composed of only a single layer of cells , the endothelium . (wikidoc.org)
  • Continuous - Continuous capillaries have a sealed endothelium and only allow small molecules, water and ions to diffuse. (wikidoc.org)
  • The endothelium is the thin layer of cells that line the interior surface of blood vessels , forming an interface between circulating blood in the lumen and the rest of the vessel wall. (wikidoc.org)
  • Nishiwaki, Y., Yoshida, M., Masuda, H. and Isobe, M. (2004) Recruitment of bone marrow-derived endothelial progenitor cells to vascular endothelium involves E-selectin dependent mechanism. (scirp.org)
  • The vascular endothelium produces a number of important substances including endothelial-derived relaxing factor or nitric oxide, endothelin-1, prostacyclin, and tissue plasminogen activator. (health.am)
  • We've confirmed that these cells have the capacity to form capillary-like structures, both in a natural material called fibrin and in a semisynthetic material called gelatin methacrylate, or GelMA," Calderon said. (sciencedaily.com)
  • Most of these methods involve culturing endothelial cells on or within ECM substrates (e.g., collagen, fibrin, fibronectin, laminin, etc.) or other types of biomaterials to form capillary-like structures [ 15 ]. (hindawi.com)
  • First, we cocultured dermal fibroblasts with dermal microvascular endothelial cells at a ratio of 2 : 1. (hindawi.com)
  • In the current study, we use a microvasculature model, where human brain vascular pericytes (HBVP) are co-cultured together with human cerebral microvascular endothelial cells, to demonstrate that IAPP oligomers (oIAPP) alter the morphology and contractility of HBVP. (lu.se)
  • Immunohistochemical studies of capillary malformations reveal a significantly decreased density of perivascular nervous tissue in lesional skin, suggesting that inadequate innervation may be in part responsible for decreased vascular tone and progressive vascular dilatation. (medscape.com)
  • The potent endothelial cell mitogen vascular endothelial growth factor (VEGF)-A and its most active receptor VEGF-R2 expression are significantly increased in capillary malformation skin tissue compared with control skin. (medscape.com)
  • Tissue engineering, also known as regenerative medicine, is a field aimed at integrating advances in stem cell biology and materials science to grow transplantable replacement tissues and organs. (sciencedaily.com)
  • While tissue engineers have found dozens of ways to coax stems cells into forming specific kinds of cells and tissues, they still cannot grow tissues with vasculature -- capillaries and the larger blood vessels that can supply the tissues with life-giving blood. (sciencedaily.com)
  • We are using 3-D bioprinting to build tissues with large vessels that we can connect to pumps, and are integrating that strategy with these iPS-ECs to help us form the smallest capillaries to better nourish the new tissue. (sciencedaily.com)
  • In this study, we constructed a scaffold-free bilayered tissue-engineered skin containing a capillary network. (hindawi.com)
  • Epithelial cells were then seeded on the fibrous sheet to assemble the bilayered tissue. (hindawi.com)
  • Thus, the long-term survival and function of 3D tissues depend on the rapid development of new blood vessels to provide nutrients and oxygen to cells in the center of the tissue grafts. (hindawi.com)
  • After the tissue has been perfused , capillaries widen to become venules and then widen more to become veins, which return blood to the heart. (wikidoc.org)
  • Capillaries are the smallest of a body's blood vessels , measuring 5-10 μm, which connect arterioles and venules , and are important for the interchange of oxygen , carbon dioxide , and other substances between blood and tissue cells. (wikidoc.org)
  • In an immune response, the endothelial cells of the capillary will upregulate receptor molecules, thus "catching" immune cells as they pass by the site of infection and aiding extravasation of these cells into the tissue. (wikidoc.org)
  • In this review, we introduce the broad application of β-TCP in tissue engineering and discuss the different approaches that β-TCP scaffolds are customized, including physical modification (e.g., pore size, porosity and roughness) and the incorporation of metal ions, other materials (e.g., bioactive glass) and stem cells (e.g., mesenchymal stem cells). (frontiersin.org)
