• induction
  • Using genome editing technology, additional stem cell lines with mutations in both GATA6 alleles were generated and demonstrate a severe block in definitive endoderm induction. (upenn.edu)
  • The variable number of genes shows the multiple routes of induction of the developing endoderm, intrinsically within the endoderm (for example, notch signaling) or from the adjacent cardiac mesoderm (Sonic hedgehog protein inhibition by Fibroblast growth factor). (wikipedia.org)
  • SOX17
  • e and f) Sections through embryo in (d) indicate equal levels of SOX17 expression in all cells of the gut endoderm layer, regardless if emVE-derived (GFP-positive) or of the DE lineage (GFP-negative). (nih.gov)
  • Inhibiting contractility resulted in an increase in the observed fibronectin FRET intensity ratio but also decreased the amount of phosphorylated nuclear SMAD2, leading to reduced expression of the definitive endoderm marker SOX17. (biologists.org)
  • We have used conditional gene deletion of mouse β-catenin in Sox17-positive embryonic and extra-embryonic endoderm as well as vascular endothelial progenitors to address the function of canonical Wnt signalling in cell lineage formation and patterning. (biologists.org)
  • Sox17 lineage tracing in the definitive endoderm (DE) shows a cell-autonomous requirement for β-catenin in midgut and hindgut formation. (biologists.org)
  • parietal
  • This thesis looks at F9 derived parietal endoderm outgrowth as a model system to investigate the mechanisms that regulate migration of parietal endoderm in the establishment of extracellular embryonic tissues . (ccsu.edu)
  • The data presented here suggest that E-cadherin is expressed in parietal endoderm and that it localizes to the cell surface . (ccsu.edu)
  • In addition the data suggest that adherens junctions are forming between parietal endoderm cells , based on the localization of key adherens junction components . (ccsu.edu)
  • posterior
  • By contrast, high β-catenin activity in the posterior endoderm inhibits foregut fate while promoting intestinal development. (biologists.org)
  • Experimentally repressing β-catenin activity in the posterior endoderm was sufficient to induce ectopic organ buds that express early liver and pancreas markers. (biologists.org)
  • epiblast
  • As is the case in several vertebrates, in the mouse there are two recognized sources of endoderm tissue, one arising from the PrE and the other from the pluripotent epiblast [ 2 , 3 ]. (royalsocietypublishing.org)
  • regulate
  • In this study we postulated that differential zygotic Wnt signaling might regulate endoderm patterning similar to the `activation-transformation' model of A-P patterning in the neural tube. (biologists.org)
  • cells
  • citation needed] The endoderm consists at first of flattened cells, which subsequently become columnar. (wikipedia.org)
  • Using the EP cell culture system to bypass the developmental block at the endoderm stage, cell lines with mutations in one or both GATA6 alleles were differentiated into β-like cells. (upenn.edu)
  • cell
  • From the inside out, the three cell layers are the endoderm, the mesoderm , and the ectoderm . (wisegeek.com)
  • The three cell layers are roughly equivalent to the position of structures in the fully formed human body, with the endoderm forming internal structures, the ectoderm forming external structures, and the mesoderm forming intermediary structures like the skeleton, skeletal muscle, and heart. (wisegeek.com)
  • citation needed] In plant biology, endoderm corresponds to the innermost part of the cortex (bark) in young shoots and young roots often consisting of a single cell layer. (wikipedia.org)