Encodes human protein serine threonine kinases. Medical search. Frequent questions

Phosphorylation of serine residues on the IKB proteins by IKB kinases marks them for destruction via the ubiquitination pathway, thereby allowing activation and nuclear translocation of the NFKB complex. (wikipedia.org)
Inhibition of the kinase domain is halted through binding of the Ras-binding domain, or residues 155-227 of the protein, to the Ras-GTP effector domain. (news-medical.net)
In addition to autoinhibition, CR3 is also inhibited when the protein is not post-translationally phosphorylated at certain serine and tyrosine residues in the CR2 hinge region. (news-medical.net)
MASTL contains a non-conserved insertion of 550 residues within its activation loop, splitting the kinase domain, and making it unique. (bvsalud.org)
The specificity of serine/threonine kinases is partly determined by interactions with a few residues near the phospho-acceptor residue, forming the so-called kinase-substrate motif. (inamericawithgrace.com)
A group of enzymes that catalyzes the phosphorylation of serine or threonine residues in proteins, with ATP or other nucleotides as phosphate donors. (lookformedical.com)
STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. (umbc.edu)
The method, named Predikin, identifies key conserved substrate-determining residues in the kinase catalytic domain that contact the substrate in the region of the phosphorylation site and so determine the sequence surrounding the phosphorylation site. (biomedcentral.com)
Predikin now consists of two components: (i) PredikinDB, a database of phosphorylation sites that links substrates to kinase sequences and (ii) a Perl module, which provides methods to classify protein kinases, reliably identify substrate-determining residues, generate scoring matrices and score putative phosphorylation sites in query sequences. (biomedcentral.com)
New features in Predikin include the use of SQL queries to PredikinDB to generate predictions, scoring of predictions, more reliable identification of substrate-determining residues and putative phosphorylation sites, extended options to handle protein kinase and substrate data and an improved web interface. (biomedcentral.com)
The post-translational modification of proteins by phosphorylation of serine, threonine or tyrosine residues is a ubiquitous process in cellular regulation. (biomedcentral.com)
The second factor, termed peptide specificity, describes the interaction between amino acid residues in the catalytic domain of the protein kinase and the substrate residues that surround the phosphorylated residue. (biomedcentral.com)
Crystal structures of protein kinases with bound substrate peptides show that substrate residues at positions -3 to +3 relative to the phosphorylated serine, threonine or tyrosine residue adopt an extended conformation and bind to a pocket in the catalytic domain of the protein kinase [ 8 ]. (biomedcentral.com)
However, it is recognised that for many protein kinase families, particularly those that phosphorylate Ser/Thr residues, peptide specificity is the major factor that determines substrate specificity. (biomedcentral.com)
The human WNT gene family consists of 19 members, encoding evolutionarily conserved glycoproteins with 22 or 24 Cys residues ( 1 ). (aacrjournals.org)
The human genome encodes for over 500 structurally similar protein kinases that transfer the gamma-phosphate of ATP to serine, threonine, or tyrosine residues of proteins. (uit.no)
can phosphorylate substrate proteins on serine, threonine, tyrosines or histidine residues. (horizondiscovery.com)

Here, we show that this non-conserved middle region (NCMR) of the protein is crucial for target specificity and activity. (bvsalud.org)
This assay has high sensitivity and excellent specificity for detection of Human Total Akt1. (assaysolution.com)
We have previously described an approach to predicting the substrate specificity of serine-threonine protein kinases. (biomedcentral.com)
The relative contribution of substrate recruitment and peptide specificity to protein kinase substrate specificity varies between protein kinases. (biomedcentral.com)
The prediction of peptide specificity is therefore the basis for most of the available computational methods aimed at predicting substrates of protein kinases. (biomedcentral.com)
Structures of Ric-8B in complex with Galpha protein folding clients reveal isoform specificity mechanisms. (stanford.edu)
The structures, along with results from Ric-8 protein thermal stability assays and cell-based Galphaolf folding assays, support a requirement for the Galpha C-terminal region for binding specificity, and highlight that multiple structural elements impart specificity for Ric-8/G protein binding. (stanford.edu)

It catalyzes phosphorylation of serine and threonine on target proteins, converting adenosine triphosphate (ATP) to adenosine diphosphate (ADP). (news-medical.net)

This gene is a putative oncogene encoding a protein belonging to a subfamily of serine/threonine kinases containing SH2-like (Src homology 2-like) domains. (origene.com)
This enzyme belongs to the AKT subfamily of serine/threonine kinases that contain SH2 (Src homology 2-like) domains. (assaysolution.com)
Serine/Threonine Kinases (STKs), cAMP-dependent protein kinase (PKA) subfamily, PRKX-like kinases, catalytic (c) subunit. (umbc.edu)
The PKA subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase. (umbc.edu)
The Ca2+/calmodulin-dependent protein kinases (CaM kinases) comprise a structurally related subfamily of serine/threonine kinases which include CaMKI, CaMKII and CaMKIV. (thermofisher.com)

