Encodes gene expression environmental exposure. Medical search. Frequent questions

Hypermethylation of specific CpG sites in the promoter regions of genes can silence their expression, while hypomethylation can activate gene transcription. (alliedacademies.org)
Many cellular signaling pathways exhibit a bowtie topology: multiple distinct signal inputs converge on a single master transcription factor, which controls the expression of downstream genes. (harvard.edu)
Fabrizio conducts transcriptomics studies using early life stage zebrafish, which previous research showed that exposure to Deepwater Horizon oil may alter or impede transcription related to kidney health. (gulfresearchinitiative.org)
Transcription, the important first step of DNA gene expression, occurs when a DNA segment is copied into RNA and encodes at least one gene. (gulfresearchinitiative.org)
Transcription analysis of all putative catabolic genes established their role in the metabolism of OPP. (nature.com)
of these, 48 encode components of the transcription-translation machinery. (tamu.edu)
The pluripotency of the initial cell and the establishment of cell types depend to a large extent on the coordinated deployment of hundreds of transcription factors that bind to specific DNA sequences to activate or repress the transcription of cell lineage genes 1 . (nature.com)
Epigenetic components (for example, Polycomb PRC1/2 and Trithorax group proteins) maintain the 'off' states of certain genes and the 'on' states of others, in a cell-type- and time-specific manner (the bottom panels show three genes, depicted schematically as chromatinized templates, in which transcription is triggered by specific transcription factors and silent or active states are maintained by PRC1/2 or Trithorax proteins, respectively). (nature.com)
encoded by Nfe2l2 gene) is a transcription factor responsible for the regulation of cellular redox balance and protective antioxidant and phase II detoxification responses in mammals [ 1 , 2 ]. (springer.com)
Nrf2 stabilization and increase in its half-life even to 200 min [ 9 ] allows nuclear translocation and activation of transcription of cytoprotective genes (Fig. 1 ). (springer.com)
After phosphorylation by JAK tyrosine kinases, STAT1 enters the nucleus to regulate transcription of many different genes. (thermofisher.com)
Several classes of genes exhibited time-dependent up regulation of transcription, including those involved in protein synthesis, metabolism, cytoskeletal proteins, and calcium binding proteins. (noiseandhealth.org)
The calmodulin-binding transcription activators (CAMTA) play critical roles in plant growth and responses to environmental stimuli. (frontiersin.org)
Furthermore, gene-gene and gene-metabolite network analyses discovered that the light-responsive expression of genes encoding bHLH, MYB, WRKY, NAC, and MADS-box transcription factors, and proteins involved in genetic information processing and epigenetic regulation such as nucleosome assembly and histone acetylation, showed a high positive correlation with grape berry phenolic accumulation in response to different light regimes. (biomedcentral.com)

Human AHI1 genome location and AHI1 gene details page in the UCSC Genome Browser. (wikipedia.org)
This means that environmental factors interact with the genome to induce stable changes in gene expression", says to Fundación Descubre the Head of the team, Prof. Manuel Ruiz Rubio. (uco.es)
In this study, we first identified all the CAMTA homologous genes in the whole genome of maize. (frontiersin.org)
The human genome is an intricate tapestry of DNA sequences that encode the instructions for building and maintaining an organism. (alliedacademies.org)
Advances in molecular biology techniques have enabled researchers to map and analyze epigenetic marks across the genome, revealing insights into the dynamic regulation of gene activity and its implications for health and disease [ 3 ]. (alliedacademies.org)
Gene families come into being through gene and/or genome duplication followed by mutation over time which results in the evolutionarily-related genes having somewhat different nucleotides, amino acids, gene structure, and functions. (mtsu.edu)
The Drosophila genome contains two genes( CG8422 and CG1237 0) orthologous to Manduca and Acheta DH-Rs. (silverchair.com)
Here, we use a computational approach to perform genome-wide identification and analysis of 611 orthologues of the Arabidopsis thaliana flowering genes. (springer.com)
Conservation of the genes belonging to the photoperiod, gibberellin and autonomous pathways was observed, while orthologues of the key genes found in the vernalisation pathway (FRI, FLC) were absent from the quinoa genome. (springer.com)
Because of this complexity, decades of experimental work, even with the aid of sophisticated molecular genetic tools (such as high resolution total genome quantitative analysis, array expression analysis or high resolution single nucleotide polymorphism (SNP) array platforms) have failed to identify specific causes in any substantial proportion of cases [ 4 , 5 ]. (biomedcentral.com)
Nonetheless, quantitative whole-genome analyses promise to identify one or a few autism-specific copy number variants (CNVs) harboring genes whose dosage alterations could be critical in causing ASD. (biomedcentral.com)
The TDH performed point prevalence surveys, discharge screening, onsite observations, and environmental testing at ACH A. The VIM-CRPA isolates underwent whole-genome sequencing (WGS). (cdc.gov)

