Encodes gene expression. Medical search. Frequent questions

Gopinathan, Karumathil P. (1994) Structural proteins of mycobacteriophage I3: cloning, expression and sequence analysis of a gene encoding a 70-kDa structural protein Gene, 143 (1). (ias.ac.in)
Figure 4: Properties of d0 (orphan) proteins and genes. (nature.com)
HJ1 and HJ4 lysogens produced beta-galactosidase fusion proteins that shared similar epitopes with each other and helveticin J. The intact helveticin J gene (hlv) was isolated by screening a library of L. helveticus chromosomal DNA in lambda EMBL3 with the insert DNA from phage HJ4 as a probe. (ncsu.edu)
Genes encoding disrupted complementary interactors tend to be risk genes, and an interaction network built from these proteins is enriched for ASD proteins. (springer.com)
Eukaryotic expression vectors containing genes encoding plant proteins for killing of cancer cells. (weeksmd.com)
consequently, genes encoding some of these proteins are being used to design constructs for the inhibition of multiplying cancer cells. (weeksmd.com)
However, existing MRI reporter genes, based primarily on metal-binding proteins or chemical exchange saturation transfer probes, are limited by their reliance on metal ions or relatively low sensitivity. (biorxiv.org)
Previous work showed that two wheat genes whose expression is stimulated when wheat flowers are treated with DON, likely encode transporter proteins that might remove DON from the wheat cells. (usda.gov)
The respective genes encode proteins of 1500 and 1497aa, respectively, which shared 97% identity. (usda.gov)
Virus-induced gene silencing of the expression of both TaABCC3 genes (using two independent gene-specific constructs) demonstrated that the respective encoded wheat ABCC proteins contribute to wheat resistance to DON. (usda.gov)
TrV1 was detected in the culture medium, suggesting that this and/or other TrIV-encoded proteins may be responsible for the observed cytopathic effect. (gc.ca)
More than half of all human genes are alternatively spliced, so it is expected that alternative pre- mRNA splicing will be responsible for the identification of more than 90 percent of all human proteins. (genomicglossaries.com)