  • The main challenge for large bone defect repair and regeneration remains the inadequate recruitment of mesenchymal stem cells (MSCs), reduced vascularization, and decreased growth factors stimulation within the scaffold construct to support cell viability and tissue growth. (frontiersin.org)
  • Endothelial tissue is a specialized type of epithelium tissue (one of the four types of biological tissue in animals). (wikidoc.org)
  • Finally, we demonstrate by immunostaining of human brain tissue against laminin that individuals with high amount of brain IAPP levels show significantly lower capillary diameter and altered mural cell morphology compared to individuals with low brain IAPP levels. (lu.se)
  • These cells are classified as totipotent and they can form any of the tissue types found in the adult body, in addition to having unlimited proliferation potential 6 . (bvsalud.org)
  • Adult stem cells are classified as pluripotent and are undifferentiated cells that remain quiescent in tissues until stimulated, when they can create cell types that are compatible with the tissue in which they reside. (bvsalud.org)
  • Distribution is generally uneven because of differences in blood perfusion, tissue binding (eg, because of lipid content), regional pH, and permeability of cell membranes. (msdmanuals.com)
  • Distribution equilibrium (when entry and exit rates are the same) between blood and tissue is reached more rapidly in richly vascularized areas, unless diffusion across cell membranes is the rate-limiting step. (msdmanuals.com)
  • Context Glucagon-like peptide-1 (GLP-1) and insulin increase muscle microvascular perfusion, thereby increasing tissue endothelial surface area and nutrient delivery. (medscape.com)
  • VEGF-induced angiogenesis was assessed in vitro using an aortic sprouting assay and a Matrigel lung endothelial cell tubulogenesis assay. (bmj.com)
  • Capillary malformations are characterized by ectatic papillary dermal capillaries and postcapillary venules in the upper reticular dermis, with some evidence of increased vessel density and no apparent proliferation of vessels. (medscape.com)
  • [ 5 ] This may suggest that VEGF and VEGF-R could contribute to the pathogenesis of capillary malformations by inducing vessel proliferation and/or vasodilatation. (medscape.com)
  • 11 ] first proved that astrocytes within adult hippocampus are able to accelerate the proliferation of stem cells and instruct them to become neurons. (degruyter.com)
  • Histopathological observations revealed hypertrophy and proliferation in gill epithelium, curling and fusion of secondary gill lamellae (SGL), distortion in chloride and pillar cells under laboratory experiment. (omicsonline.org)
  • Augmented expression of FJX1 in colon cancer cells promotes growth of xenografts in athymic mice and is associated with increased tumor cell proliferation and vascularization. (nih.gov)
  • Ca 2+ Signaling and Proliferation via Ca 2+ -Sensing Receptors in Human Hepatic Stellate LX-2 Cells. (bvsalud.org)
  • Hypoxia increases the proliferation of brain capillary endothelial cells via upregulation of TMEM16A Ca 2+ -activated Cl - channels. (bvsalud.org)
  • TMEM16A Ca 2+ -Activated Cl - Channel Regulates the Proliferation and Migration of Brain Capillary Endothelial Cells. (bvsalud.org)
  • A large body of evidence now implicates increased leukocyte-endothelial cell adhesion as a key early event in the development of diabetic retinopathy. (diabetesjournals.org)
  • We recently reported that raised activity of the glycosylating enzyme core 2 β 1,6- N -acetylglucosaminyltransferase (GlcNAc-T) through protein kinase C (PKC)β2-dependent phosphorylation plays a fundamental role in increased leukocyte-endothelial cell adhesion and capillary occlusion in retinopathy. (diabetesjournals.org)
  • Muller, W.A. (2003) Leukocyte-endothelial-cell interactions in leukocyte transmigration and the inflammatory response. (scirp.org)
  • Capillary non perfusion, documented by fluorescein angiography, is commonly present, and extensive retinal ischemia can lead to neovascularization of the retina, iris, and disc. (wikipedia.org)
  • Efficacy in several murine models of limb ischemia (immunocompromised/immunocompetent mice and mice with either Type I/II diabetes mellitus) demonstrated significantly increased blood perfusion and capillary density. (ed.ac.uk)
