Endometrial stromal stromal cells. Medical search. Frequent questions

Endometrial stromal sarcoma is a malignant subtype of endometrial stromal tumor arising from the stroma (connective tissue) of the endometrium rather than the glands. (wikipedia.org)
Low-grade endometrial stromal sarcoma consists of cells resembling normal proliferative phase endometrium, but with infiltration or vascular invasion. (wikipedia.org)
Undifferentiated uterine sarcoma, or undifferentiated (high-grade) endometrial stromal sarcoma, does not resemble normal endometrial stroma and behaves much more aggressively, frequently metastasizing. (wikipedia.org)
CD10+ muscle markers (muscle specific actin MSA, smooth muscle actin SMA and desmin) positive in areas of smooth muscle differentiation CD117- (c-kit -) h-caldesmon- A recurrent chromosomal translocation, t(7;17)(p15;q21), occurs in endometrial stromal sarcoma. (wikipedia.org)
The neoplastic cells expressed desmin, alpha-smooth muscle actin and CD10, compatible with endometrial stromal sarcoma tumor. (vin.com)
UTROSCT also lacks JAZF1 and PHF1 rearrangements, which is helpful in differentiating UTROSCT from low grade endometrial stromal sarcoma. (cedars-sinai.edu)
Leiomyosarcoma and endometrial stromal sarcoma are the most common types. (msdmanuals.com)
Symptoms suggesting uterine sarcoma usually prompt transvaginal ultrasonography and endometrial biopsy or dilation and curettage (D & C). However, these tests have limited sensitivity for sarcoma. (msdmanuals.com)
Endometrial stromal sarcoma and uterine leiomyosarcoma are often incidentally diagnosed histologically after hysterectomy or myomectomy. (msdmanuals.com)
Screening for Lynch syndrome (hereditary nonpolyposis colorectal cancer) is not usually done when patients have uterine sarcoma because this genetic syndrome increases risk of endometrial carcinoma, not sarcoma. (msdmanuals.com)
But even after evacu- made of endometrial stromal sarcoma tomography and magnetic resonance ation, the uterus appeared enlarged or poorly differentiated granulosa cel imaging [ 2 ]. (who.int)

There are three grades for endometrial stromal tumors, as follows. (wikipedia.org)
Alteration or exacerbation of malignant tumor cell migration and dissemination is the principal cause of death due to solid tumors 5 . (nature.com)
UTROSCT lacks FOXL2 and DICER1 mutations, which are found in granulosa cell tumors and Sertoli Leydig cell tumors of the ovary, respectively. (cedars-sinai.edu)
Molecular alterations of PIK3CA in uterine carcinosarcoma, clear cell, and serous tumors. (cdc.gov)
A survey of DICER1 hotspot mutations in ovarian and testicular sex cord-stromal tumors. (cdc.gov)

Microscopic evaluation of the uterus demonstrated multiple sites of ovoid and fusiform mesenchymal cell proliferation, atrophic endometrial glands, with deep smooth muscle infiltration. (vin.com)
She underwent an endometrial biopsy, which demonstrated a müllerian mesenchymal neoplasm that could not be further classified based on histologic findings and immunostains. (cedars-sinai.edu)
The tumor consists of sex cord-like and mesenchymal differentiation with various possible components, including Sertoli-like tubules, nested granulosa-like architecture, retiform growth, lipidized cells, Leydig-like cells, stromal cells with infiltrative growth, and solid sheets of smooth muscle-like cells. (cedars-sinai.edu)
We investigated the presence of aluminium (Al) in human colon cancer samples and its potential association with biological processes involved in cancer progression, such as epithelial to mesenchymal transition (EMT) and cell death. (bvsalud.org)
Extracellular vesicles released by mesenchymal stem/stromal cells (MSC-EV) are promising agents to positively influence joint homeostasis in the osteoarthritic surroundings. (bvsalud.org)
After Ang II treatment, poorly differentiated endometrial cancer cell line acquired a mesenchymal phenotype, which was characterized by induced expression of EMT-related genes (VIM, CD44, SNAI1, ZEB1 and ZEB2). (spandidos-publications.com)

