Endocardial myocardium. Medical search. Frequent questions

[ 2 ] Endocardial fibroelastosis is characterized by diffuse endocardial thickening and myocardial dysfunction. (medscape.com)
Observations that favor a viral etiology include a clinical presentation similar to that of chronic myocarditis, findings of myocarditis or myocardial fibrosis in affected patients, a higher incidence following epidemics of coxsackievirus B infection, demonstration of persistent viral infection with molecular studies, and experimental production of the disease in animal models by viral infections of the myocardium. (medscape.com)
Here, we utilize in vivo biophysical and genetic fate mapping zebrafish studies to reveal that altered hemodynamic forces due to cardiac injury activate a sequential endocardial-myocardial signaling cascade to direct cardiomyocyte reprogramming and heart regeneration. (elifesciences.org)
Consequently, Klf2a then activates endocardial Notch signaling which results in the non-cell autonomous initiation of myocardial Erbb2 and BMP signaling to promote cardiomyocyte reprogramming and heart regeneration. (elifesciences.org)
This endocardial Notch signaling can in turn non-cell autonomously initiate myocardial Erbb2 and BMP signaling to promote cardiomyocyte reprogramming and heart regeneration, whereas its inhibition through either using tissue-specific genetic-based strategies or altering blood flow impairs this reparative event. (elifesciences.org)
The noncompaction results in numerous prominent trabeculations and a loose myocardial meshwork (spongy myocardium) in the LEFT VENTRICLE. (mcw.edu)
Secondary endocardial fibroelastosis, associated with cardiac malformations, is attributed to the cardiac hypertrophy and consequent imbalance in the myocardial oxygen supply-demand relationship. (medscape.com)
Changes in myocardial PO 2 and PCO 2 in the LAD-supplied myocardium indicated the development of severe ischemia in all 10 dogs and suggested myocardial infarction in 5. (johnshopkins.edu)
This scan guarantees an accurate quantification of the myocardium to the extent of myocardial scarring. (kobv.de)
With this novel visualization, an easy distinction between endocardial, mid-myocardial, or epicardial scar is possible. (kobv.de)
Region-specific endocardial Notch activity regulates heart morphogenesis through the interaction with multiple myocardial-, epi … It makes up the tissue called the myocardium. (web.app)
In rabbit experiments from the same study epicardial pacing relative to endocardial pacing produced a net increase of 17 ± 5 and 22 ± 5 ms in the QT interval and transmural dispersion of repolarization respectively.5 The effects of LV epicardial pacing on repolarization may be explained by the distinct properties of the different myocardial layers. (immune-source.com)
The diastolic dysfunction may be observed in myocardial (restrictive cardiomyopathy [RCM] and phenocopies), endocardial/endomyocardial (fibrosis, elastosis), and pericardial (constriction, effusion) diseases (see Fuster and Hurst's Central Illustration). (mhmedical.com)

Noncompaction cardiomyopathy (NCCM) is a rare condition characterized by prominent trabeculae, deep intertrabecular recesses, and a left ventricular myocardium with a two-layered structure, characterized by a spongy endocardial layer and a thinner and compacted epicardial one. (nih.gov)
Endocardial and epicardial blood flows were measured by the radioactive microsphere technique prior to the application of the stenosis and after one hour and 2 hours of fibrillation. (johnshopkins.edu)
Endocardial and epicardial flow in the distribution of the unstenosed circumflex coronary artery remained unchanged. (johnshopkins.edu)
Afterwards, the endocardial and epicardial boundary is estimated by either a filter or learning based method in combination with a minimal cost path search in polar space. (kobv.de)
For the endocardial and epicardial boundary estimation also a filter based or learning based approach can be applied in combination with dynamic programming in polar space. (kobv.de)
axis on pregnancy outcome in nonobese diabetic mice and wild-type controls Proximity relationship between epicardial adipose tissue and the endocardial Hjärtvävnaden delas in i endocardium, myocardium och den del av for a number of different cells such as odontoblasts, melanoblasts and connective tissue cell different responses depending on the transmitter and the receptor type. (web.app)
Thymosin β4, a peptide with roles in vascular development, was required for endocardial compaction, epicardial vessel expansion, and smooth muscle cell recruitment. (jci.org)
The endocardial and epicardial surfaces of the magnitude images were segmented to produce a mask for the myocardium, excluding the papillary muscles. (biomedcentral.com)
We are able to reproduce human epicardial, endocardial, and M cell action potentials and show that differences can be explained by differences in the transient outward and slow delayed rectifier currents. (ox.ac.uk)

