Encode transcription factors genes homeobox. Medical search. Frequent questions

This gene is found on chromosome 20 near NKX2-4, and these two genes appear to be duplicated on chromosome 14 in the form of TITF1 and NKX2-8. (nih.gov)
This gene is one of several homeobox HOXD genes located at 2q31-2q37 chromosome regions. (wikipedia.org)
This gene is one of several homeobox HOXC genes located in a cluster on chromosome 12. (nih.gov)
The Aristaless-related homeobox ( ARX ) gene is located on the X chromosome and encodes a transcription factor that is essential for brain development. (bmj.com)
The NKX2-5 gene on chromosome 5q34 consists of two exons which encode a 324 amino acid protein. (cdc.gov)
This gene is part of the A cluster on chromosome 7 and encodes a DNA-binding transcription factor which may regulate gene expression, morphogenesis, and differentiation. (antibodypedia.com)
It is noteworthy that the HOXB13 gene is located on chromosome 17q, the loss of heterozygosity of which has been noted in cancer of the kidney, breast, ovary, colon and some haematological malignancies. (biomedcentral.com)
Also, our chromosome-level assembly allows the inference of ancient gene linkages (synteny) for the homeobox-containing genes, even though a number of the homeobox gene clusters, like the Hox/ParaHox clusters, are undergoing dispersal in molluscs such as this oyster. (st-andrews.ac.uk)
For example, the TP53 gene, located on chromosome 17, encodes a 53-kd nuclear protein that functions as a cell cycle checkpoint. (medscape.com)
Subject A has a large deletion on chromosome 11 that removes one copy of the BDNF gene. (medscape.com)
The deletion of varying lengths of chromosomal material along the short arm of chromosome 11 is the underlying defect, and developmental abnormalities are related to the contiguous loss of neighboring genes. (medscape.com)

When genes are active, copies of the DNA are made using molecules of ribonucleic acid (RNA) and these can then be used as templates to make proteins. (elifesciences.org)
Another way to control genes is by nonsense-mediated decay, where incorrect or incomplete RNA molecules are destroyed before they can be used to make defective proteins. (elifesciences.org)
This gene encodes a member of the bicoid subfamily of the paired (PRD) homeobox family of proteins. (thermofisher.com)
The main scientific interests of Dr. Zaraisky are focused on structural and functional study of genes and proteins that regulate embryonic development of the brain. (ibch.ru)
An important achievement of the laboratory of molecular bases of embryogenesis is discovering of two novel families of secreted proteins, Noggin2 and Noggin4, whose genes are controlled by Anf homeodomain factors. (ibch.ru)
These novel representatives of Noggin proteins are able to bind and thereby inhibit a number of growth factors of the TGF-β superfamily. (ibch.ru)
What are the largest genes and proteins? (cshlpress.com)
Since the discovery of the Kn1 gene, a large number of transcription factor (TF) genes encoding proteins with homeodomains have been found in all plants and there are about 135 family members in maize. (grassius.org)
A member of the KNOTTED class of homeodomain proteins encoded by the STM gene of Arabidopsis. (grassius.org)
This gene encodes a member of the RIEG/PITX homeobox family, which is in the bicoid class of homeodomain proteins. (utsouthwestern.edu)
They are regulatory genes encoding nuclear proteins that act as transcription factors. (fapesp.br)
Homeobox proteins are master regulators of develop-ment and control many cellular processes, including proliferation, apoptosis, cell shape, and cell migration. (123dok.net)
Like Rb protein, many of the proteins encoded by tumor suppressor genes act at specific points in the cell cycle. (medscape.com)
There are a myriad of mutations identified in genes encoding cardiac transcription factors, ion channels, gap junctions, energy metabolism regulators, lamins and other structural proteins. (medscape.com)
A family of predominantly nuclear proteins that regulate gene transcription and protein degradation. (bvsalud.org)

This gene belongs to the homeobox family of genes. (wikipedia.org)
The HOX gene family belongs to the homeobox superfamily of transcription factors. (biomedcentral.com)

