• Recent studies point to the broad spectrum benefits of whole grape extract in reducing inflammation and improving endothelial function. (lifeextension.com)
  • An ever growing body of evidence shows that components of red grapes can have powerful effects on vascular health, reducing platelet aggregation and lipid peroxidation while improving endothelial function. (lifeextension.com)
  • BACKGROUND: Enhanced external counterpulsation improves symptoms and exercise tolerance in patients with symptomatic coronary artery disease (CAD). (elsevierpure.com)
  • METHODS: Reactive hyperemia-peripheral arterial tonometry (RH-PAT), a noninvasive method to assess peripheral endothelial function by measuring reactive hyperemic response in the finger, was performed in 23 patients with refractory angina undergoing a 35-h course of EECP. (elsevierpure.com)
  • CONCLUSIONS: Enhanced external counterpulsation enhances peripheral endothelial function with beneficial effects persisting at one-month follow-up in patients with a positive clinical response. (elsevierpure.com)
  • This suggests that improvement in endothelial function may contribute to the clinical benefit of EECP in patients with symptomatic CAD. (elsevierpure.com)
  • The usefulness of vascular function tests for management of patients with a history of coronary artery disease is not fully known. (tokushima-u.ac.jp)
  • We measured flow‐mediated vasodilation (FMD) and brachial-ankle pulse wave velocity (baPWV) in 462 patients with coronary artery disease for assessment of the predictive value of FMD and baPWV for future cardiovascular events in a prospective multicenter observational study. (tokushima-u.ac.jp)
  • In patients with coronary artery disease, both FMD and baPWV were significant predictors of cardiovascular events. (tokushima-u.ac.jp)
  • Effect of exercise on coronary endothelial function in patients with coronary artery disease. (bmj.com)
  • RA patients have a higher incidence of cardiovascular diseases compared to the general population. (hindawi.com)
  • Diabetes constitutes one of the major independent cardiovascular risk factors, and patients with this disease suffer from premature cardiovascular morbidity and mortality. (scirp.org)
  • Also, physical movement is necessary, especially among chronic lung disease patients, as these ailments can lead to muscle loss and strain. (nfpt.com)
  • Serum VEGF-D level is correlated with renal dysfunction and proteinuria in patients with diabetic chronic kidney disease. (nih.gov)
  • Physiologically, in patients with a normal endothelial response, acetyl-choline will cause released access to the vasodilators, and result in dilation of blood vessels and hyperaemia. (escardio.org)
  • In patients with endothelial dysfunction, this process is disturbed and results in decreased vasodilation, thus demonstrating the dysfunction. (escardio.org)
  • However, in certain patients, a paradoxical vasoconstriction event ensues (4) such that this technique actually carries a risk of coronary ischemia. (escardio.org)
  • tion everses endothelial vasomotor dysfunction in patients with coronary artery disease. (21food.com)
  • The Department of Cardiovascular Biology and Medicine, Juntendo University has actively treated patients with wide variety of cardiovascular disease. (juntendo.ac.jp)
  • Disturbed lipid and carbohydrate metabolism are manifested by enhanced inflammation and endothelial dysfunction in patients with simply obesity. (medsci.org)
  • However in patients with baseline heart rate more than 70 bpm, ivabradine significantly reduced the risk of hospitalisation for fatal and non-fatal myocardial infarction by 36% (p=0.001) and the risk of coronary revascularisation by 30% (p=0.016). (sciencedaily.com)
  • Hence the results of BEAUTIFUL constitute a step further in the management of these coronary patients with heart rate above 70 bpm because, for the first time it has been shown that pure heart rate reduction with ivabradine further reduces coronary events even in patients receiving the current optimal cardiovascular therapy. (sciencedaily.com)
  • Commenting on the results the Chairman of the Steering Committee, Prof Roberto Ferrari said 'Often a lot of investigations are performed in coronary patients but a simple heart rate measurement is not done. (sciencedaily.com)
  • Of translational relevance, several candidate drugs which are endothelial protective have been shown to improve clinical manifestations of COVID-19 patients. (nature.com)
