AnatomyDiseasesChemicals and DrugsAnalytical, Diagnostic and Therapeutic Techniques and EquipmentInformation ScienceHealth Care
SimvastatinHydroxymethylglutaryl-CoA Reductase InhibitorsAnticholesteremic AgentsLovastatinAzetidinesHypolipidemic AgentsHeptanoic AcidsHypercholesterolemiaPravastatinMevalonic AcidPyrrolesFluorobenzenesCholesterol, LDLCholesterolPolyisoprenyl PhosphatesLipidsNiacinRhabdomyolysisDrug Therapy, CombinationDouble-Blind MethodEncyclopedias as TopicNitric Oxide SynthaseNitric Oxide Synthase Type INitric OxideNitric Oxide Synthase Type IINitric Oxide Synthase Type IIIEndothelium, Vascular
DysfunctionCellsStatinsInflammationAtherosclerosisPravastatinEndotheliumLovastatinNitric oxideGenetically determinedImprovesCardiovascularRosuvastatinPermeabilityVEGFMechanismsPulmonaryStimulationExtracellularCholesterolCellEzetimibeProteinParadigmCytokineVivoPlaceboFunctionPromotesMechanismRoleZocorDependentTreatmentSystemicExpressionPatients
Dysfunction24
  • To date therapeutics to reverse increased vascular stiffness, and in turn prevent endothelial cell dysfunction leading to increased endothelium permeability, have been limited and unsuccessful. (cornell.edu)
  • SARS-CoV-2 infection primarily affects the pulmonary system, but accumulating evidence suggests that it also affects the pan-vasculature in the extrapulmonary systems by directly (via virus infection) or indirectly (via cytokine storm), causing endothelial dysfunction (endotheliitis, endothelialitis and endotheliopathy) and multi-organ injury. (nature.com)
  • The purpose of this review is to provide a latest summary of biomarkers associated with endothelial cell activation in COVID-19 and offer mechanistic insights into the molecular basis of endothelial activation/dysfunction in macro- and micro-vasculature of COVID-19 patients. (nature.com)
  • We envisage further development of cellular models and suitable animal models mimicking endothelial dysfunction aspect of COVID-19 being able to accelerate the discovery of new drugs targeting endothelial dysfunction in pan-vasculature from COVID-19 patients. (nature.com)
  • A number of viral species, such as dengue, ebola and cytomegalovirus can infect endothelial cells (ECs) and cause endothelial dysfunction [ 5 ]. (nature.com)
  • Taken together, the concerted actions of above factors lead to dysfunctional status of the vascular endothelium (endothelial dysfunction) (Fig. 1 ) [ 14 ]. (nature.com)
  • Fig. 1: SARS-CoV-2 induced endothelial dysfunction. (nature.com)
  • SARS-CoV-2 infection alters the balance of endothelial protective molecules and endothelial damaging molecules, leading to endothelial dysfunction. (nature.com)
  • Endothelial-Derived Extracellular Vesicles Induce Cerebrovascular Dysfunction in Inflammation. (open.ac.uk)
  • A decrease in the number and dysfunction of endothelial progenitor cells (EPC) may increase the risk for progression of cardiovascular disease (CVD) in type 1 diabetic patients with diabetic nephropathy (DN). (ku.dk)
  • One of the sentinel features of atherosclerosis is endothelial cell dysfunction that manifests itself in a variety of ways including poor nitric oxide production, poor vasodilatory response, and increased adhesiveness to leukocytes ( 1 ). (diabetesjournals.org)
  • Another potential endothelial dysfunction commonly observed in diabetes is altered permeability to macromolecules. (diabetesjournals.org)
  • Atherosclerosis is a chronic vascular inflammatory disease associated to oxidative stress and endothelial dysfunction. (hindawi.com)
  • Therefore, with the aim to summarize the current knowledge on the initiation of the atherosclerotic process, in this paper, we review the early markers of atherosclerosis and we address the main therapeutic targets for preventing atheroma formation at its very initial stages focusing on inflammation, oxidative stress, endothelial dysfunction, and the interaction between platelets and endothelium. (hindawi.com)
  • Reduced sleep efficiency and increased sleep irregularity in adolescents and young adults with type 1 diabetes are associated with higher HbA1c levels, insulin resistance, and endothelial dysfunction, highlighting the significance of addressing sleep-related factors in diabetes care for improved overall health. (contemporarypediatrics.com)
  • pulmonary and systemic oxidative stress and inflammatoryresponses provoking endothelial dysfunction, disturbance of the platelet function, blood coagulability, andthrombosis are suggested to be the effects of air pollutants. (civilica.com)
  • endothelial dysfunction in apoE- / - mice. (civilica.com)