The aim of this study was to investigate the expression and silencing of the S100A8 gene, which encodes the S100 calcium-binding protein A8 (S100A8), and apoptosis and phosphorylation of protein kinase B (Akt) in tissue samples of endometrial carcinoma and HEC-1A endometrial adenocarcinoma cells in vitro . (medscimonit.com)
Immunohistochemistry (IHC) was used to detect expression of the S100A8 protein in 74 tissue samples of endometrial cancer and 22 normal endometrial tissue samples. (medscimonit.com)
flanking region indicated the presence of a consensus motif that occurs in all milk-protein-encoding genes, except the kappa-casein-encoding gene. (eurekamag.com)
Very little research has been conducted concerning the expression and function of this important gene and its protein product. (vt.edu)
Our findings indicate that matK RNA and protein is expressed in a variety of plant species, and expression of MatK protein is regulated by development. (vt.edu)
The locus of enterocyte effacement-encoded regulator (Ler) is a regulatory protein that controls bacterial pathogenicity of enteropathogenic Escherichia coli (EPEC) and enterohemorrhagic Escherichia coli (EHEC). (wikipedia.org)
The transcript encoding the Ler protein is the open reading frame 1 on the LEE1 operon. (wikipedia.org)
Fis, a nucleoid associated protein essential for EPEC's ability to form attaching and effacing lesions, partly acts through activation of Ler expression. (wikipedia.org)
Successful cloning and expression of the 70-kDa protein-encoding gene of phage I3 in Escherichia coli and its complete nucleotide sequence determination have been accomplished. (ias.ac.in)
Here, we have targeted expression of synapto-pHluorin, a pH-sensitive protein that reports synaptic vesicle fusion, to olfactory sensory neurons in mouse. (nih.gov)
Characterisation of expression of a gene encoding the asparagus intracellular PR protein Aopr1. (le.ac.uk)
ORF2 could encode an 11,808-Da protein. (ncsu.edu)
ORF3 could encode a 37,511-Da protein. (ncsu.edu)
Antibodies prepared against the denatured 51 kD subunit of wheat endosperm ADP-glucose pyrophosphorylase recognise a 48 kD polypeptide in soluble protein extracts of wheat leaves, suggesting that wheat leaf and wheat endosperm ADP-glucose pyrophosphorylases may be the products of different genes. (warwick.ac.uk)
Analyzing 5′-upstream non-protein-encoding regions of the human mitochondrial function-associated genes, we speculate that mitochondrial functions could be recovered or improved at a transcriptional level. (intechopen.com)
Effect of Methyl Jasmonate on the Gene Expression, Encoding Non-Protein Thiol Enzymes in Wheat under Cadmium. (bvsalud.org)
A classic example is the heat shock protein system, particularly Hsp90 , whose expression is environmentally plastic and increases under thermal stress, but buffers phenotypic changes induced by mutations to maintain homeostasis 2 , a process termed canalization 3 . (nature.com)
A gene encoding the rice 16.9-kDa class I low-molecular-mass (LMM) heat- shock protein (HSP), Oshsp16.9, was introduced into Escherichia coli using the pGEX-2T expression vector to analyze the possible function of this LMM HSP under heat stress. (ncu.edu.tw)
Immunoblot analysis revealed that lipid infusion also increased the expression of collagens and the connective tissue growth factor protein. (elsevierpure.com)
One of those genes turns out to be a protein named BRD4. (sciencedaily.com)
This protein controls the expression and activity of yet another transcription factor, cMyc, which plays a central role in driving the aberrant metabolism and growth of GBM cells. (sciencedaily.com)
The human genome contains about 20,000 protein-coding genes, but the coding parts of our genes account for only about 2 percent of the entire genome. (phys.org)
We investigate the functional relevance of de novo missense variants, specifically whether they are likely to disrupt protein interactions, and nominate novel genes in risk for ASD through integrated genomic, transcriptomic, and proteomic analyses. (springer.com)
Finally, we integrate protein interactions and cell-type-specific co-expression networks together with published association data to implicate novel genes in ASD risk in a cell-type-specific manner. (springer.com)
Consistent with other studies, genes identified by disrupted protein interactions are expressed early in development and in excitatory and inhibitory neuronal lineages. (springer.com)
Disrupted protein interactions identify gene sets involved in risk for ASD. (springer.com)
Using the newly released and larger ASC dataset, we confirm these observations and take them in several new directions: (1) By defining a set of genes encoding these disrupted protein interactors in ASD subjects and another for their siblings, we evaluate their expression patterns in developing brain from fetal to early postnatal development and within general cell types of brain tissue. (springer.com)
P). Gene expression studies indicate that TaABCC3.1 is part of the early host response to DON and that activation of TaABCC3.1 expression is not just a secondary effect of the toxins primary mode of action (i.e. inhibition of the elongation step in protein synthesis). (usda.gov)
it encodes a 102 amino acid protein showing 79% similarity to TrV1. (gc.ca)
Because alternative RNA splicing allows different types of mRNA molecules to be created from a single gene, it generates the diversity of protein function and structure that is essential to complex organisms. (genomicglossaries.com)
Highly specific and effective gene silencing of any disease can be achieved by an accurate knowledge of the target mRNA sequence and rational design of its complementary antisense agents for the downregulation of its protein message. (genomicglossaries.com)
The impor- objectives of determining the frequencies tance of FVII in normal haemostasis is il- of these gene polymorphisms in the popula- lustrated by the severe bleeding diathesis tion and clarifying the genotype association associated with low plasma levels of the of the R353Q and 0/10 bp insertion poly- protein [ 3 ]. (who.int)
It encodes a membrane-associated protein called the cystic fibrosis transmembrane conductance regulator (CFTR). (msdmanuals.com)
MicroRNAs (miRNAs) are small, noncoding RNAs that bind to the 3' UTR of target mRNAs, and silence gene expression by inducing degradation of target mRNAs or inhibition of protein translation [ 10 ]. (cdc.gov)