This kinase, as well as CDK4, has been shown to phosphorylate, and thus regulate the activity of, tumor suppressor protein Rb. (cancerindex.org)
Its protein localizes to the nucleus and has been shown to promote the stability and nuclear accumulation of a transcriptionally active p53 molecule and, in vitro, to phosphorylate Thr18 of p53 and reduce p53 ubiquitination. (thermofisher.com)
The great majority are serine/threonine kinases, which phosphorylate the hydroxyl groups of serines and threonines in their targets. (inamericawithgrace.com)
The orthologous gene product in humans can associate with and phosphorylate polo-like kinase 1, and overexpression of a kinase-dead version of the protein interferes with normal cell cycle progression. (utsouthwestern.edu)

RAF genes encode serine and threonine kinase proteins downstream of Ras in the pathway. (news-medical.net)
There are three human RAF genes: ARAF, CRAF-1, and BRAF. (news-medical.net)
A curated database of candidate human ageing-related genes and genes associated with longevity and/or ageing in model organisms. (senescence.info)
Database of human genes associated with cellular senescence. (senescence.info)
You will find two carefully related GSK3 isoforms encoded by unique genes: GSK3 (51 kDa) and GSK3 (47 kDa) [5]. (techblessing.com)
The ROCK isoforms are encoded by two different identified genes and are ubiquitously expressed. (cloudfront.net)
In order to assess the importance of S/T kinases to Neurospora biology, we embarked on a global analysis of 86 S/T kinase genes in Neurospora. (inamericawithgrace.com)
We demonstrate our method in postmortem human brain using multiplex single-molecule fluorescent in situ hybridization and compare candidate TREGs against classic housekeeping genes. (biomedcentral.com)
This domain occurred 395 times on human genes ( 899 proteins). (umbc.edu)
Protein kinases, the enzymes responsible for protein phosphorylation, make up almost 2% of protein-encoding genes in the human genome [ 1 ] and an estimated 30-50% of human proteins are phosphorylated [ 2 ]. (biomedcentral.com)
Another cluster included genes encoding enzymes in the mitochondrial beta-oxidation pathway. (biomedcentral.com)
Differentially expressed candidate genes for ageing previously identified in the human blood transcriptome up-regulated in PP cows were mainly associated with T-cell function ( CCR7 , CD27 , IL7R , CAMK4 , CD28 ), mitochondrial ribosomal proteins ( MRPS27 , MRPS9 , MRPS31 ), and DNA replication and repair ( WRN ). (biomedcentral.com)
Genes and pathways associated with lactation number in cows were identified for the first time to date, and we found that many were comparable to those known to be associated with ageing in humans and model organisms. (biomedcentral.com)

AKT/PI3K forms a key component of many signalling pathways that involve the binding of membrane-bound ligands such as receptor tyrosine kinases, G-protein coupled receptors, and integrin-linked kinase. (senescence.info)

This kinase is a catalytic subunit of the protein kinase complex that is important for cell cycle G1 phase progression and G1/S transition. (cancerindex.org)
A well-known example of a lipid kinase is phosphoinositide 3-kinase which is implicated in a number of cancers, mainly through alterations to its catalytic subunit - PIK3CA. (horizondiscovery.com)

These proteins are phosphorylated by phosphoinositide 3-kinase (PI3K). (senescence.info)
mTOR (mammalian target of rapamycin) is a serine/threonine protein kinase which belongs to the family of phosphoinositide 3-kinase related kinases (PIKK), which also includes ATR, ATM, DNA-PK, SMG1 and TRRAP. (ucl.ac.uk)

AKT proteins are recruited to the cell membrane by phosphatidylinositol 3,4,5-trisphosphate (PIP3) after phosphorylation of phosphatidylinositol 4,5-bisphosphate (PIP2) by PI3K. (senescence.info)
In glioblastoma cells, may function downstream of phosphatidylinositol 3-kinase (PI(3)K) and PDPK1 in the promotion of cell survival by phosphorylating and inhibiting the pro-apoptotic factor BAD. (cusabio.com)
ATR belongs to the phosphatidylinositol 3-kinase-related kinase protein family. (netlify.app)
It was shown that the activation occurs through phosphatidylinositol 3-kinase. (origene.com)