  • Simvastatin reduces pulmonary arterial pressure and right ventricular hypertrophy in animal models of pulmonary arterial hypertension (PAH) and is thought to restore endothelial dysfunction. (faculti.net)
  • Background: Reduced endothelial nitric oxide bioavailability, a hallmark of endothelial dysfunction, is commonly encountered in cardiovascular diseases. (walshmedicalmedia.com)
  • Increased oxidative stress is linked with endothelial dysfunction in atherosclerosis, and may have an important role in the pathogenesis of cardiovascular events [ 2 ]. (walshmedicalmedia.com)
  • Systemic hypertension, hypercholesterolaemia and diabetes are associated with endothelial dysfunction that promotes inflammation, oxidation of lipoproteins, smooth-muscle proliferation, extracellular matrix deposition or lysis, accumulation of lipid-rich material, platelet activation, thrombus formation and insulin resistance. (radcliffecardiology.com)
  • All of these consequences of endothelial dysfunction and insulin resistance may contribute to the development and clinical expression of atherosclerosis. (radcliffecardiology.com)
  • Advances in the understanding of the vascular biology of atherosclerosis raise the possibility of novel therapies that address more directly the various aspects of endothelial dysfunction and the role of endothelial dysfunction in atherogenesis. (medscape.com)
  • Familial hypercholesterolaemia and COVID-19: A two-hit scenario for endothelial dysfunction amenable to treatment. (cdc.gov)
Cells21
  • Endothelial cells are sentinels lining the innermost layer of blood vessel that gatekeep micro- and macro-vascular health by sensing pathogen/danger signals and secreting vasoactive molecules. (nature.com)
  • Once produced in endothelial cells, NO diffuses across the vascular smooth muscle cell membranes and activates the enzyme soluble guanylate cyclase (sGC), which catalyzes the conversion of guanosine triphosphate into cyclic guanosine monophosphate (cGMP). (wikipedia.org)
  • An In Vitro Blood-Brain Barrier Model to Study Firm Shear Stress-Resistant Leukocyte Adhesion to Human Brain Endothelial Cells. (open.ac.uk)
  • Potential mechanisms underlying the diabetes-related changes in the blood-brain barrier (BBB) include altered expression of key structural and enzymatic proteins, alterations in the lipid composition and fluidity of the membranes, alterations in the neurotransmitter activity, and increased oxidative damage of the endothelial cells ( 2 , 6 ). (diabetesjournals.org)
  • Atherosclerosis starts with dysfunctional changes in the endothelium induced by disturbed shear stress which can lead to endothelial and platelet activation, adhesion of monocytes on the activated endothelium, and differentiation into proinflammatory macrophages, which increase the uptake of oxidized LDL (oxLDL) and turn into foam cells, exacerbating the inflammatory signalling. (hindawi.com)
  • Endothelial cells have also been demonstrated to have a crucial role as binding sites for various clotting factors at the sites of injury. (medscape.com)
  • Those include production of nitric oxide and prostacyclin (PGI2) as well as CD39 from endothelial cells. (medscape.com)
  • Endothelial cells and mice (C57BL/6, Toll-like receptor 4 knockout (TLR4-/-) and inducible nitric oxide synthase knockout (iNOS-/-)) were challenged with eEVs isolated from PAI-1-stimulated endothelial cells. (bvsalud.org)
  • The eEVs derived from PAI-1-stimulated endothelial cells could recognize TLR4 to stimulate a downstream signaling cascade identified as the Janus kinase 2/3 (JAK2/3)-signal transducer and activator of transcription 3 (STAT3)-interferon regulatory factor 1 (IRF-1) pathway, along with iNOS induction, and cytokine/chemokine production in vascular endothelial cells and C57BL/6 mice, ultimately contributing to ALI. (bvsalud.org)
  • Statins are lipid lowering drugs and are routinely administered in treatment of hyperlipidemia.1,2 In the last two decades, scientists have found that statins have other mechanisms that may be bene- ficial in bone regeneration.3 Lipophilic statins such as Simvastatin increase osteogenesis by enhancing differentiation of mesenchy- mal cells into osteoblasts, upregulating bone morphogenetic pro- tein-2 (BMP-2) and down regulating osteoblast apoptosis. (syksignaling.com)
  • A novel effect of statins directly inhibiting the membrane raft redox signaling in cultured endothelial cells highlights another possible benefit of statin therapy. (kalenbiomed.com)
  • Membranes of endothelial cells contain dynamic areas known as membrane rafts which are involved in mediating and amplifying cellular signals. (kalenbiomed.com)
