AnatomyOrganismsDiseasesChemicals and DrugsAnalytical, Diagnostic and Therapeutic Techniques and EquipmentPsychiatry and PsychologyPhenomena and ProcessesDisciplines and OccupationsInformation ScienceHealth CareGeographicals
Brain IschemiaIschemiaMyocardial IschemiaReperfusionIschemic Attack, TransientReperfusion InjuryGerbillinaeBrainNeuroprotective AgentsInfarction, Middle Cerebral ArteryBrain ChemistryBrain InfarctionBrain InjuriesBrain EdemaRats, Sprague-DawleyIschemic PreconditioningDisease Models, AnimalCerebrovascular CirculationRats, WistarCerebral InfarctionCerebral CortexNeuronsTime FactorsBrain NeoplasmsHippocampusHypoxia-Ischemia, BrainMiddle Cerebral ArteryMenispermumBrain MappingHypoxia, BrainHypothermia, InducedCell DeathBlood-Brain BarrierMagnetic Resonance ImagingStrokeMyocardial Reperfusion InjuryMongoliaRecovery of FunctionWarm IschemiaArterial Occlusive DiseasesAstrocytesMice, Inbred C57BLPhenazocineGlutamic AcidCerebral ArteriesCerebrovascular DisordersOxygenImmunohistochemistryRats, Inbred StrainsBrain StemNerve Tissue ProteinsCorpus StriatumRats, Inbred SHRPhosphotungstic AcidAnalysis of VarianceCold IschemiaNecrosisThiocarbamatesCell HypoxiaNerve DegenerationGlial Fibrillary Acidic ProteinBody TemperatureThiopentalCells, CulturedBlotting, WesternSpinal Cord IschemiaMice, KnockoutMyocardiumNeurologic ExaminationSus scrofaGlucoseBlood PressureRNA, MessengerAnimals, NewbornAcute DiseaseEncephalitisApoptosisElectroencephalographyMicrogliaBehavior, AnimalLactatesIschemic Preconditioning, MyocardialCA1 Region, HippocampalDose-Response Relationship, DrugBrain AbscessIntracranial Embolism and ThrombosisReceptors, N-Methyl-D-AspartateRats, Long-EvansAcid Sensing Ion ChannelsIn Situ Nick-End LabelingRandom AllocationAntioxidantsNervous System DiseasesHeart ArrestMyocardial ReperfusionUltrasonography, Doppler, TranscranialIsofluraneCell SurvivalOxidative StressCell Count
CerebralHypoxiaInfarctionMyocardialTraumaStrokeOxygenTraumatic brainAcuteAbnormalitiesVulnerableCerebrovascularPhysiologicalSpectrumTissueBlindnessAxonalArteriesDisordersDeep brain stimuSpinalDisruptionMicrogliaCerebellumSevereBloodOccurPathologiesUltrasoundWideNeuronsDiseasesInjuryReductionDamageAreasSlicesNervous systemConditionGlobal brainIncreasesVaryLeadsDeath
Cerebral14
  • This leads to poor oxygen supply or cerebral hypoxia and thus leads to the death of brain tissue or cerebral infarction/ischemic stroke. (wikipedia.org)
  • Similar to cerebral hypoxia, severe or prolonged brain ischemia will result in unconsciousness, brain damage or death, mediated by the ischemic cascade. (wikipedia.org)
  • Different strokes for different folks: the rich diversity of animal models of focal cerebral ischemia. (anthropogeny.org)
  • Disruption of blood-brain barrier (BBB) facilitating entrance of neurotoxic antibodies into the central nervous system (CNS), neuroinflammation and cerebral ischemia are the key mechanisms. (bmj.com)
  • Male C57Bl/6 mice were subjected to focal cerebral ischemia and periods of reperfusion (0, 8 and 24 h). (biomedcentral.com)
  • Microglia were both hyper- and de-ramified in striatal and cortical brain regions (respectively) after 60 min of focal cerebral ischemia. (biomedcentral.com)
  • Secondly, it may be that immature babies who are particularly vulnerable to cerebral haemorrhage and ischaemia sustain injury as a result of intrapartum and neonatal complications. (bmj.com)
  • 10 A third possibility is that cerebral palsy represents the endpoint of a continuum of adverse events which occur throughout the period when the brain is especially vulnerable to ischaemia. (bmj.com)
  • The term cerebrovascular disease includes all disorders in which an area of the brain is temporarily or permanently affected by ischemia or bleeding and one or more of the cerebral blood vessels are involved in the pathological process. (wblk.com)
  • To offer more metrics for clinical decision-making and therapy augmentation, brain tissue oxygen monitoring systems are used for monitoring both oxygen and temperature in the cerebral cavity. (factmr.com)
  • These systems keep an eye on indicators such as neural activity, pressure around the brain, cerebral oxygenation capacity, strokes, traumatic cranial damage, blood pressure, and other dangerous situations. (factmr.com)
  • We have demonstrated in a murine model that CM results in a vasculopathy with increased levels of endothelin- 1 (ET-1), leading to a reduction of cerebral blood flow and a decrease in NAA/Cr ratio in the brains of mice on MRS [2]. (elsevierpure.com)