Some pharmaceutical companies are developing inhibitors of B-Raf protein as anticancer therapies. (news-medical.net)
The activity of this kinase first appears in mid-G1 phase, which is controlled by the regulatory subunits including D-type cyclins and members of INK4 family of CDK inhibitors. (cancerindex.org)
Nevertheless, these inhibitors aren't just inhibiting GSK3, but will also be influencing CDK kinase (2 and 5) and several other kinases. (techblessing.com)
Here, we show that MASTL/Greatwall, a cell cycle kinase that supports mitosis by phosphorylating the PP2A/B55 inhibitors ENSA/ARPP19, inhibits PI3K-AKT activity by sustaining mTORC1- and S6K1-dependent phosphorylation of IRS1 and GRB10. (bvsalud.org)
We show that TLK2 mutations involved in intellectual disability impair kinase activity, and the docking of several small-molecule inhibitors of TLK activity suggest that the crystal structure will be useful for guiding the rationale design of new inhibition strategies. (bvsalud.org)

Deregulation of TBK1 activity and mutations in this protein are associated with many diseases. (wikipedia.org)
Scope includes mutations and abnormal protein expression. (cancerindex.org)

Subsequent phosphorylation of both threonine residue 308 and serine residue 473 is required for full activation of the AKT1 protein encoded by this gene. (senescence.info)
The Akt kinase family comprises three highly homologous isoforms: Akt1 (PKBα), Akt2 (PKBβ), and Akt3 (PKBγ) [4,14]. (inamericawithgrace.com)
No significant cross-reactivity or interference between Human Total Akt1 and analogues was observed. (assaysolution.com)
ELISA: Human Total Akt1 ELISA Kit (Colorimetric These standard curves are provided for demonstration only. (assaysolution.com)
RAC-alpha serine/threonine-protein kinase is an enzyme that in humans is encoded by the AKT1 gene. (assaysolution.com)
As the inhibitor of AKT1 (RAC-alpha serine/threonine-protein kinase is an enzyme that in humans is encoded by the AKT1), the aforementioned compounds may have implication in preventing complications of cancers. (ac.ir)
The serine-threonine protein kinase encoded by the AKT1 gene is catalytically inactive in serum-starved primary and immortalized fibroblasts. (origene.com)
Survival factors can suppress apoptosis in a transcription-independent manner by activating the serine/threonine kinase AKT1, which then phosphorylates and inactivates components of the apoptotic machinery. (origene.com)

A family of highly conserved serine-threonine kinases that are involved in the regulation of MITOSIS. (lookformedical.com)
Kinases are a large family of enzymes with over 500 encoded in the human genome and all share a highly conserved kinase domain. (horizondiscovery.com)

LKB1, also known as STK11 , is a master kinase that serves as an energy metabolic sensor and is involved in cell polarity regulation. (biomedcentral.com)
The tumor suppressor gene LKB1, also known as serine/threonine protein kinase 11 (STK11 ), encodes a serine/threonine protein kinase that has multiple cellular functions, including tumor suppression, cell cycle regulation, and promotion of apoptosis. (biomedcentral.com)

Regarded as constitutively active enzymes, known to participate in many, diverse biological processes, the intracellular regulation bestowed on the CK1 family of serine/threonine protein kinases is critically important, yet poorly understood. (inamericawithgrace.com)
However, sometimes in pharmacology, the term is also used to include other proteins that are drug-targets, such as enzymes, transporters and ion-channels.Serine protease, D- or L-serine arginine rich enzyme of serine threonine kinase with serine that is encoded by the codons UCU, UCC, UCA, UCG, AGU and AGC is an ɑ-amino acid that is used in the biosynthesis of proteins. (tgf-a.com)

These AKT proteins therefore regulate a wide variety of cellular functions including cell proliferation, survival, metabolism, and angiogenesis in both normal and malignant cells. (senescence.info)
The encoded protein responds to mTOR (mammalian target of rapamycin) signaling to promote protein synthesis, cell growth, and cell proliferation. (genetex.com)
Proto-oncogene with serine/threonine kinase activity involved in cell survival and cell proliferation and thus providing a selective advantage in tumorigenesis (PubMed:15528381, PubMed:1825810, PubMed:31548394). (inamericawithgrace.com)

it still remains to be determined if there are more proteins that can regulate the RPs-MDM2-p53 pathway. (elifesciences.org)
Protein kinases and their substrates regulate essentially all cellular processes through complex regulatory networks, in which phosphorylated proteins act as switches that tune the response of the cell to environmental stimuli. (biomedcentral.com)
Mammalian Ric-8 proteins act as chaperones to regulate the cellular abundance of heterotrimeric G protein alpha subunits. (stanford.edu)

