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In this study, we evaluated the association between neuroendocrine gene signature and 18F-FDG uptake-associated genes including glucose transporters (GLUTs) and hexokinases, with the goal of providing a genomic signature to explain the reported 18F-FDG avidity of PSMA-suppressed tumors. (bvsalud.org)
Here, we examined the genetic diversity, distribution and mobilisation of iuc and iro loci amongst 2503 K . pneumoniae genomes using comparative genomics approaches and developed tools for tracking them via genomic surveillance. (biomedcentral.com)
This study provides a framework for identifying and tracking these important virulence loci, which will be important for genomic surveillance efforts including monitoring for the emergence of hypervirulent MDR K . pneumoniae strains. (biomedcentral.com)
These high-risk pathogens have developed mainly by acquiring different mobile genetic elements (MGEs), including plasmids and genomic islands (GIs) encoding an array of virulence and antibiotic resistance factors[ 2 ]. (biorxiv.org)
PCR cloning of the argD gene from genomic E. coli DNA, expression, and purification yielded homogeneous E. coli NAcOATase. (unipr.it)
26 genomic loci were identified whose haploinsufficiency can modify these CDK8- or CycC-specific phenotypes. (sdbonline.org)
Analysis of rlrA negative isolates revealed heterogeneity in the genomic region downstream of the rfl gene, the region where the islet is found in other isolates, compatible with recent loss of the islet in some lineages. (biomedcentral.com)
Therefore comparative genomic analysis of T . equi was undertaken to: 1) identify genes contributing to immune evasion and persistence in equid hosts, 2) identify genes involved in PBMC infection biology and 3) define the phylogenetic position of T . equi relative to sequenced apicomplexan parasites. (biomedcentral.com)
Comparative genomic analysis of T . equi revealed the phylogenetic positioning relative to seven apicomplexan parasites using deduced amino acid sequences from 150 genes placed it as a sister taxon to Theileria spp . (biomedcentral.com)

Whole genome sequences of these isolates were determined and analysed to compute bacterial multilocus sequence types and plasmid replicon types, infer phylogenetic relationships, and identify antimicrobial resistance and virulence genes. (biomedcentral.com)
In particular, we identified hospital outbreaks, detected introductions from abroad, and uncovered clonal expansions associated with resistance and virulence genes. (klebnet.org)
Long-Read Sequencing Reveals Evolution and Acquisition of Antimicrobial Resistance and Virulence Genes in Salmonella enterica. (cdc.gov)

This phenomenon, designated lysis inhibition (LIN), was first described in the 1940s and is genetically defined by mutations in diverse T4 r genes. (tamu.edu)
For practical purposes, depending on the enzyme activity and the presence of mutations in the G6Pase and T genes, respectively, GSD type I may be subdivided into 2 major forms. (medscape.com)
It is an autosomal recessive disorder in which there is an AGL gene mutations which causes deficiency in glycogen debranchinging enzyme and limited storage of dextrin. (medscape.com)
Mutations in this gene are associated with an increased susceptibility to viral, bacterial and parasitic infections and to several autoimmune diseases. (origene.com)
Mutations in B3GALT6, which encodes a glycosaminoglycan linker region enzyme, cause a spectrum of skeletal and connective tissue disorders. (genscript.com)
Via positional cloning, we show that mutations in a zebrafish LTCC encoding gene, cav1.3a , underlie the auditory-vestibular defects of gemini ( gem ) circler mutants. (jneurosci.org)
There are currently 20 retinal genes whose mutations cause the phenotype of LCA, accounting for about 70% of the cases, while the genes underlying the remaining 30% of patients await discovery. (aao.org)
Visual acuity (VA) in children with LCA varies significantly among patients with differing gene mutations and can be as low as no light perception (NLP). (aao.org)
USH2A gene mutations in rabbits lead to progressive retinal degeneration and hearing loss. (harvard.edu)
Antimicrobial resistance occurs through different mechanisms, which include spontaneous (natural) genetic mutations and horizontal transfer of resistant genes through deoxyribonucleic acid (DNA). (who.int)

