2023CytokineCytokinesOvarianCancersTissuesStromal fibroblastsImplantationEctopicFibroblastsVitroInflammatoryReceptorGenesIL11MRNATranscriptional2022InhibitionMechanismsGeneStimulatesCancerPromotesMolecular2016UterusRegenerationELISAExpressionProteinTumorEndometriosisAdhesionSignificantlyDecidualProteinsRoleCellPatientsGrowthPrimarily
20232
- 26(11): 108158, 2023 Nov 17. (bvsalud.org)
- 2023 Mar.11(6):275. (moffitt.org)
Cytokine6
- IL-11 is a cytokine that was first isolated in 1990 from bone marrow-derived fibrocyte-like stromal cells. (wikipedia.org)
- IL-11 is a member of the IL-6-type cytokine family, distinguished based on their use of the common co-receptor gp130. (wikipedia.org)
- The inflammatory cytokine interleukin-6 (IL-6) is a powerful inducer of the hepatic acute-phase response, and it has been proposed to be a central mediator in the pathogenesis of coronary heart disease through a combination of autocrine, paracrine, and endocrine mechanisms ( 8 ). (ispub.com)
- In particular we are studying the role of eicosanoids in normal pregnancy and preeclampsia, the contribution of a purinergic receptor to the release of the cytokine interleukin-1beta in pregnancy as well as investigation of the inflammasome in coordinating inflammatory pathways coupled to cytokine release. (nottingham.ac.uk)
- The PD-L1 binding to PD-1 causes immunosuppressive results and enables the tumor in order to avoid immune system devastation by inhibiting the proliferation and success of cytotoxic T cells and reducing cytokine creation (generally interleukin-2) [4,5]. (eprf.ca)
- Leukemia inhibitory element (LIF), an interleukin (IL) 6-type cytokine, is among the few substances obligatory for fertility in mice [8]. (cancerhugs.com)
Cytokines3
- SP promoting decidualizing of eSFs of women with and without inflammatory disorders (polycystic ovary syndrome (PCOS), endometriosis) in a way that is not mediated by amyloid semen and those associated with the response transcription powerful, including the induction of interleukin ( IL ) - 11 , cytokines important for the SP-induced decidualizing. (il-11.com)
- Synchronized endometrial receptivity and blastocyst competence is vital for implantation and it is achieved with a controlled network of paracrine and autocrine elements, including cytokines [7]. (cancerhugs.com)
- 12). B-cell chronic lymphocytic leukemia/lymphoma 6 (BCL-6) is a protein encoded by a proto-oncogene present on chromosome 3 (3q27.3) that stimulates inflammatory cytokines such as interleukin-6 (IL-6), IL-8, and IL-17 in the peritoneal fluid of people with endometriosis. (nezhat.org)
Ovarian6
- Dr. Shahzad's clinical interests are in the surgical management of advanced gynecologic malignancies, including cytoreductive surgery for ovarian cancer, complex minimally invasive laparoscopic and robotic surgery for endometrial and cervical cancers as well as fertility sparing surgical techniques. (moffitt.org)
- (1) A study from Beijing compared three treatment methods to find the most effective treatment for endometrial ovarian cysts. (avicenna.co.uk)
- 152 patients with endometrial ovarian cysts were divided into three groups: an integrated laparoscopy and Chinese herbal medicine (combination group), a Chinese herbal medicine group, and a Danazol group. (avicenna.co.uk)
- The authors conclude that combining laparoscopy with Chinese herbal medicine is an effective treatment for endometrial ovarian cysts with minimal side effects and a maximal preservation of the reproductive function. (avicenna.co.uk)
- Wu Y, Hua L, Jin Y [Clinical study on endometrial ovarian cyst treated by integrated laparoscopy and Chinese herbal medicine] Zhongguo Zhong Xi Yi Jie He Za Zhi. (avicenna.co.uk)
- Ovarian cancer, uterine cervical cancer, endometrial cancer, and trophoblastic neoplasms are gynecologic malignancies for which tumor markers are in clinical use. (medscape.com)
Cancers4
- More recently it has been discovered that over-expression of IL-11 is associated with a variety of cancers and may provide a link between inflammation and cancer. (wikipedia.org)
- As IL-11 over expression is associated with a number of cancers, inhibition of its signaling pathway may have utility in treating cancer. (wikipedia.org)
- A review of the world's literature shows that non-diabetics with high blood sugar levels suffer a marked increase in breast, colon, liver, stomach, pancreatic and endometrial cancers. (thelajollachiropractor.com)
