Encodes a member genes homeobox. Medical search. Frequent questions

This gene encodes a member of the bicoid subfamily of the paired (PRD) homeobox family of proteins. (thermofisher.com)
The encoded protein belongs to a novel class of cystein-cystein-histidine-cystein zinc finger proteins that function in the developing mammalian central nervous system. (nih.gov)
This gene encodes a member of the RIEG/PITX homeobox family, which is in the bicoid class of homeodomain proteins. (utsouthwestern.edu)
Since the discovery of the Kn1 gene, a large number of transcription factor (TF) genes encoding proteins with homeodomains have been found in all plants and there are about 135 family members in maize. (grassius.org)
A member of the KNOTTED class of homeodomain proteins encoded by the STM gene of Arabidopsis. (grassius.org)
Proteins encoded by homeobox genes (GENES, HOMEOBOX) that exhibit structural similarity to certain prokaryotic and eukaryotic DNA-binding proteins. (lookformedical.com)
Homeodomain proteins are involved in the control of gene expression during morphogenesis and development (GENE EXPRESSION REGULATION, DEVELOPMENTAL). (lookformedical.com)
The proteins encoded by homeobox genes are called HOMEODOMAIN PROTEINS. (lookformedical.com)
The protein encoded by this gene is a member of the Zfh1 family of 2-handed zinc finger/homeodomain proteins. (beds.ac.uk)
The main scientific interests of Dr. Zaraisky are focused on structural and functional study of genes and proteins that regulate embryonic development of the brain. (ibch.ru)
An important achievement of the laboratory of molecular bases of embryogenesis is discovering of two novel families of secreted proteins, Noggin2 and Noggin4, whose genes are controlled by Anf homeodomain factors. (ibch.ru)
2. Schena M,Davis R W. HD-Zip proteins:members of an Arabidopsis homeodomain protein superfamily[J]. Proceedings of the National Academy of Sciences of the United States of America,1992,89(9):3894-3898. (nefu.edu.cn)
The Arabidopsis Athb-8,-9 and-14 genes are members of a small gene family coding for highly related HD-ZIP proteins[J]. Plant Molecular Biology,1998,38(4):609-622. (nefu.edu.cn)
Moreover, we discuss how these regions can be traced back in development to the function of a few key genes, including those that encode fibroblast growth factors (FGFs), sonic hedgehog (SHH), bone morphogenetic proteins (BMPs), forkhead box G1 (FOXG1), paired box 6 (PAX6) and LIM homeobox protein 2 (LHX2), that pattern the early telencephalon. (nyu.edu)
There are a myriad of mutations identified in genes encoding cardiac transcription factors, ion channels, gap junctions, energy metabolism regulators, lamins and other structural proteins. (medscape.com)

There is also strong evidence from sequencing studies of candidate genes involved in clefting that mutations in the MSX1 gene may be associated in the pathogenesis of cleft lip and palate. (wikipedia.org)
Mutations in this gene, which was once known as homeobox 7, have also been associated with Witkop syndrome, Wolf-Hirschhorn syndrome, and autosomal dominant hypodontia. (wikipedia.org)
MSX1 is one of the strongest candidate genes for specific forms of tooth agenesis, mutations in this gene was detected only in some affected individuals. (wikipedia.org)
Mutations in this gene have been associated with an autosomal dominant form of cognitive disability and with autism spectrum disorder. (nih.gov)
Mutations in this gene are associated with Axenfeld-Rieger syndrome, iridogoniodysgenesis syndrome, and sporadic cases of Peters anomaly. (utsouthwestern.edu)
Mutations in the gene for the antennapedia homeodomain protein are associated with the conversion of antenna to leg or leg to antenna DROSOPHILA. (lookformedical.com)
Their sequences contain a 180 nucleotide sequence designated the homeobox, so called because mutations of these genes often results in homeotic transformations, in which one body structure replaces another. (lookformedical.com)
Mutations in this gene are associated with Hirschsprung disease/Mowat-Wilson syndrome. (beds.ac.uk)
Recurrent mutations in the gene encoding additional sex combs-like 1 ( ASXL1 ) are found in various hematologic malignancies and associated with poor prognosis. (jci.org)
As a scientist she has been involved in mapping the human genome and identifying genes and mutations, which give rise to heritable disorders. (bepress.com)
Human genetic studies have identified mutations in the sodium channel SCN5A gene causing tachyarrhythmia disorders, as well as progressive cardiac conduction system diseases, or overlapping syndromes. (medscape.com)

