• In search for subgroups of diffuse large B-cell lymphoma (DLBCL) with different histogenetic origin and prognosis, as has been described by gene expression profiling, we examined tumor specimens from 125 patients with DLBCL, uniformly treated by either cyclophosphamideAdriamycin-vincristine-prednisone or methotrexate, doxorubicin, cyclophosphamide, vincristine, prednisone, and bleomycin in a multicenter trial set by the Nordic Lymphoma Group 1989-1994. (aacrjournals.org)
  • Diffuse large B-cell lymphoma (DLBCL) is a cancer of B cells, a type of lymphocyte that is responsible for producing antibodies. (wikipedia.org)
  • The causes of diffuse large B-cell lymphoma are not well understood. (wikipedia.org)
  • HIV), and the Helicobacter pylori bacterium are also associated with the development of certain subtypes of diffuse large B-cell lymphoma. (wikipedia.org)
  • Diffuse large B-cell lymphoma encompasses a biologically and clinically diverse set of disease subtypes, many of which are difficult to separate from one another based on well-defined and widely accepted criteria. (wikipedia.org)
  • Based on further research, the World Health Organization, 2016, reclassified DLBCL into its most common subtype, diffuse large B-cell lymphoma, not otherwise specified (DLBCL, NOS). (wikipedia.org)
  • DLBCL cases that do not fit the distinctive clinical presentation, tissue morphology, neoplastic cell phenotype, and/or pathogen-associated criteria of other DLBCL subtypes are termed Diffuse large B-cell lymphoma, not otherwise specified: DLBCL, NOS, while representing 80-85% of all DLBCL cases, is a diagnosis of exclusion. (wikipedia.org)
  • In our study 52, 64, 101, 500 and 246 PWH with histological confirmation of TCL, primary CNS, Burkitt's, diffuse large B-cell lymphoma (DLBCL) and Hodgkin's lymphoma (HL) respectively and 450 TCL without HIV were eligible for analysis. (cdc.gov)
  • Cutaneous tumors encompass a vast array of malignancies, ranging from neuroendocrine to lymphoid in origin. (medscape.com)
  • Primary cutaneous CD30+ anaplastic large cell lymphomas mimicking KAs have been reported. (medscape.com)
  • Cutaneous T-cell lymphoma (CTCL) (see the image below) is a heterogeneous group of lymphoproliferative disorders characterized by localization of neoplastic T lymphocytes to the skin, with no evidence of extracutaneous disease at the time of diagnosis. (medscape.com)
  • Early patch-stage cutaneous T-cell lymphoma. (medscape.com)
  • Related articles include Cutaneous B-Cell Lymphoma and Cutaneous Pseudolymphoma . (medscape.com)
  • Among the changes to CTCL classification were the addition of primary cutaneous acral CD8 + T-cell lymphoma as a new provisional entity. (medscape.com)
  • Also, the term "primary cutaneous CD4 + small/medium T-cell lymphoma" was changed to "primary cutaneous CD4 + small/medium T-cell lymphoproliferative disorder" because of its indolent clinical behavior and uncertain malignant potential. (medscape.com)
  • Mycosis fungoides is the most common type, accounting for 60% of CTCLs and almost half of all primary cutaneous lymphomas. (medscape.com)
  • On the other hand, clear cell acanthoma is a rare, benign epithelial cutaneous tumor. (medscape.com)
  • As with all tumors, whether benign or malignant, identification of the cell or cell layer of origin is of the utmost importance. (medscape.com)
  • Most benign spindle cell tumors of the urinary bladder are an inflammatory myofibroblastic tumor (IMT). (medscape.com)
  • 11] The oldest large series of 38 spindle cell tumors in the urinary bladder included 17 pseudotumors, 4 postoperative spindle cell nodules (PSCNs), and 13 sarcomas. (medscape.com)
  • 4] IMT includes tumors with necrosis in up to 30% of cases and also encompasses tumors with recurrence in up to 31% of cases, so it is tempting to suggest that, of the tumors classified in 2001 as sarcoma (at least the 7 low-grade ones), most may have been considered by others as IMT or, conversely, that IMT is truly a low-grade sarcoma. (medscape.com)
  • As with all tumors, whether benign or malignant, the paradigm of comprehension depends on identifying the cell or cell layer of origin. (medscape.com)
  • Skin malignancies, Merkel cell carcinoma and rare appendageal tumors. (medscape.com)
  • Twenty-five percent of all lung tumors belong to the group of neuroendocrine tumors [ 2 ] including typical carcinoid (TC) and atypical carcinoid (AC), large-cell neuroendocrine cancer (LCNEC), and small-cell lung cancer (SCLC). (oncotarget.com)
  • A group of heterogeneous lymphoid tumors generally expressing one or more B-cell antigens or representing malignant transformations of B-lymphocytes. (lookformedical.com)