We previously demonstrated the critical involvement of SRC-2 in murine embryo implantation as well as in human endometrial stromal cell (HESC) decidualization, a cellular transformation process required for trophoblast invasion and ultimately placentation. (frontiersin.org)
We also found that SRC-3 depletion in cultured HESCs results in a significant attenuation in the induction of a wide-range of established biomarkers of decidualization, despite exposure of these cells to a deciduogenic stimulus and normal progesterone receptor expression. (frontiersin.org)
The differentiation of endometrial stromal cells into decidual cells, termed decidualization, is an integral step in the establishment of pregnancy. (bioone.org)
Primary human endometrial stromal cells (HESCs) were subjected to small interfering RNA knockdown of WNK1 followed by in vitro decidualization. (bioone.org)
Although ROS-dependent JNK signaling is disabled on decidualization, the cells continue to mount a transcriptional response, albeit distinct from that observed in undifferentiated HESCs. (warwick.ac.uk)
Decidualization is the progestin-induced differentiation of estrogen-primed endometrial stromal cells (ESCs), which is crucial for implantation and maintenance of pregnancy. (elsevierpure.com)
We here show that trichostatin A (TSA), a specific HDAC inhibitor, enhances the up-regulation of decidualization markers such as insulin-like growth factor binding protein-1 (IGFBP-1) and prolactin in a dose-dependent manner that is directed by 17β-estradiol (E 2 ) plus progesterone (P 4 ) in cultured ESCs, but not glandular cells, both isolated from human endometrium. (elsevierpure.com)

type II consists of serous carcinoma, clear cell carcinoma, and carcinosarcoma. (karger.com)
Typical sites of metastasis of endometrial carcinoma are pelvic and para-aortic lymph nodes, vagina, peritoneum, and lungs [ 2 ]. (karger.com)
The patient had a past surgical history of a total abdominal hysterectomy for endometrial carcinoma, which was performed 5 months prior to presentation. (karger.com)
OBJECTIVES: I. Evaluate the efficacy of paclitaxel and carboplatin with amifostine on progression free survival and overall survival in patients with metastatic or recurrent epithelial endometrial carcinoma not amenable to surgery or radiotherapy. (knowcancer.com)
The differential diagnosis includes endometrial stromal tumor with sex cord-like differentiation, endometrial carcinoma with sex cord-like differentiation, adenosarcoma with extensive sex cord-like differentiation, and mesonephric adenocarcinoma. (cedars-sinai.edu)
Polyphyllin I (PPI), a promising pharmaceutical candidate, has shown potential therapeutic advantages in the treatment of sorafenib-resistant hepatocellular carcinoma (SR-HCC cells). (bvsalud.org)
Between the period of 1983 and 2009, there were a total of 25 cases of small cell carcinoma, 20 of squamous carcinoma, and 10 of adenocarcinoma, wherein prediagnosis urine cytology was available. (cytojournal.com)
There were eight cases (12 samples) of small cell carcinoma, four cases (6 samples) of squamous cell carcinoma and four cases (5 samples) of adenocarcinoma. (cytojournal.com)
Of the nine samples of small cell carcinoma, categorized as atypical, suspicious for carcinoma, three (33%) were categorized as suspicious for small cell carcinoma, while the others were not further classified, due to limitations of cellular preservation. (cytojournal.com)
In the squamous cell carcinoma subgroup, the samples with 'atypical, suspicious for carcinoma' diagnoses did not show any keratinization and were interpreted as atypical urothelial cells. (cytojournal.com)
None of the samples of small cell carcinoma had a false negative diagnosis on cytology, while only one case of squamous cell carcinoma was diagnosed as negative. (cytojournal.com)
Majority are well differentiated and mimic proliferative endometrial glands and, as such, are referred to as endometrioid carcinoma. (slideserve.com)