  • The purpose of this review is to provide a latest summary of biomarkers associated with endothelial cell activation in COVID-19 and offer mechanistic insights into the molecular basis of endothelial activation/dysfunction in macro- and micro-vasculature of COVID-19 patients. (nature.com)
  • We envisage further development of cellular models and suitable animal models mimicking endothelial dysfunction aspect of COVID-19 being able to accelerate the discovery of new drugs targeting endothelial dysfunction in pan-vasculature from COVID-19 patients. (nature.com)
  • A case-control study of hospitalized patients found that the blood plasma levels of CMTM5 protein and CMTM5 messenger RNA (i.e. mRNA) in 350 patients with coronary artery disease were significantly higher than a matched group of 350 patients without this disease. (wikipedia.org)
  • The same research group similarly studied 124 hospitalized patients who had in place a coronary artery stent. (wikipedia.org)
  • During January 8-14, 1998, six of eight patients undergoing elective intraocular surgery at a Veterans Affairs medical center (VAMC) in St. Louis, Missouri, developed corneal endothelial decompensation (corneal edema and opacification) 24 hours after surgery. (cdc.gov)
  • All patients had post-operative findings of persistent low visual acuity, cloudy corneas with corneal endothelial decompensation, and iris paralysis with dilated pupils. (cdc.gov)
  • In patients with established coronary artery disease, the adverse effects of nighttime noise on vascular function were, as expected, even stronger," Münzel said. (medscape.com)
  • Stein, J.H., Keevil, J.G., Wiebe, D.A., Aeschlimann, S. and Folts, J.D. (1999) Purple Grape Juice Improves Endothelial Function and Reduces the Susceptibility of LDL Cholesterol to Oxidation in Patients with Coronary Artery Disease. (scirp.org)
  • Percutaneous Coronary Intervention Vs Coronary Artery Bypass Graft in Female Patients With Unprotected Left Main Disease: A Meta-Analysis. (creighton.edu)
  • DESIGN 33 patients were studied, 27 with previous Kawasaki disease and six with congenital heart disease. (bmj.com)
  • All Kawasaki disease patients were followed for more than 10 years from disease onset. (bmj.com)
  • and group 4 comprised the six patients with congenital heart disease as controls, with a total of 27 normal coronary angiography sites. (bmj.com)
  • RESULTS Coronary angiography in all 22 patients in groups 1 and 2 and in all the patients in group 3 was normal, with no stenoses and no irregularity of the arterial wall. (bmj.com)
  • CONCLUSIONS There is evidence of persisting abnormal vascular wall morphology and vascular dysfunction at the site of regressed coronary aneurysms in patients with previous Kawasaki disease. (bmj.com)
  • However, the long term prognosis and natural history of Kawasaki disease, particularly in patients with regressed coronary aneurysms or with normal coronary arteries, remain uncertain. (bmj.com)
  • Intravascular ultrasound imaging of coronary arteries now allows detailed visualisation of coronary wall morphology and the healing process in patients with Kawasaki disease. (bmj.com)
  • One-third of patients with chest pain with known coronary disease, negative ECG, and biomarkers subsequently have adverse cardiac events. (medscape.com)
  • Coronary artery wall shear stress is associated with progression and transformation of atherosclerotic plaque and arterial remodeling in patients with coronary artery disease. (medscape.com)
  • Coronary artery calcium among patients with heterozygous familial hypercholesterolaemia. (cdc.gov)
  • Patients with High Genome-Wide Polygenic Risk Scores for Coronary Artery Disease May Receive Greater Clinical Benefit from Alirocumab Treatment in the Odyssey Outcomes Trial. (cdc.gov)
  • Risk of Premature Atherosclerotic Disease in Patients With Monogenic Versus Polygenic Familial Hypercholesterolemia. (cdc.gov)
  • Impact of Self-Reported Family History of Premature Cardiovascular Disease on the Outcomes of Patients Hospitalized for Acute Coronary Syndrome (from the Acute Coronary Syndrome Israel Survey [ACSIS] 2000 to 2013). (cdc.gov)
  • Nitric oxide (NO) from the endothelium , produced by oxidation of l-arginine to L-citruline for the action at the endothelial nitric oxide synthase (eNOS), is considered an important atheroprotective factor. (bvsalud.org)
  • Atherosclerosis and endothelial dysfunction are diffuse disease processes affecting coronary and peripheral arteries, hence, the physiological basis in assessing endothelium-dependent vasomotion in peripheral vessels. (escardio.org)