Among cardiac GATA factors, there was preferential synergy with GATA5, implicated in endocardial differentiation. (nih.gov)
Maredia N, English K, Greenwood J. Assessment of endocardial fibroelastosis by cardiac MRI. (medscape.com)
Similarly, statistical analysis showed that the image quality scores for the endocardial border definition, myocardium, cardiac motion were equivalent for the two methods. (biomedcentral.com)
In addition treatment with T. terrestris decreased the leakage of CK-MB and LDH enzymes from myocardium, there was a significant improvement in cardiac function as evidenced by correction of MAP, HR, LVEDP and contractility and relaxation. (scialert.net)
Non-compaction of the left ventricle (NCLV), also known as left ventricular non-compaction (LVNC), is a rare congenital cardiac abnormality characterized by prominent trabeculations and deep recesses in the myocardium of the left ventricle (LV). (medicosnotes.com)
In summary, non-compaction of the left ventricle is a congenital cardiac abnormality characterized by excessive trabeculations and deep recesses within the myocardium. (medicosnotes.com)
A single group remains unassociated with other cardiac abnormalities, and this is termed "primary" endocardial fibroelastosis. (jamanetwork.com)
The experimental and clinical possibilities for studying cardiac arrhythmias in human ventricular myocardium are very limited. (ox.ac.uk)
Cardiac amyloidosis (CA) is defined by the presence of extracellular amyloid deposition within the myocardium of the whole heart, leading to biventricular wall thickening with impaired relaxation and the loss of ventricular elasticity [ 1 ]. (hindawi.com)

Mutations in the alpha-dystrobrevin gene are associated with Autosomal Dominant type of Noncompaction of the Left Ventricular Myocardium. (bvsalud.org)
Mutations in the tafazzin gene are associated with X-Linked Isolated Noncompaction of the Left Ventricular Myocardium. (bvsalud.org)

[ 2 ] aortic stenosis, or atresia.The two pathologic forms of primary endocardial fibroelastosis are dilated, which is most common, and contracted. (medscape.com)
The 2 pathologic forms of primary endocardial fibroelastosis include dilated, which is most common, and contracted. (medscape.com)

Endocardial fibroelastosis (EFE) refers to a pronounced, diffuse thickening of the ventricular endocardium and presents as unexplained heart failure in infants and children. (medscape.com)
The underlying pathophysiology of endocardial fibroelastosis (EFE) is believed to be deposition of acellular fibrocartilagenous tissue in the subendothelial layer of the endocardium predominantly involving the inflow tracts, apices of either left or both ventricles. (medscape.com)
Dilated endocardial fibroelastosis is characterized by a markedly enlarged globular heart, mainly involving the left ventricle (LV) and left atrium (LA). The LV endocardium is opaque, glistening, milky white, and diffusely thickened to about 1-2 mm. (medscape.com)
Although the endocardium is thickened, the ventricular wall (myocardium) thickness is within the reference range. (medscape.com)
Tbx20 was expressed in myocardium and endocardium, including high levels in endocardial cushions. (nih.gov)
The myocardium forms a thick middle layer between the outer epicardium layer and the inner endocardium layer. (web.app)
1 Restrictive physiology can be observed in diseases affecting endocardium, myocardium, and epipericardial layers/structures ( Table 44-1 ). (mhmedical.com)