Epigenetic mechanisms regulate gene expression and mediate interactions between genetic factors and environmental exposures. (harvard.edu)
Although defects from prenatal alcohol exposure can be replicated in mouse models [ 10 ], identifying genetic factors that contribute to susceptibility to FASD is virtually impossible in human populations since time, dose, and frequency of exposure are generally unknown, and manifestations of FASD are diverse and become evident long after exposure. (biomedcentral.com)
Twins, family and adoption studies have suggested that nicotine addiction is closely related to genetic and environmental factors, and genetic factors play an important role in the risk to the development of addiction [ 11 , 12 ]. (hindawi.com)
Melanoma is an aggressive type of skin cancer whose aetiology remains elusive as both environmental and genetic factors can contribute to its development. (biomedcentral.com)
Regarding the etiology, it is generally accepted that genetic factors play a major role and it has become clear that, with the exception of a minority of instances (about 1%) in which the phenotype is caused by a single gene alteration, the genetic component leading to autism is complex, being based on interactions of multiple genetic changes and/or epigenetic regulation of gene expression. (biomedcentral.com)
Researchers suspect that environmental or other genetic factors help determine whether an individual will develop the condition. (medlineplus.gov)

Finally, we used gene knockout strains to validate the potential target genes related to ethanol tolerance. (biomedcentral.com)
CAMTAs participate in gene expression regulation by binding to the cis -elements in the promoter regions of numerous target genes. (frontiersin.org)

AHI1 specifically encodes the Jouberin protein and mutations in the expression of the gene is known to cause specific forms of Joubert syndrome. (wikipedia.org)
Identification of the first AHI1 gene mutations in nephronophthisis-associated Joubert syndrome" (PDF). (wikipedia.org)
Functional analyses indicate that MFSD12 encodes a lysosomal protein that affects melanogenesis in zebrafish and mice, and that mutations in melanocyte -specific regulatory regions near DDB1/TMEM138 correlate with expression of UV response genes under selection in Eurasians . (mixedracestudies.org)
Epigenetic modifications may also play a role, as demonstrated by the occurrence of autism in genetic conditions caused by mutations in imprinted genes or regions. (biomedcentral.com)
Mutations in genes concerned with production of enzymes for metabolism of tobacco products may lead to increased risk of carcinogenesis with respect to oral mucosa. (bvsalud.org)
Mutations in several genes, including IL36RN and CARD14 , increase the risk of developing GPP. (medlineplus.gov)
IL36RN gene mutations involved in GPP reduce the amount of IL-36Ra protein in the skin. (medlineplus.gov)
The CARD14 gene mutations associated with GPP increase the activity of the CARD14 protein, leading to uncontrolled inflammation signaling in the skin. (medlineplus.gov)
IL36RN gene mutations are most often associated with GPP alone and are only rarely found in individuals who also have PV. (medlineplus.gov)
Mutations in this gene appear to be the most common genetic risk factor for GPP alone. (medlineplus.gov)
CARD14 gene mutations are more frequently found in individuals with both GPP and PV, although changes in this gene have also been found in individuals with GPP alone. (medlineplus.gov)
Mutations in other genes, some of which have not been identified, may also be associated with the condition. (medlineplus.gov)
which means both copies of the gene in each cell have mutations. (medlineplus.gov)
mutations in the gene. (medlineplus.gov)
People with mutations in either the IL36RN or CARD14 gene inherit an increased risk of GPP, not the condition itself. (medlineplus.gov)
Not all people with this condition have mutations in one of these genes, and not all people with a mutation in one of these genes will develop the disorder. (medlineplus.gov)

Recent advances have been made in the of host factors, polymorphisms, and candidate genes associated characterization of the immune response to low-molecular- with occupational asthma may improve our understanding of weight agents. (cdc.gov)

Epigenetics refers to the heritable changes in gene expression that do not involve alterations to the DNA sequence itself. (alliedacademies.org)
In the context of adipogenesis, DNA methylation patterns are dynamically regulated, leading to changes in gene expression that impact fat cell development[ 1 ]. (alliedacademies.org)
However, the changes in gene expression that underlie these biological changes are poorly understood. (noiseandhealth.org)
Our approach to investigating this problem is to use gene microarrays to measure the changes in gene expression in the chinchilla inner ear following a 3 h or 6 h noise exposure (95 dB SPL, 707-1414 Hz). (noiseandhealth.org)
Since the strongest hybridization occurred with mouse clones, mouse cDNA microarrays were used to study noise-induced changes in gene expression. (noiseandhealth.org)
Changes in gene expression form the basis for important biological processes, including repair, regeneration, and plasticity. (noiseandhealth.org)
We are therefore using a battery of molecular approaches to identify and compare changes in gene expression following noise trauma in birds and mammals. (noiseandhealth.org)
To examine the mammalian response, gene microarrays on nylon membranes (Clontech Atlas Gene Arrays) were used to examine global changes in gene expression 30 minutes after TTS (110 dB broadband noise 50% duty cycle) or PTS (125 dB, 100% duty cycle) noise overstimulation (each for 90 minutes) in the rat cochlea. (noiseandhealth.org)
Environmental factors such as chronic stress, trauma, or drug exposure can induce stable changes in gene expression, which can alter functioning in neural circuits and ultimately impact behavior. (anothersolution.org)

We constructed sex-specific genetic networks associated with alcohol-dependent modulation of gene expression that include protein-coding genes, Novel Transcribed Regions (NTRs, postulated to encode long non-coding RNAs) and female-specific coordinated regulation of snoRNAs that regulate pseudouridylation of ribosomal RNA. (biomedcentral.com)