We obtained DEG (differentially expressed genes) between the two clusters, and constructed a risk model of RNA modification-related genes using DEGs. (bvsalud.org)
The differentially expressed genes between the two clusters were obtained, and these genes were used for modeling. (bvsalud.org)
The most common protein domains encoded in these embryonic, differentially expressed genes are the homeobox and RNA Recognition Motif (RRM). (xenbase.org)
C) classification of genes according to sequence similarities, values are given as percentages of the number of unique, differentially expressed genes (NZ723), FL, Full-Length Open Reading Frame. (xenbase.org)
RNA-Seq analysis of poplar roots, stems and leaves under salt stress was conducted for the differentially expressed genes in different tissues, and reveal the molecular mechanism of the response to stress environment. (nefu.edu.cn)

Age-related gene expression profiles of the short-lived model animals Caenorhabditis elegans and Drosophila melanogaster share a common adult-onset expression program of genes involved in mitochondrial metabolism, DNA repair, catabolism, peptidolysis and cellular transport 3 . (nature.com)
DLX1 encodes a member of a homeobox transcription factor gene family similiar to the Drosophila distal-less gene. (ern-ithaca.eu)

There is a highly conserved structural organization of the members of the MSX family of genes and their abundant expression at sites of inductive cell-cell interactions in the embryo suggest that they have a pivotal role during early development. (wikipedia.org)
The predicted protein sequence contained a highly conserved homeodomain and the WUS-box domain, which is present in some members of the WOX protein family. (gc.ca)
Genes that encode highly conserved TRANSCRIPTION FACTORS that control positional identity of cells (BODY PATTERNING) and MORPHOGENESIS throughout development. (lookformedical.com)

The gene is located within the major histocompatibility complex (MHC) on chromosome 6. (genscript.com)
[ 4 , 5 , 6 ] Moreover, genetic analysis using polymerase chain reaction-based tests has shown that this autosomal dominant anomaly has been associated with a recurrent 17 bp duplication on the 3( PITX3 ) gene on chromosome 10. (medscape.com)
The following are some of the gene count estimates of human chromosome 1. (wikidoc.org)
Because researchers use different approaches to genome annotation their predictions of the number of genes on each chromosome varies (for technical details, see gene prediction ). (wikidoc.org)
The following is a partial list of genes on human chromosome 1. (wikidoc.org)
It is caused by a mutation in the PAX6 gene on chromosome 11. (medscape.com)

I describe the temporal and spatial expression patterns of these genes through embryonic development. (rice.edu)

This gene encodes a member of the zinc finger superfamily of transcription factors whose expression, thus far, has been found only in neuronal tissues. (nih.gov)
Gene expression profiles in animals that exhibit slow aging or negligible senescence may reveal distinct insight into potential mechanisms involved in long-term maintenance of tissues and healthy aging. (nature.com)
Few genes show differential expression with age in tissues (brain, liver and kidney) of naked mole rats and, contrary to other mammals and short-lived model animals, mitochondrial gene expression does not change with age 13 . (nature.com)
Gene expression stability during aging was also observed in tissues of the long-lived giant mole-rat ( Fukomys mechowii ) with a maximum lifespan of more than 20 years 14 . (nature.com)
Spatio-temporal expression pattern showed that these genes were expressed in many tissues with different levels, and they had distinct expression pattern during adventitious root formation and development. (biomedcentral.com)
Tissue-specific expression profile of this gene in 14 tissues was also determined using qRT-PCR. (biomedcentral.com)
This gene was specifically high-expressed in beaks than other tissues. (biomedcentral.com)
Using a sequential blast pipeline, we phylogenetically classified these genes, as well as those associated with other tissues, in order to define tissue-specific profiles of gene emergence. (biomedcentral.com)
Our comparative analyses show that, among different tissues, the neural crest exhibits a particularly high rate of gene emergence during vertebrate evolution. (biomedcentral.com)

This gene is a member of the caudal-related homeobox transcription factor gene family. (ebiocell.com)