  • limb perfusion was assessed 21 days later using laser Doppler and gastrocnemius muscle capillary density defined histologically. (bmj.com)
  • The abnormal perfusion stimulates the production of substances in the blood that activate or injure endothelial cells. (health.am)
  • According to the International Society for the Study of Vascular Anomalies (ISSVA) classification, vascular malformations are classified according to their predominant vessel type, such as arterial, venous, lymphatic, capillary, or complex (a combination of different vessels). (medscape.com)
  • The vascular malformations can be further subdivided into arterial, venous, capillary, and lymphatic malformations. (medscape.com)
  • These cell- and when occurring in the lung or brain lead to to-cell connections allow for the formation of serious consequences related to impaired gas inter-endothelial gaps through which substances exchange and cerebral function, respectively. (bvsalud.org)
  • Based on the prominent role of TNF-α in the development of diabetic retinopathy, these observations further validate the significance of core 2 GlcNAc-T in the pathogenesis of capillary occlusion, thereby enhancing the therapeutic potential of specific enzyme inhibitors. (diabetesjournals.org)
  • These terminal endothelial cells also displayed intracytoplasmic channels and pinocytotic vesicles, extensive cytoplasmic processes and a high cytoplasmic volume-percent of mitochondria suggesting active transport capabilities of lymphatic endothelia. (arizona.edu)
  • Brain capillaries also possess few fenestrae and few endocytic vesicles, compared with the capillaries of other organs ( Pardridge, 1999 ). (aspetjournals.org)
  • In some cases, vesicles contained in the capillary membrane use endocytosis and exocytosis to transport material between blood and the tissues. (wikidoc.org)
  • Active transport processes centered in such endothelial cells could account for a portion of lymph formation, and explain the continued accumulation of lymphedema distal to blocked lymphatic collection ducts when lymphatic intraluminal pressure is greatly increased. (arizona.edu)
  • Both blood and lymphatic capillaries are composed of a single layer of endothelial cells. (wikidoc.org)
  • The neurovascular unit (NVU) contains endothelial cells joined by tight junctions that shield the brain from the blood via the blood brain barrier (BBB). (lu.se)
  • Endothelial dysfunction , or the loss of proper endothelial function, is a hallmark for vascular diseases, and often leads to atherosclerosis . (wikidoc.org)
  • One of the main mechanisms of endothelial dysfunction is the diminishing of nitric oxide , often due to high levels of asymmetric dimethylarginine , which interfere with the normal L-arginine -stimulated nitric oxide synthesis . (wikidoc.org)
  • The hematologic changes of preeclampsia, ie, thrombocytopenia and microangiopathic hemolytic anemia, are similar to those found in thrombotic thrombocytopenic purpura or hemolytic uremic syndrome - disorders in which endothelial dysfunction is thought to be important. (health.am)
  • Activation of the clotting cascade and increased sensitivity to pressors are compatible with endothelial cell dysfunction. (health.am)
  • Conclusions: This study has identified dysfunction of the systemic vascular endothelial cell in patients with normal pressure glaucoma. (bmj.com)
  • We subsequently discuss how β-TCP can regulate osteogenic processes to aid bone repair/healing, namely osteogenic differentiation of mesenchymal stem cells, formation of blood vessels, release of angiogenic growth factors, and blood clot formation. (frontiersin.org)
  • In the latter, IAPP is often found in vessels, where it is highly toxic for pericytes, mural cells that have contractile properties and regulate capillary blood flow. (lu.se)
  • Thus, GLP-1 and insulin may regulate skeletal and cardiac muscle endothelial surface area and nutrient delivery under physiological conditions. (medscape.com)
  • Perivascular CD8 T cell infiltrates in skin correlated with vWF plasma concentrations in patients with GVHD (p=0.01), and activated cytotoxic T lymphocytes and endothelial injury were present in these same samples. (nih.gov)
  • Pericytes are perivascular cells that line the entire microvasculature. (lu.se)