  • Any of a group of malignant tumors of lymphoid tissue that differ from HODGKIN DISEASE, being more heterogeneous with respect to malignant cell lineage, clinical course, prognosis, and therapy. (lookformedical.com)
  • The only common feature among these tumors is the absence of giant REED-STERNBERG CELLS, a characteristic of Hodgkin's disease. (lookformedical.com)
  • B-cell lymphoid tumors that occur in association with AIDS. (lookformedical.com)
  • 1 The most frequent primary tumor types of anterior mediastinal masses are thymic tumors and lymphoma, with approximate proportions of 35% and 25% among mediastinal lesions, respectively. (allenpress.com)
  • Juxta-articular giant cell tumors of the lower end radius are common and present a special problem of reconstruction after tumor excision. (jbstjournal.com)
  • Giant cell tumors (GCT) of the bone are aggressive and are recognised for variable clinical behaviour, which is not always related to radiographic or histological appearance [1]. (jbstjournal.com)
  • Tumors situated away from the eloquent cortices may reach a large or giant size before presenting with symptoms of raised intracranial pressure. (neurosurgicalatlas.com)
  • Other lesions mimicking a convexity meningioma include hemangiopericytomas , primary bony tumors, dural-based metastases, and potentially lymphoma. (neurosurgicalatlas.com)
  • Younger patients' asymptomatic tumors may be observed until growth is identified, but if the patient has a large or symptomatic lesion, surgical resection is the primary treatment modality. (neurosurgicalatlas.com)
  • Thus "Hodgkin's disease" comprises two distinct lymphomas, deserving of a name change, to "Hodgkin's lymphomas" (HLs). (nih.gov)
  • Highlight: PET scans for Non-Hodgkin's Lymphoma: Answering the Critical Questions to. (authorea.com)
  • Standard management of pediatric Non-Hodgkin's Lymphoma (NHL) patients have included an initial assessment of the disease at presentation to establish it's extent. (authorea.com)
  • Valemetostat is under clinical development by Daiichi Sankyo and currently in Phase II for Follicular Lymphoma. (pharmaceutical-technology.com)
  • According to GlobalData, Phase II drugs for Follicular Lymphoma have a 45% phase transition success rate (PTSR) indication benchmark for progressing into Phase III. (pharmaceutical-technology.com)
  • Follicular cell-derived thyroid cancer is a common endocrine malignancy, which histologically consists of papillary thyroid cancer (PTC), follicular thyroid cancer (FTC) and anaplastic thyroid cancer (ATC) [ 1 - 3 ]. (oncotarget.com)
  • It is the most common form of non-Hodgkin lymphoma among adults, with an annual incidence of 7-8 cases per 100,000 people per year in the US and UK. (wikipedia.org)
  • A form of non-Hodgkin lymphoma having a usually diffuse pattern with both small and medium lymphocytes and small cleaved cells. (lookformedical.com)
  • Numerous subtypes of DLBCL have been identified which differ in their clinical presentations, biopsy findings, aggressive characteristics, prognoses, and recommended treatments. (wikipedia.org)
  • However, the usual treatment for most subtypes of DLBCL is chemotherapy combined with a monoclonal antibody drug that targets the disease's cancerous B-cells, usually rituximab. (wikipedia.org)
  • The World Health Organization, 2008, classification system defined more than a dozen subtypes, each of which was identified based on the location of the tumor, the presence of other cell types such as T cells in the tumor, and whether the patient had certain other illnesses related to DLBCL. (wikipedia.org)
  • [ 1 ] CTCL subtypes demonstrate a variety of clinical, histologic, and molecular features, and can follow an indolent or a very aggressive course. (medscape.com)
  • The 2005 World Health Organization-European Organization for Research and Treatment of Cancer (WHO-EORTC) classification of CTCLs is divided into those with indolent clinical behavior and those with aggressive subtypes. (medscape.com)
  • Usually DLBCL arises from normal B cells, but it can also represent a malignant transformation of other types of lymphoma (particularly marginal zone lymphomas) or, in rare cases termed Richter's transformation, chronic lymphocytic leukemia. (wikipedia.org)
  • In fact, clear cell acanthoma possesses a similar staining pattern to inflammatory dermatoses such as psoriasis vulgaris, lichen planus, and discoid lupus erythematosus and might be a localized form of inflammatory eruption rather than a neoplasm. (medscape.com)