Here we show that the transcriptional regulator Deaf1 controls the expression of genes encoding PTAs in the pancreatic lymph nodes (PLNs). (nih.gov)
Both the NOD mouse and human Deaf1 variant isoforms suppressed PTA expression by inhibiting the transcriptional activity of canonical Deaf1. (nih.gov)
Most cells have intracellular sensors of viral za virus and appear partially responsible for the ability of products that, when activated, initiate a signaling cascade influenza viruses to infect multiple animal species, which likely contributes to the generation of new pandemic virus- that results in transcriptional induction of the IFN gene. (cdc.gov)
Here, we examined the lung transcriptional response after inhalation of GMA-SS fume and used gene network-based analysis to compare with previous aspiration data. (cdc.gov)
MicroRNAs (miRNAs) are an integral part of the post-transcriptional machinery of gene expression and have been implicated in the carcinogenic cascade. (cdc.gov)

Although the cause and effect relationship between FFAs and insulin resistance is complex, plasma FFA is negatively correlated with the expression of peroxisome proliferator activated receptor-γ cofactor-1 (PGC-1) and nuclear encoded mitochondrial genes. (elsevierpure.com)
These data suggest that an experimental increase in FFAs decreases the expression of PGC-1 and nuclear encoded mitochondrial genes and also increases the expression of extracellular matrix genes in a manner reminiscent of inflammation. (elsevierpure.com)
Fukao T, Yamaguchi S, Orii T, Hashimoto T. Molecular basis of beta-ketothiolase deficiency: mutations and polymorphisms in the human mitochondrial acetoacetyl-coenzyme A thiolase gene. (medlineplus.gov)
Kano M, Fukao T, Yamaguchi S, Orii T, Osumi T, Hashimoto T. Structure and expression of the human mitochondrial acetoacetyl-CoA thiolase-encoding gene. (medlineplus.gov)

2004), Distribution of the mRNAs encoding the thyrotro. (xenbase.org)
Distribution of the mRNAs encoding the thyrotropin-releasing hormone ( TRH ) precursor and three TRH receptors in the brain and pituitary of Xenopus laevis: effect of background color adaptation on TRH and TRH receptor gene expression. (xenbase.org)
In the present study, we have examined the distribution of the mRNAs encoding proTRH and the three receptor subtypes (xTRHR1, xTRHR2 , and xTRHR3) in the frog CNS and pituitary , and we have investigated the effect of background color adaptation on the expression of these mRNAs. (xenbase.org)
A good correlation was generally observed between the expression patterns of proTRH and xTRHR mRNAs. (xenbase.org)
The induced mRNAs include both novel and previously described genes, with diverse time courses of expression. (jneurosci.org)
and reduced expression of mRNAs encoding major coho odorant receptors (ORs). (cdc.gov)

The nucleotide sequences in this region of variable promoters showed a high propensity for DNA bending and a periodic distribution of particular dinucleotides, encoding preferences for DNA-nucleosome interaction. (elsevierpure.com)
This is a unique example of how promoter sequences intrinsically encode regulatory flexibility, which is vital for biological processes such as adaptation, development and evolution. (elsevierpure.com)
Most of the enhancers activated by EGFRvIII bore signature DNA sequences that are bound by dozens of transcription factors--regulators of gene expression--expressed at high levels in GBM. (sciencedaily.com)
Southern analysis suggests that each gene maps to a different TrIV genome segment, with homologous sequences apparently present on other segments. (gc.ca)

Using such probes, one can obtain a fingerprint of the gene expression activity in a macroscopic sample. (lu.se)

Instead, they boost the expression of their target coding genes. (sciencedaily.com)