Finally, higher-order 3D chromosome folding is also thought to modulate gene expression and might contribute to inheritance 15 . (nature.com)
The STAT1 gene is located on chromosome 2. (thermofisher.com)
The responsible gene has been localized on the long arm of chromosome 7. (msdmanuals.com)

Cadmium exposure differentially alters odorant-driven behaviors and expression of olfactory receptors in juvenile coho salmon (Oncorhynchus kisutch). (cdc.gov)
These associations were sex-dependent, suggesting that in utero arsenic exposure differentially impacts male and female fetuses. (biomedcentral.com)
Exposure to 41 °C induced 1160 differentially expressed genes (DEGs) between the heat-acclimated and unacclimated larvae. (biomedcentral.com)
Although the heat-acclimated and unacclimated larvae upregulated expression of heat shock protein genes under heat stress including HSP70 , HSP27 and CRYAB , their biosynthesis, metabolism and detoxification-related genes expressed differentially. (biomedcentral.com)

We showed that gene by inhaled corticosteroids and gene by smoking interactions also play a role in the clinico-pathological expression of the disease. (rug.nl)
Most of this vulnerability arises from complex interactions among multiple genes and genetic interactions with environmental influences. (anothersolution.org)
This gene/protein family is characterized by the presence of three specific protein domains: PDZ, SH3, and GUK, all of which aid in protein-protein interactions. (mtsu.edu)

Behavioral alterations on exposure to 0.3 and 2 µg/L Cd were associated with increased mt1a, but not with major histological or OR molecular changes, likely indicating disrupted OST as a major mechanism underlying the behavioral dysfunction at the low-level Cd exposures. (cdc.gov)
An AHI1 heterozygous knockout mouse model was studied by Bernard Lerer and his group at Hadassah Medical Center in Jerusalem to elucidate the correlation between alterations in AHI1 expression and the pathogenesis of neuropsychiatric disorders. (wikipedia.org)
To extend our knowledge on molecular effects of tobacco smoke exposure in pregnancy, we analyzed transcriptome alterations in passive smokers (PS) and compared them to those in active smokers (AS). (nih.gov)
The study, conducted in a non-human primate model, found that prenatal THC exposure resulted in alterations to the placental and fetal epigenome - the intricate chemical modifications to DNA that oversee gene regulation and expression. (earth.com)
A number of genetic studies led to the identification of genes and/or copy number variants whose alterations are associated with autism, but no specific factor has been found so far to be responsible for a substantial proportion of cases. (biomedcentral.com)
published this month in BMC Medicine , reports on genomic and epigenetic alterations of OXTR , the gene encoding the receptor for oxytocin. (biomedcentral.com)
The nature of this epigenetic dysregulation is unknown but, if proved to be true, might explain the failure to identify sequence alterations in a host of candidate genes. (biomedcentral.com)

Interestingly, cuticular-related protein genes (chinase and chitin) were predominantly downregulated, which was also confirmed in the functional enrichment analysis. (cdc.gov)

Cadmium exposures inhibited behavioral responses towards L-cysteine and conspecific odorants, with effects persisting following the depuration. (cdc.gov)
Sex-specific factors play a major role in human health and disease, including responses to environmental stresses such as toxicant exposure. (biomedcentral.com)
Thus, there is a crucial need for an improved understanding of the molecular mechanisms underlying sexually dimorphic responses in utero, in order to effectively prevent, diagnose and treat the effects of prenatal toxicant exposure. (biomedcentral.com)
The core temperatures and corticosterone secretions of the heterozygous knockout mice after exposure to environmental and visceral stress exhibited extreme repression of autonomic nervous system and hypothalamic-pituitary-adrenal responses. (wikipedia.org)
The results showed that ethanol exposure induced genes involved in common stress responses, transporting and cell envelope modification. (biomedcentral.com)
STAT1 is known to regulate several genes which are involved in cell growth, apoptosis, immune responses, and lipid metabolism. (thermofisher.com)
Furthermore, the expression pattern of ZmCAMTA genes under RBSDV infection was analyzed to investigate their potential roles in responses of different maize cultivated varieties to RBSDV. (frontiersin.org)
Third, we examine the link between transcriptomic responses to environmental stress and biogeographic distributions in blue mussels, Mytilus trossulus and Mytilus galloprovincialis . (biologists.com)
Fourth, we present a comparison of transcriptomic datasets and identify 175 genes that share common responses to heat stress across Mytilus species. (biologists.com)

Using Illumina Expression Beadchip with 24,526 transcript probes, gene expression patterns were assayed in placentas from PS (N=25) exposed to environmental tobacco smoke (ETS) throughout pregnancy and non-exposed (NS) counterparts (N=35), and in cord blood cells from their newborns. (nih.gov)
The changes in transcript level of genes were related to heat acclimation of larvae, especially these genes in sensory organ development, structural constituent of eye lens, and oxidoreductase activity. (biomedcentral.com)
Both genes showed an increase in transcript levels until 36 h after explant inoculation, and a subsequent down-regulation, before the initiation of exponential growth. (frontiersin.org)
DcAOX genes' were further explored in a plant pot experiment in response to chilling, which confirmed the early AOX transcript increase prior to the induction of a specific anti-freezing gene. (frontiersin.org)
Two alternatively spliced transcript variants encoding distinct isoforms of STAT1 have been described. (thermofisher.com)
By microarray analysis, the CG8422 transcript was detectable in Drosophila head mRNA of different genotypes and under different environmental conditions. (silverchair.com)