  • These are useful in the subclassification of HL and in distinguishing HL from two recently described, aggressive lymphomas that were in the past often diagnosed as HL: anaplastic large-cell lymphoma, T-cell type (ALCL), and T-cell/histiocyte-rich large B-cell lymphoma (T/HRBCL). (nih.gov)
  • At the time of TCL diagnosis, Anaplastic large-cell lymphoma (ALCL) was the most common TCL subtype within PWH. (cdc.gov)
  • Histologically, the fully formed domelike lesion reveals a mass of proliferating squamous epithelial cells, which created the central core of keratin. (medscape.com)
  • KA lesions can easily be mistaken for squamous cell carcinoma (SCC). (medscape.com)
  • [ 7 ] In KAs, cells that stain positive with proliferating-cell nuclear antigen immunostaining are distributed only in the outer edges of the tumor, corresponding to the proliferating squamous epithelial cells. (medscape.com)
  • To evaluate the expression of E-cadherin (E-cad) in oral epithelial dysplasia (OED) and oral squamous cell carcinoma (OSCC). (ijpmonline.org)
  • Immunohistochemistry was used to detect E-cad expression in 20 cases each of normal oral mucosa, oral epithelial dysplasia and squamous cell carcinoma. (ijpmonline.org)
  • We observed a significant decrease in E-cad expression from dysplasia to poorly differentiated squamous cell carcinoma suggesting that loss of expression of E-cad is closely related to carcinoma. (ijpmonline.org)
  • Watch this slideshow of precancerous lesions that may lead to skin cancer over time, including melanoma, basal cell carcinoma, and squamous cell carcinoma. (medicinenet.com)
  • Pathology is the study and diagnosis of disease through examination of organs , tissues , cells and bodily fluids . (bionity.com)
  • The adaptation of cells to hypoxia appears to be mediated via hypoxia inducible factor-1α (HIF-1α) which is also said to be associated with malignant transformation of epithelial cells in various other carcinomas like prostate and cervical carcinoma. (ijpmonline.org)
  • DLBCL can arise in virtually any part of the body and, depending on various factors, is often a very aggressive malignancy. (wikipedia.org)
  • Metastasis: Standard-risk patients usually do not have evidence of metastasis, which means that the cancer cells have not spread from the primary tumor site in the cerebellum to other parts of the central nervous system (CNS) or outside the CNS. (neurosurgery.directory)
  • This means that the cancer cells have spread from the primary tumor site in the cerebellum to other areas within the CNS or even outside the CNS, such as the spinal cord or other parts of the body. (neurosurgery.directory)
  • Peripheral T cell lymphomas (PTCLs) are generally chemotherapy resistant and have a poor prognosis. (mdpi.com)
  • 4.2 Adoptive T Cell Therapy Take action is a malignancy immunotherapy method in which T cells are collected from your tumor, lymph nodes, or peripheral blood of a patient and returned Vanin-1-IN-1 to the patients body after proliferation and selection of tumor-specific T cells. (azd1152.com)
  • A group of malignant lymphomas thought to derive from peripheral T-lymphocytes in lymph nodes and other nonlymphoid sites. (lookformedical.com)
  • Many of the sites of these lymphomas, such as the stomach, salivary gland, and thyroid, are normally devoid of lymphoid tissue. (lookformedical.com)
  • Through a genome-wide search for such genes that were epigenetically controlled by the PI3K pathway in thyroid cancer cells, we found a wide range of genes with broad functions epigenetically targeted by the PI3K pathway. (oncotarget.com)
  • Demethylating the hypermethylated REC8 gene restored its expression in thyroid cancer cells in which the PI3K pathway was genetically over-activated and induced expression of REC8 protein inhibited the proliferation and colony formation of these cells. (oncotarget.com)
  • The results of phase I and II trials showed that the use of Newcastle virus-infected tumor cells reduced recurrence and increased OS in CRC patients (44, 219). (azd1152.com)
  • Giant cell tumor (GCT) of bone is a benign but locally aggressive tumor with tendency for local recurrence [2]. (jbstjournal.com)
  • Their excision should encompass a wide dural margin and the involved bone, especially for young patients, to decrease the risk of tumor recurrence. (neurosurgicalatlas.com)
  • It is highly expressed in eosinophils and basophils, and is also detected in TH1 and TH2 cells, as well as in airway epithelial cells. (cancerindex.org)
  • This presence of melanin provides pigmentation to the benign tumor, and this occurrence has been termed pigmented clear cell acanthoma. (medscape.com)