The gradual conversion from endosymbiont to organelle during the course of evolution has clearly been accompanied by a dramatic reduction in genome size as the chloroplasts lost most of their genes to the nucleus. (frontiersin.org)
The m alpha La gene occurs in a single copy per haploid genome and is specifically expressed in the mammary gland where it is induced during late pregnancy. (eurekamag.com)
Using whole-genome quantitative gene expression as a model, here we study how the genetic architecture of regulatory variation in gene expression changed in a population of fully sequenced inbred Drosophila melanogaster strains when flies developed in different environments (25 °C and 18 °C). We find a substantial fraction of the transcriptome exhibited genotype by environment interaction, implicating environmentally plastic genetic architecture of gene expression. (nature.com)
EGFRIII changes the cell's internal signaling network, its uptake and use of nutrients, key elements of its gene-reading machinery known as transcription factors and its epigenetic landscape--the distribution of chemical tags that determines which parts of its genome are available for reading. (sciencedaily.com)
Interacting DNA-encoded regulatory subsystems in the GENOME that coordinate input from activator and repressor TRANSCRIPTION FACTORS during development, cell differentiation, or in response to environmental cues. (bvsalud.org)

The nucleotide sequence, expression, and evolution of one member of a multigene family encoding the small subunit of ribulose-1,5-bisphosphate carboxylase in soybean. (wikidata.org)
CLONING, EXPRESSION, AND NUCLEOTIDE-SEQUENCE OF THE LACTOBACILLUS-HELVETICUS-481 GENE ENCODING THE BACTERIOCIN HELVETICIN-J. JOURNAL OF BACTERIOLOGY, 172(11), 6339–6347. (ncsu.edu)
We report the nucleotide sequence of a 2.37-kb region containing the coronafacate ligase-encoding gene (cfl) which is required for the amide linkage of CFA and CMA. (uea.ac.uk)

The chloroplast matK gene has been identified as a rapidly evolving gene at nucleotide and corresponding amino acid levels. (vt.edu)
matK is the only proposed chloroplast-encoded group II intron maturase. (vt.edu)
There are 15 genes in the chloroplast that would require a maturase for RNA splicing. (vt.edu)
Light-stimulated transcription of genes for two chloroplast polypeptides in isolated pea leaf nuclei. (wikidata.org)

The prin2.2 and csp41b-2 single mutants displayed pale phenotypes, abnormal chloroplasts with reduced transcript levels of photosynthesis genes and defects in embryo development. (frontiersin.org)
In addition to environmental factors, phenotypes can also respond to genetic perturbations in a plastic or homeostatic manner, which characterizes the potential of an organism to express phenotypes when genes mutate. (nature.com)

The 3' regulatory regions have a great diversity of cis -regulatory elements directly involved in polyadenylation, stability, transport and mRNA translation, essential to achieve the desired levels of gene expression. (frontiersin.org)
Although a small number of 3' regulatory regions have been identified and validated so far, many studies have shown that plant 3' regulatory regions have a higher potential to regulate gene expression in plants compared to widely used 3' regulatory regions, such as NOS and OCS from Agrobacterium tumefaciens and 35S from cauliflower mosaic virus. (frontiersin.org)
In this review, we discuss the role of 3' regulatory regions in gene expression, and the superior potential that plant 3' regulatory regions have compared to NOS, OCS and 35S 3' regulatory regions. (frontiersin.org)
Ler is regulated by many factors such as plasmid encoded regulator (Per), integration host factor, Fis, BipA, a positive regulatory loop involving GrlA, and quorum sensing mediated by luxS. (wikipedia.org)

abstract = "Variation in gene expression is an essential material for biological diversity among single cells, individuals and populations or species. (elsevierpure.com)
ABSTRACT Factor VII gene polymorphisms may contribute to elevations in factor VII coagulant (FVIIc) levels that have been associated with cardiovascular risk. (who.int)

Genetically encoded probes show great promise in permitting functional imaging of specified neuronal populations in the intact nervous system, yet their in vivo application has been limited. (nih.gov)
Targeted expression of synapto-pHluorin in mouse will permit the analysis of previously inaccessible neuronal populations and chronic imaging from genetically identified neurons in vivo. (nih.gov)
In this work, we introduce a new class of genetically encoded reporters for MRI that work by altering water diffusivity. (biorxiv.org)
Overall, our results establish AQP1 as a new, metal-free, nontoxic and sensitive genetically encoded reporter for diffusion weighted MRI. (biorxiv.org)