The activation of multiple hormone signaling pathways after both light exclusion and re-exposure treatments was inconsistent with the changes in phenolic accumulation, indicating a limited role of plant hormones in mediating light/darkness-regulated phenolic biosynthesis processes. (biomedcentral.com)
Further, emerging evidence suggests that nicotine can also regulate the expression of genes/proteins involved in various functions such as ERK1/2, CREB, and c-FOS [ 20 - 22 ], as well as the expression state of multiple biochemical pathways, for example, mitogen-activated protein kinase (MAPK), phosphatidylinositol phosphatase signaling, growth factor signaling, and ubiquitin-proteasome pathways [ 23 - 25 ]. (hindawi.com)
However, current knowledge of the molecular basis of quinoa flowering is limited and the details of flowering genes and associated pathways in quinoa remain elusive (Jarvis et al. (springer.com)
This RNA-Seq analysis presents a detailed picture of the candidate detoxification genes and other pathways that are potentially associated with pyrethroid and organophosphate resistance in Ae. (cdc.gov)
exposures and lifestyle alter critical advances as well as the uniqueness and These developments have also led to molecular pathways and promote cancer strengths of IARC. (who.int)
orthogonal exPeriMental changes and pathways induced by EGE investigated the impact of aSSeSSMent of ePigenetic environmental factors in cancer causation, both current H. pylori infection and driver geneS and their link to underpinning studies of etiology e , pigenetic memory of past (eradicated) environMental carcinogenS carcinogen evaluation, and prevention. (who.int)
The IL-36Ra protein, produced from the IL36RN gene, blocks the activity of specific proteins that trigger signaling pathways to promote skin inflammation. (medlineplus.gov)

Using NanoString technology, we further analyzed the fetal placenta samples from the NHBCS for the expression of genes encoding arsenic transporters and metabolic enzymes. (biomedcentral.com)
Oxidative and electrophilic stresses are sensed by Keap1, which activates Nrf2 to achieve cytoprotection by regulating the expression of drug-metabolizing and antioxidative stress enzymes/proteins. (aacrjournals.org)
Various products of these genes are enzymes involved in the activation or degradation of carcinogens/pro-carcinogens. (bvsalud.org)

The analyses revealed that THC exposure fundamentally altered the epigenome, a process wherein the information encoded in a gene is translated into a function or an observable trait. (earth.com)

Genomic analysis identified two orthologous operons encoding the ortho -cleavage of benzoic acid (BA) ( ben/cat ). (nature.com)
Our analysis indicated that on average each Arabidopsis flowering gene has two orthologous copies in quinoa. (springer.com)

We investigated the role of genes encoding proteins involved in epithelial integrity, chronic airway inflammation and airway remodeling in asthma. (rug.nl)

This article explores the fascinating world of epigenetic regulation in the context of obesity, shedding light on how environmental factors can influence gene expression, ultimately impacting our weight and overall health. (alliedacademies.org)

Based on these results and prior studies, increased AQP9 expression may lead to increased arsenic transport in the female fetal placenta, which in turn may alter the expression patterns of key developmental genes that we have previously shown to be associated with arsenic exposure. (biomedcentral.com)
Studies have shown that changes in DNA methylation patterns can affect the expression of genes involved in adipocyte differentiation and lipid metabolism. (alliedacademies.org)
Altered histone acetylation patterns in response to dietary changes or environmental factors can disrupt the balance between appetite-stimulating and appetite-suppressing signals, potentially contributing to overeating and obesity[ 2 ]. (alliedacademies.org)
The resulting software combines a variety of visualization and interaction techniques which work together to allow biologists to explore their data and reveal temporal patterns of gene activity. (biomedcentral.com)
A final evaluation demonstrated the tools effectiveness in allowing users to find unexpected temporal patterns and the benefits of functionality such as the overlay of gene groupings and the ability to store patterns. (biomedcentral.com)
We have developed a new exploratory analysis tool, MaTSE, that allows users to find unexpected patterns of temporal activity in gene expression time-series data. (biomedcentral.com)
Soon after fertilization, the vast majority of methylcytosine in sperm is converted by the Tet3 enzyme to hydroxymethylcytosine that gets lost by dilution during replication, effectively erasing cytosine methylation patterns except for a subset that is maintained, including those of some imprinted genes. (i-sis.org.uk)
The results showed that nine ZmCAMTA genes showed highly diversified gene structures and tissue-specific expression patterns. (frontiersin.org)
Here, we applied Illumina RNA-Seq to study the gene expression patterns associated with resistance to three widely used insecticides (malathion, alphacypermethrin, and lambda-cyhalothrin) in Ae. (cdc.gov)