The encoded protein is a major regulator of intestine-specific genes involved in cell growth an differentiation. (ebiocell.com)
Homeobox (HOX) genes encode evolutionarily conserved transcription factors that are essential for embryonic morphogenesis and differentiation [5]. (cancerhugs.com)
HOX genes exert pleiotropic functions in many cell types and may control cell proliferation, differentiation, adhesion, and migration [7]. (cancerhugs.com)
Latest research claim that HOX genes might play essential jobs in ovarian cancer differentiation [9-11]. (cancerhugs.com)
Homeobox genes that encode transcription factors play important roles in development and differentiation of both plant and animal systems. (elsevierpure.com)
To understand the development of adiposity, it is crucial to identify the genes which expression is associated with adipogenic differentiation. (biomedcentral.com)
Proliferation cluster comprised 1028 genes up-regulated from days 3 to 8 of culture meanwhile the differentiation cluster was characterized by 2140 induced genes from days 15 to 21. (biomedcentral.com)
On the other hand, the terminal differentiation phase was enriched with genes involved in energy production, lipid and carbohydrate metabolism. (biomedcentral.com)
Overall, our study demonstrates the coordinated expression of functionally related genes during proliferation and differentiation of rainbow trout adipocyte cells. (biomedcentral.com)
Homeobox genes are master development control genes that act at the top of genetic hierarchies regulating aspects of morphogenesis and cell differentiation in animals. (fapesp.br)
Thus, LMX1B regulates the expression of multiple podocyte genes critical for podocyte differentiation and function. (nih.gov)
These findings demonstrate that chronic exposure of esophageal keratinocytes to acid pH induces transcription of cdx 2, an intestinal specific homeobox gene known to play a critical role in the differentiation and maintenance of intestinal epithelial functions. (silverchair.com)
HOX and homeobox genes play an important role in the regulation of many processes including cell proliferation, differentiation, angiogenesis, receptor signaling, apoptosis and regulate transcription of target androgen receptor genes [ 16 ]. (biomedcentral.com)

Those studies used mice lacking serotonergic neurons resulting from the loss of function mutations in the gene encoding the LIM homeobox transcription factor 1 ( Lmx1b ). (aspetjournals.org)
The germline mutations of cardiac specific transcription factors are the major causes of CHD. (city-made.com)
Mutations in this gene have been reported in patients with defects in ocular development, including microphthalmia, anophthalmia, and coloboma. (antibodies-online.cn)
Mutations in the human RAX homeobox gene in a patient with anophthalmia and sclerocornea. (antibodies-online.cn)
Somatic mutations were identified in NXK2-5 and its molecular partners, TBX5 and GATA4 , as well as the transcription factor HEY2 in formalin fixed tissue taken from a collection of hearts with atrial septal defects (ASD), 8 ventricular septal defects (VSD), and atrioventricular canal defects (AVCD). (cdc.gov)
Mutations in this gene are associated with Axenfeld-Rieger syndrome, iridogoniodysgenesis syndrome, and sporadic cases of Peters anomaly. (utsouthwestern.edu)
In cases with mutations in the HOXB13 gene, the family history of cancer was negative. (biomedcentral.com)
Human genetic studies have identified mutations in the sodium channel SCN5A gene causing tachyarrhythmia disorders, as well as progressive cardiac conduction system diseases, or overlapping syndromes. (medscape.com)