Gene, 1991 Jul 22. (nih.gov)

ATP2C1 encodes the secretory pathway Ca 2+ /Mn2 ATPase (hSPCA1). (medscape.com)
[ 4 ] . Study of familial and sporadic cases of familial benign pemphigus in the Chinese population has revealed a number of mutations scattered throughout the ATP2C1 gene. (medscape.com)
The pump mutation is in ATP2C1 , a gene localized on chromosome 3. (medscape.com)
The gene ATP2C1 encodes the human secretory pathway Ca ++ -ATPase hSPCA1, which is dysfunctional and causes abnormal calcium release from the Golgi apparatus and endoplasmic reticulum. (medscape.com)
Two novel mutations of the ATP2C1 gene in Chinese families with Hailey-Hailey disease. (medscape.com)

A complex interaction between the cleavage and polyadenylation molecular complex and cis -elements determine the polyadenylation site, which may result in the choice of non-canonical sites, resulting in alternative polyadenylation events, involved in the regulation of more than 80% of the genes expressed in plants. (frontiersin.org)
In addition, genes encoding the expression of molecules involved in T lymphocyte and natural killer cell regulation were increased (CD86 and CD69). (cdc.gov)

This gene is found in the large histone gene cluster on chromosome 6. (nih.gov)
The responsible gene has been localized on the long arm of chromosome 7. (msdmanuals.com)

RNAseq of the dorsolateral prefrontal cortex and the nucleus accumbens, two brain areas strongly associated with addiction pathophysiology, showed that certain genes were expressed differently in people with OUD compared to controls. (eurekalert.org)

Ler positively regulates the LEE genes by competition with its homolog, H-NS. (wikipedia.org)
Here, we describe the cloning and functional characterisation of this gene, TaABCC3.1, as well as of its homolog (TaABCC3.2). (usda.gov)

Polyadenylation is essential for the stability of the transcript, preventing the mRNA from being the target of posttranscriptional gene silencing (PTGS) via RNA-dependent RNA polymerase 6 (RDR6) in plants ( Luo and Chen, 2007 ). (frontiersin.org)
a plastid-encoded bacterial-type RNA polymerase (PEP) and a nuclear-encoded phage-type RNA polymerase (NEP), which recognize distinct types of promoters. (frontiersin.org)
Genomic polymerase chain reaction (PCR) demonstrated that the ayu rhodopsin gene is intron-less. (bioone.org)

The EnCoDe project used the model plant Arabidopsis to elucidate how this process is regulated and to understand its significance in natural populations. (europa.eu)
We have isolated two maize cDNAs and the corresponding genes encoding fatty acid desaturase with Arabidopsis thaliana FAD7 gene as a probe. (elsevierpure.com)

Through APA, a single gene containing multiple PAS can generate a considerable number of transcript isoforms, thereby producing a highly diversified transcriptome ( Tian and Manley, 2013 ). (frontiersin.org)
CRISPR-Cas9 makes it easy to knock out or tweak a single gene to determine its effect on an organism or cell, or even another gene. (phys.org)
Autosomal Recessive Genetic disorders determined by a single gene (Mendelian disorders) are easiest to analyze and the most well understood. (msdmanuals.com)

The genomic clones of ZmFAD7 and ZmFAD8 consist of 8 exons and 7 introns as same as in the cases of A. thaliana FAD7 and FAD8 genes and the sizes of the 6 internal exons were identical among them. (elsevierpure.com)

Tissue-specific and light-regulated expression of a pea nuclear gene encoding the small subunit of ribulose-1,5-bisphosphate carboxylase. (wikidata.org)
Exon 8 of the mouse α 6 subunit gene was disrupted by homologous recombination. (jneurosci.org)
For example, cerebellar granule cells express six subunit genes abundantly (α 1 , α 6 , β 2 , β 3 , γ 2 , and δ), and so they probably have several distinct GABA A receptor subtypes of unknown subunit stoichiometry. (jneurosci.org)