Both differential display and subtractive hybridisation were used to identify genes whose expression increased in the chick basilar papilla immediately following exposure to an octave band noise (118 dB, centre frequency 1.5 kHz) for 4-6 hr. (noiseandhealth.org)
To identify genes affecting skin pigmentation in Africa, we used a DSM II ColorMeter to quantify light reflectance from the inner arm as a proxy for melanin levels in 2,092 ethnically and genetically diverse Africans living in Ethiopia , Tanzania , and Botswana (table S1 and figs. S1 and S2) (8). (mixedracestudies.org)

In summary, low-level Cd exposures associated with polluted waterways can induce differential and persistent olfactory dysfunction in juvenile coho salmon. (cdc.gov)
For example, they found that that exposure to PAHs during a fish's early life stages (embryo and larvae) can induce sublethal impacts , such as reduced cardiac function, that affect the organism's overall fitness and health. (gulfresearchinitiative.org)
Furthermore, we found that heat exposure alone can significantly induce E2F1 expression. (biomedcentral.com)

Moreover, AQP9 expression associated with that of a subset of female-specific arsenic-responsive genes. (biomedcentral.com)
While over 350 pigmentation genes have been identified in animal models, only a subset of these genes have been linked to normal variation in humans (5). (mixedracestudies.org)

Comparison of PS and AS indicated that ETS exposure and active smoking in pregnancy partly employ the same molecular mechanisms. (nih.gov)
Epigenetic mechanisms include DNA methylation, histone modifications, and non-coding RNA molecules, all of which contribute to the regulation of gene expression. (alliedacademies.org)
The variety of mechanisms that have evolved among vertebrates to achieve the same goal-a rhythm in melatonin-underlines the important role melatonin plays as the hormonal signal of environmental lighting in vertebrates. (nih.gov)
To understand the underlying mechanisms, we established a heat-acclimated strain via multigenerational selection at 39 °C. After heat shock at 41 °C for 1 h, the transcriptomes of the heat-acclimated (S-39) and unacclimated (S-27) larvae were sequenced, using the unacclimated larvae without exposure to 41 °C as the control. (biomedcentral.com)
Proteins/genes with a putative catabolic role and bacterium adaptation mechanisms during OPP degradation were identified via genomic and proteomic analysis. (nature.com)
Secondly, they have shown that this male hormone produces effects in the nematode through epigenetic mechanisms, which do not affect the DNA sequence of genes but stably influence their expression. (uco.es)
Through epigenetic mechanisms, the environment can cause long-term genetic adaptations-influencing the pattern of active or silent genes in encoding proteins-without altering the DNA sequence. (anothersolution.org)
In summary, by analyzing the overall characteristics of the nicotine addiction related genes, this study provided valuable information for understanding the molecular mechanisms underlying nicotine addiction. (hindawi.com)
My research focuses on fish and other aquatic invertebrates and has ranged from investigating the mechanisms of toxicity of environmental chemicals using (epi)genomics approaches to understanding disease susceptibility within aquaculture. (exeter.ac.uk)
Environmental factors that can detect specific IgE antibodies against most low-molecular- affect the initiation of occupational asthma include the intrinsic weight agents has resulted in a search for alternative or characteristics of causative agents as well as the influence of the complementary physiopathologic mechanisms leading to airway level and route of exposure at the workplace. (cdc.gov)

Several genes, including classic immediate early response genes such as c-fos, EGR1/NGFI-A, and NGFI-B, were upregulated at this early time point following the PTS exposure, but were not upregulated following the TTS exposure. (noiseandhealth.org)
Several genes including orthologues of MIF1, FT and TSF were identified as homologue-rich genes in quinoa. (springer.com)

Cord blood of newborns of PS displayed differential expression of 116 genes encoding mainly neuronal factors, regulators of immunologic response, and protooncogenes. (nih.gov)
Ethanol intake, estrogen therapies, hemochromatosis genes, and hepatitis and human immunodeficiency viral infections are among these contributory factors. (medscape.com)
[ 1 ] The increased oxidative stress associated with all of these factors has been shown to reduce hepatic expression of the gene encoding hepcidin, a regulator of iron absorption and metabolism, thus increasing iron absorption and iron overload. (medscape.com)
[ 16 ] Reduction of hepatic UROD activity to approximately 25% of normal, most often reflecting effects of multiple genetic and/or exogenous inhibitory factors, is required for clinical disease expression. (medscape.com)
But how an individual responds to Genomics Advances for Gene-Environment (GxE) Discovery those factors in different ways is based on their unique and Validation, aims to better understand the connection biological makeup. (medlineplus.gov)
The ability of Escherichia coli to survive at low pH is strongly affected by environmental factors, such as composition of the growth medium and growth phase. (tamu.edu)
STAT1 is activated to regulate gene expression in response to extracellular signaling polypeptides including cytokines, interferons, and growth factors. (thermofisher.com)
Both substance use disorders and other mental illnesses are caused by overlapping factors such as genetic and epigenetic vulnerabilities, issues with similar areas of the brain, and environmental influences such as early exposure to stress or trauma. (anothersolution.org)
Scientists are also beginning to understand the very powerful ways genetic and environmental factors interact at the molecular level. (anothersolution.org)
Studies suggest that environmental factors interact with genetic vulnerability during particular developmental periods to increase the risk for mental illnesses and addiction. (anothersolution.org)
Carcinogenesis is a multistep process and individual risk to development of cancer depends not only on environmental factors or extrinsic exposure to carcinogens but also on genetic susceptibility of an individual. (bvsalud.org)
In head and neck cancer, tobacco exposure and alcohol consumption are predominantly the most significant external factors for tumor formation. (bvsalud.org)
Factors that influence the tobacco exposed individuals developing a malignancy may thus include a combination of total tobacco exposure and genetic susceptibility of the individual 12 . (bvsalud.org)