  • This is called atheromatosis, an inflammatory arterial change that leads to dysfunction of the endothelium and the deposition of lipids or fats in the artery walls. (news-medical.net)
  • Taken together, the concerted actions of above factors lead to dysfunctional status of the vascular endothelium (endothelial dysfunction) (Fig. 1 ) [ 14 ]. (nature.com)
  • The resulting increase in reactive oxygen species leads to decreased bioavailability of the endothelium-derived signaling molecule nitric oxide via oxidative inactivation and thereby induces endothelial dysfunction. (uni-muenchen.de)
  • The vascular endothelium and human diseases. (koreamed.org)
  • 10 , 14 , 15 Acetylcholine chloride, an endothelium dependent vasodilator, is believed to dilate normal coronary arteries by promoting the release of a vasorelaxant substance from the endothelium, probably nitric oxide (NO). 15-20 In coronary atherosclerosis, muscarinic cholinergic vasodilatation is impaired, and paradoxical vasoconstriction is induced by acetylcholine. (bmj.com)
  • Endothelial nitric oxide synthase G894T gene polymorphism in Chilean subjects with coronary artery disease and controls. (bvsalud.org)
  • Elevated levels of homocysteine lead to increased generation of superoxide anion in endothelial cells by a biochemical mechanism involving nitric oxide synthase, and, to a lesser extent, by an increase in the chemical oxidation rate of homocysteine and other aminothiols in the circulation. (uni-muenchen.de)
  • In addition to previous studies that indicated that a significant source of reactive oxygen species in homocysteine-treated endothelial cells might be endothelial nitric oxide synthase, experiments using inhibitors of nitric oxide synthase in THP-1 cells indicated that nitric oxide synthase-dependent generation of superoxide anion also occurs in homocysteine-incubated THP-1 cells. (uni-muenchen.de)
  • Periodontal pathogens have been found in carotid and coronary atherosclerotic plaques. (medscape.com)
  • P gingivalis has also been found in carotid and coronary atheromas. (medscape.com)
  • Malik M, Suboc TM, Tyagi S, et al: Lactobacillus plantarum 299v supplementation improves vascular endothelial function and reduces inflammatory biomarkers in men with stable coronary artery disease. (msdmanuals.com)
  • We will review several projects based on the use of panels of biomarkers for a better understanding of risk of disease and prognosis. (lu.se)
  • These cells can be differentiated into mature endothelial cells, which are involved in processes of angiogenesis and vessel regeneration. (intechopen.com)
  • One complementary therapy could be 're-activating' vasculogenesis (i.e. the differentiation of precursor cells into mature endothelial cells), a mechanism that occurs in the heart during development but is quiescent in adult hearts. (elifesciences.org)
  • In conclusion, vigorous aerobic activity in susceptible individuals may promote oxidative stress and coronary atherosclerosis. (duke.edu)
  • A number of tests may help with diagnoses including: electrocardiogram, cardiac stress testing, coronary computed tomographic angiography, and coronary angiogram, among others. (wikipedia.org)
  • Some of the life style factors that raise the risk of coronary artery disease include smoking, alcoholism, obesity, a diet high in saturated fats and low in fibre, a sedentary lifestyle and a lack of exercise. (news-medical.net)
  • Suboc TM, Dharmashankar K, Wang J, et al: Moderate obesity and endothelial dysfunction in humans: Influence of gender and systemic inflammation. (msdmanuals.com)
  • Coronavirus disease 2019 (COVID-19) caused by SARS-CoV-2 infection represents an ongoing public health burden leading to extensive morbidity and mortality worldwide [ 1 ]. (nature.com)
  • The authors add it can take decades to progress to a clinically detectable degree, and thus further follow-up of our cohort is necessary to determine whether a substantial absolute increase in morbidity and mortality from therapy-related cardiovascular disease will emerge. (natap.org)
  • We have studied the relationship between clinical and biochemical parameters and C-peptide and anti-inflammatory IL-10, as well as selected markers of inflammation and endothelial dysfunction such as: CCL2, CRP, sICAM-1, sVCAM-1 and E-selectin in obese women with various degree of glucose metabolism disturbance. (medsci.org)
  • Another study found that magnesium supplementation improved endothelial function in people with coronary artery disease. (healthnoise.com)
  • While ADMA has been implicated as a cardiovascular risk factor, arginine supplementation has been indicated as a treatment in cardiac diseases. (medscape.com)