Walter Gehring made a second discovery of fundamental importance in developmental biology as he identified the Pax6 gene (which contains a Homeobox as well), a "master control gene" for eye development in all animals, including humans. (balzan.org)
The transcription factor of the Pax6 gene is critical for the development of the eye in all organisms endowed with a visual system. (balzan.org)
In 1995, Walter Gehring demonstrated the importance of Pax6 in an elegant experiment in which targeted ectopic expression of this gene in the fly generated eyes on legs, wings or antennae. (balzan.org)
Regulation of eye formation by the Rx and pax6 homeobox genes. (antibodies-online.cn)
The homeobox gene Pax6, which participates in eyes primordium perseverance and handles the pluripotency of retinal progenitor cells, regulates Atoh7 transcription [17]C[19] positively. (baxkyardgardener.com)
Meanwhile, the deletion of one copy of the PAX6 gene is responsible for aniridia. (medscape.com)
A neighboring gene, PAX6 , is responsible for the development of the iris. (medscape.com)
Deletion of the PAX6 gene as part of the band 11p13 deletion in patients with AGR or WAGR syndrome results in aniridia. (medscape.com)
Deletion of the PAX6 gene, which plays a role in myelinization of the cerebral hemispheres during CNS development, may also be responsible for the mental retardation seen in the WAGR association. (medscape.com)

The maize homeobox gene knotted1 ( kn1 ) encodes an AP2/ERF transcription factor (Hake et al. (springer.com)
Vollbrecht E, Veit B, Sinha N, Hake S. The developmental gene Knotted-1 is a member of a maize homeobox gene family. (grassius.org)

DUX4 is a double homeobox transcription factor that is normally expressed in the testis and causes apoptosis and FSHD when misexpressed in skeletal muscle. (elifesciences.org)
We have previously identified a double homeobox gene ( DUX4 ) within each D4Z4 unit that encodes a transcription factor expressed in FSHD but not control myoblasts. (fshfriends.org)

The transcription factor encoded by the homeobox gene A10 (HOXA10) regulates the identity imparted to the undifferentiated paramesonephric duct during embryogenesis. (usp.br)
It is also expressed in embryonic and adult olfactory neuroepithelia where it complexes with eukaryotic translation initiation factor 4E (eIF4E) and possibly regulates mRNA transport or translation. (abnova.com)
2021). ZmHOX32 , a member of the HD-ZIP III family (that also harbor a START domain that is able to bind to steroid ligands), appears to function in leaf morphogenesis and plant photosynthesis as judged by the enriched category of downstream genes that it regulates (Miao et al. (grassius.org)
The gene is expressed early in the eye primordia, and is required for retinal cell fate determination and also regulates stem cell proliferation. (antibodies-online.cn)
The encoded protein acts as a transcription factor and regulates procollagen lysyl hydroxylase gene expression. (utsouthwestern.edu)

The protein encoded by this gene contains a homeobox domain and may be involved in the morphogenesis of the central nervous system. (nih.gov)
The homeobox genes encode a highly conserved family of transcription factors that play an important role in morphogenesis in all multicellular organisms. (wikipedia.org)
This homeobox transcription factor is expressed during early cardiac morphogenesis and serves as a master regulatory protein. (cdc.gov)

This gene encodes a homeobox-containing transcription factor that is the homolog to the 'empty spiracles' gene in Drosophila. (abnova.com)
Age-related gene expression profiles of the short-lived model animals Caenorhabditis elegans and Drosophila melanogaster share a common adult-onset expression program of genes involved in mitochondrial metabolism, DNA repair, catabolism, peptidolysis and cellular transport 3 . (nature.com)
DLX1 encodes a member of a homeobox transcription factor gene family similiar to the Drosophila distal-less gene. (ern-ithaca.eu)