Cloning and expression of the gene for lactacin F, a Lactobacillus acidophilus bacteriocin, using an amino acid sequence-derived DNA probe. (ncsu.edu)

The researchers show that as EGFRvIII alters the epigenetic landscape of activated enhancers, it also noticeably boosts the expression of SOX9 and FOXG1. (sciencedaily.com)
The underlying mechanism responsible for the effects of lunasin on NK cells is likely due to epigenetic modulation on target gene loci. (weeksmd.com)
Researchers can use ENCODE data-- are associated with epigenetic changes that may lead to which has been combined with other data, such as cancer, cardiovascular diseases, autoimmune diseases, environmental information--to better understand diseases and neurological disorders. (medlineplus.gov)

The effect of the phytohormone methyl jasmonate (MJ) on the expression of the TaGS1 and TaPCS1 genes encoding glutathione synthetase and phytochelatin synthase, respectively, which are key enzymes in the synthesis of glutathione and phytochelatins in wheat (cv. (bvsalud.org)

More specifically, Ler regulates the locus of enterocyte effacement (LEE) pathogenicity island genes, which are responsible for creating intestinal attachment and effacing lesions and subsequent diarrhea: LEE1, LEE2, and LEE3. (wikipedia.org)
GrlA is also a LEE encoded regulator of the LEE pathogenicity island. (wikipedia.org)

Microarray analysis also revealed that lipid infusion caused a significant overexpression of extracellular matrix genes and connective tissue growth factor. (elsevierpure.com)

PCR products and Southern blots confirmed integration of the D4E1 gene, while RT-PCR of cotton RNA confirmed the presence of D4E1 transcripts. (kennesaw.edu)
Among other stresses, high-salt treatment induced the accumulation of the ZmFAD7 and ZmFAD8 transcripts in roots but drought had no effect on their expression. (elsevierpure.com)
It was shown for the first time that pretreatment of plants by exogenous MJ (1 µM) leads to an increase in the accumulation of transcripts of the TaGS1 and TaPCS1 genes in leaves without cadmium effect. (bvsalud.org)
Transcripts from this gene lack polyA tails but instead contain a palindromic termination element. (nih.gov)
Since genes are composed of a given alphabet (A, T, C, G) with fixed pairing properties A-T and C-G, probes can be constructed that attract gene transcripts extracted from cell tissues and cultures. (lu.se)

BRC1 encodes a transcription factor that can inhibit branching. (europa.eu)

Structure and expression of the human gene encoding testicular H1 histone (H1t). (nih.gov)
Because miRNAs may regulate approximately 60% of human genes [ 11 ], the relationship between miRNAs and human diseases has been extensively explored in the last decade. (cdc.gov)

Type 1 diabetes may result from a breakdown in peripheral tolerance that is partially controlled by the expression of peripheral tissue antigens (PTAs) in lymph nodes. (nih.gov)
A tissue-specific transcription enhancer element is located in the major intron of a rearranged immunoglobulin heavy chain gene. (wikidata.org)
The tissue-specific expression and DNA sequence data indicate that both genes encode plastidic ω-3 fatty acid desaturases. (elsevierpure.com)
To identify differing patterns of gene expression, they used RNA sequencing (RNAseq), a technique that reflects how strongly genes are being expressed in a given tissue. (eurekalert.org)
Levels of gene expression are measured using a preparation of fluorescently labeled tissue RNA (copies of DNA), together with reference RNA labeled with a different fluorochrome, hybridized onto the slides. (lu.se)
Typically when data are presented, the fluor- escent intensity from the tissue is pseudo-colored red and the intensity from the reference green, and the logarithmic ratio of background corrected red and green intensities for each gene (spot) is subject to analysis (see Fig. 1 ). (lu.se)

To find out if this potentially therapeutic effect might be induced by a drug, the researchers examined the genes whose expression is controlled by SOX9 and FOXG1. (sciencedaily.com)

