To address this, concentrations of testosterone, sex hormone binding globulin, androstanediol glucuronide (a metabolite of dihydrotestosterone) and estradiol were measured in stored serum specimens from men examined in the morning sample of the first phase of NHANES III (1988-1991). (cdc.gov)
nmol/L), estradiol (pg/mL), and androstanediol glucuronide (ng/dL)] in a sample of 748 males aged 20 years and older from the 1999-2004 cycles of the National Health and Nutrition Examination Survey (NHANES). (cdc.gov)
RESULTS: No associations were found between the risk of prostate cancer and serum concentrations of testosterone, calculated free testosterone, dihydrotestosterone, dehydroepiandrosterone sulfate, androstenedione, androstanediol glucuronide, estradiol, or calculated free estradiol. (ox.ac.uk)
Compounds6
The UGT substrates include many endogenous and xenobiotic compounds. (aspetjournals.org)
It is responsible for the hepatic uptake of drugs and endogenous compounds from the blood. (solvobiotech.com)
Within the liver endogenous and exogenous compounds are eliminated through many metabolizing enzymes. (helsinki.fi)
Endogenous and exogenous compounds having a carboxyl group, such as a-arylpropionic acid derivatives, undergo a phase II metabolic reaction to produce an amino acid conjugate through the acyl CoA thioester as well as the acyl glucuronide. (elsevierpure.com)
Phytoestrogens are plant-derived polyphenolic compounds, such as isoflavones and lignans that are structurally similar to endogenous estrogens (Cornwell, et al. (cdc.gov)
The glucuronidation and elimination of endogenous compounds ( e.g. , bilirubin) and xenobiotics, including HPPH, the major, para -hydroxylated metabolite of the anticonvulsant drug phenytoin (diphenylhydantoin) ( Butler, 1957 ), are catalyzed by a superfamily of membrane-bound isozymes known collectively as UGTs ( Dutton, 1980 ). (aspetjournals.org)
Ethyl glucuronide3
Evidence of seasonal variation of ethyl glucuronide in hair: Modeling a seven-year data series. (unito.it)
Systematic optimisation of ethyl glucuronide extraction conditions from scalp hair by design of experiments and its potential effect on cut-off values appraisal. (unito.it)
Direct alcohol biomarkers include alcohol itself and ethyl glucuronide (EtG). (medscape.com)
Endogenous estrogens are largely responsible for the development and maintenance of the female reproductive system and secondary sexual characteristics. (theodora.com)
Testosterone5
Etiocholanolone glucuronide (ETIO-G) is an endogenous, naturally occurring metabolite of testosterone. (wikipedia.org)
Along with androsterone glucuronide, it is one of the major inactive metabolites of testosterone. (wikipedia.org)
Testosterone is the primary endogenous androgen. (theodora.com)
Endogenous testosterone released from the sample by ANS (8-anilino-1-naphthalene sulfonic acid) and norgestrel competes with the added testosterone derivative labeled with ruthenium complex for the binding sites on the biotinylated antibody. (cdc.gov)
Steroid abusers, on the other hand, aren t lacking in endogenous naturally produced testosterone, and they re using these chemicals to cheat natural processes, oral dianabol recipe. (youthsportsdietitian.com)
Hormones7
The latter include, for example, ingested drugs or plant substances, but also endogenous steroid hormones. (dailyzhealthpress.com)
Mounting evidence of sex differences in chronic diseases suggest that perturbations in endogenous sex hormones may influence disease risk. (cdc.gov)
Endogenous sex hormones and prostate cancer: a collaborative analysis of 18 prospective studies. (ox.ac.uk)
Endogenous Hormones and Prostate Cancer Collaborative Group None. (ox.ac.uk)
METHODS: Data on serum concentrations of sex hormones from 18 prospective studies that included 3886 men with incident prostate cancer and 6438 control subjects were pooled by the Endogenous Hormones and Prostate Cancer Collaborative Group. (ox.ac.uk)
CONCLUSIONS: In this collaborative analysis of the worldwide data on endogenous hormones and prostate cancer risk, serum concentrations of sex hormones were not associated with the risk of prostate cancer. (ox.ac.uk)
DHEA and DHEAS (an active, sulfated form of DHEA), are endogenous hormones secreted by the adrenal cortex in primates and a few non-primate species in response to ACTH. (medilabcompounding.com)
Sulfate2
It is metabolized mainly in the liver and excreted in the urine as sulfate and glucuronide conjugates. (drugs.com)
Assay precision is improved by incorporating carbon-13 labeled internal standards for each of the analytes, as well as a 4-methylumbelliferyl glucuronide and 4-methylumbelliferyl sulfate standards to monitor deconjugation efficiency. (cdc.gov)
Steroid1
It is great as a first approach to building muscle, however I strongly recommend only using Tren (rather than simply taking any other anabolic/endogenous steroid) until you take the time to learn proper supplementation, tren iasi constanta. (anewviewhomekeeping.com)
Substances2
Analysis of heterologous expression systems of rOAT1 in oocytes and culture cells revealed that rOAT1 has the ability to transport anionic drugs, such as β-lactam antibiotics, NSAIDs, methotrexate, and antiviral drugs, as well as various endogenous organic anions and exogenous substances. (aspetjournals.org)
This, glucuronidation represents a major means of converting most drugs, steroids, and many toxic and endogenous substances to metabolites that can then be excreted into the urine or bile. (wikidoc.org)