Furthermore, this study also provides insights into how aberrant activation of a developmental patterning gene promotes tumor pathogenesis. (tmc.edu)
Currently, the role of these genes in development and tumor progression has been extensively studied. (fapesp.br)
Thus the genetic basis leading to a better or worse prognosis for survival in cancer patients may be dependent on functional polymorphisms in genes such as genes responsible for tumor transformation, xenobiotic metabolism, oxidative stress, detoxification and DNA repair. (biomedcentral.com)
A mutation in the TP53 gene overexpresses the p53 protein and increases the risk of tumor progression [ 7 ]. (biomedcentral.com)
Altered expression of HOX genes may be important for oncogenesis and tumor suppression by influencing various pathways that promote tumorigenesis and metastasis. (biomedcentral.com)
Healthy animals injected with pro-inflammatory IL-1β and tumor necrosis factor alpha (TNF-α) cytokines demonstrate 'sickness behavior' associated with social withdrawal [ 12 ]. (biomedcentral.com)
In addition, these alterations affect 3 principal categories of genes, as follows: proto-oncogenes, tumor suppressor genes, and DNA repair genes. (medscape.com)
This article briefly discusses tumor suppressor genes and then focuses on the role of proto-oncogenes in childhood cancer. (medscape.com)
Inactivation of tumor suppressor genes, whose products normally provide negative control of cell proliferation, contributes to malignant transformation in various cell types. (medscape.com)
[ 1 ] His prediction was subsequently supported by the cloning of the retinoblastoma tumor suppressor gene ( RB1 ) and by functional studies of the retinoblastoma protein, Rb. (medscape.com)
Another important class of tumor suppressor genes involved in cell cycle control and in the generation of human cancers is the cyclin-dependent kinase (CDK) inhibitors. (medscape.com)
See Wilms Tumor: A Pediatric Oncology Success Story , a Critical Images slideshow, to help identify the clinical features, staging evaluation, prognostic factors, and therapeutic options for this tumor. (medscape.com)
The constitutional loss of one allele of the Wilms tumor gene ( WT1 ) results in GU anomalies and forms the first of 2 genetic events in the development of a Wilms tumor. (medscape.com)
The identification of the gene responsible for Wilms tumor did not occur until 1990, when 3 groups independently identified the WT1 gene on band 11p13. (medscape.com)
Both the GU abnormalities and the development of a Wilms tumor in patients with WAGR syndrome are related to the loss of WT1 gene function. (medscape.com)

CDX2 is a homeobox gene that encodes an intestine-specific transcription factor. (micro-shop.pl)

Search for RefSeq genes (e.g. (vectorbuilder.kr)

Deletions that removed the entire HOXD gene cluster or 5' end of this cluster have been associated with severe limb and genital abnormalities. (wikipedia.org)
The deletion of both Nr2f genes causes almost agenesis of the hippocampus with abnormalities of trisynaptic circuit and adult neurogenesis. (elifesciences.org)
Abnormalities in cardiac conduction can occur due to a variety of factors, including developmental and congenital defects, acquired injury or ischemia of portions of the conduction system, or less commonly due to inherited diseases that alter cardiac conduction system function. (medscape.com)

The effects of a maize knotted1 ( kn1) gene under the control of the cauliflower mosaic virus 35S promoter on genetic transformation efficiencies of six citrus genotypes were tested. (springer.com)
Genetic analysis of plant architecture has led to the discovery of key genes that function in meristems, including the maize ( Zea mays ) transcription factor knotted1 ( kn1 ), the founding member of the kn1 homeobox ( knox ) gene family (Vollbrecht et al. (grassius.org)
Bolduc N, Tyers RG, Freeling M, Hake S. Unequal redundancy in maize knotted1 homeobox genes. (grassius.org)

In a genome-wide association study we found highly significant associations between RLS and intronic variants in the homeobox gene MEIS1, the BTBD9 gene encoding a BTB(POZ) domain as well as variants in a third locus containing the genes encoding mitogen-activated protein kinase MAP2K5 and the transcription factor LBXCOR1 on chromosomes 2p, 6p and 15q, respectively. (tum.de)
In a genome-wide association study we found highly significant associations between RLS and intronic variants in the homeobox gene MEIS1, the BTBD9 gene encoding a BTB(POZ) domain as well as variants in a third locus containing the genes encoding mitogen-activated protei. (tum.de)
Alternatively spliced transcript variants encoding distinct isoforms have been described. (utsouthwestern.edu)
and (iv) genes harboring germline non-silent variants presumed to confer a risk of sporadic ALL. (haematologica.org)
Two transcript variants encoding two different isoforms have been found for this gene, with only one of the isoforms containing the homeodomain region. (antibodypedia.com)
The genes encoding enzymes involved in the process of metabolic activation, detoxification and DNA repair are polymorphic and there are some structural variants of genes in the population associated with different activity of the enzyme they encode. (biomedcentral.com)