  • We propose that as a result of a reduction in cerebral blood flow, there is ischemia and neuronal damage associated with abnormalities in the insulin signaling/ survival pathway. (elsevierpure.com)
  • Previous studies of global brain hypoxia ischemia have primarily focused on injury to the cerebral cortex and to the hippocampus. (cdc.gov)
Hypoxia4
  • If your child suffered from a deprivation of oxygen during birth, including hypoxia, ischemia or asphyxia, he or she may have experienced damage to the visual cortex that will affect your baby's sight. (birthinjuryinfo.org)
  • Global hypoxia-ischemia interrupts oxygen delivery and blood flow to the entire brain. (cdc.gov)
  • We therefore investigated the impact of global brain hypoxia-ischemia on the thalamic circuit function in the somatosensory system of young rats. (cdc.gov)
  • Global brain hypoxia-ischemia during cardiac arrest has a long-term impact on processing and transfer of sensory information by thalamic circuitry. (cdc.gov)
Infarction2
  • If the brain becomes damaged irreversibly and infarction occurs, the symptoms may be permanent. (wikipedia.org)
  • OSA is a risk factor for cardiovascular disorders including hypertension, congestive heart failure (CHF), myocardial ischemia, arrhythmias and infarction, and cerebrovascular conditions including stroke [ 3 ]. (hindawi.com)
Myocardial2
  • This researcher's remarkable career covered work that ranged from myocardial ischemia and the role of anesthetic agents to neurological injury after cardiac surgery. (cas.ca)
  • Myocardial Ischemia in Trauma and Critical Care. (icebe.es)
Trauma2
  • Advances in research in the field of brain injury, including stroke, trauma and global ischemia, have never been more exciting and encouraging to identify novel effective treatments. (moleac.com)
  • however, they can also be signs of more encompassing brain trauma as well. (birthinjuryinfo.org)
Stroke3
Oxygen4
Traumatic brain1
  • Diffuse axonal injury (DAI), an important pathoanatomical subgroup of traumatic brain injury (TBI), refers to intracranial injury caused by rapid and sustained deceleration or acceleration of the brain, leading to higher mortality and functional impairment. (researchsquare.com)
Acute3
  • Live cell morphology and process activity were measured from movies acquired in acute brain slices from GFP-CX3CR1 transgenic mice after IS and 24-h reperfusion. (biomedcentral.com)
  • Treatment encompasses prevention, acute cares, and recovery. (moleac.com)
  • The lack of obvious pathology after parasitic cure suggests that these long-term neuro- cognitive deficits are the result of potentially reversible biochemical and physiological changes in brains of CM mice subsequent to the decreased blood flow and ischemia during the acute infection. (elsevierpure.com)
Abnormalities4
  • Brain ischemia has been linked to a variety of diseases or abnormalities. (wikipedia.org)
  • BACKGROUND AND PURPOSE: Fetal brain MR imaging is clinically used to characterize fetal brain abnormalities. (bvsalud.org)
  • Pathologically, despite primary mechanical breaking of the axonal cytoskeleton, DAI encompasses a spectrum of abnormalities ranging from inflammation, intracellular calcium overload, transport interruption, swelling, and proteolysis through secondary physiological changes [ 2 ] . (researchsquare.com)
  • In neurological testing, brain monitoring systems are used to identify any abnormalities in the way that brain cells (neurons) work that can result in the emergence of neurological illnesses such as Parkinson's disease, dementia, epilepsy, sleep disorders, and Alzheimer's. (factmr.com)
Vulnerable2
  • Posterior spinal artery syndrome is much rarer than its anterior counterpart as the white matter structures that are present are much less vulnerable to ischemia since they have a better blood supply. (wikipedia.org)
  • If treated with cardiopulmonary resuscitation, however, cardiac arrest is survivable, but survivors often show evidence of injury in selectively vulnerable regions of the brain. (cdc.gov)
Cerebrovascular1
  • Neuropsychiatric systemic lupus erythematosus (NPSLE) is an emerging frontier in lupus care encompassing a wide spectrum of clinical manifestations among which cerebrovascular accidents, seizures, cognitive dysfunction, demyelinating syndromes, psychosis and optic neuritis/myelitis have received increased attention in recent years. (bmj.com)
Physiological1
  • it projects to most key brain regions and modulates numerous physiological functions. (hindawi.com)
Spectrum1