Xenobiotic1
Identifying the underlying molecular mechanisms by which BA regulation is disrupted by endogenous and/or xenobiotic factors will aid in not only understanding disease pathogenesis, but also providing novel strategies to prevent and/or treat diseases associated with BA dysregulation. (aspetjournals.org)
Metabolites2
High exposure to VPA can lead to carnitine depletion causing a misbalance between the intra-mitochondrial beta-oxidation and the microsomal co-oxidation, a pathway that produces toxic metabolites such as 4-en-VPA which inhibits ammonia elimination. (unav.edu)
The number of previously reported metabolites in human urine is limited, and most analytical methods rely on targeting epitrenbolone, trenbolone glucuronide, and epitrenbolone glucuronide. (youthsportsdietitian.com)
Glucuronidation1
The 3 hydroxybenzodiazepines oxazepam, temazepam, and also lorazepam employed for his or her anxiolytic, tranquilizer, and also anticonvulsant components are usually digested by simply glucuronidation, which is main walkway within the settlement system involving exogenous and also endogenous materials through cycle Two metabolism. (acyltransferase-receptor.com)
Excretion1
These results suggest an important role of hOAT3 in the excretion/detoxification of endogenous and exogenous organic anions in the kidney. (aspetjournals.org)
Prodrug1
The ability to image ßG activity in patients would assist in personalized glucuronide prodrug cancer therapy. (bvsalud.org)
Urine3
Urine has been found to be a useful biological fluid for monitoring the endogenous release of inflammatory mediators. (ersjournals.com)
In this study, we describe a liquid chromatographic /mass spectrometric method with a simple column switching technique to determine diastereomeric flurbiprofen acyl glucuronides in human urine specimens. (elsevierpure.com)
The proposed method applied to urine specimens demonstrates high accuracy and reproducibility for the determination of flurbiprofen glucuronides in a quantitative range from 0.74 to 146.5 mg /mL, with a detection limit of 7.4 pg (17.6 fmol)/injection of S-flurbiprofen glucuronide, at a signal-to-noise ratio of 10 under the selected ionmonitoring mode. (elsevierpure.com)
Steroids1
Endogenous androgens are C-19 steroids with a side chain at C-17, and with two angular methyl groups. (theodora.com)
Androstenedione1
After menopause, most endogenous estrogen is produced by conversion of androstenedione, which is secreted by the adrenal cortex, to estrone in the peripheral tissues. (pfizermedicalinformation.com)
Probe1
We generated a (124)I-tyramine-conjugated difluoromethylphenol beta-glucuronide probe (TrapG) to form (124)I-TrapG that could be selectively activated by ßG for subsequent attachment of (124)I-tyramine to nucleophilic moieties near ßG-expressing sites. (bvsalud.org)
Enzyme1
The enzyme-assisted combination was made as well as seo'ed through the use of microsomal UGT from fresh swine lean meats to get multimilligram numbers of the particular benzodiazepine glucuronides, which were not available by simply standard man made processes, much like the Koenigs-Knorr- and Williamson-ether-synthesis. (acyltransferase-receptor.com)
Urinary1
The urinary concentration of R-flurbiprofen glucuronides in healthy subjects determined by the proposed method were 6.8-29.4 mg /mL, and those values were slightly higher than that of S-flurbiprofen glucuronides (3.9-18.0 mg /mL). (elsevierpure.com)
Biological1
Accordingly, a reliable method to measure diastereomeric flurbiprofen glucuronides in human biological fluids is required. (elsevierpure.com)
Extraction1
The epimeric twos associated with benzodiazepine glucuronides have been split up through preparative high performance liquefied chromatography (HPLC) accompanied by sound phase extraction (SPE) to get the natural benzodiazepine glucuronide epimers. (acyltransferase-receptor.com)
Reactions1
Recent observations, however, have demonstrated that the nonenzymatic formation of a covalently protein-bound drug, which is produced by the action of the acyl glucuronide, may cause hypersensitive reactions. (elsevierpure.com)
Hormone1
Endogenous DHEA Capsules are a complex hormone, and researchers still have much to discover in regards to its physiologic effects in males and females. (medilabcompounding.com)
Production3
Similarly, LTB 4 glucuronides have been used as a marker for the whole-body production of LTB 4 11 . (ersjournals.com)
Suppression of the production of corticotropin may lead to suppression of endogenous corticosteroids. (drugs.com)
These findings indicate that oxidative O -de--ethyl-ation, keto conversion, and γ -deca-rboxylation are involved in the biotransformation of bucetin, leading to the endogenous production of N -(4-hy-droxy-phen-yl)acetamide, the relevant analgesic compound. (iucr.org)
Role1
Researchers continue to investigate the role of both endogenous and exogenous DHEA in CNS, psychiatric, endocrine, gynecologic and obstetric, immune, and cardiovascular functions.1 GeneLabs Technologies, Inc., submitted an NDA in September 2000 for its proprietary DHEA product, called prasterone (Prestara™, formerly known Aslera™ or GL-701). (medilabcompounding.com)
Important1
Endogenous DHEA is thought to be important in several endocrine processes, but current medical use of DHEA is limited to controlled clinical trials. (medilabcompounding.com)