  • Diabetes and radiation primarily damage the retinal capillaries. (wikipedia.org)
  • Undifferentiated endothelial cells are critical to the development of retinal vessels. (medscape.com)
  • [ 7 ] Retinal endothelial cells give rise to primitive capillaries that further differentiate into mature vessels. (medscape.com)
  • In the present study, we demonstrate that following exposure to plasma from diabetic patients, the human promonocytic cell line U937 exhibits a significant elevation in core 2 GlcNAc-T activity and increased adherence to cultured retinal capillary endothelial cells. (diabetesjournals.org)
  • Diabetic retinopathy is a progressive vision-threatening complication of diabetes, characterized by capillary occlusion, formation of microvascular lesions, and retinal neovascularization adjacent to ischemic areas of the retina ( 1 - 2 ). (diabetesjournals.org)
  • The exact pathogenic mechanism by which capillary nonperfusion, as demonstrated by fluorescein angiography, occurs is still unclear, but recent experimental animal studies ( 3 - 5 ) demonstrate that increased leukocyte entrapment in retinal capillaries of diabetic rats is an early event associated with areas of capillary nonperfusion and the development of endothelial cell damage. (diabetesjournals.org)
  • Aberrant vascular remodeling contributes to the progression of many aging-associated diseases, including idiopathic pulmonary fibrosis (IPF), where heterogeneous capillary density, endothelial transcriptional alterations and increased vascular permeability correlate with poor disease outcomes. (researchgate.net)
  • Capillary permeability can be increased by the release of certain cytokines . (wikidoc.org)
  • Changes in vascular permeability are lial cells tethered together by junctional proteins commonly present in certain clinical diseases such as tight and adherens junctions. (bvsalud.org)
  • Confocal microscopy was used to examine the existence of lumen inside cord-like and tube-like structures developed at different stages of cell culture. (elsevierpure.com)
  • Rouget, C. Memoire sur le developpement, la structures et les proprietes des capillaries sanguins et lymphatiques. (nature.com)
  • A fibrous sheet was formed by the interactions between the fibroblasts and the endothelial cells, and capillary-like structures were observed after 20 days of coculture. (hindawi.com)
  • Immunostaining showed that the epithelium promoted the formation of capillary-like structures. (hindawi.com)
  • Transmission electron microscopy (TEM) analysis showed that the capillary-like structures were typical microblood vessels. (hindawi.com)
  • However, the engineering of more complex tissues consisting of large 3D structures remains a critical challenge because the penetration of oxygen, which is required for cell survival, is limited by diffusion to a distance of approximately 150 to 200 mm from the nearest blood vessel. (hindawi.com)
  • Endothelial cell heterogeneity across vascular beds, as well as their metabolism, are increasingly being uncovered thanks to single cell RNA-sequencing and other state-of-the-art tools. (grc.org)
  • The PhysiCell model was modified by introducing heterogeneity on cell division in addition to the introduction of cancer stem cells as a new type of cells. (europa.eu)
  • Interaction of nanoparticles and cancer cells was simulated and analysed using the STEPS model, which allowed for the consideration of spatial heterogeneity of cells. (europa.eu)
  • [ 3 ] Confocal microscopic studies demonstrate an inverse correlation between nerve density and blood vessel diameter and evidence that capillary malformations with the lowest nerve density exhibit the highest blood vessel density and the poorest response to laser intervention. (medscape.com)
  • Figure 1: Delayed capillary dilation and reduced capillary red blood cell flow in response to a hindlimb stimulus in 1- to 2-month-old pericyte-deficient Pdgfrb +/− mice. (nature.com)
  • 1. Microvascular blood flow responses to injury and capillary ultrastructure were assessed by laser Doppler flowmetry and detailed light and electron microscopy respectively in skin biopsied from 28 patients with insulin-dependent diabetes and 17 control subjects. (portlandpress.com)