- The TPD52 gene is located on chromosome 8 at the region frequently amplified in various human cancers [ 10 , 11 ]. (biomedcentral.com)
Tissues4
- To delve into the relationship between EMS and microbiota, Ectopic (EM) and eutopic (EU) endometrial tissues, pharyngeal swabs, and stools were collected from EMS patients. (bvsalud.org)
- SD rats were implanted with endometrial tissues and treated with KTC for three weeks. (hindawi.com)
- Endometriosis is a condition in which endometrial tissue, which normally lines the inside of the uterus, deposits in other tissues. (biomedcentral.com)
- According to the model of retrograde menstruation, endometrial tissues are shed through the fallopian tubes into the pelvic cavity during menstruation, resulting in the formation of ectopic endometriotic lesions on the peritoneal tissue or pelvic organs. (biomedcentral.com)
Stromal fibroblasts2
- Seminal plasma promotes decidualization of endometrial stromal fibroblasts in vitro from women with and without inflammatory disorders in a manner dependent on interleukin-11 signaling. (il-11.com)
- Is the seminal plasma (SP) and its constituents affect decidualizing capacity and transcriptome of Human main endometrial stromal fibroblasts (eSFs)? (il-11.com)
Implantation4
- In mice, interperitoneal (IP) shots of an extremely potent, PEGylated (conjugated to polyethylene glycol) LIF antagonist (PEGLA) through the peri-implantation period blocks endometrial epithelial LIF actions and buy BQ-788 prevents blastocyst implantation [19], producing PEGLA a appealing pharmacological contraceptive. (cancerhugs.com)
- We previously demonstrated the critical involvement of SRC-2 in murine embryo implantation as well as in human endometrial stromal cell (HESC) decidualization, a cellular transformation process required for trophoblast invasion and ultimately placentation. (frontiersin.org)
- Defective immune surveillance is thought to play a role in the implantation and growth of ectopic endometrial tissue [ 6 ]. (biomedcentral.com)
- Currently, altered endometrial receptivity and progesterone resistance describe the leading mechanisms behind endometriosis-related implantation failure. (nezhat.org)
Ectopic1
- Our findings suggest that KTC could inhibit the growth of ectopic endometrial tissue through upregulating the level of TNF- α and its downstream signaling, including caspases and cytochrome c. (hindawi.com)
Fibroblasts1
- In fibroblasts, IL-11 drives an ERK-dependent autocrine loop of fibrogenic protein synthesis that is at a nexus of fibrotic signalling and required for the pro-fibrotic activity of TGFB1, PDGF, endothelin1, angiotensin and many other pro-fibrotic factors. (wikipedia.org)
Vitro1
- The env gene maintained an ORF coding for a 538-amino acid polypeptide that has all the characteristic features of env proteins and mediates intercellular fusion in vitro [ 11 - 13 ]. (ecancer.org)
Inflammatory1
- Single-cell and spatial gene expression analyses of pancreatic ductal adenocarcinoma uncover a population of interleukin-1β-expressing macrophages that drive inflammatory reprogramming of neighboring tumour cells leading to disease progression and poor prognosis for patients. (nature.com)
Receptor2
- IL-11 through its binding to its transmembrane IL-11Rα receptor and resultant activation of downstream signaling pathways has been thought to regulate adipogenesis, osteoclastogenesis, neurogenesis and platelet maturation. (wikipedia.org)
- This protein is a receptor for interleukin 8 (IL8). (cancerindex.org)
Genes4
- in one study, 31 genes in breast CAFs, which were identified using Affymetrix Human Genome U133 Plus 2.0 and an empirical Bayesian model, were different from those in NFs ( 11 ). (spandidos-publications.com)
- Of the 31 genes, the 21 upregulated genes were primarily associated with cell paracrine and intracellular signaling, transcription regulation and cell adhesion and migration, and their transcriptional products included transforming growth factor-β2 (TGF-β2), insulin-like growth factor-binding protein 2 and transcriptional factor AP-2α/γ ( 11 ). (spandidos-publications.com)
- By contrast, the 10 downregulated genes were primarily associated with epithelial membrane proteins ( 11 ). (spandidos-publications.com)