High transformation efficiency of citrus is of great importance for large scale characterization of gene functions and also cultivar development via transgenic and genome editing technologies. (springer.com)
The homeobox transcription factor HOXC13 upregulates human papillomavirus E1 gene expression and contributes to viral genome maintenance. (nih.gov)
Genome-wide transcriptional profiling using RNA-Seq revealed few age-related changes in gene expression in muscle and esophagus tissue. (nature.com)
Gene expression is a key determinant of cellular phenotype, and genome-wide expression analysis can provide insight into the molecular events underlying complex processes such as aging. (nature.com)
How many genes are in the human genome? (cshlpress.com)
How many mobile elements, simple sequence repeats, or protein kinases are encoded in the genome? (cshlpress.com)
How Many Protein-coding Genes Are Present in the Genome? (cshlpress.com)
Which Genes Are Present in the Mitochondrial Genome? (cshlpress.com)
How Are Genes Organized in the Mitochondrial Genome? (cshlpress.com)
How Are microRNA Genes Distributed in the Genome? (cshlpress.com)
What Is the Size Distribution of snRNA Genes and Related Sequences in the Genome? (cshlpress.com)
How Many Protein Kinases Are Encoded in the Genome? (cshlpress.com)
In animals, some homeobox genes are clustered together in the genome, either as remnants from ancestral genomic arrangements, or due to coordinated gene regulation. (st-andrews.ac.uk)
Consequently, analyses of homeobox gene organization across animal phylogeny provide important insights into the evolution of genome organization and developmental gene control, and their interaction. (st-andrews.ac.uk)

Mammals possess four similar homeobox gene clusters, HOXA, HOXB, HOXC and HOXD, located on different chromosomes, consisting of 9 to 11 genes arranged in tandem. (wikipedia.org)
We proven that three HOXA genes previously, HOXA4, HOXA7 and HOXA10, had been overexpressed in serous ovarian adenocarcinomas in comparison with harmless serous tumors or tumors with low malignant potential. (cancerhugs.com)

There was an age-related upregulation in expression of genes involved in synaptogenesis, axonogenesis and neuroprotection suggesting preservation of neuronal processes with age. (nature.com)
The reduced expression of genes involved in mitochondrial oxidative respiration occurs in early adulthood, before the onset of functional decline, and more abruptly than a damage-response model would predict, which supports the possibility of programmed age-related transcriptional regulation 3 . (nature.com)
TP53 activates the expression of genes involved in apoptosis, cell cycle regulation (p21), and MDM2. (medscape.com)

Studies of the mouse and chick homolog suggest the encoded protein may play a role in developing teeth and craniofacial mesenchyme of neural crest origin. (nih.gov)

Mammalians have at least 39 HOX genes that are arranged in four clusters termed HOX A, B, C, and D [6]. (cancerhugs.com)
In vertebrates, the genes encoding the class of transcription factors called homeobox genes are found in clusters named A, B, C, and D on four separate chromosomes. (antibodypedia.com)

Total count of NCBI Gene Reference Into Function hits for target listed in parenthesis, and summary table with links to publications per PMID with the specific text in article that includes the reported target. (nih.gov)

The p19ARF protein, which is encoded by the same locus as p16, also leads to cell cycle arrest by inhibiting the ability of MDM2 to inactivate TP53. (medscape.com)
This locus, however, also encodes a protein from an alternative reading frame, designated p19ARF. (medscape.com)

Genes are sequences of DNA that contain instructions for the cell that must be carefully controlled because it is not always appropriate or safe for these instructions to be followed. (elifesciences.org)
He showed that the Homeodomain binds to specific DNA sequences of the promoter region of certain genes. (balzan.org)
Which Sequences Are Shared in Helix-loop-helix Transcription Factors? (cshlpress.com)
We identified several LMX1B binding sites in the putative regulatory regions of both CD2AP and NPHS2 (podocin) and demonstrated that LMX1B binds to these sequences in vitro and can activate transcription through them in cotransfection assays. (nih.gov)
Furthermore, external acid environment triggered expression of the GFP reporter gene fused downstream of the cdx 2 intestinal homeogene regulatory sequences in P3E6 transfected cells. (silverchair.com)
[ 2 ] The product of the WT1 gene has zinc finger arrays that bind to specific DNA sequences, whereas the amino terminus appears to regulate transcription. (medscape.com)