Homeobox protein MSX-1, is a protein that in humans is encoded by the MSX1 gene. (wikipedia.org)
MSX1 has been shown to interact with DLX5, CREB binding protein, Sp1 transcription factor, DLX2, TATA binding protein and Msh homeobox 2. (wikipedia.org)

It was identified by its similarity to a homeobox gene which is involved in t(1;19) translocation in acute pre-B-cell leukemias. (genscript.com)
The left -most part represents the result of sequence similarity searches from cDNA sequences representing these genes: gene symbol, gene name or description of the best hit. (xenbase.org)

Number of Gene Ontology (GO) annotations for this target, consisting of the sum of GO Functions and GO Processes. (nih.gov)
We classified 363 of the 723 genes for which a Gene Ontology annotation for molecular function could be attributed and found 'DNA binding' and 'enzyme' the most represented terms. (xenbase.org)
Classification of genes according to Gene Ontology molecular function controlled vocabulary. (xenbase.org)
To determine the origin of neural crest genes, we analyzed Phenotype Ontology annotations to select genes that control the development of this tissue. (biomedcentral.com)

According to gene annotations in Arabidopsis thaliana, the functions of HD-Zip transcription factor in poplarwere predicted.The conserved domains, structural characteristics and chemical properties of HD-Zip family members were also studied by bioinformatics, providing reference for gene functions of HD-Zip family in poplar. (nefu.edu.cn)

1991). The maize Kn1 gene was found to encode a homeodomain-containing protein, the first identified in the plant kingdom. (grassius.org)

Members of this family have numerous roles, including regulation of cell adhesion, cell differentiation, directed cell motility, intracellular signaling and stabilization of f-actin at the sarcomeric Z-line in muscle. (rice.edu)
HS6ST2 has ability to encodes a member of the heparan sulfate (HS) sulfotransferase gene family, which catalyze the transfer of sulfate to HS and a crucial regulator of cell growth, differentiation, adhesion, and migration. (bvsalud.org)
The encoded protein is a major regulator of intestine-specific genes involved in cell growth an differentiation. (ebiocell.com)
miR-125a reduced expression of C-type lectin domain family 5, member a ( Clec5a ), which is involved in myeloid differentiation. (jci.org)
It may regulate gene expression, morphogenesis, and differentiation and it may also play a role in the cell cycle progession. (novusbio.com)
Second, networks of genes and hormones regulate the advancement of sex determination and gonad differentiation, known as the gonadal sex phase. (lidsen.com)
To understand the development of adiposity, it is crucial to identify the genes which expression is associated with adipogenic differentiation. (biomedcentral.com)
Proliferation cluster comprised 1028 genes up-regulated from days 3 to 8 of culture meanwhile the differentiation cluster was characterized by 2140 induced genes from days 15 to 21. (biomedcentral.com)
On the other hand, the terminal differentiation phase was enriched with genes involved in energy production, lipid and carbohydrate metabolism. (biomedcentral.com)
Overall, our study demonstrates the coordinated expression of functionally related genes during proliferation and differentiation of rainbow trout adipocyte cells. (biomedcentral.com)
Homeobox (HOX) genes encode evolutionarily conserved transcription factors that are essential for embryonic morphogenesis and differentiation [5]. (cancerhugs.com)
HOX genes exert pleiotropic functions in many cell types and may control cell proliferation, differentiation, adhesion, and migration [7]. (cancerhugs.com)
Latest research claim that HOX genes might play essential jobs in ovarian cancer differentiation [9-11]. (cancerhugs.com)

HS6ST2 expression was correlated with immune cell infiltration, immune-related genes, tumor immune microenvironment, and drug resistance in various cancers. (bvsalud.org)
Furthermore, this study also provides insights into how aberrant activation of a developmental patterning gene promotes tumor pathogenesis. (tmc.edu)
For some of the genomic regions that are deleted in some neuroblastomas, on 1p, 3p and 11q, candidate tumor suppressor genes have been identified. (biomedcentral.com)

2021). ZmHOX32 , a member of the HD-ZIP III family (that also harbor a START domain that is able to bind to steroid ligands), appears to function in leaf morphogenesis and plant photosynthesis as judged by the enriched category of downstream genes that it regulates (Miao et al. (grassius.org)
The induction cascades of early morphogenesis involve numerous growth factors, homeobox genes, and paired domain genes. (medscape.com)