Defects in the tafazzin protein, encoded by TAZ gene, result in a form of autosomal dominant familial endocardial fibroelastosis. (childrensmercy.org)

Secondary endocardial fibroelastosis is associated with other congenital heart diseases. (medscape.com)
The less common contracted type of primary endocardial fibroelastosis is associated with a relatively hypoplastic or normal LV size. (medscape.com)

Careful assessment of the heart for any associated congenital heart disease including coronary artery anomalies is essential before making a diagnosis of primary endocardial fibroelastosis. (medscape.com)
Andersen and Kelly, 2 in 1956, showed that many children with congenital heart disease develop endocardial fibroelastosis, apparently secondary to hemodynamic factors or anoxia in the malformed heart. (jamanetwork.com)

The non-compacted myocardium is characterized by multiple, prominent trabeculations separated by deep intertrabecular recesses. (medicosnotes.com)
The deep intertrabecular recesses can restrict blood flow within the non-compacted myocardium, leading to increased ventricular stiffness. (medicosnotes.com)

Arya SO, Karpawich PP, Gupta P, Buddhe S, Singh HR, Hussein Y. Primary endocardial fibroelastosis presenting in a young child as incessant ventricular tachycardia and dilated cardiomyopathy. (medscape.com)
In such circumstances non-pharmacological methods of arrhythmia management such as endocardial resection and ventricular tachycardia ablation are currently employed, despite the high risk of these procedures in the unstable patient. (bmj.com)
The distorted architecture of the myocardium disrupts the normal electrical conduction pathways, leading to arrhythmias such as ventricular tachycardia, ventricular fibrillation, and atrioventricular block. (medicosnotes.com)

The endocardial thickening is believed to be caused by persistent and increased wall tension in the ventricles, possibly secondary to damaged myocardium, mitral regurgitation, or both. (medscape.com)
Achiron R, Malinger G, Zaidel L, Zakut H. Prenatal sonographic diagnosis of endocardial fibroelastosis secondary to aortic stenosis. (medscape.com)

Primary endocardial fibroelastosis is not associated with any significant structural anomaly of the heart. (medscape.com)
Primary endocardial fibroelastosis prognosis is relatively poor, although the condition is not universally fatal. (medscape.com)
Primary endocardial fibroelastosis: an underappreciated cause of cardiomyopathy in children. (medscape.com)
3 The etiology of primary endocardial fibroelastosis is not certain, but it has been suggested that this lesion is a genetically determined developmental anomaly, possibly due to an enzymatic defect of the myocardium. (jamanetwork.com)
1 The occurrence of primary endocardial fibroelastosis in siblings is rare. (jamanetwork.com)

From this study, it is concluded tht the myocardium distal to a critical stenosis suffers a progressive reduction in flow during ventricular fibrillation which does not occur in regions supplied by unstenosed coronary arteries. (johnshopkins.edu)

Used in LGE assessment, gadolinium is an extracellular chelating agent that permeates the interstitial space of both normal and abnormal myocardium . (medscape.com)
A region of interest (ROI) was placed on native T1-maps in the "most-affected myocardium", characterized by the presence of late gadolinium enhancement (LGE), or regional wall motion abnormalities (RWMA) on cines. (ox.ac.uk)

Rare congenital cardiomyopathies characterized by the lack of left ventricular myocardium compaction. (mcw.edu)

Endocardial thickening extends to the LA, right ventricle, and right atrium. (medscape.com)
HN - 2008 BX - Granulosa Cells, Cumulus MH - Coronary Sinus UI - D054326 MN - A07.231.908.194.500 MS - A short vein that collects about two thirds of the venous blood from the MYOCARDIUM and drains into the RIGHT ATRIUM. (bvsalud.org)