Due to an inability to genetically manipulate Las at the present time, the translocase (tlc) open reading frame was cloned and expressed in Escherichia coli to determine if this putative gene was in fact functional. (usda.gov)
The genome of the model actinomycete Streptomyces coelicolor A3(2) encodes seven putative LPMOs, of which, upon phylogenetic analysis, four group with typical chitin-oxidizing LPMOs, two with typical cellulose-active LPMOs, and one which stands out by being part of a subclade of non-characterized enzymes. (nature.com)
T . equi has lost the putative genes for host cell transformation, or the genes were acquired by T . parva and T . annulata after divergence from T . equi . (biomedcentral.com)

Bacterial DNA is placed into the bacteriophage genome via bacterial transduction. (wikipedia.org)
A single translocase encoding gene was identified through an in silico analysis of the recently completed Las genome. (usda.gov)
The TMV genome encodes four proteins which participate in several viral functions required for a successful infection. (biomedcentral.com)
How many genes are in the human genome? (cshlpress.com)
How many mobile elements, simple sequence repeats, or protein kinases are encoded in the genome? (cshlpress.com)
How Many Protein-coding Genes Are Present in the Genome? (cshlpress.com)
Which Genes Are Present in the Mitochondrial Genome? (cshlpress.com)
How Are Genes Organized in the Mitochondrial Genome? (cshlpress.com)
How Are microRNA Genes Distributed in the Genome? (cshlpress.com)
What Is the Size Distribution of snRNA Genes and Related Sequences in the Genome? (cshlpress.com)
How Many Protein Kinases Are Encoded in the Genome? (cshlpress.com)
Indeed, a number of genes identified as potential manipulators of the host cell phenotype are absent from the T . equi genome. (biomedcentral.com)

The final result of conjugation, transduction, and/or transformation is the production of genetic recombinants, individuals that carry not only the genes they inherited from their parent cells but also the genes introduced to their genomes by conjugation, transduction, and/or transformation. (wikipedia.org)
Botstein is honored for contributions that include developing methods for defining genetic pathways, mapping genomes, and analyzing gene expression. (genestogenomes.org)
Using Pathogenwatch, we found that GHRU genomes were dominated by a small number of epidemic drug-resistant clones of K. pneumoniae . (klebnet.org)
The genomes of Antiqua and Nepal516 are 4.7 Mb and 4.5 Mb and encode 4,138 and 3,956 open reading frames, respectively. (asm.org)
The genomes of the pediococcal strains were sequenced and searched for genes encoding aminotransferases to test the hypothesis that AABA could result from the transamination of α-ketobutyrate. (springeropen.com)
RCandy: an R package for visualising homologous recombinations in bacterial genomes. (cdc.gov)
The population of P. aeruginosa in the Philippines was diverse, with clonal expansions of XDR genomes belonging to multi-locus sequence types ST235, ST244, ST309, and ST773. (who.int)

It was discovered that a locus in Solanum lycopersicoides, termed Pseudomonas tomato race 1 (Ptr1), confers resistance to race 1 Pst strains by recognizing the type III effector AvrRpt2. (cornell.edu)
however, individual strains vary in their virulence potential due to the presence of mobile accessory genes. (biomedcentral.com)
Concerningly, iuc has also been reported in MDR strains in the hospital setting, where it was associated with increased mortality, highlighting the need to understand, detect and track the mobility of these virulence loci in the K . pneumoniae population. (biomedcentral.com)
However, only the hly, cnf, pap and iroN genes occurred significantly Selleck PD 332991 more frequently when comparing the strains from pregnant women (48) with those from nonpregnant women (38) (Table 2). (proteasomesignaling.com)
Strategies and Components Bacterial strains, plasmids, and mass media. (technuc.com)
The bacterial strains and plasmids found in this scholarly research are shown in Desk ?Desk1.1. (technuc.com)
We uncovered 13 mutant strains that resolved into multiple alleles of each of three deflagellation genes: (Finst 1998). (healthcarecoremeasures.com)
Phylogenomics of two ST1 antibiotic-susceptible non-clinical Acinetobacter baumannii strains reveals multiple lineages and complex evolutionary history in global clone 1. (cdc.gov)