[ 4 ] The Hox genes, well described as the master regulators of development, encode a set of transcription factors that specify the identity of particular segments during embryogenesis. (medscape.com)

With all six genotypes of citrus tested including Eureka lemon, a cultivar difficult to be transformed, our results demonstrate that the kn1 gene may provide an effective molecular tool to enhance genetic transformation efficiencies of various citrus varieties. (springer.com)
Other genes whose mutation produces homeotic transformations were discovered and analysed by Edward Lewis in the United States using classical genetic techniques. (balzan.org)
Moreover, the conservation of this genetic control of eye development throughout evolution was demonstrated by the fact that insect and mammalian genes are interchangeable. (balzan.org)
Which genes are commonly associated with genetic diseases? (cshlpress.com)
Abnormal cardiac development appears to occur through a process that is heterogeneous and complex, with both environmental and genetic risk factors. (cdc.gov)
Historically, genetic factors identified by conventional karyotyping have been used to diagnose ALL and to risk-stratify children with the disease. (haematologica.org)
Explore the normal functions of human genes and the health implications of genetic changes. (medlineplus.gov)
The genetic structure includes 4 zinc-finger regions, which suggest that WT1 may be important in controlling the expression of other genes. (medscape.com)

Description: Pancreatic duodenal homeobox-1 protein (PDX-1), also designated Insulin promoter factor (IPF1), Insulin upstream factor 1 (IUF1), somatostatin transactivating factor-1 (STF-1) and glucose-sensitive factor (GSF), is a 282 amino acid homeodomain-containing transcription factor present in pancreatic cells. (lifchem.com)

How Does Codon Usage Vary Among Human Genes? (cshlpress.com)

Description: PDX1 (pancreatic and duodenal homeobox 1), also known as insulin promoter factor 1, is a transcription factor in the ParaHox gene cluster. (lifchem.com)

In contrast, radial nerve showed an unexpected level of complexity with the expression of 3,370 genes significantly altered more than two-fold with age, including genes involved in nerve function, signaling, metabolism, transcriptional regulation and chromatin modification. (nature.com)
The protein encoded by this gene is a transcriptional activator of several genes, including insulin, somatostatin, glucokinase, islet amyloid polypeptide, and glucose transporter type 2. (lifchem.com)

HOXC-AS2 mediates the proliferation, apoptosis, and migration of non-small cell lung cancer by combining with HOXC13 gene. (nih.gov)
The TP53 gene is also capable of stimulating apoptosis of cells containing damaged DNA. (medscape.com)

The rostral division of the neural tube into its 3 main sections falls under the control of homeobox (Hox) family of genes. (medscape.com)
Further investigation of the gene network related to the functioning of Anf led to the discovery of a novel, the 8th, a family of small GTFases, named as Ras-dva, which are specifically expressed in the forebrain rudiment and regulate its early development. (ibch.ru)
The HD-ZIP gene family is composed of two functional domains, i.e. (grassius.org)
HD-ZIP Gene Family: Potential Roles in Improving Plant Growth and Regulating Stress-Responsive Mechanisms in Plants. (grassius.org)
This gene is a member of the caudal-related homeobox transcription factor gene family. (ebiocell.com)
The WUSCHEL (WUS)-related homeobox (WOX) gene family coordinates transcription during the early phases of embryogenesis. (gc.ca)
This gene encodes a protein belonging to the B7 costimulatory protein family. (transcriptionfactor.org)
Background: HOX genes encode a family of homeodomain-containing transcription factors involved in the determination of cell fate and identity during embryonic development. (123dok.net)
This gene encodes a member of a large protein family which contains the LIM domain, a unique cysteine-rich zinc-binding domain. (origene.com)