Comparing HESC controls with HESCs deficient in SRC-3, gene enrichment analysis of the differentially expressed gene set revealed an overrepresentation of genes involved in chromatin remodeling, cell proliferation/motility, and programmed cell death. (frontiersin.org)
Gene ontology and upstream regulator pathway analysis showed that WNK1 regulates cell migration, differentiation, and proliferation. (bioone.org)
Proliferation of the cancer cells was significantly increased through the steroid sulfatase pathway, which metabolizes androgens, estrone sulfate, and estradiol sulfate as its substrates. (scirp.org)
We evaluated the effects of STS inhibitor and aromatase inhibitors on the proliferation of estrogen-dependent endometrial cancer cells. (scirp.org)
Interference with and overproduction of GRP78 in vitro impacted the proliferation, migration, invasion, and metastasis of HCC cells. (bvsalud.org)
EndoECM supported in vitro culture of human endometrial cells in two- and three-dimensional conditions and improved proliferation of endometrial stem cells with respect to collagen and Matrigel. (datadryad.org)
We also showed that dose-dependent induction of proliferation was connected with changes in the expression of MKI67, CCND1 and CCNE1 genes in well- and poorly differentiated cancer cells. (spandidos-publications.com)
Our study revealed that Ang II influences EC cells in terms of cancer-related processes, and is responsible for increased proliferation, reduction in apoptosis, increased mobility and modulation of adhesion potential. (spandidos-publications.com)
One of the postulated key processes in the development of endometrial tumours is uncontrolled proliferation stimulated by physiological local factors ( 3 ). (spandidos-publications.com)
Therefore, various biologically active peptides such as angiotensin, affecting cell proliferation, have become a new area of study in endometrial cancer research. (spandidos-publications.com)
Recently, a number of studies have shown that Ang II plays an important role in proliferation, invasiveness and migration of tumour cells, alteration of expression of cancer-related genes, as well as in physiological tissue remodelling. (spandidos-publications.com)
Rab27b can promote the cell proliferation, migration and invasion of ESCs. (bvsalud.org)

In this study, we aimed to evaluate the possible effects of tumor-stromal interactions on local estrogen biosynthesis in endometrial cancer. (scirp.org)
We isolated stromal cells from endometrial cancer patients to examine local biosynthesis of estrogens and tumor-stromal interactions. (scirp.org)
Tumor cell dissemination in cancer patients is associated with a significant reduction in their survival and quality of life. (nature.com)
The ubiquitination pathway plays a fundamental role in the maintenance of protein homeostasis both in normal and stressed conditions and its dysregulation has been associated with malignant transformation and invasive potential of tumor cells, thus highlighting its value as a potential therapeutic target. (nature.com)
In order to identify novel molecular targets of tumor cell migration and invasion we performed a genetic screen with an shRNA library against ubiquitination pathway-related genes. (nature.com)
We extended our investigation in vivo and confirmed that mice injected with USP19 depleted cells display increased tumor-free survival, as well as a delay in the onset of the tumor formation and a significant reduction in the appearance of metastatic foci, indicating that tumor cell invasion and dissemination is impaired. (nature.com)
More importantly, we demonstrated that USP19 catalytic activity is important for the control of tumor cell migration and invasion, and that its molecular mechanism of action involves LRP6, a Wnt co-receptor. (nature.com)

The ability of ROS to induce a sustained hypersumoylation response, or interfere with PR activity, was lost upon differentiation of HESCs into decidual cells. (warwick.ac.uk)
Differentiation of endometrial fibroblasts into specialized decidual cells controls embryo implantation and transforms the cycling endometrium into a semi-permanent, immune-protective matrix that accommodates the placenta throughout pregnancy. (a-star.edu.sg)
Its effect and effectiveness appear to be highly connected with the differentiation status of the cancerous cells, as Ang II appears to play a crucial role in the early and late stages of malignant transformation. (spandidos-publications.com)