The antimicrobial resistance (AMR) and/or virulence determinants possessed by the associated bacteria are generally found on mobile genetic elements (MGEs) that transmit between K . pneumoniae cells via horizontal gene transfer (HGT) [ 4 ]. (biomedcentral.com)
The multi-locus sequence type, presence of antimicrobial resistance (AMR) determinants, and relatedness between the isolates were derived from the sequence data. (who.int)

In some cases, the DNA repair capability provided by recombination during transformation facilitates survival of the infecting bacterial pathogen. (wikipedia.org)
Although the bacterial translocase has been characterized in other intercellular pathogens such as Chlamydia trachomatis and Rickettsia prowazeki, this is the first characterization of an ATP/ADP translocases in an obligate-intracellular plant pathogen and, given the conservation of the ATP uptake mechanism, may represent an evolutionary link between plant and animal pathogens. (usda.gov)
tomato (Pst) is a persistent pathogen of tomato that causes bacterial speck disease. (cornell.edu)

In contrast, bacteria also import genes in a process called homologous recombination, first discovered by the observation of mosaic genes at loci encoding antibiotic resistance. (wikipedia.org)
The discovery of homologous recombination has made an impact on the understanding of bacterial evolution. (wikipedia.org)
For example, bacterial recombination has been shown to promote the transfer of multi drug resistance genes via homologous recombination that goes beyond levels purely obtained by mutation. (wikipedia.org)

A gene encoding a novel transmembrane protein was identified by DNA sequence analysis within the insulin-dependent diabetes mellitus (IDDM) locus IDDM4 on chromosome 11q13. (nih.gov)
To be able to directly compare the impact of the PC on the levels of neutralizing antibody (NT-abs) responses, a PC-positive variant of the HCMV laboratory strain Towne was established by bacterial artificial chromosome (BAC) mutagenesis (Towne-UL130rep). (asm.org)
The use of selected polymorphic markers showed that this locus, denoted DSTM1 (Delayed Systemic Tobamovirus Movement 1), is positioned on the large arm of chromosome II. (biomedcentral.com)
Slc11a1 is encoded in the Idd5.2 region on mouse chromosome 1. (biomedcentral.com)
The gene is located in an approximately 400 kb region of high linkage disequilibrium (LD) on chromosome 2q35. (biomedcentral.com)
de Bary] on chromosome 4 of a dihaploid potato clone (Solanum tubersoum subsp. (hutton.ac.uk)
The bacterial artificial chromosome (BAC) collection was from Clemson School Genomics. (healthcarecoremeasures.com)

Bacterial recombination is a type of genetic recombination in bacteria characterized by DNA transfer from one organism called donor to another organism as recipient. (wikipedia.org)
Today, genetic exchange, or gene transfer is viewed as a major driving force in the evolution of prokaryotes. (wikipedia.org)
The cells undergo horizontal gene transfer in which the genetic material is transferred. (wikipedia.org)
Ten plasmids encoding either KPC-2, NDM-1, or NDM-7 carbapenemases were characterized, including novel plasmids with increased resistance gene load and a novel genetic environment for bla KPC-2 gene. (biorxiv.org)
Genetic crosses between Col-0 and Uk-4 ecotypes, followed by analysis of viral movement in F 1 and F 2 populations, revealed that this delayed movement correlates with a recessive, monogenic and nuclear locus. (biomedcentral.com)
2006. Construction of a 10,000 marker ultradense genetic recombination map of potato: providing a framework for accelerated gene isolation and genomewide physical map . (hutton.ac.uk)
Which genes are commonly associated with genetic diseases? (cshlpress.com)
[ 1 ] Three biovars (with minor genetic variations) have been identified within the Y pestis clone-Antiqua, Medievalis, and Orientalis. (medscape.com)
The virulence of this bacterium results from the 32 Y pestis chromosomal genes and two Y pestis -specific plasmids, constituting the only new genetic material acquired since its evolution from its predecessor. (medscape.com)

Based on its chromosomal position, this gene is a candidate for conferring susceptibility to diabetes. (nih.gov)

However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. (origene.com)
Sequence analysis identified both of these sequences as being identical to corresponding sequences from the PLP-dependent E. coli argD-encoded N-acetylornithine aminotransferase (NAcOATase). (unipr.it)
The following B3GALT6 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). (genscript.com)