High- fidelity mRNA amplification for gene profiling. (genomicglossaries.com)

Diagnosis is by sweat test or identification of 2 cystic fibrosis-causing gene variants in patients with a positive newborn screening test result or characteristic clinical features. (msdmanuals.com)

BipA, a ribosomal binding GTPase and prolific regulator of EPEC virulence, transcriptionally regulates Ler from an upstream position where it also regulates other genes. (wikipedia.org)
To identify the photoreceptive molecule that regulates photoperiodic responses, in the present study, we have cloned and characterized the cDNA encoding an opsin gene expressed in the ayu brain, a putative site of the photoreceptor for photoperiodism. (bioone.org)

A cDNA clone (WL:AGA.l) encoding wheat leaf ADP-glucose pyrophosphorylase has been Isolated from a Xgtll expression library, by immunological screening with anti-spinach leaf ADP-glucose pyrophosphorylase serum. (warwick.ac.uk)
A wheat endosperm cDNA library, consisting of 1.6x10s bacteriophage particles, was subsequently constructed in the Xgtll expression vector. (warwick.ac.uk)

We have analyzed the immunohistochemical expression of three molecules involved in bone metabolism, namely osteonectin, TGF-1, and BMP2/4. (bvsalud.org)

First, they regulate the expression of the BRC1 gene in buds. (europa.eu)

We found that inhalation of GMA-SS welding fume was associated with activation of complement (C2, C3, C1QA-C, C4B), type 1 interferon pathways and increased expression of monocyte and lymphocyte chemotactic genes such as CCL2, CCL7 and CCL8. (cdc.gov)

presents an opportunity to manipulate gene expression within the cells to treat various diseases, and acts as a powerful tool for studying gene function utilizing antisense agents to manage the diseases by regulating the expression of the specific factor that actually causes the particular disease. (genomicglossaries.com)

Upon comparison of the datasets, a greater number of genes were changed with inhalation versus aspiration exposure. (cdc.gov)

The plasmid encoded regulator (per) directly activates the region of the LEE1 operon which encodes Ler. (wikipedia.org)
We studied FVII gene poly- then activates factors IX and X leading to morphisms in healthy Tunisians with the the generation of thrombin [ 2 ]. (who.int)

In this study, we examined the expression, function and evolution of MatK using a combination of molecular and genetic methods. (vt.edu)
The molecular interactions of genes and gene products underlie fundamental questions of biology. (lu.se)
Optimized expression of a synthetic gene encoding a beta-glucosidase in E. coli using molecular chaperones. (lu.se)

Genetic variance in expression increases at 18 °C relative to 25 °C for most genes that have a change in genetic variance. (nature.com)
Using the 6-hydroxydopamine lesion model of Parkinson's disease and differential display PCR, we have identified a set of more than 30 genes whose expression rapidly increases in response to stimulation of striatal dopamine D 1 receptors. (jneurosci.org)

In what follows we limit ourselves to the analysis of gene expression measurements obtained using microarrays with small spots of DNA fixed to glass slides. (lu.se)

Across cell types, these genes affect neuronal morphogenesis and neuronal communication, while neural progenitor cells show strong enrichment for development of the limbic system. (springer.com)

Phage-resistant strains that carry plasmids encoding abortive defenses have already been constructed using genetic strategies. (ncsu.edu)
Finally, although genotype by environment interaction in gene expression could potentially disrupt genetic networks, the co-expression networks are highly conserved across environments. (nature.com)
[ 6 ] This gene defect is similar to the genetic defect in Darier disease , which also is a calcium pump defect, ATP2A2 . (medscape.com)

Variable expression is likely to occur during removal of this nucleosome for gene activation. (elsevierpure.com)
Anaplastic large cell lymphomas (ALCLs) are distinguished from other lymphomas by their anaplastic cytology and constant membrane expression of the CD30 antigen (an activation marker for B or T cells). (medscape.com)