Thus GRN analysis of the cushion-enriched gene lists in chick and mouse provided insight into the relationships between genes known to regulate endocardial EMT and identified candidate signaling pathways for functional analysis. (researchassistantresume.com)

These extended into the myocardium but were not full thickness (Figure 8). (flockandherd.net.au)

05) correlation (r=-.73 to r=-.55) between MCE defect size and normalized endocardial blood flow. (elsevierpure.com)

A report suggests that the epicardium-derived mesenchymal cells could be the origin of the endocardial fibroelastosis fibroblasts. (medscape.com)
Coronary vessels supplying arterial blood to the heart penetrate the epicardium before entering the myocardium. (web.app)
The quiescent epicardium is reactivated and, while direct cellular contribution to new vessels is minimal, it supports the directional expansion of the neovessel network toward the infarcted myocardium. (jci.org)

For the endocardial contour refinement, an additional scar exclusion step is added. (kobv.de)
After the segmentation of the left ventricle's myocardium, the scar tissue is quantified. (kobv.de)
Therefore, the scar tissue is divided into three layers depending on the location of the scar within the myocardium. (kobv.de)
Overall scar burden and border zone scar were highly predictive of VT/VF CID 755673 in a recent cohort of CRT patients 7 consistent with previous prior studies showing the importance of myocardium. (immune-source.com)

Restrictive endomyocardial diseases include endomyocardial fibrosis of right, left, or both ventricles, frequently with involvement of valves, Hedinger syndrome of the right-sided heart valves in patients with neuroendocrine tumors and carcinoid syndrome, as well as endocardial fibroelastosis associated with congenital heart anomalies. (mhmedical.com)
The myocardium may also be involved in inflammatory and autoimmune diseases. (mhmedical.com)

Modes of spread to the myocardium are via lymphatics from mediastinal nodes, directly from the pericardium , or via a hematogenous route. (radiopaedia.org)
The pericardium, myocardium, heart valves, and coronary arteries may be involved either singly or in various combinations. (mhmedical.com)

Once regarded as a common cause of unexplained heart failure, endocardial fibroelastosis is now considered rare. (medscape.com)
We propose that Tbx20 plays an integrated role in the ancient myogenic program of the heart, and has been additionally coopted during evolution of vertebrates for endocardial cushion development. (nih.gov)
The coronary circulation is in place as only 1/10 mm of the endocardial heart layer is supplied by blood from the chambers. (onteenstoday.com)
This image depicted a human heart that had been partially dissected in order to expose its interior structures, and endocardial lining within the right side of the heart. (cdc.gov)

Injection of myoblasts into infarcted myocardium has been shown to augment systolic and diastolic functions in experimental animal studies (7). (escardio.org)
The trabeculations within the non-compacted myocardium are not efficiently contractile, leading to reduced systolic function. (medicosnotes.com)

Endocardial spread may occur from myocardium. (radiopaedia.org)
In NCLV, the normal compaction of the myocardium does not occur, leading to the persistence of excessive trabeculations and deep recesses. (medicosnotes.com)

Viral infection of the myocardium in endocardial fibroelastosis. (medscape.com)

The right and left atria and the right ventricle are markedly enlarged and hypertrophied, with minimal or no endocardial sclerosis. (medscape.com)

Because of the high level of oxygen extraction by the myocardium during resting conditions, increases in oxygen demand produced by exercise (increasing up to 6-fold during maximal exercise) are mediated principally by an increase in coronary blood flow. (onteenstoday.com)

The contribution of inflammatory cells to the electrophysiological properties of injured myocardium is unknown. (edu.sa)
Three distinct cell populations were identified: inflammatory, fibroblastic and endocardial cells. (edu.sa)

Cell therapy is currently emerging as a potential new treatment for post MI patients with the assumption that recolonization of the areas of scarred myocardium with exogenously supplied surrogates or precursors of cardiomyocytes can restore function and ultimately affect clinical outcomes. (escardio.org)
Endocardial fibroelastosis: a clinical and anatomic study of 47 patients with emphasis on its relationship to mitral insufficiency. (medscape.com)