We conclude that rs3731685 (INT4) in the SLC11A1 gene may be associated with T1D susceptibility in the European ancestry population studied. (biomedcentral.com)
A total of 110 clinical isolates of A. baumannii , collected in a recent 2-year period, were tested for carbapenem antibiotic susceptibility, followed by a molecular analysis of carbapenemase genes. (frontiersin.org)

When Fink's career began, the discovery of DNA and the molecular biology revolution had changed little about the study of yeast genetics because there was no method to introduce DNA into a yeast cell, a critical step for tinkering with genes in vivo . (genestogenomes.org)
The molecular sequence of this clone aligns with the gene accession number as a point of reference only. (origene.com)
This universal term is currently commonly used to spell it out the sensation whereby the deposition of the diffusible, low-molecular-weight indication molecule (occasionally known as a pheromone or autoinducer) allows specific bacterial cells to feeling when the minimal people device or quorum of bacterias has been attained for the concerted people response to become initiated (15). (technuc.com)
reported the dissemination of MDR OXA-23-producing A. baumannii clones throughout multiple cities in China, but little is known about the molecular mechanisms of resistance to carbapenems in western China. (frontiersin.org)

This approach, which exploits recent technical developments in high-throughput nucleotide sequence determination and combines them with conceptual advances in bacterial population biology, has proved to be successful for a number of bacteria ( 12 - 15 ). (cdc.gov)
Bacteria reproduces asexually, where daughter cells are clones of the parent. (wikipedia.org)
He started working with the organism as a Yale graduate student spurred by the recent discovery in bacteria of operons-clusters of genes with related function controlled by a shared regulatory element transcribed into a single messenger RNA. (genestogenomes.org)
This finding may explain why numerous investigations have failed to identify genetically the bacterial dapC locus, and suggests that this enzyme may be an attractive target for antibacterial inhibitor design due to the essential roles of these two pathways in bacteria. (unipr.it)
Streptomyces , the dominating genus of the actinobacteria phylum, are Gram-positive and mostly facultative aerobic, soil bacteria that possess a vast number of genes encoding Carbohydrate-Active enZymes (CAZymes), providing a multifaceted repertoire of enzymes for deconstruction of complex structural carbohydrates of high recalcitrance. (nature.com)
Upon detection of environmental alterations, bacteria adjust their gene expression in order to obtain a phenotype that is suitable for the environment to which they are exposed ( Federle, 2012 ). (frontiersin.org)
After ingestion of infected blood, the bacteria survive in the midgut of the flea owing to a plasmid-encoded phospholipase D that protects them from digestive juices. (medscape.com)

In particular, gene clusters encoding the biosynthesis of siderophores aerobactin ( iuc ) and salmochelin ( iro ) are associated with invasive disease and are common amongst hypervirulent K . pneumoniae clones that cause severe community-associated infections such as liver abscess and pneumonia. (biomedcentral.com)
The most abundant carbapenemase gene family in the K. pneumoniae isolates (33/39) was bla OXA-232 , with bla NDM-1 additionally identified in 19 of them. (biomedcentral.com)
Multidrug and carbapenem-resistant K. pneumoniae (CR- Kp ) are considered critical threats to global health and key traffickers of resistance genes to other pathogens. (biorxiv.org)

We readily detected off-target alterations induced by four out of six RGENs targeted to endogenous loci in human cells by examination of partially mismatched sites. (cdc.gov)

High resistance to most of the antibiotics tested was observed among the isolates, five ST25, three ST11, one ST45, and one ST505, which harbored a total of 44 plasmids, many of them predicted to be conjugative and carrying genes conferring resistance to a variety of antibiotic, metals, and disinfectants. (biorxiv.org)

This is because they invariably consist of multi-gene loci which encode several enzymes that synthesise complex glycan structures. (ukri.org)
The genes encoding the seven enzymes needed to synthesize L-lysine from aspartate semialdehyde and pyruvate have been identified in a number of bacterial genera, with the single exception of the dapC gene encoding the PLP-dependent N-succinyl-L, L-diaminopimelate:alpha-ketoglutarate aminotransferase (DapATase). (unipr.it)