  • Giant cell tumor is a benign bone tumor, locally aggressive with low malignant potential. (jbstjournal.com)
  • 25% of all lung cancer cases are neuroendocrine (NELC) including typical (TC) and atypical carcinoid (AC), large-cell neuroendocrine (LCNEC) and small cell lung cancer (SCLC). (oncotarget.com)
  • The lack of targeted immunotherapeutic approaches for T cell malignancies results in part from potential risks associated with targeting broadly expressed T cell markers, namely T cell depletion and clinically significant immune compromise. (mdpi.com)
  • The term encompasses both the medical specialty which uses tissues and body fluids to obtain clinically useful information, as well as the related scientific study of disease processes. (bionity.com)
  • In order to distinguish between KA and SCC, further histologic studies can be used, including proliferating-cell nuclear antigen immunostaining. (medscape.com)
  • In contrast, cells within an SCC that stain positive with proliferating-cell nuclear antigen immunostaining are more diffusely distributed. (medscape.com)
  • There are no studies comparing the prognosis for mature T-cell lymphoma (TCL) in people with human immunodeficiency virus (PWH) to people without HIV (PWoH) and to AIDS-defining B-cell lymphomas (A-BCL) in the modern antiretroviral therapy (ART) era. (cdc.gov)
  • 9] The term IMT is now used more often than pseudotumor, but IMT may include a more aggressive but overlapping set of lesions. (medscape.com)
  • Case reports in the literature report clear cell acanthomas with multiple lesions, (ie, polypoid clear cell acanthoma). (medscape.com)
  • The mutation-specific CD8+ T cells were selected and returned to the patient, resulting in the removal of 85% of metastatic lesions (227). (azd1152.com)
  • Large lesions invading the dural sinuses often lead to significant bleeding during surgery and preoperative hematologic studies and precautions for intraoperative venous air embolism detection and management are warranted. (neurosurgicalatlas.com)
  • The majority of mantle-cell lymphomas are associated with a t(11;14) translocation resulting in overexpression of the CYCLIN D1 gene (GENES, BCL-1). (lookformedical.com)
  • Two important discoveries have prompted changes in classification and nomenclature: first, the recognition that there are two distinct lymphomas encompassed within this category (classical and nodular lymphocyte-predominant [NLP] types), and second, the discovery that the Reed-Sternberg (RS) cells in most cases are monoclonal B cells. (nih.gov)
  • A classification of B-lymphocytes based on structurally or functionally different populations of cells. (lookformedical.com)
  • and or tumor cells infected with oncolytic viruses release PAMPs, which increases immune responses (217, 218). (azd1152.com)
  • A second concern is usually cytokine release syndrome due to the CAR-T cells activation following binding to antigens in both tumor cells and normal cells (226). (azd1152.com)
  • Ezharmia is indicated for the treatment of patients with relapsed or refractory adult T-cell leukemia/lymphoma. (pharmaceutical-technology.com)
  • It accounts for about 5% of adult non-Hodgkin lymphomas in the United States and Europe. (lookformedical.com)
  • Malignant lymphoma composed of large B lymphoid cells whose nuclear size can exceed normal macrophage nuclei, or more than twice the size of a normal lymphocyte. (lookformedical.com)
  • It is commonly manifested as a large osteolytic lesion in the jaw or as an abdominal mass. (lookformedical.com)
  • One of the mechanisms by which CELL DEATH occurs (compare with NECROSIS and AUTOPHAGOCYTOSIS). (lookformedical.com)
  • 2, 4, 5, 6] Postoperative spindle cell nodule (PSCN) is usually described as histologically identical to IMT, except that a history of instrumentation or trauma to the bladder can be elicited, and plasma cells are often less prominent. (medscape.com)
  • 9] Among the 38 cases, the mean age of patients was 38 years for pseudotumor (age range, 15-74 years), 65 years for postoperative spindle cell nodule, 51 years for sarcoma, and 76 years for carcinoma. (medscape.com)
  • In a large series of 38 cases, after review and immunohistochemical workup, 17 patients had inflammatory pseudotumor (myofibroblastic tumor), 4 patients had postoperative spindle cell nodule, and 1 patient had leiomyoma. (medscape.com)
  • Typically, the clinical presentation of clear cell acanthoma is a solitary nodule in the lower extremities. (medscape.com)