Mutations in the ACAT1 gene cause beta-ketothiolase deficiency. (medlineplus.gov)
Mutations in the ACAT1 gene reduce or eliminate the activity of the ACAT1 enzyme. (medlineplus.gov)
which means both copies of the gene in each cell have mutations. (medlineplus.gov)

About 60% of GBM tumors are fueled by the mutation or rampant over-expression of EGFR, most often by the EGFRvIII mutant. (sciencedaily.com)

The PEP enzyme recognizes the -10 and -35 cis -elements, similar to those found in bacterial promoters whereas the NEP enzyme recognizes the YRTA-motif, which can also be found upstream of several genes with PEP promoters indicating that these genes can be transcribed by both polymerases ( Pfannschmidt and Liere, 2005 ). (frontiersin.org)

Differential expression and 5' end mapping of actin genes in Dictyostelium. (wikidata.org)

Cadmium exposure differentially alters odorant-driven behaviors and expression of olfactory receptors in juvenile coho salmon (Oncorhynchus kisutch). (cdc.gov)

For genes encoding the disrupted interactions, we evaluate their expression patterns across developing brains and within specific cell types, using both bulk and inferred cell-type-specific brain transcriptomes. (springer.com)

Although the majority of expression quantitative trait loci (eQTLs) for the gene expression traits in the two environments are shared and have similar effects, analysis of the environment-specific eQTLs reveals enrichment of binding sites for two transcription factors. (nature.com)
Every two weeks one animal per group from the aquaria was slaughtered to determine the hormone levels as well as the gene expression profile using semi quantitative Real Time-PCR (RT-PCR). (huji.ac.il)

The current study investigated the effects of the supplementation of lambs with algae on the expression of genes that direct the accumulation of long chain omega-3 polyunsaturated fatty acids (LCn-3PUFA). (edu.au)

The effects of expression of the S100A8 gene by endometrial cancer cells was investigated by the MTT assay, cell cycle and apoptotic assays, qRT-PCR, and Western blotting. (medscimonit.com)
Gene therapy has attracted attention for its potential to specifically and efficiently target cancer cells with minimal toxicity to normal cells. (weeksmd.com)
Here we examined 145 SNPs in 6 miRNA processing genes and in 78 miRNAs which target genes known to be important in breast cancer among 906 African American (AA) and 653 European American (EA) cases and controls enrolled in the Women's Circle of Health Study (WCHS). (cdc.gov)
We found a number of SNPs in miRNAs and processing genes in association with breast cancer overall or stratified by estrogen receptor (ER) status. (cdc.gov)
A recent study of the disparity in breast cancer mortality between AA and EA women concluded that differences in mortality are driven by higher hazard rates of breast cancer death in AA women, irrespective of ER expression [ 9 ]. (cdc.gov)

Anatomy26

Organisms16

Diseases4

Chemicals and Drugs70

Analytical, Diagnostic and Therapeutic Techniques and Equipment34

Phenomena and Processes101

Disciplines and Occupations4

Information Science8

Health Care3

Proteins12

Protein34

Transcriptional5

Mitochondrial4

MRNAs6

Sequences4

Fingerprint1

Target codin1

Genome5

Nucleotide sequence3

Chloroplast4

Phenotypes2

Regulatory4

Abstract2

Genetically4

19911

ATP2C15

Regulation2

Chromosome2

Certain genes1

Homolog2

Polymerase3

Arabidopsis2

Single gene3

Exons1

Subunit3

Amino acid1

Epigenetic3

Enzymes1

Pathogenicity2

Microarray1

Transcripts5

Transcription factor1

Human2

Tissue6

Researchers1

MRNA1

Variants1

Regulates2

CDNA2

Molecules involved1

Regulate1

Pathways1

Diseases1

Datasets1

Activates2

Molecular3

Increases2

Analysis of gene expression1

Neuronal1

Genetic3

Activation2

Mutations3

Mutation1

Upstream1

Differential Expression1

Receptors1

Interactions1

Quantitative2

Accumulation1

Cancer5