The product of this gene may play a role in the development of hair, nail, and filiform papilla. (nih.gov)
These genes encode for the homeodomain transcription factors, which play a key role in regulation of the early forebrain development in Vertebrates. (ibch.ru)
Transforming growth factor-b (TGF-b) is a cytokine that plays essential roles in regulating embryonic development and tissue homeostasis. (tmc.edu)
Transcription factor, which is involved in craniofacial development, in odontogenesis and in stomach organogenesis. (nih.gov)
This gene encodes a homeobox-containing transcription factor that functions in eye development. (antibodies-online.cn)
transcription increased during seed development and declined after the embryos matured, suggesting that WOX2 is associated with embryo development in Ae. (gc.ca)
Despite of the relevance of this issue, very little is known about the factors regulating the development of adipose tissue in fish, and the possible health alterations associated to an increased fat deposition. (biomedcentral.com)
In order to understand the development of adiposity, it is crucial to identify the factors and mechanisms that regulate the recruitment of mesenchymal stem cells (MSCs) of the vascular stromal fraction of the adipose tissue and its transformation into lipid-filled adipocytes. (biomedcentral.com)
This is an important study demonstrating distinct roles for the nuclear receptor genes COUP-TFI and COUP-TFII in hippocampal development. (elifesciences.org)
The encoded nuclear protein is involved in the early development of the pancreas and plays a major role in glucose-dependent regulation of insulin gene expression. (lifchem.com)
The encoded protein may be involved in the placement of hindbrain segments in the proper location along the anterior-posterior axis during development. (antibodypedia.com)
Because chronic exposure to acid pH is known to be a critical factor for BE development,culture medium at pH 3.5 was added into the apical chamber of cell cultures. (silverchair.com)
Genes whose expression leads to the development of bladder and kidney cancer are being searched for. (biomedcentral.com)
Background: Homeobox-containing genes encode crucial transcription factors involved in animal, plant and fungal development, and changes to homeobox genes have been linked to the evolution of novel body plans and morphologies. (st-andrews.ac.uk)
The encoded protein is a transcription factor important for the development of the renal and urogenital systems. (origene.com)
Next, the importance of embryonic developmental genes such as homeobox and T-box transcription factors are highlighted in conduction system development and function. (medscape.com)

Homeobox protein Hox-D9 is a protein that in humans is encoded by the HOXD9 gene. (wikipedia.org)
Results: In this study, we found high expression of the HOXD9 gene transcript in glioma cell lines and human glioma tissues by quantitative real-time PCR. (123dok.net)
The HOXD9 gene was highly expressed in a side population (SP) of SK-MG-1 cells that was previously identified as an enriched-cell fraction of glioma cancer stem-like cells. (123dok.net)
Conclusions: Our results suggest that HOXD9 may be a novel marker of GCSCs and cell proliferation and/or survival factor in gliomas and glioma cancer stem-like cells, and a potential therapeutic target. (123dok.net)

Number of Gene Ontology (GO) annotations for this target, consisting of the sum of GO Functions and GO Processes. (nih.gov)

The muscle disease facioscapulohumeral muscular dystrophy (FSHD) is caused by the loss of the chemical tags that normally keep certain genes switched off in many cell types. (elifesciences.org)

On this basis, Homeobox-containing genes are called developmental control genes. (balzan.org)

ZEB1 encodes a zinc finger transcription factor that represses T-lymphocyte-specific IL2 gene (MIM 147680) expression by binding to a negative regulatory domain 100 nucleotides 5-prime of the IL2 transcription start site (Williams et al. (novusbio.com)
The protein encoded by ZEB1 gene (Zinc finger E-box-Binding homeobox) may be a potential indicator of invasive endometriosis. (endonews.com)
The protein encoded by ZEB1 gene ( Z inc finger E -box -B inding homeobox) may be a potential indicator of invasive endometriosis and its action may be related to its epithelial-mesenchymal transition properties. (endonews.com)
ZEB1 is a transcription factor that has been implicated in the malignant progression of tumors, such as lung cancers. (endonews.com)
in their recent article that will be published in Acta Obstet Gynecol Scand, report that the protein encoded by ZEB1 gene ( Z inc finger E -box -B inding homeobox) is a potential indicator of invasive endometriosis. (endonews.com)