When a substrate such as GTP-bound RhoA binds to the Rho-binding region of the coiled-coil domain, the interactions between the N-terminus and the C-terminus are disrupted, thus activating the protein. (cloudfront.net)
How a particular protein kinase recognises its substrate protein(s) is therefore a key question. (biomedcentral.com)
Two major factors determine the formation of a protein kinase-substrate complex [ 4 ]. (biomedcentral.com)
The first, termed substrate recruitment, encompasses any process that increases the effective concentration of the protein kinase substrate. (biomedcentral.com)
Dependent on the substrate they act upon they can be broadly classified into 3 categories: protein kinases, carbohydrate kinases and lipid kinases. (horizondiscovery.com)

Ribosomal proteins (RPs) play important roles in modulating the MDM2-p53 pathway. (elifesciences.org)
Plastid-specific ribosomal proteins (PSRPs) have been proposed to play roles in the light-dependent regulation of chloroplast translation. (cipsm.de)

Alternatively spliced transcript variants encoding different isoforms have been found for this gene. (antibodies-online.com)
Homologues of GSK3 isoforms from varieties as faraway from one another as flies, zebrafishes and human beings screen over 90% series similarity inside the kinase domain name [7,8]. (techblessing.com)
Multiple transcript variants encoding different isoforms have been found for this gene. (abeomics.com)
There is only one mTOR gene in higher vertebrates, which is known to encode two splicing isoforms: mTORα and mTORβ. (ucl.ac.uk)

TBK1 (TANK-binding kinase 1) is an enzyme with kinase activity. (wikipedia.org)
Serine/Threonine Protein Kinase A Raf (Proto Oncogene A Raf or Proto Oncogene Pks or ARAF or EC 2.7.11.1) - Serine/threonine-protein kinase A-Raf is an enzyme that in humans is encoded by the ARAF gene. (researchandmarkets.com)
Enzyme activity of ROCK1 is inhibited when the pleckstrin-homology and Rho-binding domains in the C-terminus independently bind to the N-terminus kinase domain. (cloudfront.net)
The sensitivity of the enzyme can also be increased by PHORBOL ESTERS and it is believed that protein kinase C is the receptor protein of tumor-promoting phorbol esters. (lookformedical.com)
OH-ATP - AT75 - 2012 - Aerospatiale ATR 72-212A - Finnair - AirNav RadarBox Database - Live Flight Tracker, Status, History, Route, Replay, Status, Airports Arrivals Departures Serine/threonine-protein kinase ATR also known as ataxia telangiectasia and Rad3-related protein (ATR) or FRAP-related protein 1 (FRP1) is an enzyme that, in humans, is encoded by the ATR gene. (netlify.app)

Inhibition of IκB kinase (IKK) and IKK-related kinases, IKBKE (IKKε) and TANK-binding kinase 1 (TBK1), has been investigated as a therapeutic option for the treatment of inflammatory diseases and cancer, and a way to overcome resistance to cancer immunotherapy. (wikipedia.org)

Tousled-like kinases (TLKs) are required for genome stability and normal development in numerous organisms and have been implicated in breast cancer and intellectual disability. (bvsalud.org)
While loss of wild-type p53 causes fatal damages to the genome, it is not surprising that the TP53 gene is mutated in more than 50% human cancers, and the functions of p53 are often impeded through various mechanisms in the remainder ( Levine and Oren, 2009 ). (elifesciences.org)

Mitotic checkpoint serine/threonine-protein kinase BUB1 is a protein in humans that is encoded by BUB1 gene. (cusabio.com)
An aurora kinase that localizes to the CENTROSOME during MITOSIS and is involved in centrosome regulation and formation of the MITOTIC SPINDLE. (lookformedical.com)
Mammalian aurora-A belongs to a multigenic family of mitotic serine/threonine kinases comprising two other members: aurora-B and aurora-C. In this review we will focus on aurora-A that starts to localize to centrosomes only in S phase as soon as centrioles have been duplicated, the protein is then degraded in early G1. (lookformedical.com)
A family of serine/threonine kinase Aurora constitutes a key regulator in the orchestration of mitotic events. (lookformedical.com)