- The best known of the human env-derived genes is syncytin-1, or ERVWE1, which originated from a human endogenous retrovirus (HERV) of the HERV-W family inserted on chromosome 7q21 in human-pre-hominoids 40-45 million years ago [ 11 , 10 ]. (ecancer.org)
IL111
- Interleukin 11 (IL-11 or adipogenesis inhibitory factor) is a protein that in humans is encoded by the IL11 gene. (wikipedia.org)
MRNA3
- Endometrial biopsies were collected from 6 RM and 9 SM during oestrus and 24 h after infusion of frozen/thawed spermatozoa and the mRNA expression of TLR4 and IL-8 was quantified by rt-PCR. (aber.ac.uk)
- 4 ) found that uPA mRNA seems to be up-regulated in endometriotic glands and endometrial stroma as well as PAI-1 mRNA in endometriotic and endometrial stroma from women with endometriosis. (ispub.com)
- It was demonstrated that expression of interleukin‑8 (IL‑8) mRNA was significantly upregulated in Gem‑R PaCa cells by cDNA microarray and RT‑qPCR analyses. (cancerindex.org)
Transcriptional2
- In other instances, in stromal cells, IL-11 activates non-canonical MAPK/ERK-dependent signalling to initiate the post-transcriptional upregulation of specific subsets of transcripts in the absence of an effect on transcription. (wikipedia.org)
- Transcriptional inhibition of interleukin-12 promoter activity in Leishmania spp. (cornell.edu)
20221
- 2022 Nov.41(11):864-873. (moffitt.org)
Inhibition1
- Inhibition of interleukin-1β plays a protective role in Alzheimer's disease by promoting microRNA-9-5p and downregulating targeting protein for xenopus kinesin-like protein 2. (xenbase.org)
Mechanisms2
- Bell, S. (1990) Contraception and mechanisms of endometrial bleeding. (scirp.org)
- Accordingly, pregnancy success rates currently achieved by natural or assisted conception for women at high-risk for EPL or RPL can only be increased by an improved understanding of the cellular and molecular mechanisms that control endometrial function during the periimplantation period. (frontiersin.org)
Gene2
- The human IL-11 gene, consisting of 5 exons and 4 introns, is located on chromosome 19, and encodes a 23 kDa protein. (wikipedia.org)
- Interleukin-12: an update on its immunological activities, signaling and regulation of gene expression. (cornell.edu)
Stimulates1
- Transforming growth factor β1 (TGFβ1) through up-regulation of IL-11, stimulates collagen production and is important in wound healing. (wikipedia.org)
Cancer3
- British Journal of Cancer , Jan 4,2011;104 (1): 6-11 and European Journal of Clinical Nutrition , 2007;61(Suppl 1):S112-S121). (thelajollachiropractor.com)
- The overall strategic vision endometrial cancer. (who.int)
- No tumor markers with high sensitivity and high specificity for endometrial cancer are known at present, although CA-125 is often used in clinical practice. (medscape.com)
Promotes1
- 2011. TSLP promotes interleukin-3-independent basophil haematopoiesis and type 2 inflammation. . (cornell.edu)
Molecular3
- A role for two-pore potassium (K2P) channels in endometrial epithelial function Journal of Cellular and Molecular Medicine. (nottingham.ac.uk)
- 2009. Oviduct-specific glycoprotein is a molecular marker for invasion in endometrial tumorigenesis identified using a relevant mouse model. . (cornell.edu)
- Since perturbation of normal homeostatic levels of SRC-3 is linked with common gynecological disorders diagnosed in reproductive age women, this endometrial coregulator-along with its new molecular targets described here-may open novel clinical avenues in the diagnosis and/or treatment of a non-receptive endometrium, particularly in patients presenting non-aneuploid early pregnancy loss. (frontiersin.org)
20161
- 2016 Feb 3;11(2):e0148189. (bridgeporthospital.org)
Uterus1
- Endometriosis is defined as the deposit and growth of endometrial tissue that normally lines the inside of the uterus outside the uterine cavity [ 1 ]. (biomedcentral.com)
Regeneration2
- IL-11 has also been described in various aspects of tissue regeneration, predominantly in regenerative species like the zebrafish or the axolotl. (wikipedia.org)
- Here, activation of STAT3 by IL-11 is mandatory to allow regeneration and to prevent injury-induced fibrotic remodeling and scar formation. (wikipedia.org)
ELISA1
- uPA, PAI-1 and interleukin-6 were determined by enzyme linked immunosorbent assay (ELISA) in non oncological diseases (n=34) and in healthy individuals (n=20) and correlated with vitamin E treatment after operations. (ispub.com)
Expression4