  • 1 The term hypertensive crisis is sometimes used to describe the spectrum of severe uncontrolled hypertension, encompassing both hypertensive emergency and hypertensive urgency. (nursingcenter.com)
Tissue2
  • and global ischemia, which encompasses wide areas of brain tissue. (wikipedia.org)
  • The extension of the necrotic core into the penumbra is influenced by additional factors such as regional differences in the composition of brain tissue, the vulnerability of different cell types to ischemia, residual tissue perfusion and additional events such as reperfusion [ 2 - 4 ]. (biomedcentral.com)
Blindness3
  • Symptoms of brain ischemia can include unconsciousness, blindness, problems with coordination, and weakness in the body. (wikipedia.org)
  • Ischemia within the arteries branching from the internal carotid artery may result in symptoms such as blindness in one eye, weakness in one arm or leg, or weakness in one entire side of the body. (wikipedia.org)
  • Keep in mind that cortical blindness is a condition of the brain - the real indicator that your child is affected is a lack of reaction to visual stimulus or an inability to fix his or her eyes on an object to follow that object. (birthinjuryinfo.org)
Axonal2
Arteries6
  • Ischemia within the arteries branching from the vertebral arteries in the back of the brain may result in symptoms such as dizziness, vertigo, double vision, or weakness on both sides of the body[citation needed]. (wikipedia.org)
  • Individuals with sickle cell anemia, compressed blood vessels, ventricular tachycardia, plaque buildup in the arteries, blood clots, extremely low blood pressure as a result of heart attack, and congenital heart defects have a higher predisposition to brain ischemia in comparison to the average population. (wikipedia.org)
  • citation needed] Blockage of arteries due to plaque buildup may also result in ischemia. (wikipedia.org)
  • Arteries to the brain on magnetic resonance angiogram (MRA). (medscape.com)
  • FMD can affect arteries around the heart, but patients with FMD often have the condition in other arteries, too, including those in the kidney and brain. (scadalliance.org)
  • Ischemia is caused by a blockage in blood flow within the heart's arteries. (scadalliance.org)
Disorders1
  • Brain disorders, which encompass a variety of psychiatric, neurodegenerative, and developmental illnesses, are a rising source of morbidity around the world. (factmr.com)
Deep brain stimu2
  • Deep Brain stimulation (DBS) treatment significantly elevates the disease symptoms including tremor. (lidsen.com)
  • Pathological aggressiveness is an invalidating condition that can be successfully treated by deep brain stimulation (DBS) at posteromedial hypothalamus (PMH). (lidsen.com)
Spinal4
  • When posterior spinal artery syndrome does occur, dorsal columns are damaged and ischemia may spread into the posterior horns. (wikipedia.org)
  • Cervical malformations arise from the anterior spinal artery and lie within the cord, whereas thoracolumbar malformations can be internal, external or encompass both areas of the cord. (wikipedia.org)
  • Your CNS comprises your brain and spinal cord, while your peripheral nervous system comprises all the nerve fibers that branch out to and from the rest of your body, including your extremities. (drlamcoaching.com)
  • MRI is used to visualize brain or spinal pathologies. (bmj.com)
Disruption1
Microglia2
  • Microglia cells continuously survey the healthy brain in a ramified morphology and, in response to injury, undergo progressive morphological and functional changes that encompass microglia activation. (biomedcentral.com)
  • The microglia process length/cell and number of endpoints/cell was quantified from immunofluorescent confocal images of brain regions using a skeleton analysis method developed for this study. (biomedcentral.com)
Cerebellum1
Severe1
Blood12
  • An interruption of blood flow to the brain for more than 10 seconds causes unconsciousness, and an interruption in flow for more than a few minutes generally results in irreversible brain damage. (wikipedia.org)
  • Sickle cell anemia may cause brain ischemia associated with the irregularly shaped blood cells. (wikipedia.org)
  • Sickle shaped blood cells clot more easily than normal blood cells, impeding blood flow to the brain. (wikipedia.org)
  • citation needed] Large blood clots can also cause ischemia by blocking blood flow. (wikipedia.org)
  • citation needed] A heart attack can also cause brain ischemia due to the correlation that exists between heart attack and low blood pressure. (wikipedia.org)