The molecular sequence of this clone aligns with the gene accession number as a point of reference only. (origene.com)
The following PBX2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). (genscript.com)
These sequences represent the protein coding region of the PBX2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. (genscript.com)
The sequence consisted of 2045 bp, and contained an open reading frame (ORF), encoded 322 amino acids. (gc.ca)
Sequence analysis and clustering yielded 723 unique genes displaying a differential expression pattern. (xenbase.org)
Whole mount in situ hybridisations and sequence annotation of ubiquitous gene examples. (xenbase.org)
The study highlighted several mechanisms underlying species diversification, including selection acting on existing standing variation, high rates of gene duplication, novel microRNAs and rapid sequence divergence in otherwise conserved non-coding elements. (biomedcentral.com)

6. Olsson A S,Engstr m P,S derman E. The homeobox genes ATHB12 and ATHB7 encode potential regulators of growth in response to water deficit in Arabidopsis [J]. Plant Molecular Biology,2004,55(5):663-677. (nefu.edu.cn)
The HAT2 gene,a member of the HD-Zip gene family,isolated as an auxin inducible gene by DNA microarray screening,affects auxin response in Arabidopsis [J]. The Plant Journal,2002,32(6):1011-1022. (nefu.edu.cn)
ClassⅢ homeodomain-leucine zipper gene family members have overlapping,antagonistic,and distinct roles in Arabidopsis development[J]. The Plant Cell,2005,17(1):61-76. (nefu.edu.cn)
Characterization of the class Ⅳ homeodomain-leucine zipper gene family in Arabidopsis [J]. Plant Physiology,2006,141(4):1363-1375. (nefu.edu.cn)
We characterize early patterning during de novo development of the Arabidopsis shoot meristem using fluorescent reporters of known gene and protein activities required for shoot meristem development and maintenance. (biologists.com)

Fifty-nine putative orthologs of human disease genes, and 254 organ or cell specific marker genes were identified. (xenbase.org)

encodes a member of the ERF (ethylene response factor) subfamily B-6 of ERF/AP2 transcription factor family. (or.jp)
There are 12 members in this subfamily including RAP2.11. (or.jp)
This gene belongs to the subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). (nih.gov)

The homeodomain domain is generally composed of about 60 amino acids encoded homeobox, which form three alpha helices. (biomedcentral.com)
The presence of a homeodomain (HD), which comprises 60 amino acids, makes a three-helix tertiary structure, that binds the promoter regions of specific target genes (Sharif et al. (grassius.org)
OTX2 is a 289 amino acid containing protein encoding a member of the bicoid sub-family of homeodomain-containing transcription factors. (thermofisher.com)

However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. (origene.com)

We confirm that differential gene expression is prevalent during embryogenesis since 24% of the clones are expressed non-ubiquitously and 8% are organ or cell type specific marker genes. (xenbase.org)
In conclusion, this study represents an atlas of gene expression patterns, which reveals embryonic regionalization, provides novel marker genes, and makes predictions about the functional role of unknown genes. (xenbase.org)
The systemic inhibition of Shh signalling by cyclopamine led to bilateral expression of LR marker genes in rabbit. (studylibde.com)

Homeobox domain genes are mainly involved in controlling the growth and developmental processes such as transition through phases in an organism by encoding a certain transcription factor. (grassius.org)
Any of the processes by which nuclear, cytoplasmic, or intercellular factors influence the differential control of gene action during the developmental stages of an organism. (lookformedical.com)

The encoded protein functions as a transcriptional repressor during embryogenesis through interactions with components of the core transcription complex and other homeoproteins. (wikipedia.org)

Bolduc N, Tyers RG, Freeling M, Hake S. Unequal redundancy in maize knotted1 homeobox genes. (grassius.org)

In contrast, radial nerve showed an unexpected level of complexity with the expression of 3,370 genes significantly altered more than two-fold with age, including genes involved in nerve function, signaling, metabolism, transcriptional regulation and chromatin modification. (nature.com)
The reduced expression of genes involved in mitochondrial oxidative respiration occurs in early adulthood, before the onset of functional decline, and more abruptly than a damage-response model would predict, which supports the possibility of programmed age-related transcriptional regulation 3 . (nature.com)
These genes encode for the homeodomain transcription factors, which play a key role in regulation of the early forebrain development in Vertebrates. (ibch.ru)