- Endometrial TLR4 expression appeared to increase after insemination in SM. (aber.ac.uk)
- Proteomic analysis revealed the expression of plant homeodomain finger 11 (PHF11) was notably downregulated in EFA. (bvsalud.org)
- And the downregulated expression of PHF11 was accompanied by the upregulated expression of interleukin 8 (IL-8). (bvsalud.org)
- Interleukin 37 expression protects mice from colitis. (nature.com)
Protein1
- It was developed as a recombinant protein (rhIL-11) as the drug substance oprelvekin. (wikipedia.org)
Tumor1
- Positive PD-L1 appearance in NSCLC sufferers is seen in 50% to 70% of situations, and high appearance in 50% of tumor cells in 7.4%C10.6% of NSCLCs sufferers [6,7,8,9,10,11,12,13,14]. (eprf.ca)
Endometriosis6
- It has been shown that hormonal medication, including progestin, oral contraceptives, and gonadotropin-releasing hormone analogs (GnRHa) are effective in reducing endometriosis-induced pain and decreasing disease recurrence [ 10 , 11 ]. (hindawi.com)
- Although the clinical efficacy of KTC has been widely acceptable in China, its effect on endometrial thickness has not yet been clarified and there is no report on the treatment of endometriosis. (hindawi.com)
- Liu J, Li X, Hu X. [Clinical observations on treatment of endometriosis by tonifying kidney and removing blood stasis] Zhongguo Zhong Xi Yi Jie He Za Zhi. (avicenna.co.uk)
- Li J, Zheng J, Wang D. [Clinical observation on treatment of endometriosis by tonifying qi and promoting blood circulation to remove stasis and purgation principle] Zhongguo Zhong Xi Yi Jie He Za Zhi. (avicenna.co.uk)
- Our two-sample MR analysis of 11 coagulation factors in the UK Biobank suggested a reliable causal effect of genetically predicted plasma ADAMTS13 level on decreased endometriosis risk. (biomedcentral.com)
- 7). Some theories that can explain how endometriosis can affect fertility include abnormal utero-tubal transport, ovulatory dysfunction, dyssynchronous oocyte maturation, altered cell-mediated immunity, distorted pelvic anatomy, decreased oocyte quality, and altered endometrial receptivity (8). (nezhat.org)
Adhesion1
- Entirely these studies claim that LIF modulates adhesion between endometrial epithelial and trophoblast cells. (cancerhugs.com)
Significantly3
- Our results show that uPA, PAI 1, and interleukin-6 values were significantly higher in non oncological gynecological cases in comparison with healthy individuals (8.3 times, 3.8 times, and 9.8 times, respectively, P≤ 0.0001). (ispub.com)
- uPA, PAI-1, and interleukin-6 were significantly higher after abdominal gyneocological operation than before operation in the group of patients who were not treated with vitamin E after operation (P≤ 0.0001). (ispub.com)
- uPA and interleukin-6 decreased significantly after abdominal gyneocological operation in the patients treated with vitamin E in comparison with the group of patients without such treatment (P≤ 0.0001). (ispub.com)
Decidual1
- Abruptions (decidual hemorrhage) produce excess thrombin which acts as autocrine/paracrine inducer of decidual cell expressed matrix metalloproteinases and of neutrophil chemoattractant and activator, interleukin-8. (scirp.org)
Proteins1
- IL-11 has been demonstrated to improve platelet recovery after chemotherapy-induced thrombocytopenia, induce acute phase proteins, modulate antigen-antibody responses, participate in the regulation of bone cell proliferation and differentiation IL-11 causes bone-resorption. (wikipedia.org)
Role2
- However, the role of equine endometrial cell TLR4 during post-breeding endometritis has not been determined. (aber.ac.uk)
- Moreover, the rise of endometrial uPA indicates its role in this process. (ispub.com)
Cell1
- The activity of natural killer cell of peripheral blood, T lymphocyte subsets, secreting interleukin-II and the EmAb were determined. (avicenna.co.uk)
Patients1
- The purpose of this study was to determine whether there is a stimulation of production of uPA, PAI-1 and interleukin-6 before and after operation in plasma patients with gynecological diseases, and whether vitamin E could inhibit this process. (ispub.com)
Growth1
- In addition, oligohydramnios is associated with intrauterine fetal growth restriction and prolonged labor [ 11 ]. (researchsquare.com)
Primarily1
- The differentially expressed lncRNAs were primarily located in chromosomes 2, 1, and 11. (researchsquare.com)