  • In the broadest sense, nearly all research which links manifestations of disease to identifiable processes in cells, tissues, or organs can be considered experimental pathology. (bionity.com)
  • The term "oncotarget" encompasses all molecules, pathways, cellular functions, cell types, and even tissues that can be viewed as targets relevant to cancer as well as other diseases. (oncotarget.com)
  • This mode of cell death serves as a balance to mitosis in regulating the size of animal tissues and in mediating pathologic processes associated with tumor growth. (lookformedical.com)
  • Pathology is a broad and complex scientific field which seeks to understand the mechanisms of injury to cells and tissues , as well as the body's means of responding to and repairing injury. (bionity.com)
  • and finally, radiosurgery in combination with immunotherapy for non-small cell lung cancer and melanoma. (pennmedicine.org)
  • Campanacci's staging system for giant cell tumour of the bone [5] was used for cortical breach. (jbstjournal.com)
  • Large cortical vasculature (large parasagittal veins or vein of Labbe) and their involvement should be studied preoperatively through the use of complementary studies such as a computed tomography (CT) angiogram or MR venogram. (neurosurgicalatlas.com)
  • In the context of mCRC, CAR-T cells as monotherapy or in combination with cytokines such as IL-12 had encouraging effects such as tumor reduction and long-term disease Vanin-1-IN-1 stability in some Vanin-1-IN-1 patients (222C225). (azd1152.com)
  • 4, 8, 9] The first large series of 38 cases was comprised of patients aged 2.5 months to 87 years. (medscape.com)
  • Fields et al reviewed 500 patients with Merkel cell carcinoma in a single-institution study. (medscape.com)
  • These proliferating cells exhibit no cytologic abnormalities and have a normal nuclear-to-cytoplasmic ratio. (medscape.com)
  • Other findings specific to sarcoma were more nuclear atypia, less prominent microvasculature, less variable cellularity, consistently ≥1 mitotic figure per 10 high-power fields (see Image 4 in the figure below), and predominant acute inflammation without plasma cells. (medscape.com)
  • A group of lymphomas exhibiting clonal expansion of malignant T-lymphocytes arrested at varying stages of differentiation as well as malignant infiltration of the skin. (lookformedical.com)
  • Take action can be performed with unmanipulated cells or designed cells that express chimeric antigen receptors (CAR-T cells). (azd1152.com)
  • The cells within the acanthotic epidermis stain faintly because of the overload of glycogen content in the keratinocytes. (medscape.com)
  • Their cells are translucent because of the presence of glycogen, which can be demonstrated by a periodic acid-Schiff (PAS) stain (and eliminated with diastase) or electron microscopy. (medscape.com)
  • With antikeratin antibodies, the clear cell acanthomas stain for AE1 and AE3, but did not stain for CAM5.2. (medscape.com)
  • In a matrigel invasion assay, interferon-gamma, a specific inhibitor of eotaxin-related homing, significantly reduced the transmigration of PC-3 cells, under co-cultured condition with MSCs, in a dose-dependent manner (P (cancerindex.org)
  • To assay for α3α4α5(IV) heterotrimer formation and secretion, we measured luminescence in cell lysates and culture supernatants from transfected cells.Immunostaining suggested that the collagen α3α4α5(IV) network was present throughout the patient's GBMs. (stanford.edu)
  • In the C-terminal split luciferase-based α3α4α5(IV) heterotrimer formation assays, luminescence levels for G394S were comparable to WT, but in the N-terminal tag assays, the extracellular luminescence levels for G394S were decreased by approximately 50% compared with WT.Our cell-based assay provides a platform to test COL4 VUS and shows that G394S impairs assembly of the α3α4α5(IV) N-terminus and subsequent trimer secretion. (stanford.edu)
  • However, most cases of this disease are associated with the unexplained step-wise acquisition of increasing numbers of gene mutations and changes in gene expression that occur in, and progressively promote the malignant behavior of, certain B-cell types. (wikipedia.org)
  • The use of tumor-specific unmanipulated cells has also yielded positive results in CRC. (azd1152.com)
  • Lung cancers are classified as either small cell or non-small cell cancers. (medicinenet.com)
  • Mesenchymal stem cells up-regulate the invasive potential of prostate cancer cells via the eotaxin-3/CCR3 axis. (cancerindex.org)
  • We investigated the homing-related chemokine expression levels of MSCs treated with a prostate cancer cell line (PC-3) -conditioned medium. (cancerindex.org)