  • To this end, flow mediated dilatory capability of brachial artery testing, peripheral arterial tonometry, venous occlusion pletismography and study of circulatory markers are non-invasive alternatives to intra-arterial and or intravacular testing. (escardio.org)
  • High-resolution vascular ultra-sound investigation of the brachial artery before and during reactive hyperaemia (1) shows vasodilatation from the release of nitric oxide as a response to stress induced during increased blood flow. (escardio.org)
  • One hundred subjects with various cardiovascular risk factors were selected and endothelial dysfunction was assessed by measuring flow-mediated dilation of brachial artery. (nepjol.info)
  • Damage to ECs is catastrophic and induces endothelial cell dysfunction. (koreamed.org)
  • Up-regulation of autophagy induces endothelial cell regeneration/differentiation and improves the function of impaired ones. (koreamed.org)
  • The first primary outcome was coronary events, and the second primary outcome was a composite of coronary events, stroke, heart failure, and sudden death. (tokushima-u.ac.jp)
  • The primary outcome was cardiometabolic disorders, including cardiovascular disease (coronary heart disease and stroke), diabetes, and metabolic syndrome. (bmj.com)
  • The highest levels of chocolate consumption were associated with a 37% reduction in cardiovascular disease (relative risk 0.63 (95% confidence interval 0.44 to 0.90)) and a 29% reduction in stroke compared with the lowest levels. (bmj.com)
  • Regular use of low dose aspirin (75mg) has been shown to have a protective effect on the heart, reducing the risk of death form cardiovascular disease and of cardiovascular events such as heart attack or stroke. (news-medical.net)
  • The most common cause of mortality worldwide is cerebrovascular disease (CVD), which includes coronary heart disease (CHD), congestive heart failure, CVD and stroke, peripheral artery diseases, carotid artery diseases, and aortoiliac disease. (medscape.com)
  • therefore, the association between certain periodontal pathogens and coronary artery disease or stroke is gaining more importance. (medscape.com)
  • The latest findings indicate that full spectrum grape extract can help support cardiac health by maintaining youthful endothelial function, regulating platelet aggregation, and reducing inflammation. (lifeextension.com)
  • With aggressive cardiac risk factor modification and, at a minimum, annual follow-up with routine non-invasive cardiac evaluation, the majority of aircrew with coronary artery disease can safely return to flight duties. (bmj.com)
  • The consequences of coronary angiographic findings are different in aircrew compared with the general population, and consideration for continuing flight duties of aircrew with known CAD requires a detailed aeromedical review by a cardiac specialist with aviation medicine experience. (bmj.com)
  • Sarsam L, Arouni A, Haddad T, Onaiwu C, Erickson C. "An Atypical Cardiac Manifestation of Fabry Disease from a Novel Pathological Variant on the GLA Gene. (creighton.edu)
  • Coronary sinus, normally located between the LEFT ATRIUM and LEFT VENTRICLE on the posterior surface of the heart, can serve as an anatomical reference for cardiac procedures. (bvsalud.org)
  • To determine the effects of medications on SAA-stimulated human coronary artery endothelial cells (HCAEC). (hindawi.com)
  • The first report in 2007, on SAA-stimulated human coronary artery endothelial cells (HCAEC), exhibited a substantial and significantly higher induction of released IL-6 protein and mRNA levels as compared to HUVEC [ 17 ], as well as increased responsiveness to IL-1 β [ 18 ]. (hindawi.com)
  • Human endothelial progenitor cells (hEPCs) are adult stem cells, located in the bone marrow and peripheral blood. (intechopen.com)
  • Different phenotypes and subtypes of endothelial progenitor cells (EPCs), such as early and late EPCs, have been described according to their functionality. (intechopen.com)
  • Thus, it has been shown that early EPCs release cytokines that promote tissue regeneration and neovasculogenesis, whereas late EPC and endothelial colony forming cells (ECFCs) contribute to the formation of blood vessels and stimulate tube formation. (intechopen.com)
  • In this study, we aimed to examine the effects of RCE in endothelial cells challenged with hypoxic exposure and to elucidate the underlying mechanisms. (mdpi.com)