In humans, the similar TLK1 and TLK2 interact with each other and TLK activity enhances ASF1 histone binding and is inhibited by the DNA damage response, although the molecular mechanisms of TLK regulation remain unclear. (bvsalud.org)
Calcium- and diacylglycerol-independent serine/ threonine-protein kinase that plays a general protective role against apoptotic stimuli, is involved in NF-kappa-B activation, cell survival, differentiation and polarity, and contributes to the regulation of microtubule dynamics in the early secretory pathway. (cusabio.com)
Aurora kinase C is a chromosomal passenger protein that interacts with aurora kinase B in the regulation of MITOSIS. (lookformedical.com)
An aurora kinase that is a component of the chromosomal passenger protein complex and is involved in the regulation of MITOSIS. (lookformedical.com)
CaMKII is an ubiquitously expressed serine/threonine protein kinase that is activated by Ca2+ and calmodulin (CaM) and has been implicated in regulation of the cell cycle and transcription. (thermofisher.com)
The heterochromatin-enriched HP1 proteins play a critical role in regulation of transcription. (cipsm.de)
Mitogen-activated protein kinases such as RAF kinases involved in the MAPK signaling pathways and cyclin dependent kinases (CDKs) involved in cell cycle regulation are prime examples of pathways implicated in cancers. (horizondiscovery.com)
In contrast to the full length mTORα protein, mTORβ lacks most of its protein-protein interaction modules, HEAT and FAT, but retains domains responsible for FKBP12/rapamycin binding, protein kinase activity and regulation. (ucl.ac.uk)

Vemurafenib can extend the life of patient with metastatic melanoma by about a year, if it is one of the 60+% of tumours that has a mutation in the gene encoding the serine-threonine protein kinase B-RAF (BRAF). (bmj.com)
Epigenetic silencing and loss-of-function mutation of negative regulators of the canonical WNT pathway occur in a variety of human cancer. (aacrjournals.org)
The frameshift mutation results in the formation of a truncated protein which cannot fold properly, promoting aggregation, and subsequent deposition in tubular cells. (medscape.com)

In the canonical NFkB pathway, the NF-kappa-B (NFKB) complex of proteins is inhibited by I-kappa-B (IKB) proteins, which inactivate NFKB by trapping it in the cytoplasm. (wikipedia.org)
B-Raf is a protein encoded by the BRAF gene and is involved in the RAS/MAPK pathway, which regulates cellular growth and division. (news-medical.net)
AKT proteins also participate in the mammalian target of rapamycin (mTOR) signalling pathway which controls the assembly of the eukaryotic translation initiation factor 4F (eIF4E) complex and this pathway, in addition to responding to extracellular signals from growth factors and cytokines, is disregulated in many cancers. (senescence.info)
The encoded protein, a component of a cytokine-activated protein complex that is an inhibitor of the essential transcription factor NF-kappa-B complex, phosphorylates sites that trigger the degradation of the inhibitor via the ubiquination pathway, thereby activating the transcription factor. (sitoolsbiotech.com)
This protein plays a role in regulating the MAP kinase/ERKs signaling pathway, which affects cell division, differentiation, and secretion. (utsouthwestern.edu)
Here, we identify SPIN1 (Spindlin 1) as a novel binding partner of human RPL5/uL18 that is important for this pathway. (elifesciences.org)
After the optimization, derivatives of small-molecule compound and human monoclonal antibody targeted to the WNT signaling pathway could be used in cancer medicine. (aacrjournals.org)

The protein encoded by this gene is a member of the CMGC family of serine/threonine protein kinases. (cancerindex.org)
This gene encodes a member of the vaccinia-related kinase (VRK) family of serine/threonine protein kinases. (thermofisher.com)
This gene encodes one of the three members of the human AKT serine-threonine protein kinase family which are often referred to as protein kinase B alpha, beta, and gamma. (senescence.info)
This gene encodes a family member of serine/threonine p21-activating kinases, known as PAK proteins. (antibodies-online.com)
This gene encodes a protein belonging to the raf/mil family of serine/threonine protein kinases. (utsouthwestern.edu)
The kinases of this family that have been suggested to play a role in apoptosis are the mitogen-activated protein kinase (MAPK) family, specifically p42/44 ERK, p38 MAPK and c-Jun N-terminal kinase (JNK), cyclic AMP-dependent protein kinase (PKA), protein kinase B (PKB), or Akt and protein kinase C (PKC). (inamericawithgrace.com)
FUNCTION: This gene encodes a member of the Ste20 family of serine/threonine protein kinases, and is similar to several known polo-like kinase kinases. (utsouthwestern.edu)
Noncanonical WNT signals are transduced through Frizzled family receptors and ROR2/RYK coreceptors to the Dishevelled-dependent (Rho family GTPases and c-jun NH 2 -terminal kinase) or the Ca 2+ -dependent (NLK and nuclear factor of activated T cells) signaling cascades. (aacrjournals.org)
Par4, a homologue of human LKB1, has been found to control Caenorhabditis elegans embryonic polarity by regulating activities of anillin family scaffold proteins [ 8 ],[ 9 ]. (biomedcentral.com)