  • In a paper published online in the journal Biomaterials Science , a team from the laboratories of Rice bioengineer Jordan Miller and Baylor College of Medicine biophysicist Mary Dickinson showed how to use a combination of human endothelial cells and mesenchymal stem cells to initiate a process called tubulogenesis that is crucial to the formation of blood-transporting capillaries. (sciencedaily.com)
  • Measuring just a few thousandths of a millimeter in diameter, some capillaries are so narrow that individual blood cells must squeeze through them in single-file. (sciencedaily.com)
  • Capillaries are made entirely from networks of endothelial cells, the type of cell that lines the inner surface of every blood vessel in the human body. (sciencedaily.com)
  • Ubiquitin enzymes, ubiquitin and proteasome activity in blood mononuclear cells of MCI, Alzheimer and Parkinson patients. (uibk.ac.at)
  • The capillary bed usually carries no more than 25% of the amount of blood it could contain, although this amount can be increased through autoregulation by inducing relaxation of smooth muscle . (wikidoc.org)
  • Sinusoidal - Sinusoidal capillaries are special forms of fenestrated capillaries that have larger openings in the epithelium allowing red blood cells and serum proteins to enter. (wikidoc.org)
  • These cells reduce friction of the flow of blood allowing the fluid to be pumped further. (wikidoc.org)
  • Endothelial cells also control the passage of materials - and the transit of white blood cells - into and out of the bloodstream. (wikidoc.org)
  • We investigated eight patients with acute GVHD and ten with chronic GVHD for signs of endothelial injury and microvessel loss by measurement of von Willebrand factor (vWF) in plasma and blood vessel density in biopsy samples taken from lesional skin. (nih.gov)
  • Stem cells can be found in bone marrow and blood. (bvsalud.org)
  • Hematopoietic stem cells are cells isolated from blood and bone marrow that can differentiate into a variety of different specialized cells and suffer apoptosis 1 . (bvsalud.org)
  • In the bloodstream, drugs are transported partly in solution as free (unbound) drug and partly reversibly bound to blood components (eg, plasma proteins, blood cells). (msdmanuals.com)
  • An increase in total muscle blood flow leads to more insulin and nutrients delivered to the muscle, and an expansion of the muscle microvasculature represents an enlargement of the endothelial surface area available for the transport of insulin and nutrients into the muscle interstitium from plasma. (medscape.com)
  • Scanning electron microscopy displayed severe loss of normal array of concentric microridges, swelling of microridges, damage in epithelial cells and appearance of vacuoles on the stratified epithelium, while loss of regular pattern of microridges were observed under field condition. (omicsonline.org)
  • Inflammation and endothelial injury were assessed in selected samples by immunostaining for CD8 T cells, activated cytotoxic T lymphocytes, and vascular endothelial cells. (nih.gov)
  • Rabbit vascular endothelial adhesion molecules: ELAM-1 is most elevated in acute inflammation, whereas VCAM-1 and ICAM-1 predominate in chronic inflammation. (cdc.gov)
  • The more metabolically active the cells, the more capillaries it will require to supply nutrients. (wikidoc.org)
  • For insulin to exert its metabolic effects in muscle and for nutrients to be used by the myocytes, insulin and nutrients first have to be delivered to the capillaries bathing the myocytes and then transported through the vascular wall to reach muscle interstitium. (medscape.com)
  • Mesenchymal cells in the lung are crucial during development, but also contribute to the pathogenesis of fibrotic disorders, including idiopathic pulmonary fibrosis (IPF), the most common and deadly form of fibrotic interstitial lung diseases. (researchgate.net)
  • The clinical-grade cell line RC11 was used to generate hESC-ECP which were identified as mostly endothelial (60% CD31+/CD144+), with the remainder of the subset expressing various pericyte/mesenchymal stem cell markers. (ed.ac.uk)
  • We investigated the capillary differentiation of endothelial cells cultured on microgrooved polydimethylsiloxane (PDMS) substrates coated with fibronectin. (elsevierpure.com)
  • Herein we show for the first time that microgrooved PDMS substrates of appropriate dimensions coated with fibronectin are capable of inducing capillary differentiation of endothelial cells in the absence of angiogenic growth factors. (elsevierpure.com)