  • The lab of Youyang Zhao, PhD , from Stanley Manne Children's Research Institute at Ann & Robert H. Lurie Children's Hospital of Chicago developed a unique nanoparticle to deliver genome editing technology, including CRISPR/Cas9, to endothelial cells, which are cells that line blood vessel walls. (eurekalert.org)
  • This is the first time that vascular endothelial cells could be reached for genome editing, since the usual way to deliver CRISPR/Cas9 - through a virus - does not work for this cell type. (eurekalert.org)
  • The nanoparticle we developed is a powerful new delivery system for genome editing in vascular endothelial cells, and could be used to treat many diseases, including acute respiratory distress syndrome from severe COVID-19," said senior author Dr. Zhao from Lurie Children's. (eurekalert.org)
  • Dr. Zhao explained that genome editing in endothelial cells could even treat cancers by cutting off the blood supply to the tumor or blocking cancer metastasis. (eurekalert.org)
  • It activates endothelial cells and stimulates nitric oxide release. (escardio.org)
  • Studies of human umbilical vein endothelial cells (HUVEC) and arterial endothelial cells (HAEC) showed that therapeutically relevant concentrations of MTX phosphorylate AMPKα Thr172 , and induce cytoprotective genes including manganese superoxide dismutase (MnSOD) and haem oxygenase-1 (HO-1). (bmj.com)
  • Endothelial cells are sentinels lining the innermost layer of blood vessel that gatekeep micro- and macro-vascular health by sensing pathogen/danger signals and secreting vasoactive molecules. (nature.com)
  • A number of viral species, such as dengue, ebola and cytomegalovirus can infect endothelial cells (ECs) and cause endothelial dysfunction [ 5 ]. (nature.com)
  • As the recruitment of circulating monocytes to the vessel wall plays a crucial role in the process of atherosclerosis, the purpose of this study was to examine the influence of homocysteine on the interaction of endothelial cells with monocytes. (uni-muenchen.de)
  • Exposure of endothelial monolayers to D,L- and L-homocysteine resulted in a time- and dose-dependent increase in adherent THP-1 cells by upregulating ICAM-1 expression on endothelial cells. (uni-muenchen.de)
  • The increased endothelial expression of ICAM-1 seems to be mediated by increased activation of the nuclear transcription factor NF-kB, as shown by increased nuclear translocation of NF-kB in homocysteine-incubated endothelial cells. (uni-muenchen.de)
  • In accordance, inhibition of NF-kB translocation by a synthetic inhibitor Bay 11-7082 significantly diminished homocysteine-induced ICAM-1 expression and adhesion of monocytes to endothelial cells. (uni-muenchen.de)
  • Furthermore, homocysteine-incubation of endothelial cells and monocytes resulted in a dose-dependent and significant increase in the intracellular generation of reactive oxygen species. (uni-muenchen.de)
  • In support of the role of increased oxidant stress for the above mentioned effects, treatment of endothelial cells with the superoxide scavengers MnTBAP or Tiron together with homocysteine abolished homocysteine-induced monocyte adhesion, ICAM-1 expression and the nuclear translocation of NF-kB. (uni-muenchen.de)
  • Incubation of THP-1 monocytes with Tiron abolished homocysteine-induced beta-2 integrin expression on these cells and adhesion to unstimulated endothelial cells. (uni-muenchen.de)
  • Postea, Otilia Adina (2005): Influence of homocysteine on the interaction between circulating monocytes and endothelial cells. (uni-muenchen.de)
  • These methylation changes, the studies suggest, regulate the function of immunologically active blood cells (and, perhaps, blood platelets) and thereby the development, maintenance, and/or worsening of the cited autoimmune diseases. (wikipedia.org)
  • BNP treatment increased vascularisation and the number of endothelial cells in all areas of infarcted hearts. (elifesciences.org)
  • Endothelial cell lineage tracing showed that BNP directly stimulated the proliferation of resident endothelial cells via NPR-A binding and p38 MAP kinase activation. (elifesciences.org)
  • Our results demonstrated that these immature cells have a natural capacity to differentiate into endothelial cells in infarcted hearts. (elifesciences.org)
  • The origin of new endothelial cells (i.e. resident or infiltrating) as well as the underlying mechanism leading to their proliferation (partial endothelial-to-mesenchymal transition [EndMT] or not) have long been debated. (elifesciences.org)
  • Endothelial cells (EC) are the anatomical boundaries between the intravascular and extravascular space. (koreamed.org)
  • Fig. 2 Schematic presentation of the role of autophagy in endothelial cells. (koreamed.org)
