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  • mandible
  • Except for the mandible, all of the bones of the skull are joined together by sutures-synarthrodial (immovable) joints formed by bony ossification, with Sharpey's fibres permitting some flexibility. (wikipedia.org)
  • avascular
  • Despite much research, the causes remain unclear but include repetitive physical trauma, ischemia (restriction of blood flow), hereditary and endocrine factors, avascular necrosis (loss of blood flow), rapid growth, deficiencies and imbalances in the ratio of calcium to phosphorus, and problems of bone formation. (wikipedia.org)
  • plate's
  • The purpose of this work was to study the involvement of MMP-2, -3, -9, -13, and -16 in the growth plate's response to loading and in the catch-up growth resulting from load release. (physiology.org)
  • These results demonstrate the central role of MMPs in the growth plate's response to mechanical loading, as well as in the catch-up growth followed load release. (physiology.org)
  • fibroblast
  • These 3 relatively common entities are known to be allelic to the same gene: the fibroblast growth factor receptor 3 gene on chromosome 4p. (eurorad.org)
  • process
  • Nevertheless, old age, many diseases and medicines can disturb the balance, ultimately the breakdown process exceeds the bone formation, and as a result, trabecular plates of bone are destroyed causing weakness of the structure of bone with greatly reduced bone mass. (intechopen.com)
  • Sex hormones are thought to be linked to this process because of the spatial relationship of chondroblastoma with the growth plate and its typical occurrence before growth plate fusion. (wikipedia.org)
  • Ossification (or osteogenesis) in bone remodeling is the process of laying down new bone material by cells called osteoblasts. (wikipedia.org)
  • Heterotopic ossification is a process resulting in the formation of bone tissue that is often atypical, at an extraskeletal location. (wikipedia.org)
  • Fibroblast Growth
  • The cn/cn mouse was originally named as an achondroplastic mouse but once human achondroplasia was found to be due to mutations in the gene encoding fibroblast growth factor receptor 3 [ 11 , 12 ] the cn/cn mouse was no longer considered analogous to human achondroplasia and came to be described simply as cn/cn. (biomedcentral.com)
  • During the early stages of limb development ectopic expression of several genes, including Sonic Hedgehog (Shh) and Fibroblast Growth Factor 4 (Fgf4), was found in Dorking hindlimbs. (ufl.edu)
  • frontal
  • A frontal plane mathematical simulation tested whether the calculated loading asymmetry created by muscles in a scoliotic spine could explain the observed rate of scoliosis increase by measuring the vertebral growth modulation by altered compression. (biomedcentral.com)
  • physeal
  • Based on these corresponding mouse/human findings, assessment of the cn/cn mouse has been undertaken for a clearer understanding of how the gene mutation leads to structural physeal abnormality and growth deformity. (biomedcentral.com)
  • tumor
  • Frequent promoter hypermethylation, gene silencing, association with prognosis, and growth suppression after reexpression support the hypothesis that GALR1 is a tumor suppressor gene in HNSCC. (aacrjournals.org)
  • formation
  • Role of Interleukin-10 in endochondral bone formation: Anabolic effect via BMP/Smad pathway. (uwo.ca)
  • K. Mueller, R. Cortesi, D. Modrowski, and P. J. Marie, "Stimulation of trabecular bone formation by insulin-like growth factor I in adult ovariectomized rats," American Journal of Physiology , vol. 267, no. 1, pp. (hindawi.com)
  • Despite much research, the causes remain unclear but include repetitive physical trauma, ischemia (restriction of blood flow), hereditary and endocrine factors, avascular necrosis (loss of blood flow), rapid growth, deficiencies and imbalances in the ratio of calcium to phosphorus, and problems of bone formation. (wikipedia.org)
  • hormone
  • Intriguingly, this period of growth is independent of growth hormone and the underlying mechanism is poorly understood. (biologists.org)
  • Insulin-like growth factor-I stimulates acromegaly-like specific mandibular enlargement in rats," Hormone and Metabolic Research , vol. 36, no. 10, pp. 696-701, 2004. (hindawi.com)
  • Bone growth in length is stimulated by the production of growth hormone (GH), a secretion of the anterior lobe of the pituitary gland. (wikipedia.org)
  • process
  • The growth modulation process in the vertebral body can be viewed as one type of the biologic phenomenon of mechanotransduction . (biomedcentral.com)
  • Periosteal buds carry mesenchyme and blood vessels in and the process is similar to that occurring in a primary ossification center. (wikipedia.org)
  • Sex hormones are thought to be linked to this process because of the spatial relationship of chondroblastoma with the growth plate and its typical occurrence before growth plate fusion. (wikipedia.org)
  • pathogenesis
  • It evaluates the hypothesis that in progressive scoliosis vertebral body wedging during adolescent growth results from asymmetric muscular loading in a "vicious cycle" ( vicious cycle hypothesis of pathogenesis ) by affecting vertebral body growth plates (endplate physes). (biomedcentral.com)
  • hypothesis
  • It assumes that a pre-existing scoliosis curve initiates the mechanically-modulated alteration of vertebral body growth that in turn causes worsening of the scoliosis, while everything else is anatomically and physiologically 'normal' The results provide quantitative data consistent with the vicious cycle hypothesis . (biomedcentral.com)
  • Journal
  • I. Dorup and T. Clausen, "Insulin-like growth factor I stimulates active Na + -K + transport in rat soleus muscle," American Journal of Physiology , vol. 268, no. 5, part 1, pp. (hindawi.com)
  • structure
  • Because we do not have slides of broken and healing bone, the various aspects of bone structure, growth and remodelling must be observed piecemeal in other specimens. (siumed.edu)