We show here that, like SRC-2, SRC-3 is expressed in the epithelial and stromal cellular compartments of the human endometrium during the proliferative and secretory phase of the menstrual cycle as well as in cultured HESCs. (frontiersin.org)
Since perturbation of normal homeostatic levels of SRC-3 is linked with common gynecological disorders diagnosed in reproductive age women, this endometrial coregulator-along with its new molecular targets described here-may open novel clinical avenues in the diagnosis and/or treatment of a non-receptive endometrium, particularly in patients presenting non-aneuploid early pregnancy loss. (frontiersin.org)
The fertilized egg cell later attaches itself to the endometrium inside the uterus and pregnancy starts. (asu.edu)
We obtained endometrium derived from porcine decellularized uteri to create endometrial extracellular matrix (EndoECM) hydrogels. (datadryad.org)
Further, we developed a three-dimensional endometrium-like co-culture system of epithelial and stromal cells from different origins. (datadryad.org)

Most patients with endometrial cancer present with abnormal vaginal bleeding. (medscape.com)

In contrast, overexpression of USP19 increased cell invasiveness both in vitro and in vivo, further validating our findings. (nature.com)
Our in vitro studies included scratch wound-healing migration assays and transwell assays to examine PPI's effect on HCC cell migration and invasion. (bvsalud.org)
Decellularization techniques support the creation of biocompatible extracellular matrix hydrogels, providing tissue-specific environments for both in vitro cell culture and in vivo tissue regeneration. (datadryad.org)
Biomimetic endometrial milieus offer new strategies in reproductive techniques and endometrial repair and our findings demonstrate that EndoECM has potential for in vitro endometrial culture and as treatment for endometrial pathologies. (datadryad.org)
In-vitro cultures of primary endometriotic stromal cells, immortalized endometrial stromal (St-T1b) and endometriotic epithelial (12Z) cells were used to assess the effects of resveratrol on endometrial cell mechanisms. (nih.gov)
Resveratrol showed inhibitory effects on cell behaviour related to the development of endometriosis by differentially affecting growth, apoptosis, migration and stem cell phenotype of endometrial and endometriotic cells in vitro. (nih.gov)

Endometrial adenocarcinoma is the most common gynecologic malignancy in the United States. (medscape.com)
In this report, we highlight an unusual site of metastasis of an endometrial adenocarcinoma to the small intestine. (karger.com)
Biological assays were performed on well-[Ishikawa (ISH)] moderately (MFE-296) and poorly (MFE-280) differentiated human adenocarcinoma cancer cell lines, representing the G1, G2 and G3 stage of EC. (spandidos-publications.com)
Endometrial Cancer Endometrial cancer is usually endometrioid adenocarcinoma. (msdmanuals.com)

Radiation has a key role in adjuvant treatment of endometrial cancers and sarcomas. (medscape.com)
Estrogens significantly contribute toward the growth and development of endometrial cancers. (scirp.org)
Endometrial cancers arise mainly in postmenopausal women. (slideserve.com)
Endometrial cancer (EC) is one of the most common female cancers. (spandidos-publications.com)
Endometrial cancer (EC) is one of the most common types of cancer in women, and ranks 4th (7.1%) in incidence among all female cancers. (spandidos-publications.com)
While endometrial cancer affects reproductive age as well as postmenopausal women, 75% of endometrial cancers occur in postmenopausal women, with the mean age of diagnosis at 61 years. (medscape.com)
These mutations lead to microsatellite instability in 90% of colon cancers and 75% of endometrial cancers. (medscape.com)

Approximately eighty percent of endometrial carcinomas are endometrioid adenocarcinomas. (medscape.com)