Based on existing evidence, it seems possible that both hypodontia and oligodontia are heterogeneous traits, caused by several independent defective genes, which act along or in combination with other genes and lead to specific phenotypes. (wikipedia.org)

Many of them encode known developmental regulators. (xenbase.org)
Expression of cell cycle regulators fell in two classes, containing proliferation-promoting and anti-proliferative genes, respectively. (xenbase.org)

Studies of the mouse and chick homolog suggest the encoded protein may play a role in developing teeth and craniofacial mesenchyme of neural crest origin. (nih.gov)

Forced expression of this gene in combination with the basic helix-loop-helix transcription factor NeuroD1 and the transcription factors POU class 3 homeobox 2 and achaete-scute family basic helix-loop-helix transcription factor 1 can convert fetal and postnatal human fibroblasts into induced neuronal cells, which are able to generate action potentials. (nih.gov)
Explore the normal functions of human genes and the health implications of genetic changes. (medlineplus.gov)
So CCDS's gene number prediction represents a lower bound on the total number of human protein-coding genes. (wikidoc.org)
HOX genes perform essential jobs in organogenesis and in the introduction of the human being reproductive program during embryogenesis and during organic redesigning in adults [8]. (cancerhugs.com)

Gene expression is a key determinant of cellular phenotype, and genome-wide expression analysis can provide insight into the molecular events underlying complex processes such as aging. (nature.com)
Dr. Zaraisky is a member of the Academic and Dissertation councils of Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry Russian Academy of Sciences, Editorial Boards of the journals Molecular Biology and Russian Journal of Developmental Biology. (ibch.ru)
The molecular function of the gene product is indicated by a single GO term. (xenbase.org)
A genome-wide survey of HD-Zip genes in rice and analysis of drought-responsive family members[J]. Plant Molecular Biology,2008,66(1-2):87-103. (nefu.edu.cn)
Studies have been performed to identify the teratogenic genes or molecular genetic background of beak deformity. (biomedcentral.com)

Proliferation was characterized by enrichment in genes involved in basic cellular and metabolic processes (transcription, ribosome biogenesis, translation and protein folding), cellular remodelling and autophagy. (biomedcentral.com)
Moreover, during this phase an enrichment in genes involved in the formation of the lipid droplets was evidenced as well as the activation of the thyroid-receptor/retinoic X receptor (TR/RXR) and the peroxisome proliferator activated receptors (PPARs) signalling pathways. (biomedcentral.com)
We also find that duplicated regions show enrichment for genes associated with "antigen processing and presentation" and other immune related categories. (biomedcentral.com)

4. Jain M,Tyagi A K,Khurana J P. Genome-wide identification,classification,evolutionary expansion and expression analyses of homeobox genes in rice[J]. The FEBS Journal,2008,275(11):2845-2861. (nefu.edu.cn)
Phylogenetic analyses showed that no single species tree can efficiently represent all species relationships, suggesting high levels of repeatedly occurring gene flow. (biomedcentral.com)

The HD-ZIP gene family is composed of two functional domains, i.e. (grassius.org)
In this review, we highlighted some of the main gene networks and regulatory mechanisms involved in the plasticity of sex-determining pathways that help to establish a functional ovary that can nurture the follicles to generate a good ovarian reserve, both in quantity and quality. (lidsen.com)
In Xenopus embryos, enforced expression of Tbx20a, but not Tbx20b, led to induction of mesodermal and endodermal lineage markers as well as cell migration, indicating that the long Tbx20a isoform uniquely bears functional domains that can alter gene expression and developmental behaviour in an in vivo context. (nih.gov)

Gene symbols, accession ids and various other target identifiers. (nih.gov)

This gene encodes a ubiquitously expressed member of the TALE/PBX homeobox family. (genscript.com)

A homozygous mutation of the aniridia gene may possibly be lethal. (medscape.com)

Our results showed the roles of PpHDZs on root formation, which is helpful to better understand the classification and function of peach HD-Zip genes. (biomedcentral.com)