  • It may also invade and proliferate within heart and coronary artery endothelial cells, and, along with Streptococcus sanguis, it may also induce platelet aggregation associated with thrombus formation. (medscape.com)
  • HN - 2008 BX - Granulosa Cells, Cumulus MH - Coronary Sinus UI - D054326 MN - A07.231.908.194.500 MS - A short vein that collects about two thirds of the venous blood from the MYOCARDIUM and drains into the RIGHT ATRIUM. (bvsalud.org)
  • This is the first case to our knowledge, of accelerated coronary calcification in an otherwise asymptomatic middle-aged male marathon runner devoid of traditional cardiovascular risk factors. (duke.edu)
  • Association of kidney function with coronary atherosclerosis and calcification in autopsy samples from Japanese elders: the Hisayama study. (medscape.com)
  • Research on the relationship between oral health and systemic diseases gained rapid acceleration after the death of President Theodore Roosevelt in 1919 from odontogenic sepsis. (medscape.com)
  • Increasing evidence indicates that oral microbiota participate in various systemic diseases. (medscape.com)
  • Flowchart showing the possible mechanisms linking oral/dental infections to systemic diseases. (medscape.com)
  • Several systemic diseases, such as diabetes mellitus, may increase the prevalence, incidence, or severity of gingivitis and periodontitis. (medscape.com)
  • With advanced disease, the narrowing of coronary arteries reduces the supply of oxygen-rich blood flowing to the heart, which becomes more pronounced during strenuous activities during which the heart beats faster. (wikipedia.org)
  • Low-dose weekly methotrexate (MTX), the most widely used disease-modifying drug for rheumatoid arthritis (RA), reduces disease-associated cardiovascular mortality. (bmj.com)
  • This plaque thickens the endothelial wall and narrows the space for blood to flow through, which reduces the oxygen supply to the heart muscles. (news-medical.net)
  • Risk factors for coronary artery disease (CAD) were not formally established until the initial findings of the Framingham Heart Study in the early 1960s. (medscape.com)
  • this phenomenon is termed stable angina and is associated with narrowing of the arteries of the heart. (wikipedia.org)
  • Coronary artery disease is characterized by heart problems that result from atherosclerosis. (wikipedia.org)
  • They might help prevent heart disease and have other beneficial effects. (medlineplus.gov)
  • Elevated levels of this substance appear to be linked to certain chronic conditions such as heart disease and, possibly, depression and Alzheimer's Disease . (healthyplace.com)
  • Impaired peripheral endothelial function has also independently predicted adverse outcomes in specific patient cohorts, such as heart failure cohorts (6). (escardio.org)
  • A study published in the American Journal of Clinical Nutrition revealed that individuals with higher magnesium intakes had a 30% lower risk of heart disease compared to those with lower intakes. (healthnoise.com)
  • Fighting Inflammation: While inflammation is a natural immune response that can be beneficial in the short term, chronic inflammation is associated with various diseases, including heart disease, diabetes, and cancer. (healthnoise.com)
  • Although recent progress in cardiovascular medicine has introduced major scientific and technological breakthroughs, heart disease has been the second cause of death in Japan and the leading cause of death in the entire world. (juntendo.ac.jp)
  • In coronary artery disease, fatty deposits called plaques start to form in the walls of the coronary arteries that supply the heart muscles with nutrients and oxygen. (news-medical.net)
  • In just the past decade, striking new findings have been made on how components of red grapes (including both skin and seeds) affect vascular health, ranging from increasing vital nitric oxide (critical in maintaining endothelial function) to protecting against heart muscle damage. (lifeextension.com)
  • MAINZ, GERMANY - An updated evidence review strengthens the concept that exposure to environmental noise from road traffic and aircraft may increase the risk for heart disease and gets at the potential underlying pathophysiologic mechanisms. (medscape.com)
  • Traffic noise has been shown in many studies to increase the risk for heart disease, but the precise mechanisms that lead to noise-induced heart disease have been unclear. (medscape.com)
  • Studies indicate that lowering a patient's blood pressure from 160/90 to 140/80 mmHg may decrease risk of heart disease by more than 30 percent. (massagetoday.com)