The mainstay of primary treatment in endometrial cancer and uterine sarcomas is surgery. (medscape.com)
Although no laboratory tests aid in the diagnosis of uterine cancer, CA-125 has been used in surveillance of advanced or high-grade endometrial cancer. (medscape.com)
Chemotherapy plays a role in adjuvant therapy for high-grade uterine sarcomas, in addition to high-grade, recurrent, or metastatic endometrial cancer. (medscape.com)
No evidence suggests that routine endometrial sampling or transvaginal sonography to evaluate the endometrial stripe in asymptomatic women has a role in early detection of uterine cancer, even in women who take tamoxifen after breast cancer or has a cancer syndrome. (medscape.com)
This article discusses endometrial cancer and uterine sarcomas. (medscape.com)
Endometrial cancer is the fourth most common cancer in females and is the most prevalent gynecological malignancy. (karger.com)
Metastasis from endometrial cancer to small bowel is very rare [ 3 ]. (karger.com)
Next we examined the effects of steroid sulfatase inhibitor and aromatase inhibitor in monoculture of endometrial cancer cell line (Ishikawa) and in a co-culture system involving an Ishikawa cells and stromal cells. (scirp.org)
Estrogen receptor and steroid sulfatase mRNA levels in cancer cells were significantly higher in the co-cultures compared with the monocultures of endometrial cancer cells. (scirp.org)
We identified the deubiquitinase USP19 and demonstrated that its silencing reduces the migratory and invasive potential of highly invasive breast cancer cell lines. (nature.com)
To identify novel molecular targets within the ubiquitination pathway that positively regulate migration we conducted a loss-of-function genetic screen using an epithelial cell line derived from human triple-negative breast cancer (MDAMB231) infected with a pooled shRNA interference library. (nature.com)
Transmission electron microscopy and energy-dispersive X-ray microanalysis confirmed the presence of Al specifically in intracytoplasmic electrondense nanodeposits adjacent to mitochondria of colon cancer cells. (bvsalud.org)
Al-positive samples showed a significant increase in both the number of vimentin-positive and nuclear ß-catenin-positive cancer cells compared to Al-negative samples. (bvsalud.org)
In 2012 in Poland, 5,426 women were diagnosed with endometrial cancer. (spandidos-publications.com)
With regard to mortality, endometrial cancer ranks 11 (2.76%) with 1,162 deaths in 2012. (spandidos-publications.com)
Most endometrial cancer cases are diagnosed in the early stages and therefore result in favourable clinical outcomes ( 2 ). (spandidos-publications.com)
All components of the RAS (angiotensinogen, angiotensin converting enzyme, angiotensin receptors) are expressed in many types of tumours, including endometrial cancer ( 2 , 4 ). (spandidos-publications.com)
The aim of the present study was to evaluate the influence of Ang II on human endometrial cancer cells. (spandidos-publications.com)
Moreover, we examined alterations in the expression of genes related to cancer cell behaviour after Ang II treatment. (spandidos-publications.com)
Another group of women at increased risk of premenopausal endometrial cancer are those with Lynch II syndrome, also known as hereditary nonpolyposis colorectal cancer (HNPCC). (medscape.com)
This is an autosomally dominant germline mutation in DNA mismatch repair (MMR) genes ( MSH1 , MSH2 , MSH6 ) and accounts for 9% of patients younger than 50 years with endometrial cancer. (medscape.com)
Besides colon cancer, women affected have a 40-60% risk of endometrial cancer by age 70 years, compared to a baseline population risk of 1.5% at the same age. (medscape.com)
Cancer cell 2017 Mar 31 (3): 411-423. (cdc.gov)
TCGA Classification of Endometrial Cancer: the Place of Carcinosarcoma. (cdc.gov)

Squamous cell carcinomas, adenocarcinomas, and small cell carcinomas of the urinary bladder are rare and account for less than 5, 2, and 0.5% of all bladder carcinomas, respectively. (cytojournal.com)
All the adenocarcinomas categorized as negative by urine cytology had sparse cellularity and did not reveal any atypical cells on slide review. (cytojournal.com)
Rarely, adenocarcinomas arise within endometrial polyps. (slideserve.com)

During abruptions, decidual cell and neutrophil-derived proteases effectively degrade the decidual and fetal membrane extracellular matrix to promote preterm premature rupture of the membranes and preterm delivery (PTD). (scirp.org)