The differentiation of preadipocytes into mature adipocytes involves a series of epigenetic changes that control the expression of genes responsible for fat storage and metabolism. (alliedacademies.org)
There is significant and sex-specific natural genetic variation in the transcriptional response to developmental exposure to ethanol in Drosophila that comprises networks of genes affecting nervous system development and ethanol metabolism as well as networks of regulatory non-coding RNAs. (biomedcentral.com)

Because equatorial regions receive more UVR than temperate regions, populations from these regions (including sub-Saharan Africans, South Asians, and Australo-Melanesians ) have darker pigmentation (Fig. 1), which likely mitigates the negative impact of high UVR exposure such as skin cancer and folate degradation (1). (mixedracestudies.org)
We then surveyed the distribution of stress-related cis -regulatory elements in the −1.5 kb promoter regions of ZmCAMTA genes. (frontiersin.org)
Notably, a large number of stress-related elements present in the promoter regions of some ZmCAMTA genes, indicating a genetic basis of stress expression regulation of these genes. (frontiersin.org)
Numerous studies aiming to identify the genetic variants or candidate genes have found a large number of promising genes and chromosomal regions involved in the etiology of nicotine addiction [ 13 ]. (hindawi.com)
Comparative genomics has revealed conserved gene networks, highlighted genomic regions under positive selection, and shed light on the genetic basis of speciation. (alliedacademies.org)
Microbial DNA was extracted from subgingival dental plaque (n=281) and V3-V4 regions of the 16S rRNA gene were sequenced to measure the relative abundances of 20 a priori - selected taxa with nitrate‐reducing capacity. (ahajournals.org)

The epithelial compartment can also respond to environmental stimuli with a range of cytokines (including IL-33, IL-25, TSLP, and IL-1alpha) that may trigger and perpetuate airway inflammation. (biomedcentral.com)

Gene ontology analyses highlighted some important biological processes that might be associated with placental insufficiency and fetal growth restriction in PS, such as fatty acid catabolism, coagulation, regulation of growth, and response to steroid hormone stimulus. (nih.gov)

RNA-Seq based global transcriptomic analysis provided a comprehensive view of cellular response to ethanol exposure. (biomedcentral.com)
We found substantial genetic variation in gene expression in response to ethanol with extensive sexual dimorphism. (biomedcentral.com)

In a previous report using the resources of the New Hampshire Birth Cohort Study (NHBCS), we found that low-to-moderate i n utero exposure to arsenic, a highly toxic and widespread pollutant, was associated with altered expression of several key developmental genes in the fetal portion of the placenta. (biomedcentral.com)
Multivariable linear regression analysis was used to examine their relationship with arsenic exposure and with key developmental genes, after stratification by fetal sex. (biomedcentral.com)
The high temperature of 41.8 °C inhibited nymphal development of the brown planthopper Nilaparvata lugens , and the exposure to 42.5 °C in adult stage resulted in a lower fecundity and extended developmental duration of eggs [ 7 ]. (biomedcentral.com)
Drosophila melanogaster is an excellent model to study the genetic basis of the effects of developmental alcohol exposure since many individuals of the same genotype can be reared under controlled environmental conditions. (biomedcentral.com)
We reared DGRP lines which showed extreme upregulation or downregulation of snoRNA expression during developmental alcohol exposure on standard or ethanol supplemented medium and demonstrated that developmental exposure to ethanol has genotype-specific effects on adult locomotor activity and sleep. (biomedcentral.com)
Drosophila melanogaster presents an advantageous model for studies on the genetic underpinnings associated with symptoms of developmental alcohol exposure. (biomedcentral.com)
Modulation of the Drosophila transcriptome by developmental exposure t" by Vijay Shankar, Tatiana V. Morozova et al. (clemson.edu)
With every gene making up DNA uniquely coded to contribute to various bodily and brain functions, any interference with the epigenetic processes due to drug exposure raises concerns - particularly during a critical developmental period like pregnancy. (earth.com)

Therefore, elucidation of the microbial metabolic pathway of OPP is a prerequisite for the downstream exploitation of strain P3 in any environmental application. (nature.com)
6 identified a gene cluster, hbpCAD , encoding the upper metabolic pathway of OPP which involves the transformation of OPP to 2-hydroxypenta-2,4-dienoateand benzoic acid (BA). (nature.com)
The downstream transformation of BA involved a meta -cleavage pathway, although its genetic organization and function was not revealed and the overall network of genes driving the full metabolic pathway of OPP is still not known. (nature.com)
Further, clustering of these genes resulted in six clusters with themes in synaptic transmission, signal transduction, metabolic process, and apoptosis, which provided an intuitional view on the major molecular functions of the genes. (hindawi.com)
Individual's susceptibility to cancer may be partly explained by variability in enzymatic activities of metabolic genes. (bvsalud.org)