  • Post-Menopausal Hormone Replacement Therapy, Coronary Heart Disease, and The Timing Hypothesis, American College of Cardiology Women in Cardiology Mid-West Regional Section Meeting in Omaha, Nebraska, 9/12/2020. (creighton.edu)
  • Predicting the 30-year risk of cardiovascular disease: the framingham heart study. (medscape.com)
  • Effectiveness-Based Guidelines for the Prevention of Cardiovascular Disease in Women--2011 Update: A Guideline From the American Heart Association. (medscape.com)
  • Familial hypercholesterolemia is related to cardiovascular disease, heart failure and atrial fibrillation. (cdc.gov)
  • The changing status of ejection fraction as a predictor of early mortality following surgery for acquired heart disease. (cdc.gov)
  • Previous reports from the Framingham Heart Study suggested a strong positive relationship between coronary heart disease and elevated levels of total cholesterol (TC) and low-density lipoprotein cholesterol (LDL-C) levels, in addition to an inverse relationship between the disease and high-density lipoprotein cholesterol (HDL-C) levels [ 5 - 8 ]. (cdc.gov)
  • Dysfunctional detoxification enzymes are responsible for prolonged exposure to reactive molecules and can contribute to endothelial damage, an underlying factor in coronary artery disease (CAD). (samj.org.za)
  • Even if the habit of eating frequently, or exercising regularly, or abstaining from smoking, or living a non-stressed life may lower the cholesterol concentration, there is no evidence either that this effect may influence the risk of cardiovascular disease by itself. (bmj.com)
  • Research indicates that it can help lower blood pressure, improve cholesterol levels, and prevent artery plaque buildup. (healthnoise.com)
  • [ 5 ] The primary cause of both CHD and CVD is atherosclerosis, which is defined as the pathologic narrowing of arteries due to the deposition of cholesterol and its products. (medscape.com)
  • Hyperhomocysteinemia not only leads to endothelial dysfunction but also promotes the development and propagation of atherosclerotic lesion in atherosclerosis-prone animal models. (uni-muenchen.de)
  • This assessment must incorporate angiographic findings, a detailed risk assessment and a nuanced management plan that must include aggressive control of the atherosclerotic disease process to ensure safety of flight. (bmj.com)
  • The protein encoded by this gene is a member of the platelet-derived growth factor/vascular endothelial growth factor (PDGF/VEGF) family and is active in angiogenesis, lymphangiogenesis, and endothelial cell growth. (nih.gov)
  • The endothelial-specific microRNA miR-126 governs vascular integrity and angiogenesis. (koreamed.org)
  • Retrieved on September 25, 2023 from https://www.news-medical.net/health/Coronary-Artery-Disease-and-Aspirin.aspx. (news-medical.net)
  • A lack of vasodilation would suggest decreased release of endogenous vasodilators and therefore, endothelial dysfunction, thus indicating future cardiovascular risk: increased risk for future cardiovascular events and a potential need for revascularisation (5). (escardio.org)
  • Stent induced hemodynamic changes in the coronary arteries are associated with higher risk of adverse clinical outcome. (researchgate.net)
  • Clinical practitioners are recommended to prescribe low dose aspirin to be taken daily, especially in adults who are at increased risk for coronary artery disease. (news-medical.net)
  • Further studies are required to prove that these methylations contribute to the immunologic dysregulations occurring in these (and perhaps other) autoimmune diseases and can serve as clinical markers of disease severity and/or as therapeutic targets for controlling the diseases. (wikipedia.org)
  • Coronary Artery Disease: From Mechanism to Clinical Practice. (iasp-pain.org)
  • Additional testing was performed at the California Department of Public Health Viral and Rickettsial Disease Laboratory for severe or fatal cases, and those in which clinical criteria were met but antibody titers were below case definition thresholds. (cdc.gov)
  • Genetic Tools for Coronary Risk Assessment in Type 2 Diabetes: A Cohort Study From the ACCORD Clinical Trial. (cdc.gov)
  • Systemic autoimmune diseases, such as rheumatoid arthritis (RA), exhibit accelerated atherosclerosis (AS) [ 1 - 4 ] as a consequence of endothelial dysfunction, leading to higher incidence of cardiovascular (CV) disease (at least 2-fold enhanced CV risk) and premature and higher mortality [ 5 , 6 ]. (hindawi.com)