Pneumococcal pili have the appearance of flexible rods ranging from 0.3 μm to 3 μm that are formed by a transpeptidase reaction involving sortase-mediated covalent cross-linking of the proteins containing the LPXTG-like motif and several lines of evidence suggest a one-to-one sortase-to-surface-protein correspondence for the proteins encoded by the islet [ 7 ]. (biomedcentral.com)

Fink and his students showed that many genes related to amino acid biosynthesis were controlled by a single master regulator-the transcription factor Gcn4p. (genestogenomes.org)
Using the amino acid sequence from the Las encoded translocase, a homologous protein was identified in Ca. Liberibacter solanacearum (Lso), the bacterium associated with zebra chip disease. (usda.gov)
The gene, termed low-density lipoprotein receptor related protein 5 (LRP5), encodes a protein of 1615 amino acids that contains conserved modules which are characteristic of the low-density lipoprotein (LDL) receptor family. (nih.gov)
During cheese ripening, the bacterial strain Pediococcus acidilactici FAM18098 produces the non-proteinogenic amino acid, α-aminobutyrate (AABA). (springeropen.com)

The Last r Locus Unveiled: T4 RIII Is a Cytoplasmic Antiholin. (tamu.edu)
Bacterial two-hybrid assays and pulldown assays showed that RIII interacts with the cytoplasmic N terminus of T, which is a critical domain for holin function. (tamu.edu)
Here we report that the T4 gene rIII encodes a cytoplasmic antiholin that, together with the main antiholin, RI, inhibits holin T by forming a complex of three proteins spanning two cell compartments. (tamu.edu)

This was further supported by long-read sequencing of one representative XDR isolate, which revealed the presence of an integron carrying multiple resistance genes, including bla VIM-2 , with differences in gene composition and synteny to other P. aeruginosa class 1 integrons described before. (who.int)

Positional cloning demonstrated that HST is the Arabidopsis ortholog of the importin β-like nucleocytoplasmic transport receptors exportin 5 in mammals and MSN5 in yeast. (silverchair.com)

Transgene expression using viral vectors provides an alternative, which allows for temporal expression of genes in mice with reduced cost and effort. (nature.com)
This has led to the identification of various loci involved in development of viral infections. (biomedcentral.com)

Fink's work in the budding yeast Saccharomyces cerevisiae led to our deep understanding of gene expression control in eukaryotic metabolism. (genestogenomes.org)
Yeast transformation allowed the introduction of a DNA molecule from any organism into yeast cells and enabled the manipulation of the expression of those genes. (genestogenomes.org)
This research often requires the tissue-specific expression of transgenes to better mirror human diseases, to visualize pathways being studied or to modulate the expression of a disease-related gene. (nature.com)
Ptr1 was identified by cloning of candidate NLR-encoding genes located in the Ptr1 region and testing using Agrobacterium-mediated transient expression in Nicotiana glutinosa identified one gene for the ability to activate the plant immune system in response to AvrRpt2 in the presence of tomato Rin4. (cornell.edu)
Insights into H 2 O 2 -induced signaling in Jurkat cells from analysis of gene expression. (otago.ac.nz)
This clone was engineered to express the complete ORF with an expression tag. (origene.com)
Furthermore, this analyses confirmed the positive roles of CDK9 and Yorkie in regulating Mad-dependent gene expression in vivo. (sdbonline.org)
By activating the expression of genes whose products are required for metamorphosis, ecdysone and EcR-USP are essential for the reorganization of flies' body plans before emerging from pupal cases as adults. (sdbonline.org)
Transcriptional regulators enable the microbes to sense and respond to environmental stimuli, by altering gene expression. (frontiersin.org)
Community level coordination of gene expression is known as quorum sensing (QS). (frontiersin.org)
Here, we have conducted association analysis of this candidate gene region, and then investigated potential correlations between the most T1D-associated variant and RNA expression of the SLC11A1 gene and its splice isoform. (biomedcentral.com)
2006. An atlas of gene expression from seed to seed through barley development . (hutton.ac.uk)
Housekeeping genes in the FSCN1 - ACTB (F-A) locus (Fig. 1a ) have relatively steady expression levels across various tissues and thus exogenous gene silencing resulting from chromatin inactivation might be avoided. (biomedcentral.com)
Later studies confirmed that the RlrA protein acted as a transcription factor recognizing several promoters within the rlrA islet and showed it to be essential for wild-type levels of expression of the pili structural genes and associated sortases [ 6 ]. (biomedcentral.com)