Genome-wide transcriptional profiling using RNA-Seq revealed few age-related changes in gene expression in muscle and esophagus tissue. (nature.com)
Genome-wide identification,evolutionary expansion,and expression profile of homeodomain-leucine zipper gene family in poplar ( Populus trichocarpa )[J]. PLoS One,2012,7(2):e31149. (nefu.edu.cn)
Ploidy and MYCN amplification have been used as genetic markers for risk stratification and therapeutic decision making, and, more recently, gene expression profiling and genome-wide DNA copy number analysis have come into the picture as sensitive and specific tools for assessing prognosis. (biomedcentral.com)
The applica tion of new genetic tools also led to the discovery of an important familial neuroblastoma cancer gene, ALK , which is mutated in approximately 8% of sporadic tumors, and genome-wide association studies have unveiled loci with risk alleles for neuroblastoma development. (biomedcentral.com)

HS6ST2 expression was not only associated with MSI in 5 cancer types and associated with TMB in 10 cancer types, and it's significantly correlated with DNA methylation in 13 types of cancer, but it's correlated with RNA methylation related genes in most cancer. (bvsalud.org)
ASXL1-MT resulted in derepression of homeobox A9 ( Hoxa9 ) and microRNA-125a (miR-125a) expression through inhibition of polycomb repressive complex 2-mediated (PRC2-mediated) methylation of histone H3K27. (jci.org)

We propose that the evolution of the neural crest is linked not only to the recruitment of ancestral regulatory genes but also to the emergence of signaling peptides that control the increasingly complex lineage diversification of this plastic cell population. (biomedcentral.com)

The Bcl-2 homology 3 (BH3) domain is crucial for the death-inducing and dimerization properties of pro-apoptotic members of the Bcl-2 protein family, including Bak, Bax, and Bad. (lookformedical.com)
Background: This gene is a member of the Antp homeobox family andencodes a nuclear protein with a homeobox DNA-binding domain. (hatinhibitor.com)

Encodes a dipeptide transporter expressed in pollen and ovules during early seed development. (or.jp)
Epidermal development element receptor (EGFR) is one of the receptor tyrosine kinase (RTK) family members [15]. (cancerhugs.com)
Inverted regions are enriched for genes regulating behaviour, or involved in skeletal and visual system development. (biomedcentral.com)
Next, the importance of embryonic developmental genes such as homeobox and T-box transcription factors are highlighted in conduction system development and function. (medscape.com)

The encoded protein acts as a transcription factor and regulates procollagen lysyl hydroxylase gene expression. (utsouthwestern.edu)

Alternatively spliced transcript variants encoding distinct isoforms have been described. (utsouthwestern.edu)
Alternatively spliced transcript variants have been found for this gene. (beds.ac.uk)
Three alternatively spliced transcript variants have been described for this gene. (nih.gov)

Tbx20 physically interacted with cardiac transcription factors Nkx2-5, GATA4, and GATA5, collaborating to synergistically activate cardiac gene expression. (nih.gov)

Anatomy52

Organisms26

Diseases8

Chemicals and Drugs58

Analytical, Diagnostic and Therapeutic Techniques and Equipment29

Psychiatry and Psychology1

Phenomena and Processes79

Disciplines and Occupations1

Anthropology, Education, Sociology and Social Phenomena1

Technology, Industry, Agriculture1

Information Science4

Health Care1

Proteins15

Mutations11

Differentially expressed genes5

Drosophila2

Highly conserved3

Chromosome6

Embryonic development1

Tissues9

Transcription factor gene family1

Msx12

Similarity2

Ontology4

Bioinformatics1

Homeodomain-contain1

Differentiation13

Tumor3

Morphogenesis2

Sequence7

Arabidopsis5

Putative1

Subfamily3

Amino3

Sequences1

Marker genes3

Organism2

Protein functions1

Redundancy1

Regulation3

Phenotypes1

Regulators2

Homolog1

Human4

Molecular5

Enrichment3

Analyses2

Functional3

Accession1

Ubiquitously expressed1

Mutation1

Classification1

Genome-wide4

Methylation2

Regulatory1

Domain2

Development4

Regulates1

Transcript variants3

Cardiac1