  • Coronary arterial endothelial cells treated in vitro with Medium Oxidized Low Density Lipoprotein (MOxLDL, Kalen Biomedical, LLC) form clusters of membrane rafts in the membranes. (kalenbiomed.com)
  • Simvastatin treatment increased the number of functionally active endothelial progenitor cells, whereas ezetimibe had no effect. (uruvideo.com)
  • Hsp90 associates with eNOS under inactive conditions, and upon the stimulation of endothelial cells with VEGF, estrogen, histamine, shear stress, and statins. (eurekaselect.com)
  • Endothelial Cells as Biosensors for Occupational Cardiovascular Risk Engineered nanomaterials (ENMs) have an unknown toxic potential and the relationship between the biological effects and the physicochemical properties remains uncertain. (grantome.com)
  • Rather than biased approaches that measure discrete plasma components, we propose a novel paradigm whereby primary human endothelial cells (replete with receptors / responses to biochemical stimuli) are used to assess the complete inflammatory potential of the serum. (grantome.com)
  • All responses in endothelial cells will be related back to pathology and gene responses from the NIOSH work. (grantome.com)
  • We envision 3 areas where using endothelial cells as a biosensor of plasma inflammatory potential may have value: 1) diagnosis/prognosis of cardiovascular disease;2) efficacy of therapeutic intervention;and 3) toxicology/safety testing of environmental contaminants/novel pharmaceuticals. (grantome.com)
  • Endothelial Cells as Biosensors for Occupational Cardiovascular Risk Engineered nanomaterials (ENMs) may cause cardiovascular toxicity, thus a systematic means of predicting cardiovascular safety is needed. (grantome.com)
  • Potential cellular targets include vascular smooth muscle cells, monocyte/macrophage cell lines, platelets, and endothelial cells. (medscape.com)
Statins6
  • As increased stiffness leads to increased permeability via and statins have been shown to decrease RhoA activity, this investigation examined the effect of simvastatin (Zocor®), a common statin, on endothelial cell morphology, cell traction forces, cell-cell junction widths, and endothelium permeability for endothelial cells seeded on 2.5, 5, and 10 kPa polyacrylamide substrates, mimicking the stiffness of healthy and aged vessels respectively. (cornell.edu)
  • Statins may have favorable effects on endothelial barrier function. (diabetesjournals.org)
  • Pretreatment with statins (pravastatin or simvastatin) significantly inhibited the clustering. (kalenbiomed.com)
  • J Virology September 22, Simvastatin was identified as a potent inhibitor of NP-induced endothelial activation in contrast to other statins. (punticrisene.ro)
  • Experimental and clinical studies demonstrated that combined statins and RAS blockades improve endothelial function as reflected by improved flow-mediated dilation, improved fibrinolysis potential and reduced oxidant stress, inflammatory markers and insulin sensitivity. (radcliffecardiology.com)
  • Statins reduce low-density lipoprotein (LDL) cholesterol and improve endothelial function via stimulation of nitric oxide (NO) synthase activity, and mediate antioxidant effects that result in enhanced NO bioactivity. (radcliffecardiology.com)
Inflammation2
  • Cardiovascular (CV) risk factors such as hypercholesterolemia, hyperglycaemia, obesity, hypertension, smoking, and aging promote vascular inflammation and endothelial activation [ 7 - 9 ]. (hindawi.com)
  • Analysis of interactions of these genes in the associative gene network of lymphedema can improve understanding of mechanisms of interaction between endothelial apoptosis and lymphangiogenesis, and shed light on the role of disturbance of these processes in the development of edema, chronic inflammation and connective tissue transformation during the progression of the disease. (biomedcentral.com)
Atherosclerosis1
  • Our data suggest that simvastatin may be beneficial in preventing atherosclerosis beyond its traditional lipid lowering effects b y decreasing monolayer permeability due to vascular stiffening that naturally occurs with aging. (cornell.edu)
Pravastatin1
Endothelium2
  • Our data show that simvastatin results in an elongated cell morphology, reduced endothelial cell contractility, enhanced cell-cell junction integrity, and decreased substratestiffness-dependent and thrombin-dependent increased endothelium permeability on physiologically relevant substrate stiffnesses. (cornell.edu)
  • Moreover, NO affects leukocyte adhesion to the vascular endothelium by inhibiting the nuclear factor kappa B (NF-κB), which induces vascular endothelial expression of chemokines and adhesion molecules. (wikipedia.org)