  • Stem cells can divide into two cells identical to the original stem cell or into differentiated cell types, depending on their origin and differentiation potency. (bvsalud.org)
  • By definition, adult stem cells are capable of differentiation into at least two lineages and have the property of self-renewal. (bvsalud.org)
  • In their work toward 3-D printing transplantable tissues and organs, bioengineers and scientists have demonstrated a key step on the path to generate implantable tissues with functioning capillaries. (sciencedaily.com)
  • Ultimately, we'd like to 3-D print with living cells, a process known as 3-D bioprinting, to create fully vascularized tissues for therapeutic applications," said Miller, assistant professor of bioengineering. (sciencedaily.com)
  • In the ideal case, drugs would be applied at exactly the therapeutic concentration and would precisely target desired cells or tissues. (europa.eu)
  • Vascular endothelial cells form the interface between recipient tissues and circulating alloreactive donor T cells after allogeneic stem cell transplantation. (nih.gov)
  • In physiology, respiration is defined as the transport of oxygen from the outside air to the cells within tissues, and the transport of carbon dioxide in the opposite direction. (absoluteastronomy.com)
  • Many studies have shown the utility of embryonic or adult stem cells for forming teeth and for regeneration of bone and soft tissues. (bvsalud.org)
  • Additionally, they can form specialized cell types from other tissues if they are transplanted 6 . (bvsalud.org)
  • Stromal cells are a mixed population that can create bone, cartilage and fat and also fibrous and connective tissues. (bvsalud.org)
  • Capillary malformation, usually referred to as a port-wine stain or nevus flammeus, is the most common type of vascular malformation. (medscape.com)
  • Happle contends that the term capillary malformation should be used as a more generalized designation for several congenital disorders of dilated capillaries (eg, angiokeratomas , nevus anemicus , cutis marmorata telangiectatica congenita ). (medscape.com)
  • [ 2 ] While this notion has merit, the accepted nomenclature is that capillary malformation be reserved for a patch of red-colored skin, historically referred to as a port-wine stain or a nevus flammeus. (medscape.com)
  • Conversely, one report describes expansion of a biopsy-proven capillary malformation following partial surgical excision in an adult in whom the newly expanded capillary malformation expressed marked elevations of both tyrosine kinase receptor (Tie2) and its ligand angiopoietin-1 and no increase in VEGF. (medscape.com)
  • Hypoxia and ischemia are known to stimulate production of VGEF in some cells. (medscape.com)
  • However, changes in cell signalling in response to hypoxia that are mediated by RGS5 stroke. (lu.se)
  • abstract = "Pluripotent stem cell-derived differentiated endothelial cells offer high potential in regenerative medicine in the cardiovascular system. (ed.ac.uk)
  • Here, we investigated bleomycin-induced lung injury responses in young and aged mice at single-cell resolution to gain insights into the cellular and molecular contributions of aging to fibrosis. (researchgate.net)
  • Results: Responses to K + and noradrenaline were similar in patients and controls and were unaffected by endothelial removal. (bmj.com)
  • Electron microscopic examination of lymph capillaries of the dermal papillae of rat scalp skin revealed continuous extension of the lymph collection system into 4 to 10 micron diameter lumen capillaries with thin walls, scant basement lamellae (membranes), and blind-endings of 1 to 4 micron lumen diameter within endothelial-type cells. (arizona.edu)
  • The small lumen diameter capillaries, which correspond spatially to the prelymphatics of other authors (2), typically converge in groups of three to form larger diameter lymph capillaries corresponding to the lymph "initials" previously described (2,3). (arizona.edu)
  • The capillaries do not possess this smooth muscle in their own walls, and so any change in their diameter is passive. (wikidoc.org)
  • We have established a method allowing to study the cell-specific secretome of pericytes in vitro-using Turbo-ID, a mutant non-toxic biotin ligase (6). (lu.se)