It was previously known as endolymphatic stromal myosis because of diffuse infiltration of myometrial tissue or the invasion of lymphatic channels. (wikipedia.org)
The estrogen-regulated lncRNA H19/miR-216a-5p axis alters stromal cell invasion and migration via ACTA2 in endometriosis. (iasp-pain.org)
Alterations in the H19/miR-216a-5p/ACTA2 pathway may mediate the regulation of eutopic endometrial stromal cell (euESC) invasion and migration and may represent a potential mechanism underlying fibrous tissue formation or fibrosis in women with endometriosis. (iasp-pain.org)
In this study, we sought to investigate the mechanism underlying the inhibitory effect of PPI on the invasion and metastasis of SR-HCC cells. (bvsalud.org)
The results of these experiments demonstrated that PPI increased the susceptibility of HCC to sorafenib while inhibiting SR-HCC cell growth, migration, and invasion. (bvsalud.org)
Further examination revealed that PPI hindered the expression of GRP78 protein, resulting in a suppressive effect on SR-HCC cell migration and invasion. (bvsalud.org)

Those growths, called endometrial lesions, typically form outside the uterus , but can spread to other reproductive organs such as ovaries and fallopian tubes . (asu.edu)
The egg cell goes through the fallopian tube, which attaches the ovary to the uterus , where the egg cell can meet a sperm cell that fertilizes the egg cell. (asu.edu)
Using microscopes to examine tissue samples taken from patients' bodies, Rokitansky found endometrial cells growing in unusual parts of the body, such as the myometrium, the middle tissue layer of the uterus , and the ovaries. (asu.edu)
Cullen's descriptions were some of the first to not only describe growths outside of the uterus but infer that they were of endometrial origin without suggesting that the growths were malignant as Rokitansky seemed to. (asu.edu)
There, he also introduced the theory of what he called retrograde menstruation to explain how endometrial lesions develop outside the uterus . (asu.edu)
Endometriosis is a condition in which endometrial tissue, which normally lines the inside of the uterus, deposits in other tissues. (biomedcentral.com)
Endometriosis is defined as the deposit and growth of endometrial tissue that normally lines the inside of the uterus outside the uterine cavity [ 1 ]. (biomedcentral.com)

Endometrial stripe thickness also helps in determining which women with negative findings on office endometrial biopsy samples should have a formal curettage. (medscape.com)

These molecular findings are supported at the cellular level by the inability of HESCs to morphologically transform from a stromal fibroblastoid cell to an epithelioid decidual cell when endogenous SRC-3 levels are markedly reduced. (frontiersin.org)
Using primary cultures, we show that modest levels of reactive oxygen species (ROS) increase sumoylation in human endometrial stromal cells (HESCs), leading to enhanced modification and transcriptional inhibition of the progesterone receptor (PR). (warwick.ac.uk)

Defective immune surveillance is thought to play a role in the implantation and growth of ectopic endometrial tissue [ 6 ]. (biomedcentral.com)

Stem Cell Research & Therapy. (monash.edu)
Stem cells. (nih.gov)

According to the model of retrograde menstruation, endometrial tissues are shed through the fallopian tubes into the pelvic cavity during menstruation, resulting in the formation of ectopic endometriotic lesions on the peritoneal tissue or pelvic organs. (biomedcentral.com)

De- cidual cells promote hemostasis through enhanced expression of tissue factor (TF), the primary initiator of hemostasis via thrombin generation, and plasminogen activator inhibitor-1, which inactivates tissue type plasminogen activator, the primary fibrinolytic agent. (scirp.org)
Primary cultured cells of endometrial tissues were analysed using RT-PCR and western blotting (WB) to determine expression of H19 and ACTA2. (iasp-pain.org)
However, our study showed that primary cultured cells represented endometriosis cells more clearly than cell lines. (iasp-pain.org)
0.001 to P = 0.0193) in both cell lines and primary cultures. (nih.gov)
Primary endometrial stromal cells (ESCs), decidual stromal cells (DSCs), decidual immune cells (DICs) and peripheral blood mononuclear cells (PBMCs) were isolated. (bvsalud.org)

H&E, 40x & 200x magnifications): Retiform architecture of epithelioid cells with hyaline material resembling a sex cord-like structure. (cedars-sinai.edu)

Decidual cell-derived thrombin weakens the amniotic membrane and lowers decidual cell-expressed progesterone receptor levels by increasing phospho-ERK1/2 signaling. (scirp.org)