Serine/Threonine Protein Kinase A Raf (Proto Oncogene A Raf or Proto Oncogene Pks or ARAF or EC 2.7.11.1) pipeline Target constitutes close to 7 molecules. (researchandmarkets.com)
The latest report SerineThreonine Protein Kinase A Raf - Pipeline Review, H1 2020, outlays comprehensive information on the Serine/Threonine Protein Kinase A Raf (Proto Oncogene A Raf or Proto Oncogene Pks or ARAF or EC 2.7.11.1) targeted therapeutics, complete with analysis by indications, stage of development, mechanism of action (MoA), route of administration (RoA) and molecule type. (researchandmarkets.com)
Furthermore, this report also reviews key players involved in Serine/Threonine Protein Kinase A Raf (Proto Oncogene A Raf or Proto Oncogene Pks or ARAF or EC 2.7.11.1) targeted therapeutics development with respective active and dormant or discontinued projects. (researchandmarkets.com)
V-Raf murine sarcoma viral oncogene homolog B1 ( B-RAF) is a gene that codes a protein B-Raf, which is a serine/ threonine-protein kinase. (inamericawithgrace.com)
Those transformed cells form tumours when implanted in immunodeficient mice, indicating that the kinase is an oncogene. (lookformedical.com)
The gene serves as an oncogene in the tumorigenesis of cancer cells For example, its overexpression contributes to the malignant phenotype of a subset of human ductal pancreatic cancers. (antibodypedia.com)

Full length human recombinant protein of human AKT2 (NP_001617) produced in HEK293T cell. (origene.com)
Description: Recombinant Human ALK-1 was expressed in Sf9 Insect Cells. (cd-34.com)
Explore our solutions for multiple applications - vaccines, monoclonal antibodies, recombinant proteins, cell or gene therapy. (vwr.com)

Downregulation of MASTL results in increased glucose uptake in vitro and increased glucose tolerance in adult mice, suggesting the relevance of the MASTL-PP2A/B55 kinase-phosphatase module in controlling AKT and maintaining metabolic homeostasis. (bvsalud.org)
Preexisting antivector immunity can severely compromise the ability of Salmonella enterica serovar Typhimurium live vaccines to induce protective CD8 T-cell frequencies after type III secretion system-mediated heterologous protein translocation in orally immunized mice. (cipsm.de)

mTOR is a key component of two distinct multi-protein complexes in mammalian cells, termed mTOR complex 1 (TORC1) and mTOR complex 2 (mTORC2). (ucl.ac.uk)

Cleavage of the C-terminal inhibitory domain by caspase-3 during apoptosis can also activate the kinase. (cloudfront.net)
Serine/threonine-protein kinase that acts as a regulatory link between the membrane-associated Ras GTPases and the MAPK/ERK cascade, and this critical regulatory link functions as a switch determining cell fate decisions including proliferation, differentiation, apoptosis, survival and oncogenic transformation. (inamericawithgrace.com)
In cultured neurons, prevents amyloid beta protein-induced apoptosis by interrupting cell death process at a very early step. (cusabio.com)
SPIN1 ablation activates p53, suppresses cell growth, reduces clonogenic ability, and induces apoptosis of human cancer cells. (elifesciences.org)

mTOR contains several conserved protein-protein interaction modules at the N-terminus and a protein kinase domain at the C-terminus. (ucl.ac.uk)
The regulatory interactions of mTOR are mainly mediated by HEAT (Huntingtin, Elongation factor 3, protein phosphatase 2A, and TOR1) repeats and FAT (FRAP, ATM and TRRAP) domains. (ucl.ac.uk)
Dysregulation of mTOR signalling has been implicated in various human pathologies, including cancer, inflammation, neurodegenerative and metabolic disorders. (ucl.ac.uk)
When compared to mTORα, the mTORδ splice variant contains only the N-terminal HEAT repeats and a unique C-terminal region, while the mTORγ isoform possesses a 12 amino acid deletion in the kinase domain. (ucl.ac.uk)
The existence of the mTORδ isoform was confirmed at mRNA and protein levels by identifying corresponding EST clones and detecting the splice variant with specific anti-mTORδ antibodies. (ucl.ac.uk)
In contrast to mTORα and the mTOR activated mutant S2215Y, the stably expressed mTORδ and mTORγ lack the kinase activity in vitro. (ucl.ac.uk)

Overexpression contributes to the malignant phenotype of a subset of human ductal pancreatic cancers. (origene.com)
In human, aurora-A has focused a lot of attention, since its overexpression has been found to be correlated with the grade of various solid tumours. (lookformedical.com)
Ectopic kinase overexpression in any culture cell line leads to polyploidy and centrosome amplification. (lookformedical.com)
Analysis of cancer genomic databases suggests that SPIN1 is highly expressed in several human cancers, and its overexpression is positively correlated with poor prognosis in cancer patients. (elifesciences.org)