  • Untreated heart attacks may slow blood flow enough that blood may start to clot and prevent the flow of blood to the brain or other major organs. (wikipedia.org)
  • Microbubbles (MBs) serve as a critical catalyst to amplify local cavitation in CNS capillary lumen to facilitate focused ultrasound (FUS) to transiently open the blood-brain barrier (BBB). (nature.com)
  • The blood-brain barrier (BBB) plays an important role in regulating the exchange of nutrients and wastes between brain tissues and the circulatory system while concurrently preventing pathogens from entering the brain parenchyma. (nature.com)
  • This vascular network, referred to as the circle of Willis (see the following image), plays a critical role in shunting blood flow between adjacent territories in the brain. (medscape.com)
  • When you have ischemia, it is the pain your heart experiences when it isn't receiving enough oxygenated blood. (scadalliance.org)
  • To investigate whether DNA active demethylase TET regulates the expression of tight junction proteins in endothelial cells of the blood-brain barrier (BBB). (biomedcentral.com)
  • Systemic drug delivery to the central nervous system is limited by presence of the blood-brain barrier (BBB). (biomedcentral.com)
Occur1
  • We have found a down-regulation of the PI3K/Akt insulin signaling/ survival pathway in the brains of mice with CM. As a result of decreased Akt activation, the normal inhibition of GSK3 by Akt does not occur and tau becomes aberrantly phosphorylated. (elsevierpure.com)
Pathologies1
  • I have been involved with very diverse aspects of brain research and brain pathologies for decades. (moleac.com)
Ultrasound1
  • Dr Denault's exceptional academic achievements encompass both his outstanding research ability in echocardiography - and more recently in point-of-care ultrasound (POCUS) - and his extraordinary capabilities in teaching the management of the unstable patient. (cas.ca)
Wide1
  • These deficits encompass a wide range of neuro-cognitive dysfunction. (elsevierpure.com)
Neurons1
Diseases2
  • It poses a critical impediment to the pharmaceutical treatment of certain brain diseases. (nature.com)
  • This technology has the potential to enhance delivery of various kinds of therapeutic agents into the brain and has potential to benefit treatment of CNS diseases. (nature.com)
Injury1
  • This approach gives us the possibility to support and enhance multiple natural processes taking place into the brain and representing its ability to protect itself and to recover after an injury. (moleac.com)
Reduction1
  • Ischemia leads to alterations in brain metabolism, reduction in metabolic rates, and energy crisis. (wikipedia.org)
Damage1
  • Accordingly, this discovery raised the possibility of intervening after brain ischemia before the damage becomes irreversible. (wikipedia.org)
Areas2
  • They also report back to the brain and CNS what's happening in those areas. (drlamcoaching.com)
  • Review of specific examination findings related to Brodmann areas, lobes of the brain, subcortical areas and networks. (uschirodirectory.com)
Slices1
  • Recently, algorithms have been proposed to reconstruct high-resolution 3D fetal brain volumes from 2D slices. (bvsalud.org)
Nervous system1
  • The ENS is your gut's nervous system, and it plays an important role in the communication between your gut and brain. (drlamcoaching.com)
Condition2
  • Brain ischemia is a condition in which there is insufficient bloodflow to the brain to meet metabolic demand. (wikipedia.org)
  • Despite its name, this condition is a problem with the brain sending and receiving visual messages, not with the parts of the eye themselves. (birthinjuryinfo.org)
Global brain3
  • The global brain monitoring devices market is currently valued at US$ 6.5 billion and is expected to increase at a noteworthy CAGR of 6% to reach US$ 8.7 billion by the end of 2027. (factmr.com)
  • The global brain monitoring devices market has seen a growth in demand for non-invasive brain monitoring technologies including MRI , EEG, MEG, and more. (factmr.com)
  • According to Fact.MR, a market research and competitive intelligence provider, over the next five years, the global brain monitoring devices market is expected to expand at a CAGR of 6% and reach US$ 8.7 billion by 2027. (factmr.com)
Increases1
  • Gastrointestinal: it sends satiation signals to the brain and increases GI motility and secretions. (drlamcoaching.com)
Vary1
Leads1
  • Untreated, cardiac arrest rapidly leads to brain death. (cdc.gov)
Death1
  • Brain Death and Organ Donation. (icebe.es)