2009) Progestin and thrombin regulate tissue factor expression in human term decidual cells. (scirp.org)

Uterine sarcomas can present in a similar fashion to endometrial carcinomas with vaginal bleeding, and often pelvic pressure as well. (medscape.com)
Other histologic subtypes include adenosquamous, clear cell, and papillary serous carcinomas. (medscape.com)

This process starts during the midluteal phase of the menstrual cycle with decidual transformation of perivascular cells (PVC) surrounding the terminal spiral arterioles and endometrial stromal cells (EnSC) underlying the luminal epithelium. (a-star.edu.sg)

This abrogated expression of the decidual marker genes, insulin like growth factor binding protein 1 ( IGFBP1 ) and prolactin ( PRL ), and prevented adoption of decidual cell morphology. (bioone.org)
Abruptions (decidual hemorrhage) produce excess thrombin which acts as autocrine/paracrine inducer of decidual cell expressed matrix metalloproteinases and of neutrophil chemoattractant and activator, interleukin-8. (scirp.org)

Two-way communication between endometrial stromal cells and monocytes. (moffitt.org)

Reciprocal communication between endometrial stromal cells and macrophages. (moffitt.org)
In women with miscarriage, NRP1 was abnormally elevated in DSCs but diminished in decidual macrophages and NK cells. (bvsalud.org)

We further show that attenuated JNK signaling in decidual cells is a direct consequence of altered expression of key pathway modulators, including induction of MAP kinase phosphatase 1 (MKP1). (warwick.ac.uk)
Thus, JNK silencing uncouples ROS signaling from the SUMO conjugation pathway and maintains progesterone responses and cellular homeostasis in decidual cells under oxidative stress conditions imposed by pregnancy. (warwick.ac.uk)
The miR-182-5p/NDRG1 Axis Controls Endometrial Receptivity through the NF-κB/ZEB1/E-Cadherin Pathway. (nih.gov)

10: Does routine preparation of multiple ThinPrep ® and cell block slides improve the detection of malignancy in effusion fluid? (cytojournal.com)

The effect of resveratrol on the expression of genes related to cell migration, angiogenesis and cell stemness was evaluated by qRT-PCR. (nih.gov)

Cullen published a series of detailed diagrams and descriptions in the journal Surgery that visually represented endometrial growths that he had observed in different areas of the pelvic region. (asu.edu)

From our screen, we identified the Ubiquitin-specific protease 19 (USP19) as a candidate gene associated with the regulation of cell migration. (nature.com)
The effects of resveratrol on 12Z and St-T1b cell viability were assessed by MTT assay, apoptosis by FITC Annexin V assay and cleaved caspase-3 levels and cell migration by wound healing assay. (nih.gov)

Accordingly, pregnancy success rates currently achieved by natural or assisted conception for women at high-risk for EPL or RPL can only be increased by an improved understanding of the cellular and molecular mechanisms that control endometrial function during the periimplantation period. (frontiersin.org)
Reductions in uteroplacental flow initiate a cascade of molecular effects leading to hypoxia, thrombosis, inflammation, and endothelial cell dysfunction resulting in untoward pregnancy outcomes. (hindawi.com)

The investigation of cell free DNA and genetic causes in the evaluation of miscarriage. (bham.ac.uk)

Endometrial lesions swell and bleed during menstruation , which can cause painful and heavy menstruation , as well as infertility . (asu.edu)
After menstruation , one of the next steps of the menstrual cycle is a process called ovulation that starts at the ovaries, which are reproductive organs that release hormones and store egg cells. (asu.edu)

Moreover, Al-positive samples exhibited a significant decrease in the number of apoptotic cells, as well as the expression of the anti-apoptotic molecule BCL-2. (bvsalud.org)

In this study, we aimed to determine the expression of H19 and ACTA2 in endometrial tissues of women with endometriosis. (iasp-pain.org)

Cell motility is a complex process that requires post-translational regulation of a wide variety of proteins. (nature.com)

Anatomy35

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Analytical, Diagnostic and Therapeutic Techniques and Equipment26

Phenomena and Processes40

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