Diagnosis is by sweat test or identification of 2 cystic fibrosis-causing gene variants in patients with a positive newborn screening test result or characteristic clinical features. (msdmanuals.com)

A major advance in the study of the molecular basis of these changes was the cloning of cDNA encoding the enzyme. (nih.gov)
Here, we present data showing (1) the suitability of mouse and human complementary DNA (cDNA) clones for detecting chinchilla cochlear gene transcripts, and (2) the change in cochlear gene transcripts in noise exposed chinchillas. (noiseandhealth.org)

Gene ontology implicated the immune system, including interleukins 4 and 13, as well as antimicrobial peptides in this overexpression. (biomedcentral.com)
The gene ontology (GO) terms associated with monooxygenase, iron binding, and passive transmembrane transporter activities were significantly enriched in four out of six resistant vs. susceptible comparisons while serine protease activity was elevated in all insecticide-resistant groups relative to the susceptible strain. (cdc.gov)

It encodes a membrane-associated protein called the cystic fibrosis transmembrane conductance regulator (CFTR). (msdmanuals.com)

Biologists have long sought to understand how a fertilized egg can form an organism composed of hundreds of specialized cell types, each expressing a defined set of genes. (nature.com)
Taken together, these studies demonstrate that transcriptomics can provide an informative snapshot of the physiological state of an organism within an environmental context. (biologists.com)

Characterizing these relationships offers the potential of identifying at-risk hosts in whom preventing or delaying infection could alter the phenotypic expression of asthma. (atsjournals.org)
Quantitative real-time PCR was used to test the expression of ZmCAMTA genes under several abiotic stresses (drought, salt, and cold), various stress-related hormones [abscisic acid, auxin, salicylic acid (SA), and jasmonic acid] and biotic stress [rice black-streaked dwarf virus (RBSDV) infection]. (frontiersin.org)
Episodes can be triggered by infection, exposure to or withdrawal from certain medications, menstruation, or pregnancy, although the trigger is often unknown. (medlineplus.gov)

Epigenetic modifications, such as DNA methylation and histone modifications, can influence gene expression and play a vital role in development, aging, and disease. (alliedacademies.org)

Prenatal exposure to ethanol can cause fetal alcohol spectrum disorder (FASD), a prevalent, preventable pediatric disorder. (biomedcentral.com)
Previous research established a correlation between development of autistic behavior traits and level of exposure to testosterone during prenatal development. (uco.es)

eesim v0.1.0: Provides functions to create simulated time series of environmental exposures (e.g., temperature, air pollution) and health outcomes for use in power analysis and simulation studies in environmental epidemiology. (r-bloggers.com)
Temperature affects invertebrate hormone system, and the increased temperature induces expression of endocrine signaling genes of chironomids Chironomus riparius [ 14 ]. (biomedcentral.com)

The second phase focuses on characterizing epigenetic sequence and apply it to better understand human biology changes caused by environmental exposures in different and improve health, and thanks to a new understanding of types of cell tissues such as the brain, lung, liver, skin, and how people's genomes and epigenomes work, ENCODE's blood. (medlineplus.gov)
The discovery of the antioxidant response element (ARE) have led to the conclusion that the battery of genes, including glutamate-cysteine ligase (GCL), thioredoxin reductase 1 (Txnrd1), NAD(P)H-quinone oxidoreductase 1 (NQO1) and heme oxygenase-1 (HMOX1) is regulated through Nrf2 binding to this consensus binding sequence [ 3 ]. (springer.com)

[ 9 ] Accumulating porphyrins in hepatocytes may then further down-regulate hepcidin gene expression. (medscape.com)

The multifunctional regulator nuclear factor erythroid 2-related factor (Nrf2) is considered not only as a cytoprotective factor regulating the expression of genes coding for anti-oxidant, anti-inflammatory and detoxifying proteins, but it is also a powerful modulator of species longevity. (springer.com)
The major characteristics of Nrf2 are to some extent mimicked by Nrf2-dependent genes and their proteins including heme oxygenase-1 (HO-1), which besides removing toxic heme, produces biliverdin, iron ions and carbon monoxide. (springer.com)

Therefore variations in the expression of these genes due to heritable genetic polymorphisms might modulate the process of carcinogenesis by altering the exposure levels of tobacco derived carcinogens. (bvsalud.org)

There is also evidence that they can be reversed with interventions or environmental alteration. (anothersolution.org)
Environmental carcinogens and certain other endogenous factor (genetic alteration and mutation) interacting in a complex manner can give rise to development of cancer. (bvsalud.org)
Alteration of the pattern of gene expression by oxidants may function in the stimulation of the initiated cell during tumor promotion. (bvsalud.org)

In the hypothalamus, histone modifications have been linked to the regulation of genes involved in appetite control and energy homeostasis. (alliedacademies.org)