The stimulus is then delivered to the endocardial surfaces of the RV and LV very rapidly and the myocardium depolarizes to form the QRS . (wikidoc.org)

The term endocardial fibroelastosis was introduced by Weinberg and Himmelfarb in 1943. (medscape.com)

Risk of endocardial fibroelastosis (EFE) in subsequent pregnancies is 3-5% and warrants fetal echocardiography for early diagnosis. (medscape.com)
Contracted form of endocardial fibroelastosis: angiographic diagnosis and necropsy confirmation. (medscape.com)
Prenatal diagnosis of endocardial fibroelastosis. (medscape.com)

Of note these arrhythmias were inhibited with right ventricular endocardial pacing. (immune-source.com)

However, a study has highlighted that 25% of children who were transplanted for dilated cardiomyopathy demonstrated significant endocardial fibroelastosis on histopathology of the explanted hearts. (medscape.com)

The Left Bundle divides into a smaller anterior and a larger posterior radiation which fans out in the endocardial layers and meets again in the periphery as fibers of the Purkinje System . (wikidoc.org)

Endocardial Fibroelastosis" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (childrensmercy.org)

RCM: Presence of moderate or marked atrial enlargement, a restrictive ventricular filling pattern on Doppler echo assessment, or both, possibly coexisting with shelf of myocardium and fibrous connective tissue coursing obliquely along the endocardial surface of the ventricle. (vin.com)

Endocardial cells begin to form the myocardium. (wikipedia.org)

The exclusivity of the electrocardiographic changes solely on pacemaker output settings, consistency between the surface electrocardiogram and ventricular endocardial electrogram, and resolution of this phenomenon when dogs were re-programmed to unipolar pacing is consistent with depolarization of the ventricular myocardium by the anodal electrode of the pacing lead at high pacemaker amplitudes. (bris.ac.uk)

To reveal previously unrecognized regulators of EMT four candidate genes spatial expression of each gene was confirmed by hybridization and a functional role for each in endocardial EMT was determined by siRNA knockdown in GKT137831 a collagen gel assay. (researchassistantresume.com)

We tested the hypothesis that removing endocardial endothelium (EE) negatively effects the force-frequency relationship (FFR) of ventricular myocardium and dissected the signaling that underlies this phenomenon. (monossabios.com)

Chen S, Thompson MW, Rose V. Endocardial fibroelastosis: family studies with special reference to counseling. (medscape.com)
Another ROI was placed in the "reference myocardium" as far as possible from LGE/RWMA, and in the septum if no focal abnormality was present. (ox.ac.uk)

Anatomy30

Organisms18

Diseases39

Chemicals and Drugs71

Analytical, Diagnostic and Therapeutic Techniques and Equipment54

Phenomena and Processes47

Disciplines and Occupations2

Information Science3

Health Care5

Myocardial13

Epicardial9

Cardiac9

Noncompaction of the Left Ventricular Myocardium2

Pathologic forms of primary endocardial fibroelastosis2

Endocardium7

Autosomal Dominant1

Fibroelastosis is associated2

Congenital heart d2

Deep intertrabecular recesses2

Ventricular tachycardia3

Secondary2

Primary5

Stenosis1

Gadolinium2

Cardiomyopathies1

Right atrium2

Regulate1

Thickness1

Defect1

Epicardium3

Scar4

Diseases2

Pericardium2

Heart4

Systolic2

Occur2

Viral1

Markedly enlarged1

Coronary1

Inflammatory2

Clinical2

Surfaces1

19431

Diagnosis3

Arrhythmias1

Dilated cardiomyopathy1

Left1

MESH1

Assessment1

Form1

Surface1

Functional1

Phenomenon1

Reference2