Lovastatin1
Nitric oxide3
  • Endothelial NOS (eNOS), also known as nitric oxide synthase 3 (NOS3) or constitutive NOS (cNOS), is an enzyme that in humans is encoded by the NOS3 gene located in the 7q35-7q36 region of chromosome 7. (wikipedia.org)
  • The aim of the study was to address the effects of intermittent «Ramadan-type» fasting on endothelial function, nitric oxide bioavailability, biological parameters and blood pressure. (walshmedicalmedia.com)
  • Chem 272:21420-21426 Green D (2005) Point: flow-mediated dilation does reflect nitric oxide-mediated endothelial function. (ulster.ac.uk)
Genetically determined1
  • Simvastatin preserves cardiac function in genetically determined cardiomyopathy. (uchicago.edu)
Improves2
  • Conclusions- Four weeks of simvastatin treatment improves endothelial function independently of LDL cholesterol lowering, at least in part by reducing oxidant stress. (uruvideo.com)
  • The formation of NO improves cardiovascular endothelial functions. (eurekaselect.com)
Cardiovascular1
  • In one example of such therapy, treatment with Vytorin, which combines ezetimibe (decreases small intestinal absorption of cholesterol) with simvastatin, produced benefit in cardiovascular morbidity and mortality over and above that demonstrated for simvastatin alone. (medscape.com)
Rosuvastatin1
  • The effect of rosuvastatin and simvastatin therapy (10 mg/kg) for 5 weeks on blood-brain barrier (BBB), blood-retinal barrier (BRB), and cardiac muscle permeability of streptozotocin-induced diabetic rats was studied. (diabetesjournals.org)
Permeability1
  • Diabetes in humans and in animal models has been found to cause significant alterations in endothelial permeability in various vascular beds ( 2 - 5 ). (diabetesjournals.org)
VEGF1
  • Can the vascular endothelial growth factor (VEGF) and total estradiol 17β be used as a marker of equine oocyte maturation? (cloud-clone.com)
Mechanisms3
  • In the current work, we used well-known methods (ToppGene and Endeavour), as well as methods previously developed by us, to prioritize genes involved in endothelial apoptosis and to find potential participants of molecular-genetic mechanisms of lymphedema among them. (biomedcentral.com)
  • This systematic review clears the mechanisms of action of Simvastatin on bone metabolism and focuses on in vivo investigations that have evaluated its role on osteo- porosis and fracture repair to fi nd out (i) whether Simvas- tatin is effective on treatment of osteoporosis and fracture repair, and (ii) which of the many available protocols may have the ability to be translated in the clinical setting. (syksignaling.com)
  • Surprisingly the inventors discovered that increasing NO levels by endothelial and/or non ecNOS dependent mechanisms, or via the generation of nitric dioxide (eNOS), can affect the vasculature of brain tissue. (patentpc.com)
Pulmonary2
  • Mais Absi discusses the direct effects of simvastatin on pulmonary arteries isolated from rats with or without monocrotaline-induced PAH. (faculti.net)
  • In Aim 2, we will assess serum-induced endothelial cell responses to serum obtained following pulmonary exposures of graphene and MWCNT. (grantome.com)
Stimulation1
  • EA zocor prescription america stimulation was perin the buy zocor (simvastatin) online legit armed becaadvantageces ofmed using a battery-powered stimulator (Skylark Electro-stimulator SK-700B) connected to each join of needle electrodes. (upb.ro)
Extracellular1
  • We previously found that post-operative patients showed an increase in endothelial cell-derived extracellular vesicles (eEVs) with components of coagulation and acute inflammatory responses. (bvsalud.org)
Cholesterol1
Cell4
  • Disruption of endothelial cell apoptosis can be considered as one of the factors contributing to the development of lymphedema. (biomedcentral.com)
  • An assessment of the quality of prioritization was performed using criteria, which involved an analysis of the enrichment of the top-most priority genes by genes, which are known to have simultaneous interactions with lymphedema and endothelial cell apoptosis, as well as by genes differentially expressed in murine model of lymphedema. (biomedcentral.com)
  • This method of """"""""biosensing"""""""" is feasible due to a commonality, primarily through NF?B pathways, of endothelial cell response to numerous molecules. (grantome.com)
  • Thus, in Aim 1, we will rigorously optimize an in vitro testing platform using three primary murine endothelial cell lines, focusing on expression of adhesion molecules and generation of NO. This will involve selection of a maximally-responsive cell line (derived from aorta, coronaries, or cerebral vessels) and characterization of responses to known inflammatory stimuli. (grantome.com)