  • 5. Our findings support the hypothesis that structural abnormalities, which are characterized by an early reduction in capillary size and later thickening of basement membrane, form an important mechanism for the impaired hyperaemic response in diabetic patients. (portlandpress.com)
  • The work is an important step with fragile endothelial cells (ECs) made from "induced pluripotent stem cells," or iPSCs, a type of cell that can potentially be made from the cells of any human patient. (sciencedaily.com)
  • Since stem cells were discovered, professionals in many different areas of healthcare have been using them as an important tool for fighting diseases, particularly diseases for which science has been unable to find cures. (bvsalud.org)
  • In view of the importance of the subject, this article provides a review of the literature on studies of stem cells and their potential applications in dentistry. (bvsalud.org)
  • Stem Cells, Dentistry, Regeneration. (bvsalud.org)
  • Researchers and health professionals consider stem cells to be an important weapon in the fight against diseases, particularly those that have resisted the efforts of science for a long time, and they have become the subject of a great deal of recent research. (bvsalud.org)
  • Stem cells are nonspecific cells with powerful self-regeneration properties and they are capable of organizing other cell types in the body. (bvsalud.org)
  • Stem cells are defined as undifferentiated cells that have precursor properties, are capable of forming many different cell types and have the property of unlimited self-renewal 5 . (bvsalud.org)
  • There are basically two types of stem cells: embryonic and somatic (or adult). (bvsalud.org)
  • Embryonic stem cells are derived from the inner cell mass of a blastocyst, which is an accumulation of primordial cells (4-5 days after fertilization). (bvsalud.org)
  • Bone marrow appears to contain three stem cell populations: hematopoietic stem cells, stromal stem cells and endothelial precursor cells. (bvsalud.org)
  • Our work has important therapeutic implications because we demonstrate utilization of human cells and the ability to live-monitor their tubulogenesis potential as they form primitive vessel networks," said study lead author Gisele Calderon, a graduate student in Miller's Physiologic Systems Engineering and Advanced Materials Laboratory. (sciencedaily.com)
  • In the process of tubulogenesis -- the first step to making capillaries -- endothelial cells undergo a series of changes. (sciencedaily.com)
  • Bovine aortic endothelial (BAE) cells were cultured in Dulbecco's modified Eagle's medium (DMEM) supplemented with 10% fetal bovine serum (FBS) on PDMS substrates produced photolithographically. (elsevierpure.com)
  • Anti-vascular endothelial growth factors have been recently used for the treatment of radiation retinopathy. (wikipedia.org)
  • Levels of enzyme activity in plasma-treated U937 cells were closely dependent on the severity of diabetic retinopathy, with the highest values observed upon treatment with plasma of patients affected by proliferative retinopathy. (diabetesjournals.org)
  • 1998. Protection of human upper respiratory tract cell lines against sulphur mustard toxicity by hexamethylenetetramine (HMT). (cdc.gov)
  • With the aim of translating the use of a human stem cell-derived endothelial cell product (hESC-ECP) for treatment of critical limb ischemia (CLI) in man, we report a GMP-compatible protocol and detailed cell tracking and efficacy data in multiple pre-clinical models. (ed.ac.uk)
  • Serum from preeclamptic women, when applied to human umbilical vein endothelial cell cultures, produces no morphologic abnormalities in the cells but releases procoagulants, vasoconstrictors, and mitogens. (health.am)
  • Non-human primates (NHPs) can sustain viral replication in relevant cell types and develop a robust immune response, but they do not develop overt disease. (mdpi.com)
  • Here, we report on a novel human endothelial cell-based recycling assay (HERA) that can be used for such pre-clinical screening. (nature.com)
  • Multi-walled carbon nanotube s induce human microvascular endothelial cellular effects in an alveolar-capillary co-culture with small airway epithelial cells. (cdc.gov)
  • Neoplastic-like transformation effect of single-walled and multi-walled-carbon nanotube s compared to asbestos on human lung small airway epithelial cells. (cdc.gov)