Thus, this study suggests that AQP9 may play a role in the sex-specific effects of in utero arsenic exposure. (biomedcentral.com)
Research suggests that many genes may contribute to the risk for both mental disorders and addiction, including those that influence the action of neurotransmitters-chemicals that carry messages from one neuron to another-that are affected by drugs and commonly dysregulated in mental illness, such as dopamine and serotonin. (anothersolution.org)

RNA-seq based identification and mutant validation of gene targets related to ethanol resistance in cyanobacterial Synechocystis sp. (biomedcentral.com)
The analysis provided a list of gene targets for engineering ethanol tolerance in cyanobacterium Synechocystis . (biomedcentral.com)

Further, STAT1 plays an important role in mediating cell viability in response to different cell stimuli and pathogen exposure. (thermofisher.com)

E2F1 mRNA expression was also evaluated by RT-qPCR in the melanoma cell line, SK MEL 267, before and after exposure to heat stress. (biomedcentral.com)
Our results also suggest that environmental insults, such as heat stress, could contribute to an aberrant E2F1 activity by inducing E2F1 mRNA expression. (biomedcentral.com)
The subsequent analysis of a group of unrelated autistic subjects did not show an OXTR deletion, but rather hypermethylation of the gene promoter, with a reduced mRNA expression. (biomedcentral.com)

Differential expression analysis of ileal, transverse colon, and rectal biopsies were supplemented by a comparison of transcriptomes from platelets and leukocytes subsets, including CD4+, CD8+, CD14+, CD15+, and CD19+ cells. (biomedcentral.com)
Significant differential expression was found in the ileum alone, and not in any other cell/tissue types. (biomedcentral.com)

Ileal mucosa in asthma exhibits a specific transcriptomic profile, which includes the overexpression of innate immune genes, mostly characteristic of Paneth and goblet cells, in addition to other changes that may resemble Crohn's disease. (biomedcentral.com)

We found that maternal arsenic exposure was strongly associated with expression of the AQP9 gene, encoding an aquaglyceroporin transporter, in female but not male fetal placenta. (biomedcentral.com)
The ETS exposure was evaluated by questionnaire disclosure and cotinine measurement in maternal and cord bloods. (nih.gov)
Exposure to tobacco smoke was further evaluated by measurement of plasma cotinine levels in maternal peripheral blood and newborn cord blood using radioimmunoassay. (nih.gov)

We further focused on the susceptibility of asthmatic children to ambient air pollution, an unavoidable environmental exposure of the modern world. (rug.nl)

Fabrizio reached out and was surprised that Dr. Mager remembered their brief conversation, which led to Fabrizio joining Dr. Mager's team as his first graduate student and pursuing an environmental science degree with a toxicology focus. (gulfresearchinitiative.org)
All kinds of life experiences, good and bad, from caring mothers to environmental toxins, leave epigenetic imprints that are passed on for generations afterwards (see [2, 3] Caring Mothers Strike Fatal Blow against Genetic Determinism , and Epigenetic Toxicology , SiS 41). (i-sis.org.uk)

The study demonstrates that even low dose exposure to ETS during pregnancy leads to the significant deregulation of transcriptional regulation in placental and fetal cells. (nih.gov)

Like compounds from biological sources and low-molecular-weight nonoccupational asthma, occupational asthma is probably the chemicals cause occupational asthma after a latent period of result of multiple genetic, environmental, and behavioral exposure. (cdc.gov)

Exposure to a tumor promoter will evoke an altered response pattern wherein initiated cells, but not the normal population, are stimulated to grow. (bvsalud.org)

A characteristic member of this family is the DLG3 gene, is responsible for encoding a synapse associated protein (SAP102). (mtsu.edu)

Our results suggest that AQP9 is upregulated in response to arsenic exposure in female, but not male, fetal placenta. (biomedcentral.com)

and reduced expression of mRNAs encoding major coho odorant receptors (ORs). (cdc.gov)

Anatomy10

Organisms8

Diseases27

Chemicals and Drugs72

Analytical, Diagnostic and Therapeutic Techniques and Equipment43

Psychiatry and Psychology1

Phenomena and Processes62

Disciplines and Occupations11

Anthropology, Education, Sociology and Social Phenomena2

Technology, Industry, Agriculture6

Information Science9

Named Groups1

Health Care44

Geographicals8

Transcription14

Genome12

Genetic factors6

Target genes2

Mutations16

Candidate Genes Associated1

Changes in gene expression9

Protein-codin1

Chromosome3

Differentially4

Interactions3

Alterations7

Functional1

Responses9

Transcript6

Pathways7

Enzymes3

Epigenome1

Orthologous2

Proteins involved1

Epigenetic regulation1

Patterns9

Identify genes2

Induce3

Subset2

Mechanisms10

Several genes2

Factors13

Metabolism2

Regions6

Epithelial1

Analyses1

Response to ethanol2

Developmental8

Metabolic5

Variants1

CDNA2

Ontology2

Membrane-associated1

Organism2

Infection3

Methylation1

Prenatal2

Temperature2

Sequence2

Regulate1

Nrf22

Heritable1

Alteration3

Histone modifications1

Suggests2

Ethanol2

Stimuli1

MRNA expression3

Differential expression2

Immune1

Maternal3

Susceptibility1

Toxicology2

Placental1

Latent1

Tumor1

Characteristic1

Fetal1

MRNAs1