B3GALT6 encoding an enzyme involved in the biosynthesis of the GAG linker region is responsible for a severe skeletal dysplasia, spondyloepimetaphyseal dysplasia with joint laxity type 1. (genscript.com)

1978. Appendix II: The bacterial mutation test. (cdc.gov)

The rlrA gene was identified in the original signature tagged mutagenesis study as an essential virulence gene in murine models of infection [ 5 ]. (biomedcentral.com)

syringae, glycinea, and tomato are encoded by an operon containing Yersinia ysc homologs and elicit the hypersensitive response in tomato but not soybean. (ox.ac.uk)
They cloned the HIS4 locus, yeast's best candidate for an operon and showed that it in fact encoded a single multifunctional protein, rather than multiple proteins under common regulation. (genestogenomes.org)

tomato DC3000 (bacterial speck of tomato). (ox.ac.uk)
In summary, the Ptr1 gene has the potential to become an important component (along with Pto) in controlling bacterial speck disease. (cornell.edu)

Our analysis identified 50 genes that will be useful for definitive phylogenetic classification of T . equi and closely related organisms. (biomedcentral.com)

The overexpression of a cloned rIII gene alone impeded T-mediated lysis temporarily. (tamu.edu)

The causal genes, variants and haplotypes involved within many of these regions have yet to be identified. (biomedcentral.com)

These are colinearly arranged genes in the virC locus of Yersinia spp. (ox.ac.uk)

In bacterial conjugation, DNA is transferred via cell-to-cell communication. (wikipedia.org)
CC118 pir was employed for the structure of pCol2, pCol4, and pCol9, and S17-1 pir was employed for reporter gene conjugation and research tests. (technuc.com)

Bacterial ATP/ADP translocases transport ATP from the host cell cytosol, across the lipid bilayer, and into the bacterial cell. (usda.gov)
Of the bacterial ATP/ADP translocases characterized thus far, all have been found in endosymbionts of protozoa or pathogens of higher order animals including humans. (usda.gov)

We examined the distribution of the pilus islet, using the presence of the rlrA gene as a marker for the locus, among a collection of invasive isolates recovered in Portugal and analyzed its association with capsular serotypes, clusters defined by the pulsed-field gel electrophoretic profiles (PFGE) and multilocus sequence types. (biomedcentral.com)

These subtypes are clinically indistinguishable from one another, except for the fact that patients with GSD type Ib have altered neutrophil functions predisposing them to gram-positive bacterial infections. (medscape.com)
The NOD allele was originally identified as providing resistance to bacterial infections in mice. (biomedcentral.com)

In a previous screen for deflagellation-defective mutants, we used insertional mutagenesis to tag affected genes for subsequent cloning and identification (Finst 1998). (healthcarecoremeasures.com)

As a test bed for the platform technology we will clone and express key glycans from the major zoonotic animal pathogens Streptococcus suis (serotype 2 capsular polysaccharides) and Brucella species (lipopolysaccharide, LPS) where we have proven expertise. (ukri.org)

The enhanced efficacy and exquisite specificity of SELECTIV has broad utility in development of new mouse model systems and expands the use of AAV for gene delivery in vivo. (nature.com)

Which Genes Have the Most Exons? (cshlpress.com)

The development of transgenic mouse models that express genes of interest in specific cell types has transformed our understanding of basic biology and disease. (nature.com)
Thus, this repair pathway causes a major safety problem for gene targeting strategies, particularly for gene therapy and transgenic animal production [ 15 , 16 ]. (biomedcentral.com)
Consequently, we determined the feasibility of using Cas9n-induced SSB to stimulate homology-directed repair (HDR) and therefore provided a safe alternative for gene insertion and transgenic animal generation. (biomedcentral.com)
After a systematic selection of target sites and transgenic colonies, we successfully obtained nine exogenous natural resistance-associated macrophage protein-1 ( NRAMP1 ) gene-inserted cows through the Cas9n strategy. (biomedcentral.com)

Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (genscript.com)
Linkage and congenic strain analyses using the nonobese diabetic (NOD) mouse as a model for human type 1 autoimmune diabetes (T1D) have identified several NOD mouse Idd (insulin dependent diabetes) loci, including Slc11a1 (formerly known as Nramp1 ). (biomedcentral.com)
The nonobese diabetic (NOD) mouse develops autoimmune insulin-dependent diabetes spontaneously, which resembles human T1D, and has been widely used to study and map non-MHC T1D loci. (biomedcentral.com)

Most of these CRAB isolates (77.62%) were classified as clone complex 92 (CC92), and sequence type (ST) 92 was the most prevalent STs, followed by ST195, ST136, ST843, and ST75. (frontiersin.org)

Ptr1 detection of AvrRpt2 activity suggests it likely encodes an NLR protein or possibly a guardee such as RIN4. (cornell.edu)
The protein encoded by Ptr1 has little similarity to RPS2 or Mr5, which suggests that Ptr1 is a third example of convergent evolution in different plant species for recognition of AvrRpt2. (cornell.edu)

We identified 379 combinations of the MLST loci (sequence types) and 215 combinations of the cell-surface components among these isolates, which had been obtained from human disease, animals, food, and the environment. (cdc.gov)
Sixty-seven of the 110 isolates (60.9%) were resistant to carbapenems, 80.60% (54/67) of which carried the bla OXA-23 gene. (frontiersin.org)

The ability to undergo natural transformation is present in at least 67 bacterial species. (wikipedia.org)
Natural transformation is common among pathogenic bacterial species. (wikipedia.org)
Bacterial transformation is carried out by numerous interacting bacterial gene products. (wikipedia.org)
Yeast transformation advanced the field by making it possible to do gene editing and targeting and paved the way for the commercial use of yeast as a factory for manufacturing vaccines and other chemicals. (genestogenomes.org)

However, pili were found to be encoded by the rlrA islet that was not universally distributed in the species. (biomedcentral.com)

In addition, inspired by Barbara McClintock's work on jumping genes in maize, Fink and his postdocs discovered that yeast transposable elements, known as Ty elements, move around the chromosomes through retrotransposition via an RNA intermediate. (genestogenomes.org)
Is Gene Density Uniform Across the Chromosomes? (cshlpress.com)
Do Gene-rich Chromosomes Have Smaller Genes? (cshlpress.com)

The encoded protein is secreted by cells of both the innate and adaptive immune systems. (origene.com)

While showing several structural and functional features typical for bacterial cellulose active LPMOs, Sc LPMO10D is only active on chitin. (nature.com)
Following sequence analysis discovered an open up reading body (ORF) of 369 bp matching towards the lectin structural gene, termed (3 later, 4) and right here renamed to conform with regular hereditary nomenclature. (technuc.com)

uses and and systems are program regulates the machine straight, thus providing general coordination of quorum sensing and temporal gene appearance in Colchicine supplier response to cell-to-cell conversation (31, 67). (technuc.com)

This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. (origene.com)

Anatomy29

Organisms14

Diseases2

Chemicals and Drugs29

Analytical, Diagnostic and Therapeutic Techniques and Equipment34

Phenomena and Processes106

Disciplines and Occupations2

Anthropology, Education, Sociology and Social Phenomena1

Technology, Industry, Agriculture3

Information Science4

Health Care3

Genomic9

Virulence genes3

Mutations10

Putative3

Genome12

Genomes7

Strains8

Antimicrobial resistance2

Pathogen3

Homologous recombination3

Chromosome7

Genetic9

Chromosomal1

Sequences3

Susceptibility2

Molecular4

Bacteria7

Pneumoniae3

Endogenous1

Antibiotic1

Enzymes2

Proteins encoded1

Amino4

Cytoplasmic3

Resistance genes1

Positional1

Viral2

Expression14

Biosynthesis1

Mutation1

Infection1

Operon2

Speck2

Phylogenetic1

Overexpression1

Causal1

Yersinia1

Conjugation2

Translocases2

Multilocus1

Infections2

19981

Pathogens1

Vivo1

Exons1

Transgenic4

Diabetes3

Sequence type1

Suggests2

Isolates2

Transformation4

Species1

Chromosomes3

Immune1

Structural2

Temporal1

Variants1