We identified a novel 10 kb brain-specific cDNA interrupted by a balanced translocation in an XLIS patient that encodes a novel 40 kDa predicted protein named Doublecortin. (nih.gov)

These highly similar AKT proteins all have an N-terminal pleckstrin homology domain, a serine/threonine-specific kinase domain and a C-terminal regulatory domain. (senescence.info)

Although Doublecortin does not contain a kinase domain, it is homologous to the amino terminus of a predicted kinase protein, indicating a likely role in signal transduction. (nih.gov)
GSK3 and GSK3 are extremely homologous of their kinase domains [6]. (techblessing.com)

BRAF encodes the B-Raf protein, which is involved in signal transduction inside cells. (news-medical.net)

This is provided by adaptor proteins that interact with the dimerization domain of TBK1 to determine its location and access to substrates. (wikipedia.org)

Mutant B-Raf proteins that have been implicated in tumorigenesis often have elevated kinase activity, known as a gain of function mutaion. (news-medical.net)

p70 S6K (phospho Thr421/Ser424) antibody [HL5] detects p70 S6K (phospho Thr421/Ser424) protein at cytoplasm by immunohistochemical analysis in the presence of control peptide (left) or antigen-specific peptide (right). (genetex.com)
The protein encoded by this gene forms a heteromeric complex with type II TGF-beta receptors when bound to TGF-beta, transducing the TGF-beta signal from the cell surface to the cytoplasm. (abeomics.com)
We have previously reported the identification and characterization of an LKB1-specific adaptor protein, STRAD, which activates LKB1 and translocates it from nucleus to cytoplasm. (nih.gov)

High-resolution structures of GPR56 and LPHN3 in their active, G-protein-coupled states, reveal that after dissociation of the extracellular region, the decrypted TA peptides engage the seven-transmembrane domain core with a notable conservation of interactions that also involve extracellular loop 2. (stanford.edu)

The co-chaperone Hep1 is required to prevent the aggregation of mitochondrial Hsp70 proteins. (cipsm.de)

Structural origins of AGC protein kinase inhibitor selectivities: PKA as a drug discovery tool", Biol. (uit.no)

Serine/threonine-protein kinase that performs 2 crucial functions during mitosis. (cusabio.com)

The mouse Tzfp gene, mapped to chromosome 7 B2-B3, encodes a 465-amino acid transcription factor containing a conserved N-terminal BTB/POZ domain and three C-terminal PLZF-like C(2)H(2) zinc fingers. (lookformedical.com)

The new features significantly enhance the ability of Predikin to analyse protein kinases and their substrates. (biomedcentral.com)
In general, a protein kinase acts on a discrete set of substrates to ensure that signalling fidelity is maintained. (biomedcentral.com)

The B-Raf protein has 766 amino acids in three conserved domains. (news-medical.net)

KSHV ORF36 encodes a serine/threonine viral protein kinase, which is conserved throughout all herpesviruses. (fsu.edu)

It phosphorylates a specific sequence on protein targets. (news-medical.net)
These proteins are critical effectors that link RhoGTPases to cytoskeleton reorganization and nuclear signaling, and they serve as targets for the small GTP binding proteins Cdc42 and Rac. (antibodies-online.com)
Defects in these networks result in a variety of disease states making protein kinases important targets for drug design [ 3 ]. (biomedcentral.com)
Despite representing one of the largest classes of therapeutic targets, most inactive-state G protein-coupled receptors (GPCRs) have remained inaccessible for cryo-EM because their small size and membrane-embedded nature impedes projection alignment for high-resolution map reconstructions. (stanford.edu)

What pathways are this gene/protein implicaed in? (cancerindex.org)
Akt is a serine/threonine-specific protein kinase that plays a critical role in controlling the balance between survival and death pathways in cells. (inamericawithgrace.com)
Serine/threonine (S/T) protein kinases are crucial components of diverse signaling pathways in eukaryotes, including the model filamentous fungus Neurospora crassa. (inamericawithgrace.com)
Previous studies have identified many immune pathways which are consistently altered in humans and model organisms as they age. (biomedcentral.com)

STRAP (Serine/Threonine Kinase Receptor Associated Protein) is a Protein Coding gene. (inamericawithgrace.com)
In this sense, am olfactory receptor is a protein-molecule that recognizes and responds to endogenous-chemical signals, chemokinesor cytokines e.g. an acetylcholine-receptor recognizes and responds to its endogenous-ligand, acetylcholine. (tgf-a.com)