Ezetimibe2
Protein1
  • Decreased vascular lesion formation in mice with inducible endothelial-specific expression of protein kinase Akt. (uchicago.edu)
Paradigm1
Cytokine1
  • Importantly, endothelial responses were far more robust than measures of inflammatory plasma cytokine """"""""usual suspects"""""""", such as CRP or TNF? (grantome.com)
Vivo2
  • On this basis, we are motivated to review all the important in vivo studies that have used Simvastatin to either treat osteoporosis or accelerate and enhance bone regeneration. (syksignaling.com)
  • Then, the different in vivo investi- gations that used Simvastatin in the fi eld of bone research were systematically compared and researched in order to find out (i) whether Simvastatin is effective in treatment of osteoporosis and fracture healing, and (ii) which of the many available protocols may have the ability to be translated in the clinical setting. (syksignaling.com)
Placebo1
  • Lianne C. Krab, of the Erasmus MC University Medical Center in Rotterdam, the Netherlands, and colleagues analyzed data from 62 children with NF1 who were randomized to receive daily simvastatin or placebo for 12 weeks. (contemporarypediatrics.com)
Function4
  • Finally, recent studies have shown that inactivation of the rho-GTPase has a critical role in endothelial barrier function ( 9 , 10 ). (diabetesjournals.org)
  • Does Intermittent Fasting Improve Microvascular Endothelial Function in Healthy Middle-aged Subjects? (walshmedicalmedia.com)
  • Whether this translates into persistent improvements in endothelial function is unknown. (walshmedicalmedia.com)
  • Microvascular endothelial function of skin vessels was evaluated with a laser Doppler imager, Before-fasting, after thirty days of fasting, and one month thereafter (Post-fasting). (walshmedicalmedia.com)
Promotes1
  • Simvastatin promotes osteogenesis by increasing viability and differentiation of osteoblasts. (syksignaling.com)
Mechanism1
Role2
  • Simvastatin is a lipid lowering drug whose beneficial role on bone metabolism was discovered in 1999. (syksignaling.com)
  • Essential role of endothelial Notch1 in angiogenesis. (uchicago.edu)
Zocor1
  • Combining this and the be of consequence we mete absent from here, it seems that hESCs which must been cultured underneath physiological horizontals of oxygen sire improved razes of MYC which is likely to be experiencing an grave situation in regulating ground purchase zocor (simvastatin) 10 mg, 20 mg, 40 mg, 5 mg state of cellular pluripotency. (upb.ro)
Dependent2
  • Endothelial dependent and independent dilatations were assessed by acetylcholine and sodium nitroprusside iontophoresis, respectively. (walshmedicalmedia.com)
  • Conclusion: Intermittent fasting improved endothelial and non-endothelial dependent vasodilations and decreased blood pressure. (walshmedicalmedia.com)
Treatment3
  • The use of simvastatin was not associated with cognitive improvements in children with neurofibromatosis type 1, contrary to findings in mouse models suggesting efficacy of this treatment, according to research published in the July 16 issue of the Journal of the American Medical Association. (contemporarypediatrics.com)
  • TUESDAY, July 15 (HealthDay News) -- The use of simvastatin was not associated with cognitive improvements in children with neurofibromatosis type 1 (NF1), contrary to findings in mouse models suggesting efficacy of this treatment, according to research published in the July 16 issue of the Journal of the American Medical Association . (contemporarypediatrics.com)
  • This review showed that Simvastatin is effective in the treatment of osteoporosis and fracture healing. (syksignaling.com)
Systemic1
  • Local delivery of Simvastatin through con- trolled drug delivery systems with much lower doses and dosages than the systemic route seems to be the most valuable option in fracture healing. (syksignaling.com)
Expression2
  • Simvastatin increases the oestrogen receptor (ER) expression in order to regulate the OPG/RANKL/RANK signalling pathway and thus it inhibits osteoclasto- genesis. (syksignaling.com)
  • Simvastatin Therapy Increased miR-150-5p Expression in the Patients with Type 2 Diabetes and COVID-19. (cdc.gov)
Patients2
  • Of translational relevance, several candidate drugs which are endothelial protective have been shown to improve clinical manifestations of COVID-19 patients. (nature.com)
  • All patients receiving simvastatin or calcium-channel blockers had higher numbers of EPC compared to patients not treated with these drugs. (ku.dk)