  • Projections of Global Mortality and Burden of Disease from 2002 to 2030 PLoS Med 3(11): e442. (sciencedaily.com)
  • Decades of research have demonstrated that serum concentrations of blood lipids are associated with increased risk for cardiovascular disease and mortality [ 1 - 4 ]. (cdc.gov)
  • New, in particular, are studies demonstrating that even one night of aircraft noise exposure can cause vascular (endothelial) dysfunction in healthy subjects," said Münzel. (medscape.com)
  • The Glu298Asp (G894T) polymorphic variant of the eNOS gene has been implicated in the development of coronary artery disease (CAD). (bvsalud.org)
  • Three different isoforms of NOS are known: neuronal NOS (nNOS or NOS1), endothelial NOS (eNOS or NOS3), and inducible NOS (iNOS or NOS2). (medscape.com)
  • Premature cardiovascular disease (CVD) is a serious long-term complication of chronic systemic inflammatory diseases including rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE). (bmj.com)
  • Aerobic activity performed on a regular basis is 1 of several lifestyle recommendations endorsed to reduce risk of coronary disease. (duke.edu)
  • Traditional versus nontraditional risk factors for coronary artery disease (CAD). (medscape.com)
  • South Asians appear to have a higher independent risk for cardiovascular disease as well. (medscape.com)
  • 1 2 Furthermore, about a fifth of the world's adult population are thought to have metabolic syndrome, a cluster of factors associated with an increased risk of type 2 diabetes and cardiovascular disease. (bmj.com)
  • Nevertheless, endothelial function has, for the time being, been demonstrated to be a marker for risk of cardiovascular events in high risk groups only. (escardio.org)
  • Whether you're aiming to enhance athletic performance or reduce the risk of chronic diseases, magnesium is an essential nutrient that can help you achieve your health goals. (healthnoise.com)
  • A person's risk of developing coronary artery disease is influenced by several non-modifiable factors such as family history, age and gender. (news-medical.net)
  • However, other factors that increase the risk for coronary artery disease can be modified by taking measures to change lifestyle. (news-medical.net)
  • Metabolic syndrome is a constellation of various cardiovascular risk factors with a potential to double the risk of coronary artery disease. (nepjol.info)
  • However, in real world scenario, this is just a combination of multiple CV risk factors and its separate existence is somehow regarded as a myth in endothelial function assessment. (nepjol.info)
  • Therefore a study was designed to evaluate the role of metabolic syndrome as a cardiovascular risk factor by assessing endothelial function in subjects with it. (nepjol.info)
  • Similarly the rates of metabolic syndrome was calculated in subjects with and without endothelial dys-function in this cohorts of cardiovascular risk factors. (nepjol.info)
  • The association between metabolic syndrome and endothelial dys-function was not significantly different than the association between multiplex of risk factors and endothelial dysfunction. (nepjol.info)
  • Oxidative risk for atherothrombotic cardiovascular disease. (snpedia.com)
  • He hopes politicians create laws to protect people from environmental stressors and "take into account in particular the new findings concerning noise pollution and cardiovascular disease and to acknowledge noise as a cardiovascular risk factor," he said. (medscape.com)
  • This finding is plausible because combination antiretroviral therapy can cause adverse metabolic changes that are known risk factors for cardiovascular disease. (natap.org)
  • Genetic Risk Score for Coronary Disease Identifies Predispositions to Cardiovascular and Noncardiovascular Diseases. (cdc.gov)
  • First, erectile men with erectile dysfunction between 18 dysfunction and coronary artery disease and 59 years of age seek medical advice share many risk factors such as diabetes about their problem [ 4 ]. (who.int)
  • Secondly, it is possible their urologists for reasons other than erec- that the same vascular and endothelial tile dysfunction were found to have a histo- changes that take place in the coronary ar- ry of erectile dysfunction but failed to teries are likely to occur in the cavernosal inform their physicians about their prob- arteries that supply the penile erectile tissue lem. (who.int)
  • Whether in coronary or peripheral arteries, response to pharmacological agents and/or to hemodynamic provocation tests is assessed as a measure of endothelial function (2). (escardio.org)