Find PAK1 Proteins for a variety of species such as anti-Human PAK1, anti-Mouse PAK1, anti-Rat PAK1. (antibodies-online.com)
Hier sind PAK1 Antikörper für eine Vielzahl von Species wie anti-Human PAK1, anti-Rat PAK1, anti-Mouse PAK1 zu finden. (antikoerper-online.de)

The trimeric Sec61/SecY complex is a protein-conducting channel (PCC) for secretory and membrane proteins. (cipsm.de)

The human ROCK1 gene is located on human chromosome 18 with specific location of 18q11.1. (cloudfront.net)
Aurora kinases are found in all organisms in which their function has been conserved throughout evolution, namely the control of chromosome segregation. (lookformedical.com)
Members of this group include human PRKX (X chromosome-encoded protein kinase), Drosophila DC2, and similar proteins. (umbc.edu)

The autophosphorylation of serine 172, which requires homodimerization and ubiquitinylation of lysines 30 and 401, is necessary for kinase activity. (wikipedia.org)
We performed a phosphoproteomic assay with different MASTL constructs identifying key phosphorylation sites for its activation and determining whether they arise from autophosphorylation or exogenous kinases, thus generating an activation model. (bvsalud.org)

This protein also phosphorylates histone, casein, and the transcription factors ATF2 (activating transcription factor 2) and c-JUN. (thermofisher.com)

Protein kinases transfer phosphate groups from ATP to proteins. (uit.no)

Description: A polyclonal antibody for detection of ALK-1 from Human, Mouse, Rat. (cd-34.com)

The N-terminus of the protein contains the kinase domain (region 9-309) and the ubiquitin-like domain (region 310-385). (wikipedia.org)
One is in the activation segment of the kinase domain. (news-medical.net)
The other hotspot is the glycine -rich loop of the kinase domain. (news-medical.net)
Conserved region 3 (CR3) is a catalytic protein kinase domain. (news-medical.net)
CR1 inhibits the activity of CR3, the kinase domain, regulating the overall signaling activity of the molecule. (news-medical.net)
In order to become active, the CR3 kinase domain must be converted to its active form by phosphorylation of the activation loop. (news-medical.net)
Here we describe the crystal structure of the TLK2 kinase domain. (bvsalud.org)
The zinc finger domain of Tzfp binds to the tbs motif located at the upstream flanking region of the Aie1 (aurora-C) kinase gene. (lookformedical.com)
Catalytic domain of PRKX-like Protein Serine/Threonine Kinases. (umbc.edu)
Here we report the selection of camelid-derived single-domain antibodies (nanobodies) that modulate the conformation and spectral properties of the green fluorescent protein (GFP). (cipsm.de)

We recently showed that the interaction between Kaposi's sarcoma-associated herpesvirus (KSHV) tegument proteins ORF33 and ORF45 is crucial for progeny virion production, but the exact functions of KSHV ORF33 during lytic replication. (fsu.edu)

The protein encoded by this gene is similar to IKB kinases and can mediate NFkB activation in response to certain growth factors. (wikipedia.org)

An serine-threonine protein kinase that requires the presence of physiological concentrations of CALCIUM and membrane PHOSPHOLIPIDS. (lookformedical.com)

Background Glycogen synthase kinase 3 (GSK3) encodes a multifunctional serine/threonine proteins kinase, which is usually ubiquitously indicated in organisms which range from yeasts to mammals [1-3]. (techblessing.com)

Anatomy18

Organisms8

Diseases2

Chemicals and Drugs147

Analytical, Diagnostic and Therapeutic Techniques and Equipment21

Phenomena and Processes54

Disciplines and Occupations1

Information Science4

Residues17

Specificity7

Phosphorylation of serine1

Subfamily5

Phosphorylate4

Genes13

Tyrosine1

Subunit2

Phosphoinositide2

Phosphatidylinositol4

Inhibitors5

Mutations2

AKT18

Highly conserved2

STK112

Enzymes2

Cell proliferation3

Regulate3

Substrate5

Ribosomal proteins2

Isoforms4

Enzyme5

Inhibition1

Genome2

Mitotic4

Regulation8

Mutation3

Pathway7

Family9

Oncogene6

Recombinant3

Mice2

Mammalian1

Apoptosis4

MTOR6

Overexpression4

Balanced translocation1

Homology1

Homologous2

BRAF1

Adaptor proteins1

Tumorigenesis1

Cytoplasm3

Peptides1

Mitochondrial1

Inhibitor1

Mitosis1

Amino Acid1

Substrates2

Conserved domains1

Viral1

Targets4

Pathways4

Receptor2

Species2

Membrane Proteins1

Chromosome3

Autophosphorylation2

Casein1

Phosphate1

Antibody1

Domain10

Crucial1

Mediate1

Calcium1

Ubiquitously1