The creation of RGCs (S)-(+)-Flurbiprofen from the retinal primordium can be strictly handled by cell-intrinsic transcription elements and inspired by cell-extrinsic indicators. (baxkyardgardener.com)

The presence of a homeodomain (HD), which comprises 60 amino acids, makes a three-helix tertiary structure, that binds the promoter regions of specific target genes (Sharif et al. (grassius.org)
DUX4 and its target genes contribute to the global dysregulation of gene expression observed in FSHD. (fshfriends.org)

Which Genes Have the Most Exons? (cshlpress.com)

A number of mechanisms play a large role in the initiation of neoplastic transformation of bladder or kidney cancer, including: mutation of suppressor genes, activation of proto-oncogenes, abnormal and over-expression of oncogenes through amplification and deletion of some regions of chromosomes, and methylation. (biomedcentral.com)

This feedback loop illustrates an unexpected mode of autoregulatory behavior of a transcription factor, is consistent with 'bursts' of DUX4 expression in FSHD muscle, and has implications for FSHD pathogenesis. (elifesciences.org)

Research on this gene in humans has focused on its expression in three tissues: dorsal telencephalon, olfactory neuroepithelium, and urogenetial system. (abnova.com)

The strength of evidence is compelling , using rigorous state-of-the-art methods to demonstrate functional redundancy of these genes in regulating the Lhx2/Lhx5 axis. (elifesciences.org)

Aberrant expression of this gene is associated with intestinal inflammation and tumorigenesis. (ebiocell.com)

Germline mutation of one TP53 allele is found in patients with Li-Fraumeni syndrome who generally inherit a mutated TP53 gene from an affected parent. (medscape.com)

Defects in this gene are a cause of pancreatic agenesis, which can lead to early-onset insulin-dependent diabetes mellitus (IDDM), as well as maturity onset diabetes of the young type 4 (MODY4). (lifchem.com)

Bone marrow & Lymphoid tissues Brain Breast and female reproductive system Connective & Soft tissue Endocrine tissues Eye Gastrointestinal tract Kidney & Urinary bladder Liver & Gallbladder Lymphoid Male reproductive system Muscle tissues Myeloid Pancreas Proximal digestive tract Respiratory system Skin * nTPM: Normalized TPM levels represent consensus gene expression calculated using two data sets. (antibodypedia.com)

These are the so-called high penetration genes or so-called low penetration genes whose expression disturbs metabolism and may initiate the process of neoplastic transformation of various organs. (biomedcentral.com)

Anatomy20

Organisms17

Chemicals and Drugs116

Analytical, Diagnostic and Therapeutic Techniques and Equipment22

Phenomena and Processes77

Disciplines and Occupations2

Technology, Industry, Agriculture2

Information Science4

Health Care1

Chromosome11

Proteins15

Belongs to the homeobox2

Differentiation13

Mutations8

Pax69

Maize homeobox2

Double homeobox2

Regulates5

Morphogenesis3

Drosophila3

Tumor15

CDX21

RefSeq1

Abnormalities3

Knotted13

Variants6

Genome14

HOXA2

Expression of genes invol3

Homolog1

Clusters2

PMID1

Locus2

Sequences6

Master regulators1

Genetic8

Amino acid1

Human Genes1

Cluster1

Transcriptional2

Apoptosis2

Family9

Development16

HOXD94

Ontology1

Certain genes1

Control genes1

ZEB15

Retinal1

Target genes2

Exons1

Proto-oncogenes1

Pathogenesis1

Humans1

Redundancy1

Intestinal1

Mutation1

Pancreatic1

Tissue1

Metabolism1